Yani Triyani - Academia.edu (original) (raw)

Papers by Yani Triyani

Research paper thumbnail of Rancangan Primer Spesifik Gen Macrophage Mannose Receptor (MMR) Untuk Polymerase Chain Reaction (PCR) Dan Sekuensing Deoxyribo Nucleic Acid (Dna)

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY

The order (sequencing) determinationof DeoxyribonucleicAcid (DNA) bases is the gene's most ba... more The order (sequencing) determinationof DeoxyribonucleicAcid (DNA) bases is the gene's most basic information, using the methodof Polymerase Chain Reaction (PCR) as its stage. A key factor of successful detection by PCR is specific PCR primer design choice. Thedetection of diversity of Mycobacterium Mannose Receptor (MMR) gene, responsible for recognizing mannosylated antigen structureof Mycobacterium tuberculosis (M.tb) by DNA sequencing of exon 7 chromosome 10p12, related to susceptiblity for PulmonaryTuberculosis(TB), was first performed in China in 2012. The purpose of this study was to find specific primerfromboth design originatedfrom the research in China/primer I and my own design/primer IIby using Primer3 software. This study was based on 10 healthy subjectsand was a preliminary study of a research titled. The Relationship of Single Nucleotide Polymorphisms (SNPs) of Macrophage MannoseReceptor Gene to Pulmonary Tuberculosis Cases. The examination materials consist of 3 m...

Research paper thumbnail of Correlation between NLR and PLR with the Severity of COVID-19 Inpatients

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY

When the COVID-19 outbreak is ongoing, the classification of COVID-19 patients based on the sever... more When the COVID-19 outbreak is ongoing, the classification of COVID-19 patients based on the severity assessment is necessary to optimize the allocation of existing resources and early management interventions to improve prognosis. Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) are two of the most common, simple, inexpensive, rapid, and widely available tests in all health facilities, which indirectly indicate the inflammatory status of COVID-19 patients. This study aimed to analyze the correlation between NLR and PLR with the severity of COVID-19 inpatients. This cross-sectional study was conducted retrospectively using medical record data of COVID-19 patients hospitalized at Al Islam Hospital, Bandung, from January to March 2021. COVID-19 patients involved in this study were classified into moderate, severe, and critical degrees. Statistical analysis was carried out using ANOVA or Kruskal-Wallis and Spearman with a significant value of p < 0.05. The ...

Research paper thumbnail of Protective Effect of the T1212C Macrophage Mannose Receptor Gene Polymorphism on Pulmonary Tuberculosis

Global Medical & Health Communication (GMHC)

The interaction between the mannose receptor, which is encoded by the macrophage mannose receptor... more The interaction between the mannose receptor, which is encoded by the macrophage mannose receptor (MMR) gene, and the most virulent antigen (the mannose-capped lipoarabinomannan) cell wall of virulent strains of Mycobacterium tuberculosis trigger an innate and adaptive immune response. It also produces pro and anti-inflammatory cytokines, which play a role in the pathogenesis of tuberculosis (TB) infection. Therefore, MMR gene polymorphism is a risk factor and is associated with the prognosis for active pulmonary TB. This study aimed to determine the correlation between MMR gene polymorphism and active or latent pulmonary tuberculosis. In this phase, MMR gene polymorphism was analyzed using a case-control design consisting of 74 control group subjects (patients with latent TB) and 74 case groups (patients with active pulmonary TB). The subject’s MMR gene DNA sequencing examination. The study was conducted at the Teaching Hospital, Faculty of Medicine, Universitas Padjadjaran Bandun...

Research paper thumbnail of Peran Parameter Trombosit sebagai Biomarker Keparahan dan Prognosis Pasien Coronavirus Disease 2019

Jurnal Riset Kedokteran

Peningkatan risiko mortalitas pasien Coronavirus Disease 2019 (COVID-19) dengan gejala parah, ser... more Peningkatan risiko mortalitas pasien Coronavirus Disease 2019 (COVID-19) dengan gejala parah, sering dikaitkan dengan adanya badai sitokin. Badai sitokin dapat menyebabkan kerusakan sel progenitor bone marrow sehingga produksi trombosit berkurang menyebabkan trombositopenia. Tujuan penelitian ini untuk mengetahui peran parameter trombosit sebagai indikator potensial menilai derajat klinis pasien COVID-19. Penelitian ini menggunakan metode scoping review. Database yang digunakan yaitu PubMed, SpringerLink, dan ScienceDirect dengan jumlah artikel hasil pencarian sebanyak 788. Jumlah artikel yang sesuai dengan kriteria inklusi sebanyak 162. Hasil analisis 6 artikel yang di-review, 5 artikel menunjukkan bahwa hitung jumlah trombosit dapat menilai tingkat keparahan dan prognosis pada pasien COVID-19 serta 1 artikel menunjukkan bahwa nilai Mean Platelet Volume tidak berperan sebagai prediktor yang baik untuk tingkat keparahan penyakit COVID-19. Kesimpulan penelitian ini adalah parameter trombosit berperan sebagai biomarker keparahan dan prognosis pasien COVID-19. Hitung jumlah trombosit lebih efektif berperan sebagai biomarker keparahan dan prognosis pasien COVID-19 dibanding dengan Mean Platelet Volume, Plateletcrit, Platelet Distribution Width, dan Platelet Large Cell Ratio.

