Yakup Kumtepe - Academia.edu (original) (raw)

Papers by Yakup Kumtepe

Research paper thumbnail of Embryology

Human Reproduction, 2012

Univ Fed Sao Paulo, UNIFESP, Med Reprod Sao Paulo Hosp Santa Joana, Ctr Reprod Humana,Dept Gineco... more Univ Fed Sao Paulo, UNIFESP, Med Reprod Sao Paulo Hosp Santa Joana, Ctr Reprod Humana,Dept Ginecol,Huntington, Sao Paulo, BrazilGenesis Genet Brasil, Genet, Sao Paulo, BrazilHuntington Med Reprod, Embryol, Sao Paulo, BrazilHosp Santa Joana, Ctr Reprod Humana, Sao Paulo, BrazilUniv Sao Paulo, Ctr Reprod Humana Mario Covas, Med Reprod Sao Paulo Hosp Santa Joana, Huntington,Ctr Reprod Humana, BR-09500900 Sao Paulo, BrazilUniv Fed Sao Paulo, UNIFESP, Med Reprod Sao Paulo Hosp Santa Joana, Ctr Reprod Humana,Dept Ginecol,Huntington, Sao Paulo, BrazilWeb of Scienc

Research paper thumbnail of Measurement of Plasma Glutathione S-Transferase in Hepatocellular Damage in Pre-Eclampsia

Journal of International Medical Research, 2002

Glutathione S-transferase (GST) is a cytosolic enzyme found in high concentrations in the liver. ... more Glutathione S-transferase (GST) is a cytosolic enzyme found in high concentrations in the liver. We investigated the value of plasma GST measurements in pre-eclamptic patients. A total of 80 patients (40 in the pre-eclampsia group and 40 in the control group) were recruited. All patients were evaluated for GST, alanine aminotransferase (ALT), aspartate aminotransferase and lactate dehydrogenase. Pre-eclampsia was defined as the occurrence, after 20 weeks' gestation, of a diastolic blood pressure greater than 90 mmHg on two or more occasions at least 4 h apart, and concomitant proteinuria greater than 0.3 g/l over a 24-h urine collection period. There was no statistical difference between the pre-eclampsia and control groups in terms of ALT, gestational age, maternal age or number of previous pregnancies; a significant difference was found between the pre-eclampsia and control groups in terms of GST. Pre-eclampsia represents a significant cause of maternal and perinatal morbidity...

Research paper thumbnail of Prenatally Diagnosed Limb Body Wall Complex

In this report, a case of limb body wall complex (LBWC) diagnosed by ultrasonography is presented... more In this report, a case of limb body wall complex (LBWC) diagnosed by ultrasonography is presented. Differentiation of limb body wall complex from abdominal wall defects and evaluation of limb body wall complex in view of literature is cited. Ultrasonographic detection of abdominochisis, scoliosis, and abnormalities of the lower extremities is important for prenatal diagnosis of LBWC.

Research paper thumbnail of Gebelikte Görülen Uterus Rüptürüne BağlıMaternal ve Perinatal Sonuçlar

Research paper thumbnail of Management of Urinary Tract Endometriosis Patients by Gynecologists

Objective We aimed to report the postoperative outcomes of urinary tract endometriosis (UTE), whi... more Objective We aimed to report the postoperative outcomes of urinary tract endometriosis (UTE), which is a form of deep infiltrative endometriosis, and to contribute to the literature by presenting the obtained results. Material and Methods In the present study, 70 patients who underwent surgery for endometriosis at our clinic between 2005 and 2019 and had a diagnosis of UTE in the final pathological assessment were examined in detail. Patient information was retrospectively retrieved from the medical records. Data obtained pre-, peri-, and postoperatively were analyzed. Results Mean age of the 70 patients included according to the study criteria was 32.73 ± 7.09 years. Ureteral involvement alone was observed in 49% (n = 34) patients, bladder involvement alone was observed in 24% (n = 17) patients, and both bladder and ureteral involvement were observed in 27% (n = 19) patients. Microscopic hematuria was detected in 16% (n = 11) patients (16%), whereas preoperative urinary tract findi...

