Ram Naresh Yadav - Academia.edu (original) (raw)
Papers by Ram Naresh Yadav
Department of Chemistry, Faculty of Engineering and Technology, Veer Bahadur Singh Purvanchal Uni... more Department of Chemistry, Faculty of Engineering and Technology, Veer Bahadur Singh Purvanchal University, Jaunpur-222 003, Uttar Pradesh Department of Molecular Pathology, The University of Texas-M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030, USA Department of Mathematics and Natural Sciences, College of Sciences and Human Studies, Prince Mohammad Bin Fahd University, Al Khobar, Kingdom of Saudi Arabia E-mail: bimalbanik10@gmail.com, bbanik@pmu.edu.sa Manuscript received online 18 May 2019, accepted 12 September 2019 The regiospecific intramolecular nucleophilic ring opening (INRO) of 2-azetidinones through ultrasound-mediated indium metal/ ammonium chloride-induced reduction of aromatic nitro functionality has been achieved at ambient temperature. This method has provided an efficient entry for the facile synthesis of benzo[1,4]-oxazine-2-one derivatives in aqueous ethanol.
Current Organocatalysis, 2022
Microwave technology, together with enzymatic catalysis is a nature-friendly chemical synthesis m... more Microwave technology, together with enzymatic catalysis is a nature-friendly chemical synthesis method with low wastage of solvent and good yield of the products. Enzymes from various microorganisms can be used in the biochemical processes of a wide range of compounds assisted by microwave irradiation In this work, the microwave-induced reaction of α-keto β-lactams by Baker's yeast in organic solvent was conducted to afford optically active cis and trans-α-hydroxy-β-lactams for the first time. These hydroxy compounds are the precursors of numerous natural products of medicinal significances.
![Research paper thumbnail of Iodine-Catalyzed Microwave-Induced Multicomponent Aza-Diels Alder [4+2] Cycloaddition Reaction: A Versatile Approach Towards Bicyclo-[2,2,2]-Octanones](https://attachments.academia-assets.com/83079742/thumbnails/1.jpg)
](Modern Chemistry & Applications
Molecular iodine-catalyzed microwave-assisted one-pot three components aza-Diels-Alder reaction h... more Molecular iodine-catalyzed microwave-assisted one-pot three components aza-Diels-Alder reaction has been investigated. This method has been used for an efficient synthesis of 2-azabicyclo-[2, 2, 2]-cyclooctanones.
Asian Journal of Chemistry, 2021
Surface mediated highly regioselective nitration of aromatic compounds under diverse microwaveind... more Surface mediated highly regioselective nitration of aromatic compounds under diverse microwaveinduced conditions was investigated in this work. The effects of the penetration depth of the surfaces were found to be more crucial than other dielectric parameters. Despite significant progress of microwave-induced reactions, no reports have examined the penetration depth of the surfaces used in these processes.
International Journal of Multidisciplinary Research and Development, 2016
International Journal of Multidisciplinary Research and Development, 2016
Women are practically untalented laborers and they confront difficult issues related to work, viz... more Women are practically untalented laborers and they confront difficult issues related to work, viz., wage separation, sex and lewd behavior, undesirable job relationship, lower wages; notwithstanding these, construction industry over whelming draws in female workers. Their aptitudes are never overhauled as they are permitted to perform just certain sorts of work and as a rule they help the male workforce. India is one of the speediest growing economies of the world. There are a few approaches received by Government of India for the advancement of framework for the country’s economic development. Construction industry is the key for the achievement of the globalization of Indian economy. Construction sector is giving work to 7% of aggregate world business. The discoveries of the investigation demonstrate that women workers are apparently empowered socially and economically through their association in corporate sector. In any case, female workers confront limitations from their male f...
Green Approaches in Medicinal Chemistry for Sustainable Drug Design
Abstract The organocatalysis is the process of using small organic molecules to accelerate the re... more Abstract The organocatalysis is the process of using small organic molecules to accelerate the reaction course without affecting the equilibrium position. The small organic compounds that have these catalytic effects are commonly referred to as organocatalysts. In recent years, the use of small organic molecules as catalysts has gained tremendous attention in the synthesis of complex organic molecules. The organocatalyzed reactions have several advantages over other existing transition metal or organometallic-mediated methodology for the asymmetric synthesis. This includes the use of less toxic, environmental benign and highly economical procedures. This present study intends to compile the exciting methods based on organocatalytic cycloaddition strategies for the synthesis of unique complex bioactive molecules and their application in the diverse fields.