Research paper thumbnail of Perbandingan Cure Rate Obat-obat Antiskabies di Formularium Nasional dengan Non Formularium Nasional

Cermin Dunia Kedokteran

Skabies adalah penyakit kulit yang disebabkan oleh tungau Sarcoptes scabiei var hominis. Di Indon... more Skabies adalah penyakit kulit yang disebabkan oleh tungau Sarcoptes scabiei var hominis. Di Indonesia, skabies menduduki urutan ketiga dari 12 penyakit kulit tersering. Di antara sebelas faktor yang bisa memengaruhi prevalensi skabies di komunitas, salah satunya adalah kegagalan pengobatan. Penelitian ini bertujuan untuk mengetahui perbandingan cure rate obat-obat antiskabies di Formularium Nasional, yaitu Permethrin dan Salep 2–4 dengan Non Formularium Nasional seperti Benzyl Benzoate, Ivermectin, Gamma Benzene Hexachloride, Crotamiton, dan Tinospora cordifolia. Metode penelitian ini adalah scoping review dari September 2020–Desember 2020. Pencarian sistematis melalui database elektronik PubMed, Science Direct, Springer Link, Google Scholar, dan Cochrane sesuai kriteria inklusi dan eksklusi; skrining menggunakan kriteria PICOS (Pasien, Intervention, Comparison, Outcome, dan Study). Hasil pencarian adalah 15 artikel; 11 artikel menunjukkan bahwa Permethrin memiliki cure rate lebih t...

Research paper thumbnail of Gambaran Karakteristik Pasien Anemia dari Hasil Pemeriksaan Morfologi Apus Darah Tepi di RS Al-Islam Periode Juni−Desember 2016

Prosiding Pendidikan Dokter, Aug 10, 2017

Anemia adalah suatu kondisi yang ditandai dengan penurunan jumlah sel darah merah, sering diserta... more Anemia adalah suatu kondisi yang ditandai dengan penurunan jumlah sel darah merah, sering disertai dengan kadar hemoglobin (Hb) dan hematokrit (Ht) yang rendah atau perubahan morfologi pada sel darah merah. Terdapat beberapa faktor risiko anemia antara lain, sosial ekonomi rendah, usia, jenis kelamin dan tempat tinggal. Morfologi Apus Apus darah tepi (MADT) merupakan salah satu pemeriksaan laboratorium pada pasien dengan anemia dan memberikan informasi penting tentang sifat anemia. Tujuan Penelitian ini untuk mengetahui gambaran karakteristik pasien anemia dari hasil pemeriksaan morfologi apus darah tepi di RS Al-Islam periode Juni-Desember 2016. Penelitian ini merupakan penelitian observasional descriptive study dengan teknik total population sampling. Jumlah sampel yang diambil sebanyak 226 pasien dari 442 pasien dan data hasil interpretasi laboratorium patologi klinik dan data rekam medis pasien. Hasil penelitian diperoleh 226 pasien anemia dengan kelompok terbanyak pada usia dewasa yaitu sebanyak 79 pasien (46,9%), jenis kelamin perempuan sebanyak 129 pasien (57,1 %), alamat di kecamatan sebanyak 123 pasien (54,4%), Hb dengan kategori anemia berat sebanyak 125 pasien (55,3%), dan MADT dengan gambaran normokromik anisositosis sebanyak 105 pasien (46,5%).

Research paper thumbnail of Gambaran Konsumsi Merokok dan Tanggapan terhadap Pesan Bahaya Merokok pada Bungkus Rokok oleh Mahasiswa Fakultas Kedokteran Universitas Islam Bandung Tahun 2015-2016

Prosiding Pendidikan Dokter, Aug 11, 2016

Research paper thumbnail of Gambaran Karakteristik dan Faktor Risiko Bayi Lahir Dengan Hiperbilirubinemia di RS Al Islam Periode 2017

Prosiding Pendidikan Dokter, Aug 9, 2018

Research paper thumbnail of Perbandingan Karakteristik Anggota Keluarga Pasien TB Paru Aktif Pada Pemeriksaan Igra Positif dan Negatif

Prosiding Pendidikan Dokter, Aug 8, 2015

Tuberculosis (TB) is an infectious disease caused especially by Mycobacterium tuberculosis. Famil... more Tuberculosis (TB) is an infectious disease caused especially by Mycobacterium tuberculosis. Families of patients are in contact with active TB could become latent TB. People with latent TB has no clinical symptoms, although the bacteria inside his body remains alive but not active. Latent TB could become active and increase the incidence of active TB in the world, and this should be prevented. Latent TB could be detected by IGRA examination. The purpose of this study to compare the characteristic of the family members of active pulmonary TB in the positive and negative IGRA examination in UNPAD Education Hospital. The study is descriptive with cross sectional design. The subjects were taken from medical record of family members of active pulmonary TB patient in UNPAD Education Hospital periode March through October 2014. Data was analyzed with Chi Square Test.Results of this research showed percentage of IGRA positive (68.4%) is higher than IGRA negative (31.6%). Characteristics of family members of active pulmonary TB patient showed higher rate at age is 18-29 years (58.0%), male (50.9%) and normal BMI. The study is concluded the comparison between IGRA in age, gender and BMI was not significant with a p value> 0.05.

Research paper thumbnail of Gambaran Histopatologi Pasien BTA (+) dan (-) Biopsi Jaringan KGB

Prosiding Pendidikan Dokter, Jan 25, 2019

The most common type of Extrapulmonary tuberculosis (EPTB) is tuberculous lymphadenitis that atta... more The most common type of Extrapulmonary tuberculosis (EPTB) is tuberculous lymphadenitis that attacks the lymph nodes. EPTB can be diagnosed by clinical examination, histopathology, and bacteriology; but it is still a great challenge due to each method's weaknesses. The aim of this research is to determine the histopathological pattern and clinical symptoms of patients with positive and negative acid-fast bacilli (AFB) results from lymph nodes biopsies. This research is based on descriptive observations that were done in March-December 2018 at

Research paper thumbnail of Angka Kejadian dan Karakteristik Pasien Tb Laten pada Anggota Keluarga Pasien TB Aktif di Rumah Sakit Pendidikan Undap Periode 2014