Research paper thumbnail of Comparison of two natural tissue repair-based surgical techniques; sacrospinous fixation and uterosacral ligament suspension for pelvic organ prolapse treatment

Journal of Gynecology Obstetrics and Human Reproduction, 2020

INTRODUCTION AND PURPOSE The present study aims to compare the effectiveness and perioperative re... more INTRODUCTION AND PURPOSE The present study aims to compare the effectiveness and perioperative results of the natural tissue repair-based treatments sacrospinous fixation (SSF) and uterosacral ligament suspension (USLS) based on the preoperative Pelvic Organ Prolapse Quantification system (POP-Q). MATERIALS AND METHODS Medical records of patients with stage ≥2 uterine prolapse between January 2011 and December 2016 were retrospectively examined. Preoperative POP-Q stages, demographic characteristics, perioperative results, and recurrence ratios in mid-term follow-up for patients were compared. RESULTS Overall, 235 patients were determined according to our study's inclusion criteria. A total of 155 patients underwent vaginal hysterectomy and USLS (VH/USLS), whereas 80 patients underwent vaginal hysterectomy and SSF (VH/SSF). There were no significant differences between groups in terms of body mass index (BMI), age, and parity as well as cardiovascular disease and diabetes mellitus. There was no significant difference in terms of anatomical success and clinical success rates in the postoperative follow-up period between both groups. (p = 0.588 and 0.692, respectively). However, the assessment of results based on preoperative stages of patients revealed that recurrence and anatomical failure were higher in the stage 4 group (p < 0.001). CONCLUSION Our findings indicate that the main determinant factor in evaluating recurrence rates is preoperative POP-Q staging of the patient. Recurrence rates significantly increase with disease stage. Consistent with studies that do not report a clear superiority for USLS or SSF, we observed no significant differences between both procedures in terms of recurrence. The effectiveness of these procedures is similar. We believe that prospective, long-term follow-up studies with larger populations are required to accurately identify preoperative risk factors and compare them with mesh techniques.

Research paper thumbnail of A Rare Case Report: A Malignant Histiocytic Tumor in the Form of Ovarian Mass

Case Reports in Obstetrics and Gynecology, 2018

Research paper thumbnail of Bilateral iliac artery aneurysm: A rare cause of postpartum recurrent hemorrhage

Journal of Turkish Society of Obstetric and Gynecology, 2020

Research paper thumbnail of Comparison of the harmonic scalpel with scissors in women who experience obturator nerve injury during lymph node dissection for gynaecological malignancies

Research paper thumbnail of Pregnancy Outcomes after Tubal Reanastomosis, 10-Year Experience at a Tertiary Center

Journal of Academic Research in Medicine, 2018

Research paper thumbnail of Primer amenore ve servikal agenezi ile görülen Herlyn-Werner-Wunderlich sendromu(HWWS),nadir bir olgu sunumu

Zeynep Kamil Tıp Bülteni, 2019

Research paper thumbnail of Serum endocan levels in endometrial and ovarian cancers

Journal of Clinical Laboratory Analysis, 2016

Ovarian and endometrial carcinomas are the two most common malignancies of the female reproductiv... more Ovarian and endometrial carcinomas are the two most common malignancies of the female reproductive system. Endocan is a proteoglycan that is specific to vascular endothelial cells. Increased serum levels have been reported in some tumors. The aim of this study was to investigate serum endocan levels in cases of endometrial and ovarian cancer.

Research paper thumbnail of Gebelikte Görülen Uterus Rüptürüne BağlıMaternal ve Perinatal Sonuçlar

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2005

Research paper thumbnail of Derin Pelvik Endometriozis

Turkiye Klinikleri Journal of Gynecology and Obstetrics Special Topics, 2010

Research paper thumbnail of İkinci Trimester Gebelik Sonlandırılmasında Misoprostol

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1996

Research paper thumbnail of Ekstrauterin Yerleşimli Rahim İçi Araçlara Yaklaşım

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2004

Research paper thumbnail of Evaluation of the effects of fulvestrant and micronized progesterone on the post-operative adhesion formation and ovarian reserve in rat model with immunohistochemical and biochemical analysis