Green Approaches in Medicinal Chemistry for Sustainable Drug Design
Abstract In chemistry one-pot synthesis is a technique that allows multiple chemical transformati... more Abstract In chemistry one-pot synthesis is a technique that allows multiple chemical transformations of substrates to target molecules in single reaction flask. This strategy is considered to be an attractive approach and widely accepted reaction strategy in synthetic organic chemistry. This protocol has several significant advantages over the conventional multistep reaction processes. The most important advantages of this protocol include high atom economy, less reaction time, minimum workup, and less separation of the products after each reaction. In this chapter, we wish to focus on various one-pot syntheses toward biologically relevant molecules and chemotherapeutics agents. This method also includes various catalytic operations that are performed in one-pot.
![Research paper thumbnail of Genetic Diversity in Cluster Bean [Cyamopsis tetragonoloba (L.) Taub.] for Morphological Characters](https://attachments.academia-assets.com/83079649/thumbnails/1.jpg)
](Indian Journal of Science and Technology
Thirty genotypes of cluster bean [Cyamopsis tetragonoloba (L.) Taub.] were assessed for genetic d... more Thirty genotypes of cluster bean [Cyamopsis tetragonoloba (L.) Taub.] were assessed for genetic divergence using Mahalanobis D 2 technique. These exhibited wide ranges of genetic diversity for all the characters and grouped into 5 different clusters. The maximum intra cluster distance was observed in cluster I indicated that genotypes under this group are diverse. Based on D 2 values, 30 genotypes were classified into five clusters. Maximum inter-cluster distance was between cluster I and cluster II and intra-cluster distance in cluster III, indicating the presence of genetic diversity among the genotypes between the cluster bean. The percent contribution towards genetic diversity was highest from days to maturity (37.87%) followed by pod yield (q/ha) (22.32%) and seed yield /plant (g). On the basis of inter-cluster distances and per cent performance observed in the present study, a hybridization programme involving genotypes for a specific character may be selected using cluster mean values.
JBMR Plus
Type 2 diabetes (T2D) adversely affects the normal functioning, intrinsic material properties, an... more Type 2 diabetes (T2D) adversely affects the normal functioning, intrinsic material properties, and structural integrity of many tissues, and bone fragility is one of them. To simulate human T2D and to investigate diabetic bone fragility, many rodent diabetic models have been developed. Still, an outbred genetically normal nonobese diabetic rat model is not available that can better simulate the disease characteristics of nonobese T2D patients, who have a high prevalence in Asia. In this study, we used a combination treatment of high‐fat diet (4 weeks, 58% kcal as fat) and low‐dose streptozotocin (STZ; 35 mg/kg i.p. at the end of the fourth week) to develop T2D in female Sprague‐Dawley (SD) rats. After 8 weeks of the establishment of the T2D model, the femoral bones were excised after euthanizing rats (animal age approximately 21 to 22 weeks; n = 10 with T2D, n = 10 without diabetes). The bone microstructure (μCT), mechanical, and material properties (three‐point bending, cyclic reference point indentation, nanoindentation), mean mineral crystallite size (XRD), bone composition (mineral‐to‐matrix ratio, nonenzymatic cross‐link ratio [NE‐xLR], Fourier transform‐infrared microspectroscopy), and total fluorescent advanced glycation end products were analyzed. We found that diabetic bone had reduced whole‐bone strength and compromised structural properties (μCT). The NE‐xLRs were elevated in the T2D group, and strongly and negatively correlated with postyield displacement, which suggests bone fragility was caused by a lack of glycation control. Along with that, the decreased mineral‐to‐matrix ratio and modulus, increased indentation distance increase, and wider mineral crystallite size in the T2D group were evidence that the diabetic bone composition and material properties had changed, and bone became weaker with a tendency to easily fracture. Altogether, this model simulates the natural history and metabolic characteristics of late‐stage T2D (insulin resistance and as disease progress develops, hypoinsulinemia) for nonobese young (and/or adolescent) T2D patients (Asians) and provides potential evidence of diabetic bone fragility at various organization levels. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
Current Organocatalysis
Ascorbic acid is the most well-known vitamin found in different types of food. It has tremendous ... more Ascorbic acid is the most well-known vitamin found in different types of food. It has tremendous medical applications in several different fields such as in pharmaceuticals, cosmetics, and in organic synthesis. Ascorbic acid can be used as a substrate or mediator in organic synthesis. In this review, we report ascorbic acid-catalyzed reactions in organic synthesis. Several examples are included in this review to demonstrate that ascorbic acid is a versatile catalyst for the synthesis of diverse organic compounds. Reactions catalyzed by ascorbic acid are performed in organic or aqueous media. The ready availability and easy handling features of ascorbic acid make these procedures highly fascinating.
