Y. Békro - Academia.edu (original) (raw)
Papers by Y. Békro
The appropriated type of formulation for an efficient bioavailability of phytocompounds (PCD) and... more The appropriated type of formulation for an efficient bioavailability of phytocompounds (PCD) and plant extracts still a huge challenge for scientists and pharmaceutical industries as extracts generally contain multiple of hydrophobic and hydrophilic substances with different solubility. Even though the richness of Solanum aethiopicum L. (Solanaceae) in bioactive substances has already been reported, never the crude extract (F0) has been used in a formulation in order to assess the best way of administration of the embedded phytochemicals. The aim of this work is firstly to manufacture an extract-based microemulsion (µEm Labrasol-F0), characterize its stability and secondly, to evaluate the anticancer activity of F0 on Jurkat cells. Dynamic light scattering (DLS) results show that the particles size distribution in F1-F4 is ranged from 128 ± 14.6 nm (0.1 µm) to 3862 772 nm (4 µm). Hygroscopic values in 97 % K2SO4 RH attest a better stability of µEm Labrasol-F0, F0-F4 moreover, F0 has anti-proliferative effect against Leukemia cancer cells.
Dans le but de valoriser les plantes à propriétés anti hypertensives, notre étude a porté sur deu... more Dans le but de valoriser les plantes à propriétés anti hypertensives, notre étude a porté sur deux d'entre elles: Milicia excelsa (Moraceae) (ME) et Musa paradisiaca (Musaceae) (MP). Les constituants chimiques identifiés dans ces plantes au moyen de la chromatographie sur couche mince (CCM) ont montré que l'extrait aqueux issu de MP contient des tanins, flavonoïdes (anthocyanes, flavones méthylées, hydroxyflavonols, quercétine), terpènes, stérols, coumarines (ombélliférone, daphnétine, 7-hydroxycoumarine, 7-hydroxy-6-alkoxycoumarine), triterpènes de type lupane, oléanane et ursane, génines et des saponines stéroïdes et triterpènes. Celui de ME renferme des tanins, flavonoïdes triterpènes de type lupane, oléanane et ursane, génines et des saponines stéroïdes. Les extraits aqueux de ME et de MP induisent des hypotensions dose-dépendant. Toutefois, celui de MP montre une efficacité plus accrue (DE 50 = 4,46 mg/kg de P.C). Abstract In the goal to valorize the plants with anti hypertensive properties, our survey was about two among them: Milicia excelsa (Moraceae) (ME) and Musa paradisiacal (Musaceae) (MP). The chemical constituents identified in these plants by means of thin layer chromatography (TLC) showed that the aqueous excerpt obtained from MP contains some tannins, flavonoids (anthocyanins, methylated flavones, hydroxyflavonols, quercetine), terpens, sterols, coumarins (ombelliferone, daphnetine, 7-hydroxycoumarin, 7-hydroxy-6-alkoxycoumarin), lupane, oleanane and ursane triterpens, genines, steroïdic and triterpenic saponins. The one of ME contains tannins, flavonoids (flavones, flavonols-3-glycoside, chalcones, rutines, anthocyanins, methylated flavones hydroxyflavonols, quercetine), terpens, sterols, coumarins (ombelliferone, angelicine), lupane, oléanane and ursane triterpens, genines and steroidic saponins. The aqueous extracts of ME and MP lead dose dependent hypotensions. However, the one of MP shows an efficiency more increased (ED 50 =4.46 mg/kg b. w.).
Phytothérapie, 2014
Le terme « cancer » caractérise un large éventail de pathologies impliquant une prolifération cel... more Le terme « cancer » caractérise un large éventail de pathologies impliquant une prolifération cellulaire anormalement importante et non régulée au sein d'un tissu normal de l'organisme. Les cellules se divisent et se développent de manière incontrôlée, formant des tumeurs malignes et envahissantes des zones proches.
The appropriated type of formulation for an efficient bioavailability of phytocompounds (PCD) and... more The appropriated type of formulation for an efficient bioavailability of phytocompounds (PCD) and plant extracts still a huge challenge for scientists and pharmaceutical industries as extracts generally contain multiple of hydrophobic and hydrophilic substances with different solubility. Even though the richness of Solanum aethiopicum L. (Solanaceae) in bioactive substances has already been reported, never the crude extract (F0) has been used in a formulation in order to assess the best way of administration of the embedded phytochemicals. The aim of this work is firstly to manufacture an extract-based microemulsion (µEm Labrasol-F0), characterize its stability and secondly, to evaluate the anticancer activity of F0 on Jurkat cells. Dynamic light scattering (DLS) results show that the particles size distribution in F1-F4 is ranged from 128 ± 14.6 nm (0.1 µm) to 3862 772 nm (4 µm). Hygroscopic values in 97 % K2SO4 RH attest a better stability of µEm Labrasol-F0, F0-F4 moreover, F0 has anti-proliferative effect against Leukemia cancer cells.
Dans le but de valoriser les plantes à propriétés anti hypertensives, notre étude a porté sur deu... more Dans le but de valoriser les plantes à propriétés anti hypertensives, notre étude a porté sur deux d'entre elles: Milicia excelsa (Moraceae) (ME) et Musa paradisiaca (Musaceae) (MP). Les constituants chimiques identifiés dans ces plantes au moyen de la chromatographie sur couche mince (CCM) ont montré que l'extrait aqueux issu de MP contient des tanins, flavonoïdes (anthocyanes, flavones méthylées, hydroxyflavonols, quercétine), terpènes, stérols, coumarines (ombélliférone, daphnétine, 7-hydroxycoumarine, 7-hydroxy-6-alkoxycoumarine), triterpènes de type lupane, oléanane et ursane, génines et des saponines stéroïdes et triterpènes. Celui de ME renferme des tanins, flavonoïdes triterpènes de type lupane, oléanane et ursane, génines et des saponines stéroïdes. Les extraits aqueux de ME et de MP induisent des hypotensions dose-dépendant. Toutefois, celui de MP montre une efficacité plus accrue (DE 50 = 4,46 mg/kg de P.C). Abstract In the goal to valorize the plants with anti hypertensive properties, our survey was about two among them: Milicia excelsa (Moraceae) (ME) and Musa paradisiacal (Musaceae) (MP). The chemical constituents identified in these plants by means of thin layer chromatography (TLC) showed that the aqueous excerpt obtained from MP contains some tannins, flavonoids (anthocyanins, methylated flavones, hydroxyflavonols, quercetine), terpens, sterols, coumarins (ombelliferone, daphnetine, 7-hydroxycoumarin, 7-hydroxy-6-alkoxycoumarin), lupane, oleanane and ursane triterpens, genines, steroïdic and triterpenic saponins. The one of ME contains tannins, flavonoids (flavones, flavonols-3-glycoside, chalcones, rutines, anthocyanins, methylated flavones hydroxyflavonols, quercetine), terpens, sterols, coumarins (ombelliferone, angelicine), lupane, oléanane and ursane triterpens, genines and steroidic saponins. The aqueous extracts of ME and MP lead dose dependent hypotensions. However, the one of MP shows an efficiency more increased (ED 50 =4.46 mg/kg b. w.).
Phytothérapie, 2014
Le terme « cancer » caractérise un large éventail de pathologies impliquant une prolifération cel... more Le terme « cancer » caractérise un large éventail de pathologies impliquant une prolifération cellulaire anormalement importante et non régulée au sein d'un tissu normal de l'organisme. Les cellules se divisent et se développent de manière incontrôlée, formant des tumeurs malignes et envahissantes des zones proches.