Yakir Anavi - Academia.edu (original) (raw)

Papers by Yakir Anavi

Oral Surgery Oral Medicine and Oral Pathology, Nov 30, 1990

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, Mar 31, 2003

Clear cells have been reported in approximately 8% of cases of calcifying epithelial odontogenic ... more Clear cells have been reported in approximately 8% of cases of calcifying epithelial odontogenic tumor (CEOT). The purpose of this study was to describe the clinical and radiographic features of clear-cell CEOT (CCEOT). Eighteen cases of CCEOT were identified by review of the literature from 1958 to 2001, and a new one was added (total 19; 12 central, 7 peripheral). Fourteen tumors (74%) were located in the mandible, with the central lesions favoring the posterior area and the peripheral lesions the anterior-bicuspid area. Radiographic features were as follows: 50% radiolucent, 50% mixed radiolucent-radiopaque; 92% unilocular; 64% well-defined noncorticated borders, 27% well-defined corticated borders, 9% irregular borders. Cortical perforation was common (67%) compared with CEOT without a clear-cell component (6.7%). Recurrence was reported in 17% of the central lesions and none of the peripheral ones. CCEOT is a distinct variant of CEOT; its high tendency for cortical perforation may indicate a more aggressive behavior.

Experimental Neurology, Oct 31, 1997

Golgi-Cox method and morphometric analyses were used to study the plasticity of striatal medium s... more Golgi-Cox method and morphometric analyses were used to study the plasticity of striatal medium spiny I neurons in 6-month-old C57BL/6N mice after unilateral or bilateral lesion of the cerebral cortex or combined lesions of the ipsilateral cerebral cortex and intralaminar thalamus. In adult mouse, unilateral lesions of the cerebral cortex did not result in a net gain or loss of linear dendritic length in a randomly selected population of striatal medium spiny I neurons. In addition, there was a well-defined time course of striatal spine loss and replacement occurring after a unilateral cortical lesion. By day 3 postlesion the average 20-microm dendritic segment had lost 30% of the unlesioned control spine value, reached its nadir, lost 45.5%, at 10 days postlesion, and recovered to 80% of unlesioned control levels by 20 days postlesion. The recovery of spines was blocked by a secondary lesion on the contralateral cortex but not on the ipsilateral intralaminar thalamus. These data suggest that striatal medium spiny I neurons of adult mice have a remarkable capacity for plasticity and reactive synaptogenesis following a decortication. The recovery of spine density is primarily induced by axonal sprouting of survival homologous afferent fibers from the contralateral cortex.

Oral Surgery Oral Medicine Oral Pathology, 1992

Journal of Oral and Maxillofacial Surgery, 1990

Develop Med Child Neurol, 2008

Gingival fibromatosis, a rare but often familial condition, is described in two siblings, associa... more Gingival fibromatosis, a rare but often familial condition, is described in two siblings, associated with mental retardation, epilepsy and hypertrichosis. In one child a maxillary giant-cell tumour was found and excised. It is important to distinguish idiopathic gingival fibromatosis from phenytoin-induced gingival hypertrophy.

The Journal of Comparative Neurology, Jun 15, 1992

The zona incerta has been implicated in the control of the initiation of saccadic eye movements i... more The zona incerta has been implicated in the control of the initiation of saccadic eye movements in the primate. Complex interactions within the zona incerta must take place to integrate its varied inputs and to produce a coherent efferent signal in order for this function to occur. However, whether the anatomical substrates exist within the zona incerta to allow this integration to take place has not been established. The zona incerta in monkeys (Macaca mulatta) was examined in frontally, horizontally, and sagittally sectioned preparations stained for Nissl, myelinated fibers, or cytochrome oxidase, or impregnated by the Golgi technique. This nucleus can be separated into dorsal and ventral laminae on the basis of staining and morphological differences between these two subdivisions. Neurons are more densely packed, more darkly stained, and larger in the ventral lamina. In addition, the neuropil of the ventral lamina is much more intensely stained after cytochrome oxidase histochemistry. Two neuronal types, principal cells and interneurons, were identified on the basis of neuronal cell body, dendritic, and axonal features in Golgi-impregnated preparations. Principal cells have fusiform or polygonal somata (long axis from 18 to 40 microns) and dendrites that extend for up to 750 microns within the lamina in which the cell bodies are located. Putative local interneurons have small (12-16 microns), round or oval cell bodies with wavy dendrites (up to 400 microns). Numerous multilobed appendages and axon-like processes originate from these dendrites and make apparent contacts with other interneurons or with dendrites of principal cells. Dendrites of most neurons in both laminae are oriented preferentially along the principal axis, dorsolateral-to-ventromedial, of the nucleus. Therefore, within the limits of light microscopy, the zona incerta appears to possess the morphological heterogeneity to form complex intrinsic interactions. These interactions are hypothesized to form the integrative substrate for the large array of incertal inputs that are utilized to produce an efferent signal involved in the initiation of saccadic eye movements.

