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Books by YOGENDRAKUMAR LAHIR

In the recent years, nanoparticles are being extensively studied due to their unique physico-chem... more In the recent years, nanoparticles are being extensively studied due to their unique physico-chemical properties of large surface to volume ratio. Hence, they are considered to be promising material in biology and medicine. This study reports on the effects of zinc oxide (ZnO) nanoparticles on hepatic tissue of chick embryo using histopathological techniques. The ZnO NPs were synthesized thermal plasma reactor by gas phase homogeneous condensation process and characterized using Transmission Electron Microscopy (TEM) and X-ray diffraction method. The average size of the ZnO NPs was found to be 25 nm. The histochemical study of hepatic tissues at the doses of ZnO NPs (50 and 150µg/g egg weight) showed the concentration dependant disorganization, loss of cellular integrity and physical nature of the tissues. The observations indicate the hepatotoxic nature of ZnO NPs in present model studied. The possible interference of ZnO NPs with hepatic tissue has been explored.

Papers by YOGENDRAKUMAR LAHIR

Journal of Experimental Zoology India

Advances in Clinical Toxicology, 2016

All cellular functions are primarily related to the behavior of the components of cell and its cy... more All cellular functions are primarily related to the behavior of the components of cell and its cytoskeleton. Cells in the various tissues respond to the sudden changes in their ambient environment may it be biochemical, physiological, molecular or physicochemical in nature. Cells become the ultimate target of these changes and face their derogative and stressful impacts. Cytoskeleton is primarily concerned with the temporal and spatial organizations in both prokaryotes and eukaryotes; these should be in the form of integrated, coordinated functional capabilities in order to perform their designated functions amicably. The functional aspects of cytoskeleton play essential roles in the deliverance of cellular responses under normal circumstances and also with respect to the changed and stressful stimuli. In these regards the components of cytoskeleton have to put an effort to deal with changed conditions. Cell membrane and cell organelles exhibit responses; these are related to cellular elasticity, mobility, adhesion, invasion, proliferation and differentiation, etc. Nanotechnology enables a series of nonmaterial’s to be synthesized/engineered with precise control over their physicochemical properties, surface modifications with respect to targeted moieties, charge modification, stealth aspects which may be ambiguous but features like size, shape, or other characters can be screened in accordance to the appropriate properties of target-specifications. The impacts of nonmaterial’s on biotic components are related to these features and may inflict biochemical, physiological and physic-physiological adverse effects on the eukaryotic cells. Fairly good amount of references are available on the interactions between nonmaterial’s and cells and cell organelles while there appears to be relatively less references pertaining to the interactions between nonmaterial’s and cytoskeleton; therefore, it was thought imperative to evaluate the impressions of nonmaterial’s on cytoskeleton of eukaryotic cells. In this review, overall impacts of nonmaterial’s on the structural and functional components of the cytoskeleton have been

Advances in Clinical Toxicology, 2016

Oxidation and reduction is a ubiquitous phenomenon reflecting the structural, functional aspects ... more Oxidation and reduction is a ubiquitous phenomenon reflecting the structural, functional aspects of cell, tissue, organ and organism. Primarily oxidative process in a biological system is the imprint of structural and functional integrity because of its role to maintain a state of healthy equilibrium. This homeostatic state is the result of combined and coordinated interactions between pro oxidants, antioxidants, inactivated free radicals and oxidants present in the cell. Proteins alone and in conjugated from are amongst those biomolecules which are basically devoted to cellular structural, functional, inter and intracellular communication. Electrochemical aspects of oxidation reduction are applicable to the oxidation of proteins. High energy radiations are capable to form free radicals of oxygen, when proteins are exposed to such free radicals gross modifications in amino acids and/or fragmentation of proteins occurs. Redox metabolism reflects on the functional aspects of proteome; there is every probability that any temporal and spatial fluctuations can direct the functional aspect of cell. Conditions like resistance to insulin, dysfunction of immune system and inflammatory responses are concerned with oxidative stress. Diseased conditions and senescence are parameters directly related to the declined efficiency of antioxidant system indicating oxidative stress. This in turn is capable to causes modifications in DNA, carbohydrates, proteins and lipids. In the recent past nanotechnology has attained significant importance due to its multidimensional potentials in almost all fields of life. The nanomaterials, natural as well as engineered, are sought after to solve most of the problems related to man-kind and industries. The physicochemical properties of nanomaterials are the basis of their applications in all spheres of life. In this presentation an effort is made to over view the developments in the field of nanomaterials that have taken place in the recent past and more over their impact on redox process and protein oxidation encompassing biological, biochemical, physiological, and pathological aspects in a biological system.

