Yasuhiko Fujii - Academia.edu (original) (raw)

Papers by Yasuhiko Fujii

Research paper thumbnail of D109 膨張弁絞り機構部の気液二相流の可視化

Journal of the Visualization Society of Japan, 2007

Research paper thumbnail of Two-Phase Flow Visualization of Refrigerant Fluid at Expansion Valve

Transactions of the Japan Society of Refrigerating and Air Conditioning Engineers, 2011

Recently, the noise caused by the refrigerant fluid is spotlighted due to the demand of low noise... more Recently, the noise caused by the refrigerant fluid is spotlighted due to the demand of low noise home and office air conditioners. Especially, reduction of refrigerant fluid noise and vibration noise generated from throttle in the expansion valve is becoming important. Therefore in this study it is intended to resolve fluctuating phenomena of fluid, which may be the cause of noise, by flow visualization and measurement of fluid pressure and temperature at throttle valves, focusing on two-phase flow of refrigerant fluid. A test equipment suitable for flow visualization of R410a refrigerant was developed by epoch making design and manufacturing method. Visualization was realized by laser beam irradiated on the visualization equipment and by high-speed video camera. Test conditions are set of combinations of 4 different conditions of compressor revolution and 4 different conditions of valve opening of expansion valve. As results of the following conclusions are drawn. (1)A visualization technique of throttle of expansion valve has been developed by manufacturing visualization equipment, which is most suitable to the test. (2)It has been confirmed that refrigerants is liquid and two-phase condition in the upstream of throttle, where a needle is inserted and that refrigerant fluid flow in two-phase in the downstream of throttle.

Research paper thumbnail of 3)Soft Zone-Boundary Phonon Modes in CsPbCl_3

Research paper thumbnail of Hypoxically preconditioned human peripheral blood mononuclear cells improve blood flow in hindlimb ischemia xenograft model

American Journal of Translational Research, 2014

Transplantation of peripheral blood mononuclear cells (PBMNCs) is a promising therapeutic approac... more Transplantation of peripheral blood mononuclear cells (PBMNCs) is a promising therapeutic approach for the treatment of hindlimb ischemia. However, insufficient angiogenesis in ischemic hindlimb after cell transplantation reduces the importance and practicality of this approach. Previously, we demonstrated using mouse models that hypoxic preconditioning augmented the cellular functions of rodent PBMNCs, such as increased cell adhesion capacity and accelerated neovascularization in ischemic hindlimb. To test the clinical application of this therapeutic strategy in this study, we investigated whether the protocol of hypoxic preconditioning, which was established in a condition of 2% O2 for 24 h, can be made available for human PBMNCs (hPBMNCs). In addition, we grafted preconditioned hPBMNCs in a hindlimb ischemia mouse model. Hypoxic preconditioning enhanced cell adhesion capacity and oxidative stress resistance in hPBMNCs. We also observed an up-regulation of platelet endothelial cell adhesion molecule-1 (PECAM-1) in hPBMNCs by hypoxic preconditioning. Furthermore, preconditioned hPBMNCs significantly recovered limb blood flow in ischemic mice after transplantation. These results indicate that our established preconditioning protocol is available for hPBMNCs to effectively reinforce multiple cellular functions. Taken together with our series of study, we believe that this simple but powerful therapeutic strategy will be helpful in curing patients with severe hindlimb ischemia.

Research paper thumbnail of Irradiation of blood and blood components to prevent post-transfusion graft-versus-host disease in Japan

Nihon Shuchu Chiryo Igakukai Zasshi, 2012

Research paper thumbnail of Evidence That CD31, CD49b, and CD62L Are Immunodominant Minor Histocompatibility Antigens in HLA Identical Sibling Bone Marrow Transplants

Research paper thumbnail of The resolution function of a perfect-crystal three-axis X-ray spectrometer

Research paper thumbnail of The strength of a-sialon ceramics

Research paper thumbnail of Textures and fabrics of 700-M deep ice core obtained at Mizuho Station, east Antarctica

Memoirs of National Institute of Polar Research Special Issue, 1986

Research paper thumbnail of Recommendations for the electronic pre-transfusion check at the bedside

Blood transfusion = Trasfusione del sangue, Jan 21, 2016

Research paper thumbnail of The strength of ?-sialon ceramics

Research paper thumbnail of Transplants Histocompatibility Antigens in HLA Identical Sibling Bone Marrow Evidence That CD31, CD49b, and CD62L Are Immunodominant Minor