CLINICAL PRESENTATION A 33-year-old woman presented with a painless swelling in the right submand... more CLINICAL PRESENTATION A 33-year-old woman presented with a painless swelling in the right submandibular region that had been enlarging pro-gressively over the past 1 and 1/2 years. There was no history of local trauma or infection, and the area did not change during meals. The medical and family histories were noncon-tributory. Physical examination revealed a soft, movable, poorly cir-cumscribed swelling measuring 5 5 cm in the right sub-mandibular area (Fig 1). The overlying skin appeared normal and did not appear to blanch significantly with compression of the mass. No bruit or thrill was detected. Intraorally, the floor of the mouth was nonelevated with a normal surface mucosa. Bimanual palpation elicited equivalent submandibu-lar salivary flow from both the right and left sides. Initial panoramic and mandibular occlusal radiographs failed to disclose any abnormal findings. On subsequent ul-trasound examination, the left submandibular gland appeared to be of normal size and echog...

Surgical Science, 2013

Objective: To evaluate the feasibility and effectiveness of a new approach for craniofacial augme... more Objective: To evaluate the feasibility and effectiveness of a new approach for craniofacial augmentation by a minimally-invasive subpericranial injection. Three commercially available semi-liquid bioceramic bone-grafting materials were examined for this application in a rat model. Material and Methods: Twenty-four adult male rats were randomly assigned to undergo onlay calvarial grafting by subpericranial injection of three semi-liquid bone void fillers: Norian SRS ® (calcium phosphate), ChronOs Inject TM (porous beta-tricalcium phosphate), or BonePlast ® (calcium sulfate). Two rats in each group were harvested after 24 hours to serve as controls. The rest were studied after 16 weeks. The volume fraction of the following parameters was morphometrically measured: new bone, blood vessels, residual bone filler and inflammation. Results: In all study groups (including controls), histological examination demonstrated that bone fillers were successfully delivered to the desired subpericranial space by the percutaneous injection method. New bone formation was evidenced adjacent to the cranial bone in all the study groups. The Norian filler material survived in a significantly higher volume fraction (38.4% ± 6.5%) than the ChronOs filler (18.8% ± 1.6%; P < 0.0001) and the BonePlast filler (17.8% ± 1.5%; P < 0.0001). New bone was formed in all groups, particularly adjacent to the interface of graft material with native bone but only to minimal extent. Conclusion: This new approach for craniomaxillofacial augmentation was successfully demonstrated in a rat model. The Norian filler (calcium phosphate) demonstrated superior space preservation abilities. This model may be further applied to test new injectable bone substitutes in the craniomaxillofacial area.

Annals of dentistry, 1993

Three cases of acinic cell carcinomas in minor salivary glands of the oral cavity are reported. T... more Three cases of acinic cell carcinomas in minor salivary glands of the oral cavity are reported. The tumors were slow-growing and asymptomatic and were treated by wide local excision. A long-term follow-up showed no metastasis. One patient had local recurrence. Generally, this malignant tumor has the potential to recur and metastasize many years after initial diagnosis and treatment. Total excision has been the established treatment of choice. The contribution of radiotherapy and chemotherapy remains unclear.