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, Jan 18, 2015

To evaluate the effects of fulvestrant and micronized progesterone on post-operative adhesion for... more To evaluate the effects of fulvestrant and micronized progesterone on post-operative adhesion formation and ovarian reserve in a rat uterine horn adhesion. In this prospective randomized controlled trial, 32 female Wistar albino rats were randomly divided into four groups including control group (Group 1), the control adhesion group (Group 2), 1 mg/kg daily intramuscular fulvestrant received group (Group 3) and 1 mg/kg daily oral micronized progesterone received group (Group 4). The extent and severity of adhesions were scored and samples were taken from adhesion areas to investigate the grades of adhesions according to the immunohistochemical scoring system. Ovarian reserves were measured with anti-Müllerian hormone (AMH) and histological ovarian follicles count. The extent, severity and total adhesion scores were reduced in all treatment groups compared to control adhesion group (Group 2). Similarly, immunohistochemical adhesion scores were lower in the treatment groups. AMH and f...

Research paper thumbnail of Bir komplike over kisti olgusuna hidrodiseksiyon ile laparoskopik yaklaşım

Research paper thumbnail of Management and Patient Selection for BRCA Genetic Testing to Identify Women at Increased Risk for Breast and Ovarian Cancers: A Review

Research Journal of Medical Sciences, 2012

Research paper thumbnail of Investigation of the relationship of some antihypertensive drugs with oxidant/antioxidant parameters and DNA damage on rat uterus tissue

International journal of fertility & sterility, 2011

In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clon... more In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clonidine, methyldopa, amlodipine, ramipril and rilmenidine) on oxidant-antioxidant parameters and toxic effects on DNA in rat uterus tissue. In addition, uterus tissues were examined histopathologically. A total of 36 albino Wistar rats were divided into the following six groups: 0.075 mg/kg clonidine group; 100 mg/kg methyldopa group; 2 mg/kg amlodipine group; 2.5 mg/kg ramipril group; 0.5 mg/kg rilmenidine group; and the healthy group. Rats underwent chronic drug administration for 30 days and at the end, biochemical and histopathological examinations were performed. All data were subjected to one-way ANOVA test. We divided these drugs into the following three groups according to their effects on rat uteri: (I) mild negative effects (clonidine), (II) moderate negative effects (rilmenidine, methyldopa) and (III) drugs which had severe negative effects (amlodipine, ramipril). These data may...

Research paper thumbnail of Embryology

Human Reproduction, 2012

Univ Fed Sao Paulo, UNIFESP, Med Reprod Sao Paulo Hosp Santa Joana, Ctr Reprod Humana,Dept Gineco... more Univ Fed Sao Paulo, UNIFESP, Med Reprod Sao Paulo Hosp Santa Joana, Ctr Reprod Humana,Dept Ginecol,Huntington, Sao Paulo, BrazilGenesis Genet Brasil, Genet, Sao Paulo, BrazilHuntington Med Reprod, Embryol, Sao Paulo, BrazilHosp Santa Joana, Ctr Reprod Humana, Sao Paulo, BrazilUniv Sao Paulo, Ctr Reprod Humana Mario Covas, Med Reprod Sao Paulo Hosp Santa Joana, Huntington,Ctr Reprod Humana, BR-09500900 Sao Paulo, BrazilUniv Fed Sao Paulo, UNIFESP, Med Reprod Sao Paulo Hosp Santa Joana, Ctr Reprod Humana,Dept Ginecol,Huntington, Sao Paulo, BrazilWeb of Scienc

Research paper thumbnail of Measurement of Plasma Glutathione S-Transferase in Hepatocellular Damage in Pre-Eclampsia

Journal of International Medical Research, 2002

Glutathione S-transferase (GST) is a cytosolic enzyme found in high concentrations in the liver. ... more Glutathione S-transferase (GST) is a cytosolic enzyme found in high concentrations in the liver. We investigated the value of plasma GST measurements in pre-eclamptic patients. A total of 80 patients (40 in the pre-eclampsia group and 40 in the control group) were recruited. All patients were evaluated for GST, alanine aminotransferase (ALT), aspartate aminotransferase and lactate dehydrogenase. Pre-eclampsia was defined as the occurrence, after 20 weeks' gestation, of a diastolic blood pressure greater than 90 mmHg on two or more occasions at least 4 h apart, and concomitant proteinuria greater than 0.3 g/l over a 24-h urine collection period. There was no statistical difference between the pre-eclampsia and control groups in terms of ALT, gestational age, maternal age or number of previous pregnancies; a significant difference was found between the pre-eclampsia and control groups in terms of GST. Pre-eclampsia represents a significant cause of maternal and perinatal morbidity...