Advances in Clinical Toxicology, 2018

The cellular responses to stress are a complex phenomenon. These have faced varied impacts of the... more The cellular responses to stress are a complex phenomenon. These have faced varied impacts of the advancements in biomolecular, cellular and biomedical fields that have taken place from time to time. Nanotechnology and nanomaterials have played their major roles in these advanced achievements. The interactions between cells and the various nanomaterials are obvious due to fabricated and/or engineered nanomaterials that are designed with special features to attain specific set targets. These nanomaterials are utilized in varied modes such as drug carriers, remedial agents of environmental aspects, biotechnological and biomedical processes, implants, biosensors etc. The implications of these wonder materials in any biosystems, industrial processes and products etc ensure their interactions with cells. Nanomaterials are also capable to induce cellular stress in biosystem as they are the components of the products used in daily life. There are numerous biomolecules and the cellular processes that are involved in intra and intercellular communications. The cellular communication is the prime functional aspect for cell survival. The interaction between the cells and the nanomaterials are likely to influence this cellular communications and other cellular processes. These features in all probabilities affect cellular responses. Cellular responses are protective and/ or rendering the affected cells prone to necrosis or cellular death. Various nanomaterials with different reactive affinities are bound to influence the cellular responses with respect to the stress. This reflects on the needs to evaluate and understand the mechanism involved during the process of cellular stress and the related behavior.

Journal of Biomedical Research & Environmental Sciences, 2020

Viruses are at the threshold of living and nonliving entities. Virus particles exhibit life-activ... more Viruses are at the threshold of living and nonliving entities. Virus particles exhibit life-activities when are within their respective hosts and act as non-living when present outside their hosts. This feature is very interesting and the related investigations can help to understand the differences between the functionalities at bionanointerfaces under living and nonliving phases. Metal and metal oxide nanomaterials occur naturally and are synthesized as per the need to meet the set targets. These nanosized materials have specific physicochemical properties such as high volume to area ratio, ability to get functionalized as per the need. These ubiquitous materials have multifaceted applications in almost all fields of sciences, industries, medical, clinical diagnostics, and remedial operations; these occupy an omnipresent status in our day to day life. Since these nanomaterials are a major integral part of industries and human life; these interact with the abiotic and biotic compon...

CRC Press eBooks, May 12, 2022

Journal of Clinical Investigation, 1993

The membrane attack complex of complement (MAC) can induce reversible changes in cell membrane pe... more The membrane attack complex of complement (MAC) can induce reversible changes in cell membrane permeability resulting in significant but transient intracellular ionic changes in the absence of cell lysis. Because ion fluxes and cytosolic ionic changes are integral steps in the signaling cascade initiated when growth factors bind to their receptors, we hypothesized that the MAC-induced reversible changes in membrane permeability could stimulate cell proliferation. Using purified terminal complement components we have documented a mitogenic effect of the MAC for quiescent murine 3T3 cells. The MAC enhances the mitogenic effects of serum and PDGF, and also stimulates cell proliferation in the absence of other exogenous growth factors. MAC-induced mitogenesis represents a novel effect of the terminal complement complex that could contribute to focal tissue repair or pathological cell proliferation locally at sites of complement activation.