Prosiding Pendidikan Dokter, Aug 9, 2015

According to World Health Organization (WHO) report in 2013, one-third of global population were ... more According to World Health Organization (WHO) report in 2013, one-third of global population were infected with latent tuberculosis and one more person would be infected with M. tuberculosis in every second. Latent tuberculosis is defined as a condition when a person is infected by M. tuberculosis but that person is not sick, does not have any symptoms and the thorax x-ray is normal. Interferon Gamma Release Assau (IGRA) test is one of those indicators in diagnosing latent tuberculosis. IGRA is a blood test to detect immune response toward M. tuberculosis inside the body. This Research is a small part of "The Relationship between Single Nucleotide Polymorphism (Snps) in Macrophage Mannose Receptor Gene with Lung Tuberculosis Incidence" research in February 2014. The research was carried out by using IGRA diagnosis to all active lung tuberculosis of patients' family. This research is a descriptive study and the sampling of latent tuberculosis patients' medical record in Education Hospital UNPAD in 2014. Therefore the secondary data is administered and sorted in a form of table. The aim of this research is to determine case and characteristics of latent tuberculosis patients. The result from 143 data showed that mostly latent tuberculosis patients were males there are 75 cases (52,4%), patients with normal BMI are 69 cases (48,3%) and the highest case are in productive age group, they are 83 cases (58,04%). In conclusion, this research showed that the majority of pulmonary tuberculosis patients are man, productive ages and BMI normal status.

Research paper thumbnail of Pengaruh Kebiasaan Merokok terhadap Kadar Hemoglobin dan Tingkat Kebugaran Jasmani pada Mahasiswa Fakultas Kedokteran Unisba

Prosiding Pendidikan Dokter, Aug 11, 2016

Smoking is a habit that can affect health , smoking behavior increase at the age above 15 years o... more Smoking is a habit that can affect health , smoking behavior increase at the age above 15 years old in Indonesia. Smoking can cause various diseases because the content in cigarrettes. Nicotine is a containt of cigarettes that can increase the resistance of the lungs for entry the air and carbon monoxide which can increase bond with oxygen, so it can reduce the physical fitness and increase hemoglobin. The purpose of this research was to analyze the effects of tobacco smoke due to levels hemogolobin and level of physical fitness on the students of the Medical Faculty in Bandung Islamic University.This research was an analytical study using cross-sectional method. The subjects of the research were the students of Medical Faculty of Bandung Islamic University that divided into 2 groups, 29 students smokers and 29 students non smokers. Samples chosen by simple random sampling method. This research was done by analyzing and the results of physical fitness test with Harvard Step Test method and results of hemoglobin levels with automated hemoglobin analyze. The results showed that smokers respondents have higher hemoglobin levels than non-smokers: 15.32 g/dL (smoker) and 14.60 g/dL (non-smoker), while the physical fitness level of the smokers respondent is lower than non-smokers: 87.5 (smoker) and 90 (nonsmoker).This research has been analyzed using normality test saphiro wilk test, Mann Whitney test and ttest independent which using confident interval 95% showed significant results p<0,05 with p value for effect of smoking on the level of hemoglobin: 0,008 and the level of physical fittnes: 0,004. The conclusion of this research that smoking habit can increase level of hemoglobin and reduce level of physical fitness.

Research paper thumbnail of Perbedaan Kadar Hemoglobin dan Hematokrit pada Mahasiswa Perokok dan Bukan Perokok di Fakultas Kedokteran Universitas Islam Bandung Periode 2015/2016

Prosiding Pendidikan Dokter, Aug 11, 2016

Most of the population in Indonesia are smokers. This habit causes some diseases like hypertensio... more Most of the population in Indonesia are smokers. This habit causes some diseases like hypertension and cardiac attack that become one of highest cause of fatality condition. Cause and risk factor this diseases are variative and one some of them are higher of hemoglobin and hematocrit level that can cause hemoconcentration and lead to occurred this condition. Increase of cigarette effect to hemoglobin and hematocrit level awareness be expected decrease smoker in population. Object of this study is to discover the different of hemoglobin and hematocrit level between smoker and non smoker person. The study is analytic observational with cross sectional method. The subjects were from male students of medical faculty Bandung Islamic university 2015/2016 bachelor medical educational program. The data obtained by Count Blood Cell examination of male students with inclusion criteria.Comparison was evaluated by parametric independent T-test. Result of this study showed hemoglobin and hematocrit level in smokers are 15,32 g/dL and 46,25% whereas in non smokers are 14,6 and 44,03% Result of this study also showed differentiation hemoglobin level between smoker and non smoker with (p=0,008). Differentiation hematocrit level are also found with (p=0,005). But nothing significant differences between hemoglobin and hematocrit level with the number of cigarette and long of smoking.

Research paper thumbnail of Gambaran Pola Terapi Penderita Limfadenitis Tuberkulosis di Rumah Sakit Al-Islam Bandung

Prosiding Pendidikan Dokter, Aug 9, 2018

Tuberculosis (TB) is a chronic infection caused by Mycobacterium Tuberculosis. Tuberculosis based... more Tuberculosis (TB) is a chronic infection caused by Mycobacterium Tuberculosis. Tuberculosis based on anatomical location is classified into two, namely pulmonary TB and extrapulmonary TB (TBEP). Location or organ most commonly affected is lymph node. Lymphadenitis TB becomes EPTB with the highest number of events. Lymphadenitis TB can be treated by taking a combination of at least four different medications. TB drug classification is divided into first and second line. This study aims to find out the description of theurapical patterns of lymphadenitis TB at Al-Islam Hospital in 2017. This research uses descriptive research design. The subjects used were lymphadenitis TB patients and the study material was taken from secondary data namely medical records at Al-Islam Hospital in 2017. Samples used were 22 data. The results in this study showed that as many as 9,1% were given first-line antituberculosis drugs therapy pattern and 90,9% were given second-line antituberculosis drugs. The most widely used pattern of therapy was second-line anti-tuberculosis drugs with combination 2 as many as 13 patients (59,1%). This can be caused by the patient's resistance.