Research paper thumbnail of ２００４年から４年間の輸血関連総合アンケート調査：輸血副作用に関する調査報告

Japanese Journal of Transfusion and Cell Therapy, 2009

Research paper thumbnail of 重篤な急性輸血副作用に関する多施設共同研究

Japanese Journal of Transfusion and Cell Therapy, 2008

Research paper thumbnail of 貯血式自己血採血時の副作用について―全国大学病院輸血部会議副作用ワーキング調査から―

Japanese Journal of Transfusion and Cell Therapy, 2009

Research paper thumbnail of ＡＢＯ型不適合輸血の発生原因による解析

Japanese Journal of Transfusion and Cell Therapy, 2007

Research paper thumbnail of Hypoxically preconditioned human peripheral blood mononuclear cells improve blood flow in hindlimb ischemia xenograft model

American journal of translational research, 2014

Transplantation of peripheral blood mononuclear cells (PBMNCs) is a promising therapeutic approac... more Transplantation of peripheral blood mononuclear cells (PBMNCs) is a promising therapeutic approach for the treatment of hindlimb ischemia. However, insufficient angiogenesis in ischemic hindlimb after cell transplantation reduces the importance and practicality of this approach. Previously, we demonstrated using mouse models that hypoxic preconditioning augmented the cellular functions of rodent PBMNCs, such as increased cell adhesion capacity and accelerated neovascularization in ischemic hindlimb. To test the clinical application of this therapeutic strategy in this study, we investigated whether the protocol of hypoxic preconditioning, which was established in a condition of 2% O2 for 24 h, can be made available for human PBMNCs (hPBMNCs). In addition, we grafted preconditioned hPBMNCs in a hindlimb ischemia mouse model. Hypoxic preconditioning enhanced cell adhesion capacity and oxidative stress resistance in hPBMNCs. We also observed an up-regulation of platelet endothelial cel...

Research paper thumbnail of 呼吸不全を認めた輸血副作用症例の解析

Japanese Journal of Transfusion and Cell Therapy, 2007

Research paper thumbnail of 冷式抗体保有患者への対応抗原陽性赤血球製剤輸血：多施設共同研究による冷式抗体の臨床的意義の評価

Japanese Journal of Transfusion and Cell Therapy, 2013

Research paper thumbnail of Pulmonary Hypertension Associated with Pulmonary Occlusive Vasculopathy After Allogeneic Bone Marrow Transplantation

Transplantation, 2000

Wolters Kluwer Health may email you for journal alerts and information, but is committed to maint... more Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. ... Skip Navigation Links Home > January ...

Research paper thumbnail of D109 膨張弁絞り機構部の気液二相流の可視化

Journal of the Visualization Society of Japan, 2007

Research paper thumbnail of Two-Phase Flow Visualization of Refrigerant Fluid at Expansion Valve

Transactions of the Japan Society of Refrigerating and Air Conditioning Engineers, 2011

Recently, the noise caused by the refrigerant fluid is spotlighted due to the demand of low noise... more Recently, the noise caused by the refrigerant fluid is spotlighted due to the demand of low noise home and office air conditioners. Especially, reduction of refrigerant fluid noise and vibration noise generated from throttle in the expansion valve is becoming important. Therefore in this study it is intended to resolve fluctuating phenomena of fluid, which may be the cause of noise, by flow visualization and measurement of fluid pressure and temperature at throttle valves, focusing on two-phase flow of refrigerant fluid. A test equipment suitable for flow visualization of R410a refrigerant was developed by epoch making design and manufacturing method. Visualization was realized by laser beam irradiated on the visualization equipment and by high-speed video camera. Test conditions are set of combinations of 4 different conditions of compressor revolution and 4 different conditions of valve opening of expansion valve. As results of the following conclusions are drawn. (1)A visualization technique of throttle of expansion valve has been developed by manufacturing visualization equipment, which is most suitable to the test. (2)It has been confirmed that refrigerants is liquid and two-phase condition in the upstream of throttle, where a needle is inserted and that refrigerant fluid flow in two-phase in the downstream of throttle.

Research paper thumbnail of 3)Soft Zone-Boundary Phonon Modes in CsPbCl_3

Research paper thumbnail of Hypoxically preconditioned human peripheral blood mononuclear cells improve blood flow in hindlimb ischemia xenograft model