Journal of Ecophysiology and Occupational Health, 2011

This research paper reports on the effects of exposure of green mussel to sub lethal concentratio... more This research paper reports on the effects of exposure of green mussel to sub lethal concentrations of cadmium and zinc on GOT, GPT, ACP and ALP activities in the tissues of mantle, gill, hepatopancreas, adductor muscle, siphon, foot and gonad of Perna viridis. Exposure of sub lethal concentration of cadmium for 15 days resulted in the increase of GOT activity in all the tissues and was found to be the maximum in mantle and gonad but declined in hepatopancreas, siphon and foot. 30 days exposure of cadmium caused over all increase in GOT activity but the maximum was found to be in gonad although hepatopancreas and mantle showed higher levels of this activity. The GOT activity increased in all the tissues except in adductor muscle and the maximum in hepatopancreas and gonad as a result of exposure to lower concentration of zinc. Higher concentration of zinc for 30 days resulted in the increase in the activity in all the tissues but being higher in hepatopancreas, gill and gonad. GPT a...

ABSTARCT: Wereport on the interaction of ZnO nanoparticles (ZnO NPS) with human red blood cells i... more ABSTARCT: Wereport on the interaction of ZnO nanoparticles (ZnO NPS) with human red blood cells in relation to the osmotic fragility, hemolytic activity, cell integrity and morphology. Various microscopic techniques like fluorescence microscope, bright field and differential image contrast techniques have been used. Highest degree of osmotic fragility (in terms of hemolysis) was noticed at lower concentration of ZnOnano-particles and lowest/sensitive at higher concentrations. Changes in the morphological features of RBCs were noticed due to the interaction of ZnO NPs. Stability of RBCs was observed at lower concentration of ZnO NPs. Fluorescence study indicated concentration dependent interaction of ZnO NPs with RBCs. The overall results suggest that ZnO NPs are compatible to red blood cell at lower concentration. The possible mechanisms of interaction between ZnO NPs and RBCs have been described.

Oxidation in a biological system is primarily concerned with the energy balance and homeostasis o... more Oxidation in a biological system is primarily concerned with the energy balance and homeostasis of oxidants and antioxidants reflecting the structural, functional efficacy of the biological system in totality. This ubiquitous process is related to molecular and biochemical interactions at various levels in biological system. The lipid oxidation appears to be an effectively applicable parameter for investigation of structural, biochemical, physiological aspects of cell biology, medicine and food technology. When lipids in either combined or free forms get derogated specifically in food and other edible products like meat, fish and fish-products etc., a state of “off flavor” sets in rendering it unsuitable for use. Autoxidation, photo-oxidation and lipoxygenase activity, are the modes which accomplish the lipid oxidation although each occurs in varied conditions. Other factors which favor this process are the heavy metals and reactive species of oxygen and nitrogen produced due to eit...

This presentation is an improvement of our earlier version of “the solar powered coreless generat... more This presentation is an improvement of our earlier version of “the solar powered coreless generator”. It represents the combination of solar and wind power along with magnetic suspension. The prime features are the structural and functional aspects of the new version. There is an enhancement in the functionality of the point friction coreless generator. The degrees of scalability and performance have been improved in the present form of device. Keywords—Coreless generator; neodymium magnets; solar power; wind power; point friction; rotor; stator

ABSTRACT This paper reports on the meiofauna along the coast of TIFR which is comparatively prote... more ABSTRACT This paper reports on the meiofauna along the coast of TIFR which is comparatively protected due to security reasons of the location. TIFR coast being prohibited experiences least interference by human activities and it is encompassed within the naval area. The meiofauna observed in the sediment of the beach was heterogenous comprising of organisms between 45 to 500 µm in length. The sampling in this study was restricted to an area of 100 m, which was mostly rocky beach with a good number of sandy patches which were the source of sampling. Since the area under study is located on the coast of Mumbai, adjacent to a harbour and near a densely populated coastal area, the study of the population dynamics and biodiversity of the meiobenthos of the TIFR shore indicated that this shore is not highly disturbed ecologically. The analysis of samples revealed the presence of 6 groups of meiofauna namely; polychaetes, oligochaetes, nematodes, copepods, ostracods and ciliates. Polychaetes were found to be the dominant group followed by nematode and harpacticoid copepod.