Research paper thumbnail of Gambaran Keberhasilan Terapi Leukemia Limfoblastik Akut Anak Usia 0–15 Tahun Periode 2015–2017 Overview of the Success of Therapy for Acute Lymphoblastic Leukemia in Children Aged 0–15 in the Period 2015–2017

Prosiding Pendidikan Dokter, Jan 25, 2019

Research paper thumbnail of Hubungan Positivitas BTA Pada Jaringan Biopsi Dengan Gambaran Klinis Pada Pasien Limfadenitis Tuberkulosis

Prosiding Pendidikan Dokter, Jan 25, 2019

Research paper thumbnail of Scoping Review: Peran Rasio Neutrofil-Limfosit sebagai Biomarker pada Pasien HIV dengan Komorbid atau Tanpa Komorbid

Bandung Conference Series: Medical Science, 2021

Human Immunodeficiency Virus (HIV) is a virus that damages the function of immune cells. Laborato... more Human Immunodeficiency Virus (HIV) is a virus that damages the function of immune cells. Laboratory test that have become the gold standard for monitoring the progression of HIV stages are the examination of the CD4 T lymphocyte count. These test are expensive and trained technicians are not always available in some parts of Indonesia, making it impractical to use them for routine monitoring. The limitations of this examination cause the need for other laboratory tests that can be used as an alternative to the CD4 T lymphocyte count. The aim of this study was to determine the role of the neutrophil-lymphocyte ratio as a biomarker in comorbid and non-comorbid HIV patients. This study is a scoping review study, samples from international and national journals relating to the role of the neutrophillymphocyte ratio as a biomarker in HIV patients with comorbid or non-comorbid HIV. The databases used in this study were PubMed, Springer Link, and ProQuest with 1,170 articles. Screening results on articles that match the inclusion criteria were 714 articles. There were 699 articles that entered the exclusion criteria. The results of the eligibility criteria were obtained as many as 10 articles and then analyzed. The study was conducted during September-December 2020. The conclusion of this study is that the neutrophil-lymphocyte ratio in HIV-comorbid patients acts as a prognostic biomarker. Neutrophil-lymphocyte ratio in HIV patients without comorbids acts as a predictive biomarker and risk biomarker.

Research paper thumbnail of Scoping Review: Efektivitas Chest X-Ray Brixia Score untuk Menilai Derajat Keparahan COVID-19

Bandung Conference Series: Medical Science, 2022

The use of chest x-rays in Covid-19 pandemic has become an alternative radiological examination t... more The use of chest x-rays in Covid-19 pandemic has become an alternative radiological examination that is extensively carried out, although it is less sensitive, but is widely available and its use is mobile to detect lung abnormalities in Covid-19 patients using the brixia score assessment. The purpose of this study was to determine the effectiveness of chest x-rays using the brixia score to assess the severity of Covid-19. This research was taken by scoping review method with a sample of international scientific articles that meet the eligibility criteria. The databases used in this study are Spingerlink, Sciencedirect, Pubmed, Google scholar, and Proquest with the number of articles obtained as many as 833 articles. The results of the screening of articles that met the inclusion criteria were 275 articles and there were three articles that met the eligibility criteria. The results of the three reviewed articles, one article compared the use of chest x-ray and CT in detecting lesions of Covid-19 patients with the result that chest x-ray had low sensitivity. Two articles compared the brixia score in patients who died and discharged with higher outcomes in patients who died. The conclusion of this study shows that the use of chest x-rays is not effective for detecting earlystage abnormalities and the brixia score is effective for assessing the severity of Covid-19 patients.

Research paper thumbnail of Gambaran Faktor Risiko Maternal pada Kehamilan Trimester Pertama dan Jenis Celah Orofacial di YPPBL tahun 2017

Prosiding Pendidikan Dokter, Aug 9, 2018

The orofacial cleft is one of the most common congenital abnormalities in Indonesia. The occurren... more The orofacial cleft is one of the most common congenital abnormalities in Indonesia. The occurrence of this condition is due to impairment in the developmental process in the orofacial development section at 6th weeks of fetal development and is associated with a history of maternal conditions during pregnancy. There are several risk factors that can be modified and can't be modified. Based on this phenomenon, the problem in this research is formulated as follows: (1) How is the description of maternal risk factors modifiable and non-modifiable with children who have cleft lip and/or cleft palate in the 2017 Lip and Palate Creation Foundation?. Researcher using analytic observational research design with cross sectional approach. The sampling method is simple random sampling. The samples used are from questionnaire data which fulfill the inclusion criteria that available in the administrative part of Orofacial Cleft Coach Foundation Bandung during 2017. The analysis was done using univariate formula. In this research showed from 74 data, the dominant type of orofacial cleft is Cleft Lip and Palate (71%), most of the maternal risk factors that can not be modified during the first trimester of pregnancy are the age of the mother mostly 20-25 years old at 24% and 77% had no family history with orofacial cleft abnormalities, while the dominance of risk factors that can be modified is from the history of maternal folic acid consumption amounted to 71% of pregnant women did not consume folic acid, smoking 3%, intrauterine infection 3%, 91% mother done ANC, 23% had the same family history, using other drugs 47%, fever 1%, trauma 18%, exposure from working place 31% and 36% working as employee. Conclusion, cleft lip and palate is the most common type of orofacial cleft that occur, most of the mother was pregnant in the age of 20-25 years old and didn't consume folic acid in the first trimester of pregnancy.