Research paper thumbnail of Prenatally Diagnosed Limb Body Wall Complex

In this report, a case of limb body wall complex (LBWC) diagnosed by ultrasonography is presented... more In this report, a case of limb body wall complex (LBWC) diagnosed by ultrasonography is presented. Differentiation of limb body wall complex from abdominal wall defects and evaluation of limb body wall complex in view of literature is cited. Ultrasonographic detection of abdominochisis, scoliosis, and abnormalities of the lower extremities is important for prenatal diagnosis of LBWC.

Research paper thumbnail of Gebelikte Görülen Uterus Rüptürüne BağlıMaternal ve Perinatal Sonuçlar

Research paper thumbnail of Management of Urinary Tract Endometriosis Patients by Gynecologists

Objective We aimed to report the postoperative outcomes of urinary tract endometriosis (UTE), whi... more Objective We aimed to report the postoperative outcomes of urinary tract endometriosis (UTE), which is a form of deep infiltrative endometriosis, and to contribute to the literature by presenting the obtained results. Material and Methods In the present study, 70 patients who underwent surgery for endometriosis at our clinic between 2005 and 2019 and had a diagnosis of UTE in the final pathological assessment were examined in detail. Patient information was retrospectively retrieved from the medical records. Data obtained pre-, peri-, and postoperatively were analyzed. Results Mean age of the 70 patients included according to the study criteria was 32.73 ± 7.09 years. Ureteral involvement alone was observed in 49% (n = 34) patients, bladder involvement alone was observed in 24% (n = 17) patients, and both bladder and ureteral involvement were observed in 27% (n = 19) patients. Microscopic hematuria was detected in 16% (n = 11) patients (16%), whereas preoperative urinary tract findi...

Research paper thumbnail of Comparison of two natural tissue repair-based surgical techniques; sacrospinous fixation and uterosacral ligament suspension for pelvic organ prolapse treatment

Journal of Gynecology Obstetrics and Human Reproduction, 2020

INTRODUCTION AND PURPOSE The present study aims to compare the effectiveness and perioperative re... more INTRODUCTION AND PURPOSE The present study aims to compare the effectiveness and perioperative results of the natural tissue repair-based treatments sacrospinous fixation (SSF) and uterosacral ligament suspension (USLS) based on the preoperative Pelvic Organ Prolapse Quantification system (POP-Q). MATERIALS AND METHODS Medical records of patients with stage ≥2 uterine prolapse between January 2011 and December 2016 were retrospectively examined. Preoperative POP-Q stages, demographic characteristics, perioperative results, and recurrence ratios in mid-term follow-up for patients were compared. RESULTS Overall, 235 patients were determined according to our study's inclusion criteria. A total of 155 patients underwent vaginal hysterectomy and USLS (VH/USLS), whereas 80 patients underwent vaginal hysterectomy and SSF (VH/SSF). There were no significant differences between groups in terms of body mass index (BMI), age, and parity as well as cardiovascular disease and diabetes mellitus. There was no significant difference in terms of anatomical success and clinical success rates in the postoperative follow-up period between both groups. (p = 0.588 and 0.692, respectively). However, the assessment of results based on preoperative stages of patients revealed that recurrence and anatomical failure were higher in the stage 4 group (p < 0.001). CONCLUSION Our findings indicate that the main determinant factor in evaluating recurrence rates is preoperative POP-Q staging of the patient. Recurrence rates significantly increase with disease stage. Consistent with studies that do not report a clear superiority for USLS or SSF, we observed no significant differences between both procedures in terms of recurrence. The effectiveness of these procedures is similar. We believe that prospective, long-term follow-up studies with larger populations are required to accurately identify preoperative risk factors and compare them with mesh techniques.