Print ISSN 0974-0678, Online : 2320-9593, www.bionanofrontier.org ABSTRACT : In the recent years,... more Print ISSN 0974-0678, Online : 2320-9593, www.bionanofrontier.org ABSTRACT : In the recent years, nanoparticles are being extensively studied due to their unique physico-chemical properties of large surface to volume ratio. Hence, they are considered to be promising material in biology and medicine. This study reports on the effects of zinc oxide (ZnO) nanoparticles on hepatic tissue of chick embryo using histopathological techniques. The ZnO NPs were synthesized thermal plasma reactor by gas phase homogeneous condensation process and characterized using Transmission Electron Microscopy (TEM) and X-ray diffraction method. The average size of the ZnO NPs was found to be 25 nm. The histochemical study of hepatic tissues at the doses of ZnO NPs (50 and 150μg/g egg weight) showed the concentration dependant disorganization, loss of cellular integrity and physical nature of the tissues. The observations indicate the hepatotoxic nature of ZnO NPs in present model studied. The possible int...

Biochemical and Cellular Archives, 2009

The effects of sub-lethal concentration of nickel on the biochemical composition such as glycogen... more The effects of sub-lethal concentration of nickel on the biochemical composition such as glycogen, protein, cholesterol, lactic acid, pyruvic acid in gills, hepatopancreas, muscles and sugar contents along with haemolymph in female crab, Scylla serrata procured form local fish market in Mumbai (Sassoon Dock) were studied. The female crabs were exposed to sub-lethal dose of nickel LC and LC were 200ppm and 500ppm 0 50 respectively. Among the control set the glycogen contents were found to be the highest in muscles (44.616±0.225 mg/gm wt); protein contents were maximum in gills (66.5232±0.170 mf/gm wt); cholesterol contents were highest in ovary (2.009±0.006 mg/gm wt). The sub-lethal dose of nickel caused decline in the contents of glycogen (1.030±0.0141), protein (11.299±0.055), cholesterol (1.373±0.008) and pyruvic acid (0.440±0.195) in most of the tissues studied. The lactic acid contents increased in all the tissues studied in response to the exposure of nickel. The sugar and lact...

In the recent years, nanoparticles are being extensively studied due to their unique physico-chem... more In the recent years, nanoparticles are being extensively studied due to their unique physico-chemical properties of large surface to volume ratio. Hence, they are considered to be promising material in biology and medicine. This study reports on the effects of zinc oxide (ZnO) nanoparticles on hepatic tissue of chick embryo using histopathological techniques. The ZnO NPs were synthesized thermal plasma reactor by gas phase homogeneous condensation process and characterized using Transmission Electron Microscopy (TEM) and X-ray diffraction method. The average size of the ZnO NPs was found to be 25 nm. The histochemical study of hepatic tissues at the doses of ZnO NPs (50 and 150µg/g egg weight) showed the concentration dependant disorganization, loss of cellular integrity and physical nature of the tissues. The observations indicate the hepatotoxic nature of ZnO NPs in present model studied. The possible interference of ZnO NPs with hepatic tissue has been explored.

Journal of Experimental Zoology India

Advances in Clinical Toxicology, 2016

All cellular functions are primarily related to the behavior of the components of cell and its cy... more All cellular functions are primarily related to the behavior of the components of cell and its cytoskeleton. Cells in the various tissues respond to the sudden changes in their ambient environment may it be biochemical, physiological, molecular or physicochemical in nature. Cells become the ultimate target of these changes and face their derogative and stressful impacts. Cytoskeleton is primarily concerned with the temporal and spatial organizations in both prokaryotes and eukaryotes; these should be in the form of integrated, coordinated functional capabilities in order to perform their designated functions amicably. The functional aspects of cytoskeleton play essential roles in the deliverance of cellular responses under normal circumstances and also with respect to the changed and stressful stimuli. In these regards the components of cytoskeleton have to put an effort to deal with changed conditions. Cell membrane and cell organelles exhibit responses; these are related to cellular elasticity, mobility, adhesion, invasion, proliferation and differentiation, etc. Nanotechnology enables a series of nonmaterial’s to be synthesized/engineered with precise control over their physicochemical properties, surface modifications with respect to targeted moieties, charge modification, stealth aspects which may be ambiguous but features like size, shape, or other characters can be screened in accordance to the appropriate properties of target-specifications. The impacts of nonmaterial’s on biotic components are related to these features and may inflict biochemical, physiological and physic-physiological adverse effects on the eukaryotic cells. Fairly good amount of references are available on the interactions between nonmaterial’s and cells and cell organelles while there appears to be relatively less references pertaining to the interactions between nonmaterial’s and cytoskeleton; therefore, it was thought imperative to evaluate the impressions of nonmaterial’s on cytoskeleton of eukaryotic cells. In this review, overall impacts of nonmaterial’s on the structural and functional components of the cytoskeleton have been