Research paper thumbnail of Understanding Scabies in Religious Boarding School (Pesantren)

Proceedings of the Social and Humaniora Research Symposium (SoRes 2018), 2019

Research paper thumbnail of Rancangan Primer Spesifik Gen Macrophage Mannose Receptor (MMR) Untuk Polymerase Chain Reaction (PCR) Dan Sekuensing Deoxyribo Nucleic Acid (Dna)

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY

The order (sequencing) determinationof DeoxyribonucleicAcid (DNA) bases is the gene's most ba... more The order (sequencing) determinationof DeoxyribonucleicAcid (DNA) bases is the gene's most basic information, using the methodof Polymerase Chain Reaction (PCR) as its stage. A key factor of successful detection by PCR is specific PCR primer design choice. Thedetection of diversity of Mycobacterium Mannose Receptor (MMR) gene, responsible for recognizing mannosylated antigen structureof Mycobacterium tuberculosis (M.tb) by DNA sequencing of exon 7 chromosome 10p12, related to susceptiblity for PulmonaryTuberculosis(TB), was first performed in China in 2012. The purpose of this study was to find specific primerfromboth design originatedfrom the research in China/primer I and my own design/primer IIby using Primer3 software. This study was based on 10 healthy subjectsand was a preliminary study of a research titled. The Relationship of Single Nucleotide Polymorphisms (SNPs) of Macrophage MannoseReceptor Gene to Pulmonary Tuberculosis Cases. The examination materials consist of 3 m...

Research paper thumbnail of Correlation between NLR and PLR with the Severity of COVID-19 Inpatients

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY

When the COVID-19 outbreak is ongoing, the classification of COVID-19 patients based on the sever... more When the COVID-19 outbreak is ongoing, the classification of COVID-19 patients based on the severity assessment is necessary to optimize the allocation of existing resources and early management interventions to improve prognosis. Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) are two of the most common, simple, inexpensive, rapid, and widely available tests in all health facilities, which indirectly indicate the inflammatory status of COVID-19 patients. This study aimed to analyze the correlation between NLR and PLR with the severity of COVID-19 inpatients. This cross-sectional study was conducted retrospectively using medical record data of COVID-19 patients hospitalized at Al Islam Hospital, Bandung, from January to March 2021. COVID-19 patients involved in this study were classified into moderate, severe, and critical degrees. Statistical analysis was carried out using ANOVA or Kruskal-Wallis and Spearman with a significant value of p < 0.05. The ...

Research paper thumbnail of Protective Effect of the T1212C Macrophage Mannose Receptor Gene Polymorphism on Pulmonary Tuberculosis

Global Medical & Health Communication (GMHC)

The interaction between the mannose receptor, which is encoded by the macrophage mannose receptor... more The interaction between the mannose receptor, which is encoded by the macrophage mannose receptor (MMR) gene, and the most virulent antigen (the mannose-capped lipoarabinomannan) cell wall of virulent strains of Mycobacterium tuberculosis trigger an innate and adaptive immune response. It also produces pro and anti-inflammatory cytokines, which play a role in the pathogenesis of tuberculosis (TB) infection. Therefore, MMR gene polymorphism is a risk factor and is associated with the prognosis for active pulmonary TB. This study aimed to determine the correlation between MMR gene polymorphism and active or latent pulmonary tuberculosis. In this phase, MMR gene polymorphism was analyzed using a case-control design consisting of 74 control group subjects (patients with latent TB) and 74 case groups (patients with active pulmonary TB). The subject’s MMR gene DNA sequencing examination. The study was conducted at the Teaching Hospital, Faculty of Medicine, Universitas Padjadjaran Bandun...

Research paper thumbnail of Peran Parameter Trombosit sebagai Biomarker Keparahan dan Prognosis Pasien Coronavirus Disease 2019

Jurnal Riset Kedokteran

Peningkatan risiko mortalitas pasien Coronavirus Disease 2019 (COVID-19) dengan gejala parah, ser... more Peningkatan risiko mortalitas pasien Coronavirus Disease 2019 (COVID-19) dengan gejala parah, sering dikaitkan dengan adanya badai sitokin. Badai sitokin dapat menyebabkan kerusakan sel progenitor bone marrow sehingga produksi trombosit berkurang menyebabkan trombositopenia. Tujuan penelitian ini untuk mengetahui peran parameter trombosit sebagai indikator potensial menilai derajat klinis pasien COVID-19. Penelitian ini menggunakan metode scoping review. Database yang digunakan yaitu PubMed, SpringerLink, dan ScienceDirect dengan jumlah artikel hasil pencarian sebanyak 788. Jumlah artikel yang sesuai dengan kriteria inklusi sebanyak 162. Hasil analisis 6 artikel yang di-review, 5 artikel menunjukkan bahwa hitung jumlah trombosit dapat menilai tingkat keparahan dan prognosis pada pasien COVID-19 serta 1 artikel menunjukkan bahwa nilai Mean Platelet Volume tidak berperan sebagai prediktor yang baik untuk tingkat keparahan penyakit COVID-19. Kesimpulan penelitian ini adalah parameter trombosit berperan sebagai biomarker keparahan dan prognosis pasien COVID-19. Hitung jumlah trombosit lebih efektif berperan sebagai biomarker keparahan dan prognosis pasien COVID-19 dibanding dengan Mean Platelet Volume, Plateletcrit, Platelet Distribution Width, dan Platelet Large Cell Ratio.