Research paper thumbnail of A Rare Case Report: A Malignant Histiocytic Tumor in the Form of Ovarian Mass

Case Reports in Obstetrics and Gynecology, 2018

Research paper thumbnail of Bilateral iliac artery aneurysm: A rare cause of postpartum recurrent hemorrhage

Journal of Turkish Society of Obstetric and Gynecology, 2020

Research paper thumbnail of Comparison of the harmonic scalpel with scissors in women who experience obturator nerve injury during lymph node dissection for gynaecological malignancies

Research paper thumbnail of Pregnancy Outcomes after Tubal Reanastomosis, 10-Year Experience at a Tertiary Center

Journal of Academic Research in Medicine, 2018

Research paper thumbnail of Primer amenore ve servikal agenezi ile görülen Herlyn-Werner-Wunderlich sendromu(HWWS),nadir bir olgu sunumu

Zeynep Kamil Tıp Bülteni, 2019

Research paper thumbnail of Serum endocan levels in endometrial and ovarian cancers

Journal of Clinical Laboratory Analysis, 2016

Ovarian and endometrial carcinomas are the two most common malignancies of the female reproductiv... more Ovarian and endometrial carcinomas are the two most common malignancies of the female reproductive system. Endocan is a proteoglycan that is specific to vascular endothelial cells. Increased serum levels have been reported in some tumors. The aim of this study was to investigate serum endocan levels in cases of endometrial and ovarian cancer.

Research paper thumbnail of Gebelikte Görülen Uterus Rüptürüne BağlıMaternal ve Perinatal Sonuçlar

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2005

Research paper thumbnail of Derin Pelvik Endometriozis

Turkiye Klinikleri Journal of Gynecology and Obstetrics Special Topics, 2010

Research paper thumbnail of İkinci Trimester Gebelik Sonlandırılmasında Misoprostol

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 1996

Research paper thumbnail of Ekstrauterin Yerleşimli Rahim İçi Araçlara Yaklaşım

Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2004

Research paper thumbnail of Evaluation of the effects of fulvestrant and micronized progesterone on the post-operative adhesion formation and ovarian reserve in rat model with immunohistochemical and biochemical analysis

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, Jan 18, 2015

To evaluate the effects of fulvestrant and micronized progesterone on post-operative adhesion for... more To evaluate the effects of fulvestrant and micronized progesterone on post-operative adhesion formation and ovarian reserve in a rat uterine horn adhesion. In this prospective randomized controlled trial, 32 female Wistar albino rats were randomly divided into four groups including control group (Group 1), the control adhesion group (Group 2), 1 mg/kg daily intramuscular fulvestrant received group (Group 3) and 1 mg/kg daily oral micronized progesterone received group (Group 4). The extent and severity of adhesions were scored and samples were taken from adhesion areas to investigate the grades of adhesions according to the immunohistochemical scoring system. Ovarian reserves were measured with anti-Müllerian hormone (AMH) and histological ovarian follicles count. The extent, severity and total adhesion scores were reduced in all treatment groups compared to control adhesion group (Group 2). Similarly, immunohistochemical adhesion scores were lower in the treatment groups. AMH and f...

Research paper thumbnail of Bir komplike over kisti olgusuna hidrodiseksiyon ile laparoskopik yaklaşım

Research paper thumbnail of Management and Patient Selection for BRCA Genetic Testing to Identify Women at Increased Risk for Breast and Ovarian Cancers: A Review

Research Journal of Medical Sciences, 2012

Research paper thumbnail of Investigation of the relationship of some antihypertensive drugs with oxidant/antioxidant parameters and DNA damage on rat uterus tissue

International journal of fertility & sterility, 2011

In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clon... more In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clonidine, methyldopa, amlodipine, ramipril and rilmenidine) on oxidant-antioxidant parameters and toxic effects on DNA in rat uterus tissue. In addition, uterus tissues were examined histopathologically. A total of 36 albino Wistar rats were divided into the following six groups: 0.075 mg/kg clonidine group; 100 mg/kg methyldopa group; 2 mg/kg amlodipine group; 2.5 mg/kg ramipril group; 0.5 mg/kg rilmenidine group; and the healthy group. Rats underwent chronic drug administration for 30 days and at the end, biochemical and histopathological examinations were performed. All data were subjected to one-way ANOVA test. We divided these drugs into the following three groups according to their effects on rat uteri: (I) mild negative effects (clonidine), (II) moderate negative effects (rilmenidine, methyldopa) and (III) drugs which had severe negative effects (amlodipine, ramipril). These data may...