Advances in Clinical Toxicology, 2016

Oxidation and reduction is a ubiquitous phenomenon reflecting the structural, functional aspects ... more Oxidation and reduction is a ubiquitous phenomenon reflecting the structural, functional aspects of cell, tissue, organ and organism. Primarily oxidative process in a biological system is the imprint of structural and functional integrity because of its role to maintain a state of healthy equilibrium. This homeostatic state is the result of combined and coordinated interactions between pro oxidants, antioxidants, inactivated free radicals and oxidants present in the cell. Proteins alone and in conjugated from are amongst those biomolecules which are basically devoted to cellular structural, functional, inter and intracellular communication. Electrochemical aspects of oxidation reduction are applicable to the oxidation of proteins. High energy radiations are capable to form free radicals of oxygen, when proteins are exposed to such free radicals gross modifications in amino acids and/or fragmentation of proteins occurs. Redox metabolism reflects on the functional aspects of proteome; there is every probability that any temporal and spatial fluctuations can direct the functional aspect of cell. Conditions like resistance to insulin, dysfunction of immune system and inflammatory responses are concerned with oxidative stress. Diseased conditions and senescence are parameters directly related to the declined efficiency of antioxidant system indicating oxidative stress. This in turn is capable to causes modifications in DNA, carbohydrates, proteins and lipids. In the recent past nanotechnology has attained significant importance due to its multidimensional potentials in almost all fields of life. The nanomaterials, natural as well as engineered, are sought after to solve most of the problems related to man-kind and industries. The physicochemical properties of nanomaterials are the basis of their applications in all spheres of life. In this presentation an effort is made to over view the developments in the field of nanomaterials that have taken place in the recent past and more over their impact on redox process and protein oxidation encompassing biological, biochemical, physiological, and pathological aspects in a biological system.

Advances in Clinical Toxicology, 2018

The cellular responses to stress are a complex phenomenon. These have faced varied impacts of the... more The cellular responses to stress are a complex phenomenon. These have faced varied impacts of the advancements in biomolecular, cellular and biomedical fields that have taken place from time to time. Nanotechnology and nanomaterials have played their major roles in these advanced achievements. The interactions between cells and the various nanomaterials are obvious due to fabricated and/or engineered nanomaterials that are designed with special features to attain specific set targets. These nanomaterials are utilized in varied modes such as drug carriers, remedial agents of environmental aspects, biotechnological and biomedical processes, implants, biosensors etc. The implications of these wonder materials in any biosystems, industrial processes and products etc ensure their interactions with cells. Nanomaterials are also capable to induce cellular stress in biosystem as they are the components of the products used in daily life. There are numerous biomolecules and the cellular processes that are involved in intra and intercellular communications. The cellular communication is the prime functional aspect for cell survival. The interaction between the cells and the nanomaterials are likely to influence this cellular communications and other cellular processes. These features in all probabilities affect cellular responses. Cellular responses are protective and/ or rendering the affected cells prone to necrosis or cellular death. Various nanomaterials with different reactive affinities are bound to influence the cellular responses with respect to the stress. This reflects on the needs to evaluate and understand the mechanism involved during the process of cellular stress and the related behavior.