Research paper thumbnail of Perbandingan Cure Rate Obat-obat Antiskabies di Formularium Nasional dengan Non Formularium Nasional

Cermin Dunia Kedokteran

Skabies adalah penyakit kulit yang disebabkan oleh tungau Sarcoptes scabiei var hominis. Di Indon... more Skabies adalah penyakit kulit yang disebabkan oleh tungau Sarcoptes scabiei var hominis. Di Indonesia, skabies menduduki urutan ketiga dari 12 penyakit kulit tersering. Di antara sebelas faktor yang bisa memengaruhi prevalensi skabies di komunitas, salah satunya adalah kegagalan pengobatan. Penelitian ini bertujuan untuk mengetahui perbandingan cure rate obat-obat antiskabies di Formularium Nasional, yaitu Permethrin dan Salep 2–4 dengan Non Formularium Nasional seperti Benzyl Benzoate, Ivermectin, Gamma Benzene Hexachloride, Crotamiton, dan Tinospora cordifolia. Metode penelitian ini adalah scoping review dari September 2020–Desember 2020. Pencarian sistematis melalui database elektronik PubMed, Science Direct, Springer Link, Google Scholar, dan Cochrane sesuai kriteria inklusi dan eksklusi; skrining menggunakan kriteria PICOS (Pasien, Intervention, Comparison, Outcome, dan Study). Hasil pencarian adalah 15 artikel; 11 artikel menunjukkan bahwa Permethrin memiliki cure rate lebih t...

Research paper thumbnail of Gambaran Karakteristik Pasien Anemia dari Hasil Pemeriksaan Morfologi Apus Darah Tepi di RS Al-Islam Periode Juni−Desember 2016

Prosiding Pendidikan Dokter, Aug 10, 2017

Anemia adalah suatu kondisi yang ditandai dengan penurunan jumlah sel darah merah, sering diserta... more Anemia adalah suatu kondisi yang ditandai dengan penurunan jumlah sel darah merah, sering disertai dengan kadar hemoglobin (Hb) dan hematokrit (Ht) yang rendah atau perubahan morfologi pada sel darah merah. Terdapat beberapa faktor risiko anemia antara lain, sosial ekonomi rendah, usia, jenis kelamin dan tempat tinggal. Morfologi Apus Apus darah tepi (MADT) merupakan salah satu pemeriksaan laboratorium pada pasien dengan anemia dan memberikan informasi penting tentang sifat anemia. Tujuan Penelitian ini untuk mengetahui gambaran karakteristik pasien anemia dari hasil pemeriksaan morfologi apus darah tepi di RS Al-Islam periode Juni-Desember 2016. Penelitian ini merupakan penelitian observasional descriptive study dengan teknik total population sampling. Jumlah sampel yang diambil sebanyak 226 pasien dari 442 pasien dan data hasil interpretasi laboratorium patologi klinik dan data rekam medis pasien. Hasil penelitian diperoleh 226 pasien anemia dengan kelompok terbanyak pada usia dewasa yaitu sebanyak 79 pasien (46,9%), jenis kelamin perempuan sebanyak 129 pasien (57,1 %), alamat di kecamatan sebanyak 123 pasien (54,4%), Hb dengan kategori anemia berat sebanyak 125 pasien (55,3%), dan MADT dengan gambaran normokromik anisositosis sebanyak 105 pasien (46,5%).

Research paper thumbnail of Gambaran Konsumsi Merokok dan Tanggapan terhadap Pesan Bahaya Merokok pada Bungkus Rokok oleh Mahasiswa Fakultas Kedokteran Universitas Islam Bandung Tahun 2015-2016

Prosiding Pendidikan Dokter, Aug 11, 2016

Research paper thumbnail of Gambaran Karakteristik dan Faktor Risiko Bayi Lahir Dengan Hiperbilirubinemia di RS Al Islam Periode 2017

Prosiding Pendidikan Dokter, Aug 9, 2018

Research paper thumbnail of Perbandingan Karakteristik Anggota Keluarga Pasien TB Paru Aktif Pada Pemeriksaan Igra Positif dan Negatif

Prosiding Pendidikan Dokter, Aug 8, 2015

Tuberculosis (TB) is an infectious disease caused especially by Mycobacterium tuberculosis. Famil... more Tuberculosis (TB) is an infectious disease caused especially by Mycobacterium tuberculosis. Families of patients are in contact with active TB could become latent TB. People with latent TB has no clinical symptoms, although the bacteria inside his body remains alive but not active. Latent TB could become active and increase the incidence of active TB in the world, and this should be prevented. Latent TB could be detected by IGRA examination. The purpose of this study to compare the characteristic of the family members of active pulmonary TB in the positive and negative IGRA examination in UNPAD Education Hospital. The study is descriptive with cross sectional design. The subjects were taken from medical record of family members of active pulmonary TB patient in UNPAD Education Hospital periode March through October 2014. Data was analyzed with Chi Square Test.Results of this research showed percentage of IGRA positive (68.4%) is higher than IGRA negative (31.6%). Characteristics of family members of active pulmonary TB patient showed higher rate at age is 18-29 years (58.0%), male (50.9%) and normal BMI. The study is concluded the comparison between IGRA in age, gender and BMI was not significant with a p value> 0.05.

Research paper thumbnail of Gambaran Histopatologi Pasien BTA (+) dan (-) Biopsi Jaringan KGB

Prosiding Pendidikan Dokter, Jan 25, 2019

The most common type of Extrapulmonary tuberculosis (EPTB) is tuberculous lymphadenitis that atta... more The most common type of Extrapulmonary tuberculosis (EPTB) is tuberculous lymphadenitis that attacks the lymph nodes. EPTB can be diagnosed by clinical examination, histopathology, and bacteriology; but it is still a great challenge due to each method's weaknesses. The aim of this research is to determine the histopathological pattern and clinical symptoms of patients with positive and negative acid-fast bacilli (AFB) results from lymph nodes biopsies. This research is based on descriptive observations that were done in March-December 2018 at

Research paper thumbnail of Angka Kejadian dan Karakteristik Pasien Tb Laten pada Anggota Keluarga Pasien TB Aktif di Rumah Sakit Pendidikan Undap Periode 2014