American Journal of Translational Research, 2014

Transplantation of peripheral blood mononuclear cells (PBMNCs) is a promising therapeutic approac... more Transplantation of peripheral blood mononuclear cells (PBMNCs) is a promising therapeutic approach for the treatment of hindlimb ischemia. However, insufficient angiogenesis in ischemic hindlimb after cell transplantation reduces the importance and practicality of this approach. Previously, we demonstrated using mouse models that hypoxic preconditioning augmented the cellular functions of rodent PBMNCs, such as increased cell adhesion capacity and accelerated neovascularization in ischemic hindlimb. To test the clinical application of this therapeutic strategy in this study, we investigated whether the protocol of hypoxic preconditioning, which was established in a condition of 2% O2 for 24 h, can be made available for human PBMNCs (hPBMNCs). In addition, we grafted preconditioned hPBMNCs in a hindlimb ischemia mouse model. Hypoxic preconditioning enhanced cell adhesion capacity and oxidative stress resistance in hPBMNCs. We also observed an up-regulation of platelet endothelial cell adhesion molecule-1 (PECAM-1) in hPBMNCs by hypoxic preconditioning. Furthermore, preconditioned hPBMNCs significantly recovered limb blood flow in ischemic mice after transplantation. These results indicate that our established preconditioning protocol is available for hPBMNCs to effectively reinforce multiple cellular functions. Taken together with our series of study, we believe that this simple but powerful therapeutic strategy will be helpful in curing patients with severe hindlimb ischemia.

Research paper thumbnail of Irradiation of blood and blood components to prevent post-transfusion graft-versus-host disease in Japan

Nihon Shuchu Chiryo Igakukai Zasshi, 2012

Research paper thumbnail of Evidence That CD31, CD49b, and CD62L Are Immunodominant Minor Histocompatibility Antigens in HLA Identical Sibling Bone Marrow Transplants

Research paper thumbnail of The resolution function of a perfect-crystal three-axis X-ray spectrometer

Research paper thumbnail of The strength of a-sialon ceramics

Research paper thumbnail of Textures and fabrics of 700-M deep ice core obtained at Mizuho Station, east Antarctica

Memoirs of National Institute of Polar Research Special Issue, 1986

Research paper thumbnail of Recommendations for the electronic pre-transfusion check at the bedside

Blood transfusion = Trasfusione del sangue, Jan 21, 2016

Research paper thumbnail of The strength of ?-sialon ceramics

Research paper thumbnail of Transplants Histocompatibility Antigens in HLA Identical Sibling Bone Marrow Evidence That CD31, CD49b, and CD62L Are Immunodominant Minor

Research paper thumbnail of ２００４年から４年間の輸血関連総合アンケート調査：輸血副作用に関する調査報告

Japanese Journal of Transfusion and Cell Therapy, 2009

Research paper thumbnail of 重篤な急性輸血副作用に関する多施設共同研究

Japanese Journal of Transfusion and Cell Therapy, 2008

Research paper thumbnail of 貯血式自己血採血時の副作用について―全国大学病院輸血部会議副作用ワーキング調査から―

Japanese Journal of Transfusion and Cell Therapy, 2009

Research paper thumbnail of ＡＢＯ型不適合輸血の発生原因による解析

Japanese Journal of Transfusion and Cell Therapy, 2007

Research paper thumbnail of Hypoxically preconditioned human peripheral blood mononuclear cells improve blood flow in hindlimb ischemia xenograft model

American journal of translational research, 2014

Transplantation of peripheral blood mononuclear cells (PBMNCs) is a promising therapeutic approac... more Transplantation of peripheral blood mononuclear cells (PBMNCs) is a promising therapeutic approach for the treatment of hindlimb ischemia. However, insufficient angiogenesis in ischemic hindlimb after cell transplantation reduces the importance and practicality of this approach. Previously, we demonstrated using mouse models that hypoxic preconditioning augmented the cellular functions of rodent PBMNCs, such as increased cell adhesion capacity and accelerated neovascularization in ischemic hindlimb. To test the clinical application of this therapeutic strategy in this study, we investigated whether the protocol of hypoxic preconditioning, which was established in a condition of 2% O2 for 24 h, can be made available for human PBMNCs (hPBMNCs). In addition, we grafted preconditioned hPBMNCs in a hindlimb ischemia mouse model. Hypoxic preconditioning enhanced cell adhesion capacity and oxidative stress resistance in hPBMNCs. We also observed an up-regulation of platelet endothelial cel...

Research paper thumbnail of 呼吸不全を認めた輸血副作用症例の解析

Japanese Journal of Transfusion and Cell Therapy, 2007

Research paper thumbnail of 冷式抗体保有患者への対応抗原陽性赤血球製剤輸血：多施設共同研究による冷式抗体の臨床的意義の評価

Japanese Journal of Transfusion and Cell Therapy, 2013

Research paper thumbnail of Pulmonary Hypertension Associated with Pulmonary Occlusive Vasculopathy After Allogeneic Bone Marrow Transplantation

Transplantation, 2000

Wolters Kluwer Health may email you for journal alerts and information, but is committed to maint... more Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. ... Skip Navigation Links Home > January ...