Journal of Biomedical Research & Environmental Sciences, 2020

Viruses are at the threshold of living and nonliving entities. Virus particles exhibit life-activ... more Viruses are at the threshold of living and nonliving entities. Virus particles exhibit life-activities when are within their respective hosts and act as non-living when present outside their hosts. This feature is very interesting and the related investigations can help to understand the differences between the functionalities at bionanointerfaces under living and nonliving phases. Metal and metal oxide nanomaterials occur naturally and are synthesized as per the need to meet the set targets. These nanosized materials have specific physicochemical properties such as high volume to area ratio, ability to get functionalized as per the need. These ubiquitous materials have multifaceted applications in almost all fields of sciences, industries, medical, clinical diagnostics, and remedial operations; these occupy an omnipresent status in our day to day life. Since these nanomaterials are a major integral part of industries and human life; these interact with the abiotic and biotic compon...

CRC Press eBooks, May 12, 2022

Journal of Clinical Investigation, 1993

The membrane attack complex of complement (MAC) can induce reversible changes in cell membrane pe... more The membrane attack complex of complement (MAC) can induce reversible changes in cell membrane permeability resulting in significant but transient intracellular ionic changes in the absence of cell lysis. Because ion fluxes and cytosolic ionic changes are integral steps in the signaling cascade initiated when growth factors bind to their receptors, we hypothesized that the MAC-induced reversible changes in membrane permeability could stimulate cell proliferation. Using purified terminal complement components we have documented a mitogenic effect of the MAC for quiescent murine 3T3 cells. The MAC enhances the mitogenic effects of serum and PDGF, and also stimulates cell proliferation in the absence of other exogenous growth factors. MAC-induced mitogenesis represents a novel effect of the terminal complement complex that could contribute to focal tissue repair or pathological cell proliferation locally at sites of complement activation.

Journal of Ecophysiology and Occupational Health, 2011

This research paper reports on the effects of exposure of green mussel to sub lethal concentratio... more This research paper reports on the effects of exposure of green mussel to sub lethal concentrations of cadmium and zinc on GOT, GPT, ACP and ALP activities in the tissues of mantle, gill, hepatopancreas, adductor muscle, siphon, foot and gonad of Perna viridis. Exposure of sub lethal concentration of cadmium for 15 days resulted in the increase of GOT activity in all the tissues and was found to be the maximum in mantle and gonad but declined in hepatopancreas, siphon and foot. 30 days exposure of cadmium caused over all increase in GOT activity but the maximum was found to be in gonad although hepatopancreas and mantle showed higher levels of this activity. The GOT activity increased in all the tissues except in adductor muscle and the maximum in hepatopancreas and gonad as a result of exposure to lower concentration of zinc. Higher concentration of zinc for 30 days resulted in the increase in the activity in all the tissues but being higher in hepatopancreas, gill and gonad. GPT a...

ABSTARCT: Wereport on the interaction of ZnO nanoparticles (ZnO NPS) with human red blood cells i... more ABSTARCT: Wereport on the interaction of ZnO nanoparticles (ZnO NPS) with human red blood cells in relation to the osmotic fragility, hemolytic activity, cell integrity and morphology. Various microscopic techniques like fluorescence microscope, bright field and differential image contrast techniques have been used. Highest degree of osmotic fragility (in terms of hemolysis) was noticed at lower concentration of ZnOnano-particles and lowest/sensitive at higher concentrations. Changes in the morphological features of RBCs were noticed due to the interaction of ZnO NPs. Stability of RBCs was observed at lower concentration of ZnO NPs. Fluorescence study indicated concentration dependent interaction of ZnO NPs with RBCs. The overall results suggest that ZnO NPs are compatible to red blood cell at lower concentration. The possible mechanisms of interaction between ZnO NPs and RBCs have been described.