Prosiding Pendidikan Dokter, Aug 9, 2015

According to World Health Organization (WHO) report in 2013, one-third of global population were ... more According to World Health Organization (WHO) report in 2013, one-third of global population were infected with latent tuberculosis and one more person would be infected with M. tuberculosis in every second. Latent tuberculosis is defined as a condition when a person is infected by M. tuberculosis but that person is not sick, does not have any symptoms and the thorax x-ray is normal. Interferon Gamma Release Assau (IGRA) test is one of those indicators in diagnosing latent tuberculosis. IGRA is a blood test to detect immune response toward M. tuberculosis inside the body. This Research is a small part of "The Relationship between Single Nucleotide Polymorphism (Snps) in Macrophage Mannose Receptor Gene with Lung Tuberculosis Incidence" research in February 2014. The research was carried out by using IGRA diagnosis to all active lung tuberculosis of patients' family. This research is a descriptive study and the sampling of latent tuberculosis patients' medical record in Education Hospital UNPAD in 2014. Therefore the secondary data is administered and sorted in a form of table. The aim of this research is to determine case and characteristics of latent tuberculosis patients. The result from 143 data showed that mostly latent tuberculosis patients were males there are 75 cases (52,4%), patients with normal BMI are 69 cases (48,3%) and the highest case are in productive age group, they are 83 cases (58,04%). In conclusion, this research showed that the majority of pulmonary tuberculosis patients are man, productive ages and BMI normal status.

Research paper thumbnail of Pengaruh Kebiasaan Merokok terhadap Kadar Hemoglobin dan Tingkat Kebugaran Jasmani pada Mahasiswa Fakultas Kedokteran Unisba

Prosiding Pendidikan Dokter, Aug 11, 2016

Smoking is a habit that can affect health , smoking behavior increase at the age above 15 years o... more Smoking is a habit that can affect health , smoking behavior increase at the age above 15 years old in Indonesia. Smoking can cause various diseases because the content in cigarrettes. Nicotine is a containt of cigarettes that can increase the resistance of the lungs for entry the air and carbon monoxide which can increase bond with oxygen, so it can reduce the physical fitness and increase hemoglobin. The purpose of this research was to analyze the effects of tobacco smoke due to levels hemogolobin and level of physical fitness on the students of the Medical Faculty in Bandung Islamic University.This research was an analytical study using cross-sectional method. The subjects of the research were the students of Medical Faculty of Bandung Islamic University that divided into 2 groups, 29 students smokers and 29 students non smokers. Samples chosen by simple random sampling method. This research was done by analyzing and the results of physical fitness test with Harvard Step Test method and results of hemoglobin levels with automated hemoglobin analyze. The results showed that smokers respondents have higher hemoglobin levels than non-smokers: 15.32 g/dL (smoker) and 14.60 g/dL (non-smoker), while the physical fitness level of the smokers respondent is lower than non-smokers: 87.5 (smoker) and 90 (nonsmoker).This research has been analyzed using normality test saphiro wilk test, Mann Whitney test and ttest independent which using confident interval 95% showed significant results p<0,05 with p value for effect of smoking on the level of hemoglobin: 0,008 and the level of physical fittnes: 0,004. The conclusion of this research that smoking habit can increase level of hemoglobin and reduce level of physical fitness.

Research paper thumbnail of Perbedaan Kadar Hemoglobin dan Hematokrit pada Mahasiswa Perokok dan Bukan Perokok di Fakultas Kedokteran Universitas Islam Bandung Periode 2015/2016

Prosiding Pendidikan Dokter, Aug 11, 2016

Most of the population in Indonesia are smokers. This habit causes some diseases like hypertensio... more Most of the population in Indonesia are smokers. This habit causes some diseases like hypertension and cardiac attack that become one of highest cause of fatality condition. Cause and risk factor this diseases are variative and one some of them are higher of hemoglobin and hematocrit level that can cause hemoconcentration and lead to occurred this condition. Increase of cigarette effect to hemoglobin and hematocrit level awareness be expected decrease smoker in population. Object of this study is to discover the different of hemoglobin and hematocrit level between smoker and non smoker person. The study is analytic observational with cross sectional method. The subjects were from male students of medical faculty Bandung Islamic university 2015/2016 bachelor medical educational program. The data obtained by Count Blood Cell examination of male students with inclusion criteria.Comparison was evaluated by parametric independent T-test. Result of this study showed hemoglobin and hematocrit level in smokers are 15,32 g/dL and 46,25% whereas in non smokers are 14,6 and 44,03% Result of this study also showed differentiation hemoglobin level between smoker and non smoker with (p=0,008). Differentiation hematocrit level are also found with (p=0,005). But nothing significant differences between hemoglobin and hematocrit level with the number of cigarette and long of smoking.

Research paper thumbnail of Gambaran Pola Terapi Penderita Limfadenitis Tuberkulosis di Rumah Sakit Al-Islam Bandung

Prosiding Pendidikan Dokter, Aug 9, 2018

Tuberculosis (TB) is a chronic infection caused by Mycobacterium Tuberculosis. Tuberculosis based... more Tuberculosis (TB) is a chronic infection caused by Mycobacterium Tuberculosis. Tuberculosis based on anatomical location is classified into two, namely pulmonary TB and extrapulmonary TB (TBEP). Location or organ most commonly affected is lymph node. Lymphadenitis TB becomes EPTB with the highest number of events. Lymphadenitis TB can be treated by taking a combination of at least four different medications. TB drug classification is divided into first and second line. This study aims to find out the description of theurapical patterns of lymphadenitis TB at Al-Islam Hospital in 2017. This research uses descriptive research design. The subjects used were lymphadenitis TB patients and the study material was taken from secondary data namely medical records at Al-Islam Hospital in 2017. Samples used were 22 data. The results in this study showed that as many as 9,1% were given first-line antituberculosis drugs therapy pattern and 90,9% were given second-line antituberculosis drugs. The most widely used pattern of therapy was second-line anti-tuberculosis drugs with combination 2 as many as 13 patients (59,1%). This can be caused by the patient's resistance.