Oral surgery, oral medicine, oral pathology and oral radiology, 2013

Clinico-pathological evaluation of bisphosphonate (BP)-related osteonecrosis of jaws, comparison ... more Clinico-pathological evaluation of bisphosphonate (BP)-related osteonecrosis of jaws, comparison between oral (PO) and intravenous (IV) BPs and histomorphometric analysis of associated actinomyces. Retrospective clinical and histomorphometric analysis. Data on background, clinical, treatment and follow-up were analyzed. Actinomyces colonies were identified by typical filamentous colony morphology, Gram, and PAS stains. Colony density and relative colony surface area were measured. Fifty-two patients were included, 37 (71.2%) IV, 15 (28.8%) PO BPs. with a mean duration of 2.33 and, 4.33 years respectively. One hundred percent of cases exhibited actinomyces colonization. The relative colony surface area was significantly higher in PO treatment (P = .024), with no differences in density, healing time or antibiotic treatment periods. High frequency of diabetes mellitus (60% PO cases) and corticosteroid treatment (25% of cases) were recorded. Infection with actinomyces is a common denomi...

Ear, nose, & throat journal, 2005

The behavior of adenoid cystic carcinoma (ACC) of the salivary glands has been shown to be unpred... more The behavior of adenoid cystic carcinoma (ACC) of the salivary glands has been shown to be unpredictable in terms of local and distant spread and mortality. We retrospectively studied 35 operations in 34 patients who had had a pathologic diagnosis of ACC of the salivary glands and who had been treated over a 20-year period and followed for a minimum of 10 years. We analyzed the effect that different factors had on outcomes. The site of origin appeared to be an important factor in survival rates; survival among patients with tumors that had originated in the parotid gland was fairly good, while survival among those with tumors that originated in the minor salivary glands was significantly worse. TNM staging was another significant factor in survival. Other poor prognostic indicators were local spread, nodal positivity, distant metastasis, and local and regional recurrence. Radiation and chemotherapy did not appear to be beneficial for patients with advanced disease. We recommend radi...

Refuʾat ha-shinayim (Tel Aviv, Israel : 1983), 1991

International Journal of Oral and Maxillofacial Surgery, 2004

Ectomesenchymal chondromyxoid tumour (ECT) of the anterior tongue was first described in 1995 by ... more Ectomesenchymal chondromyxoid tumour (ECT) of the anterior tongue was first described in 1995 by SMITH et al. 3 The report included 19 tumours, all located in the anterior dorsal surface of the tongue underneath the lingual mucosa. The tumours were characterized histologically by circumscription and lobular proliferation of ovoid and fusiform cells, which often had multi-lobulated nuclei and occasional foci of atypia, in a chondromyxoid background. The immunohistochemical profile showed intense and diffuse positivity for glial fibrillary acidic protein (GFAP), and general reactivity for cytokeratin. There was variable staining for S-100 protein, smooth muscle actin (SMA) and CD-57 (Leu-7), but staining for desmin and epithelial membrane antigen (EMA) were negative. On

International Journal of Oral and Maxillofacial Surgery, 2003

Oral Surgery, Oral Medicine, Oral Pathology, 1986

A 51-year-old woman was referred because of swelling in the mandibular symphysis region and maloc... more A 51-year-old woman was referred because of swelling in the mandibular symphysis region and malocclusion.

Oral Surgery, Oral Medicine, Oral Pathology, 1990

Oral Surgery, Oral Medicine, Oral Pathology, 1992

Oral Surgery, Oral Medicine, Oral Pathology, 1991

Each month this section will bring to the reader of ORAL SURGERY, ORAL MEDICINE, AND ORAL PATHOLO... more Each month this section will bring to the reader of ORAL SURGERY, ORAL MEDICINE, AND ORAL PATHOLOGY information of practical relevance to the art and science of diagnostic imaging and diagnostic images with unusual interpretive features. Practical notes and radiographs will be accompanied by an explanation or inquiry. Please submit 5 X 7 inch glossy black-and-white prints of your illustrations. All materials for publication should be