Modern Chemistry & Applications, 2018
Modern Chemistry & Applications, 2018
Journal of Harmonized Research in Engineering
Introduction: Current era of engineering requires speed on each and every field. Hence rapidness ... more Introduction: Current era of engineering requires speed on each and every field. Hence rapidness and quick working is the most important. Now days for achieving rapidness, various machines and equipment's are manufactured. Gears are costly to manufacture. Its need to increase the efficiency of transmission which cannot be done using geared transmission. Gearless transmission mechanism is capable of transmitting power at any angle without any gears being manufactured. So here we introduced a mechanism which is very important defining application in replacement of gear. It is mainly based on the theoretical, analytical and Finite Element method. Figuring of various parameters such as number of pins, material,
Department of Chemistry, Faculty of Engineering and Technology, Veer Bahadur Singh Purvanchal Uni... more Department of Chemistry, Faculty of Engineering and Technology, Veer Bahadur Singh Purvanchal University, Jaunpur-222 003, Uttar Pradesh Department of Molecular Pathology, The University of Texas-M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030, USA Department of Mathematics and Natural Sciences, College of Sciences and Human Studies, Prince Mohammad Bin Fahd University, Al Khobar, Kingdom of Saudi Arabia E-mail: bimalbanik10@gmail.com, bbanik@pmu.edu.sa Manuscript received online 18 May 2019, accepted 12 September 2019 The regiospecific intramolecular nucleophilic ring opening (INRO) of 2-azetidinones through ultrasound-mediated indium metal/ ammonium chloride-induced reduction of aromatic nitro functionality has been achieved at ambient temperature. This method has provided an efficient entry for the facile synthesis of benzo[1,4]-oxazine-2-one derivatives in aqueous ethanol.
Current Organocatalysis, 2022
Microwave technology, together with enzymatic catalysis is a nature-friendly chemical synthesis m... more Microwave technology, together with enzymatic catalysis is a nature-friendly chemical synthesis method with low wastage of solvent and good yield of the products. Enzymes from various microorganisms can be used in the biochemical processes of a wide range of compounds assisted by microwave irradiation In this work, the microwave-induced reaction of α-keto β-lactams by Baker's yeast in organic solvent was conducted to afford optically active cis and trans-α-hydroxy-β-lactams for the first time. These hydroxy compounds are the precursors of numerous natural products of medicinal significances.
Modern Chemistry & Applications
Molecular iodine-catalyzed microwave-assisted one-pot three components aza-Diels-Alder reaction h... more Molecular iodine-catalyzed microwave-assisted one-pot three components aza-Diels-Alder reaction has been investigated. This method has been used for an efficient synthesis of 2-azabicyclo-[2, 2, 2]-cyclooctanones.
Asian Journal of Chemistry, 2021
Surface mediated highly regioselective nitration of aromatic compounds under diverse microwaveind... more Surface mediated highly regioselective nitration of aromatic compounds under diverse microwaveinduced conditions was investigated in this work. The effects of the penetration depth of the surfaces were found to be more crucial than other dielectric parameters. Despite significant progress of microwave-induced reactions, no reports have examined the penetration depth of the surfaces used in these processes.
International Journal of Multidisciplinary Research and Development, 2016
International Journal of Multidisciplinary Research and Development, 2016
Women are practically untalented laborers and they confront difficult issues related to work, viz... more Women are practically untalented laborers and they confront difficult issues related to work, viz., wage separation, sex and lewd behavior, undesirable job relationship, lower wages; notwithstanding these, construction industry over whelming draws in female workers. Their aptitudes are never overhauled as they are permitted to perform just certain sorts of work and as a rule they help the male workforce. India is one of the speediest growing economies of the world. There are a few approaches received by Government of India for the advancement of framework for the country’s economic development. Construction industry is the key for the achievement of the globalization of Indian economy. Construction sector is giving work to 7% of aggregate world business. The discoveries of the investigation demonstrate that women workers are apparently empowered socially and economically through their association in corporate sector. In any case, female workers confront limitations from their male f...
Green Approaches in Medicinal Chemistry for Sustainable Drug Design
Abstract The organocatalysis is the process of using small organic molecules to accelerate the re... more Abstract The organocatalysis is the process of using small organic molecules to accelerate the reaction course without affecting the equilibrium position. The small organic compounds that have these catalytic effects are commonly referred to as organocatalysts. In recent years, the use of small organic molecules as catalysts has gained tremendous attention in the synthesis of complex organic molecules. The organocatalyzed reactions have several advantages over other existing transition metal or organometallic-mediated methodology for the asymmetric synthesis. This includes the use of less toxic, environmental benign and highly economical procedures. This present study intends to compile the exciting methods based on organocatalytic cycloaddition strategies for the synthesis of unique complex bioactive molecules and their application in the diverse fields.
Green Approaches in Medicinal Chemistry for Sustainable Drug Design
Abstract In chemistry one-pot synthesis is a technique that allows multiple chemical transformati... more Abstract In chemistry one-pot synthesis is a technique that allows multiple chemical transformations of substrates to target molecules in single reaction flask. This strategy is considered to be an attractive approach and widely accepted reaction strategy in synthetic organic chemistry. This protocol has several significant advantages over the conventional multistep reaction processes. The most important advantages of this protocol include high atom economy, less reaction time, minimum workup, and less separation of the products after each reaction. In this chapter, we wish to focus on various one-pot syntheses toward biologically relevant molecules and chemotherapeutics agents. This method also includes various catalytic operations that are performed in one-pot.