Research paper thumbnail of Gambaran Keberhasilan Terapi Leukemia Limfoblastik Akut Anak Usia 0–15 Tahun Periode 2015–2017 Overview of the Success of Therapy for Acute Lymphoblastic Leukemia in Children Aged 0–15 in the Period 2015–2017

Prosiding Pendidikan Dokter, Jan 25, 2019

Research paper thumbnail of Hubungan Positivitas BTA Pada Jaringan Biopsi Dengan Gambaran Klinis Pada Pasien Limfadenitis Tuberkulosis

Prosiding Pendidikan Dokter, Jan 25, 2019

Research paper thumbnail of Scoping Review: Peran Rasio Neutrofil-Limfosit sebagai Biomarker pada Pasien HIV dengan Komorbid atau Tanpa Komorbid

Bandung Conference Series: Medical Science, 2021

Human Immunodeficiency Virus (HIV) is a virus that damages the function of immune cells. Laborato... more Human Immunodeficiency Virus (HIV) is a virus that damages the function of immune cells. Laboratory test that have become the gold standard for monitoring the progression of HIV stages are the examination of the CD4 T lymphocyte count. These test are expensive and trained technicians are not always available in some parts of Indonesia, making it impractical to use them for routine monitoring. The limitations of this examination cause the need for other laboratory tests that can be used as an alternative to the CD4 T lymphocyte count. The aim of this study was to determine the role of the neutrophil-lymphocyte ratio as a biomarker in comorbid and non-comorbid HIV patients. This study is a scoping review study, samples from international and national journals relating to the role of the neutrophillymphocyte ratio as a biomarker in HIV patients with comorbid or non-comorbid HIV. The databases used in this study were PubMed, Springer Link, and ProQuest with 1,170 articles. Screening results on articles that match the inclusion criteria were 714 articles. There were 699 articles that entered the exclusion criteria. The results of the eligibility criteria were obtained as many as 10 articles and then analyzed. The study was conducted during September-December 2020. The conclusion of this study is that the neutrophil-lymphocyte ratio in HIV-comorbid patients acts as a prognostic biomarker. Neutrophil-lymphocyte ratio in HIV patients without comorbids acts as a predictive biomarker and risk biomarker.

Research paper thumbnail of Scoping Review: Efektivitas Chest X-Ray Brixia Score untuk Menilai Derajat Keparahan COVID-19

Bandung Conference Series: Medical Science, 2022

The use of chest x-rays in Covid-19 pandemic has become an alternative radiological examination t... more The use of chest x-rays in Covid-19 pandemic has become an alternative radiological examination that is extensively carried out, although it is less sensitive, but is widely available and its use is mobile to detect lung abnormalities in Covid-19 patients using the brixia score assessment. The purpose of this study was to determine the effectiveness of chest x-rays using the brixia score to assess the severity of Covid-19. This research was taken by scoping review method with a sample of international scientific articles that meet the eligibility criteria. The databases used in this study are Spingerlink, Sciencedirect, Pubmed, Google scholar, and Proquest with the number of articles obtained as many as 833 articles. The results of the screening of articles that met the inclusion criteria were 275 articles and there were three articles that met the eligibility criteria. The results of the three reviewed articles, one article compared the use of chest x-ray and CT in detecting lesions of Covid-19 patients with the result that chest x-ray had low sensitivity. Two articles compared the brixia score in patients who died and discharged with higher outcomes in patients who died. The conclusion of this study shows that the use of chest x-rays is not effective for detecting earlystage abnormalities and the brixia score is effective for assessing the severity of Covid-19 patients.

Research paper thumbnail of Gambaran Faktor Risiko Maternal pada Kehamilan Trimester Pertama dan Jenis Celah Orofacial di YPPBL tahun 2017

Prosiding Pendidikan Dokter, Aug 9, 2018

The orofacial cleft is one of the most common congenital abnormalities in Indonesia. The occurren... more The orofacial cleft is one of the most common congenital abnormalities in Indonesia. The occurrence of this condition is due to impairment in the developmental process in the orofacial development section at 6th weeks of fetal development and is associated with a history of maternal conditions during pregnancy. There are several risk factors that can be modified and can't be modified. Based on this phenomenon, the problem in this research is formulated as follows: (1) How is the description of maternal risk factors modifiable and non-modifiable with children who have cleft lip and/or cleft palate in the 2017 Lip and Palate Creation Foundation?. Researcher using analytic observational research design with cross sectional approach. The sampling method is simple random sampling. The samples used are from questionnaire data which fulfill the inclusion criteria that available in the administrative part of Orofacial Cleft Coach Foundation Bandung during 2017. The analysis was done using univariate formula. In this research showed from 74 data, the dominant type of orofacial cleft is Cleft Lip and Palate (71%), most of the maternal risk factors that can not be modified during the first trimester of pregnancy are the age of the mother mostly 20-25 years old at 24% and 77% had no family history with orofacial cleft abnormalities, while the dominance of risk factors that can be modified is from the history of maternal folic acid consumption amounted to 71% of pregnant women did not consume folic acid, smoking 3%, intrauterine infection 3%, 91% mother done ANC, 23% had the same family history, using other drugs 47%, fever 1%, trauma 18%, exposure from working place 31% and 36% working as employee. Conclusion, cleft lip and palate is the most common type of orofacial cleft that occur, most of the mother was pregnant in the age of 20-25 years old and didn't consume folic acid in the first trimester of pregnancy.

Research paper thumbnail of Understanding Scabies in Religious Boarding School (Pesantren)

Proceedings of the Social and Humaniora Research Symposium (SoRes 2018), 2019