Oxidation in a biological system is primarily concerned with the energy balance and homeostasis o... more Oxidation in a biological system is primarily concerned with the energy balance and homeostasis of oxidants and antioxidants reflecting the structural, functional efficacy of the biological system in totality. This ubiquitous process is related to molecular and biochemical interactions at various levels in biological system. The lipid oxidation appears to be an effectively applicable parameter for investigation of structural, biochemical, physiological aspects of cell biology, medicine and food technology. When lipids in either combined or free forms get derogated specifically in food and other edible products like meat, fish and fish-products etc., a state of “off flavor” sets in rendering it unsuitable for use. Autoxidation, photo-oxidation and lipoxygenase activity, are the modes which accomplish the lipid oxidation although each occurs in varied conditions. Other factors which favor this process are the heavy metals and reactive species of oxygen and nitrogen produced due to eit...

This presentation is an improvement of our earlier version of “the solar powered coreless generat... more This presentation is an improvement of our earlier version of “the solar powered coreless generator”. It represents the combination of solar and wind power along with magnetic suspension. The prime features are the structural and functional aspects of the new version. There is an enhancement in the functionality of the point friction coreless generator. The degrees of scalability and performance have been improved in the present form of device. Keywords—Coreless generator; neodymium magnets; solar power; wind power; point friction; rotor; stator

ABSTRACT This paper reports on the meiofauna along the coast of TIFR which is comparatively prote... more ABSTRACT This paper reports on the meiofauna along the coast of TIFR which is comparatively protected due to security reasons of the location. TIFR coast being prohibited experiences least interference by human activities and it is encompassed within the naval area. The meiofauna observed in the sediment of the beach was heterogenous comprising of organisms between 45 to 500 µm in length. The sampling in this study was restricted to an area of 100 m, which was mostly rocky beach with a good number of sandy patches which were the source of sampling. Since the area under study is located on the coast of Mumbai, adjacent to a harbour and near a densely populated coastal area, the study of the population dynamics and biodiversity of the meiobenthos of the TIFR shore indicated that this shore is not highly disturbed ecologically. The analysis of samples revealed the presence of 6 groups of meiofauna namely; polychaetes, oligochaetes, nematodes, copepods, ostracods and ciliates. Polychaetes were found to be the dominant group followed by nematode and harpacticoid copepod.

Print ISSN 0974-0678, Online : 2320-9593, www.bionanofrontier.org ABSTRACT : In the recent years,... more Print ISSN 0974-0678, Online : 2320-9593, www.bionanofrontier.org ABSTRACT : In the recent years, nanoparticles are being extensively studied due to their unique physico-chemical properties of large surface to volume ratio. Hence, they are considered to be promising material in biology and medicine. This study reports on the effects of zinc oxide (ZnO) nanoparticles on hepatic tissue of chick embryo using histopathological techniques. The ZnO NPs were synthesized thermal plasma reactor by gas phase homogeneous condensation process and characterized using Transmission Electron Microscopy (TEM) and X-ray diffraction method. The average size of the ZnO NPs was found to be 25 nm. The histochemical study of hepatic tissues at the doses of ZnO NPs (50 and 150μg/g egg weight) showed the concentration dependant disorganization, loss of cellular integrity and physical nature of the tissues. The observations indicate the hepatotoxic nature of ZnO NPs in present model studied. The possible int...

Biochemical and Cellular Archives, 2009

The effects of sub-lethal concentration of nickel on the biochemical composition such as glycogen... more The effects of sub-lethal concentration of nickel on the biochemical composition such as glycogen, protein, cholesterol, lactic acid, pyruvic acid in gills, hepatopancreas, muscles and sugar contents along with haemolymph in female crab, Scylla serrata procured form local fish market in Mumbai (Sassoon Dock) were studied. The female crabs were exposed to sub-lethal dose of nickel LC and LC were 200ppm and 500ppm 0 50 respectively. Among the control set the glycogen contents were found to be the highest in muscles (44.616±0.225 mg/gm wt); protein contents were maximum in gills (66.5232±0.170 mf/gm wt); cholesterol contents were highest in ovary (2.009±0.006 mg/gm wt). The sub-lethal dose of nickel caused decline in the contents of glycogen (1.030±0.0141), protein (11.299±0.055), cholesterol (1.373±0.008) and pyruvic acid (0.440±0.195) in most of the tissues studied. The lactic acid contents increased in all the tissues studied in response to the exposure of nickel. The sugar and lact...