Indian Journal of Science and Technology
Thirty genotypes of cluster bean [Cyamopsis tetragonoloba (L.) Taub.] were assessed for genetic d... more Thirty genotypes of cluster bean [Cyamopsis tetragonoloba (L.) Taub.] were assessed for genetic divergence using Mahalanobis D 2 technique. These exhibited wide ranges of genetic diversity for all the characters and grouped into 5 different clusters. The maximum intra cluster distance was observed in cluster I indicated that genotypes under this group are diverse. Based on D 2 values, 30 genotypes were classified into five clusters. Maximum inter-cluster distance was between cluster I and cluster II and intra-cluster distance in cluster III, indicating the presence of genetic diversity among the genotypes between the cluster bean. The percent contribution towards genetic diversity was highest from days to maturity (37.87%) followed by pod yield (q/ha) (22.32%) and seed yield /plant (g). On the basis of inter-cluster distances and per cent performance observed in the present study, a hybridization programme involving genotypes for a specific character may be selected using cluster mean values.
JBMR Plus
Type 2 diabetes (T2D) adversely affects the normal functioning, intrinsic material properties, an... more Type 2 diabetes (T2D) adversely affects the normal functioning, intrinsic material properties, and structural integrity of many tissues, and bone fragility is one of them. To simulate human T2D and to investigate diabetic bone fragility, many rodent diabetic models have been developed. Still, an outbred genetically normal nonobese diabetic rat model is not available that can better simulate the disease characteristics of nonobese T2D patients, who have a high prevalence in Asia. In this study, we used a combination treatment of high‐fat diet (4 weeks, 58% kcal as fat) and low‐dose streptozotocin (STZ; 35 mg/kg i.p. at the end of the fourth week) to develop T2D in female Sprague‐Dawley (SD) rats. After 8 weeks of the establishment of the T2D model, the femoral bones were excised after euthanizing rats (animal age approximately 21 to 22 weeks; n = 10 with T2D, n = 10 without diabetes). The bone microstructure (μCT), mechanical, and material properties (three‐point bending, cyclic reference point indentation, nanoindentation), mean mineral crystallite size (XRD), bone composition (mineral‐to‐matrix ratio, nonenzymatic cross‐link ratio [NE‐xLR], Fourier transform‐infrared microspectroscopy), and total fluorescent advanced glycation end products were analyzed. We found that diabetic bone had reduced whole‐bone strength and compromised structural properties (μCT). The NE‐xLRs were elevated in the T2D group, and strongly and negatively correlated with postyield displacement, which suggests bone fragility was caused by a lack of glycation control. Along with that, the decreased mineral‐to‐matrix ratio and modulus, increased indentation distance increase, and wider mineral crystallite size in the T2D group were evidence that the diabetic bone composition and material properties had changed, and bone became weaker with a tendency to easily fracture. Altogether, this model simulates the natural history and metabolic characteristics of late‐stage T2D (insulin resistance and as disease progress develops, hypoinsulinemia) for nonobese young (and/or adolescent) T2D patients (Asians) and provides potential evidence of diabetic bone fragility at various organization levels. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
Current Organocatalysis
Ascorbic acid is the most well-known vitamin found in different types of food. It has tremendous ... more Ascorbic acid is the most well-known vitamin found in different types of food. It has tremendous medical applications in several different fields such as in pharmaceuticals, cosmetics, and in organic synthesis. Ascorbic acid can be used as a substrate or mediator in organic synthesis. In this review, we report ascorbic acid-catalyzed reactions in organic synthesis. Several examples are included in this review to demonstrate that ascorbic acid is a versatile catalyst for the synthesis of diverse organic compounds. Reactions catalyzed by ascorbic acid are performed in organic or aqueous media. The ready availability and easy handling features of ascorbic acid make these procedures highly fascinating.
Modern Chemistry & Applications, 2018
Modern Chemistry & Applications, 2018
Journal of Harmonized Research in Engineering
Introduction: Current era of engineering requires speed on each and every field. Hence rapidness ... more Introduction: Current era of engineering requires speed on each and every field. Hence rapidness and quick working is the most important. Now days for achieving rapidness, various machines and equipment's are manufactured. Gears are costly to manufacture. Its need to increase the efficiency of transmission which cannot be done using geared transmission. Gearless transmission mechanism is capable of transmitting power at any angle without any gears being manufactured. So here we introduced a mechanism which is very important defining application in replacement of gear. It is mainly based on the theoretical, analytical and Finite Element method. Figuring of various parameters such as number of pins, material,