Dan Ye - Academia.edu (original) (raw)

Papers by Dan Ye

The role of signal transducers and activators of transcription 5 (STAT5) in chronic myelogenous l... more The role of signal transducers and activators of transcription 5 (STAT5) in chronic myelogenous leukemia (CML) is controversial. To clarify the role of STAT5 signaling in P210(BCR/ABL) leukemogenesis, P210 was introduced into primary murine STAT5A-deficient (STAT5A(-/-)) bone marrow (BM) cells, which, unlike STAT5A/5B double knockout BM cells, have no major intrinsic hematopoietic defects. Interestingly, only 21% of mice reconstituted with P210-transduced STAT5A(-/-) BM cells developed classic CML, compared with 80% to 100% of P210/STAT5A(+/+) and P210/STAT5A(+/-)-reconstituted animals. The remainder of P210/STAT5A(-/-) animals died from an acute B-cell lymphoblastic leukemia (ALL)-like disease (32%) or a CML/ALL mix (47%), reflecting impairment in the induction and maintenance of CML, which normally predominates in this mouse model. Of mice that ultimately developed CML, P210/STAT5A(-/-) animals had prolonged survival and increased myeloid immaturity. Importantly, reconstitution of wild-type mice with BM cells coexpressing P210 and dominant-negative STAT5 also profoundly reduced the incidence of CML, without impairing the induction of ALL. Altogether, these findings indicate that STAT5 and STAT5A play an important role in the pathogenesis of the CML-like disease in mice. A greater understanding of the STAT5 target genes involved in CML induction may lead to new therapeutic targets that influence CML progenitor cell biology.

Journal of Optical Networking, 2007

We present an improved multi-Gaussian curve-fitting method for monitoring bit error rate (BER) of... more We present an improved multi-Gaussian curve-fitting method for monitoring bit error rate (BER) of optical channels that suffer from various kinds of impairments including ASE noise, in-band crosstalk, dispersion, self-phase and cross-phase modulations, and four-wave mixing. The new method is more flexible and computationally efficient, as compared with our previously proposed method. Computer simulations using commercial software are carried out to verify the effectiveness of the new method. The results show that the new method can achieve better accuracy in estimating BER over the conventional single-Gaussian approximation method, especially when the signal is severely distorted.

Journal of Clinical Virology, 2005

Background: Effective strategies to combat the spread of influenza viruses rely on accurate diagn... more Background: Effective strategies to combat the spread of influenza viruses rely on accurate diagnosis of the infection, which is greatly affected by the sensitivity of the assays used. Objectives: To determine if the sensitivity of assays used to detect influenza varies with the viral strains. Study design: This prospective study used 142 respiratory specimens submitted to the clinical virology laboratory during the 2003/2004 influenza season, when the H3N2 Fujian strain was first detected in our community, to assess sensitivities of rapid immunoassay (RIA), shell-vial (SV), hemadsorption (HA)-, and fluorescent antibody (FA)-based conventional tissue culture (TC). Results were compared with similar evaluations performed in 2002/2003 or earlier seasons. Results: Sensitivities of RIA, SV, HA-TC, and FA-TC were 44, 70, 82, and 100%, respectively for influenza virus circulating in 2003/2004. The comparison with results obtained in previous influenza seasons showed a significantly decreased sensitivity of HA-TC (p = 0.02) and lower sensitivity of RIA but without reaching statistical significance (44% versus 72%, p = 0.2).

Journal of Virology, 2005

The H3N2 influenza A/Fujian/411/02-like virus strains that circulated during the 2003-2004 influe... more The H3N2 influenza A/Fujian/411/02-like virus strains that circulated during the 2003-2004 influenza season caused influenza epidemics. Most of the A/Fujian/411/02 virus lineages did not replicate well in embryonated chicken eggs and had to be isolated originally by cell culture. The molecular basis for the poor replication of A/Fujian/411/02 virus was examined in this study by the reverse genetics technology. Two antigenically related strains that replicated well in embryonated chicken eggs, A/Sendai-H/F4962/02 and A/Wyoming/03/03, were compared with the prototype A/Fujian/411/02 , which also resulted in the increased HA receptor-binding activity. Thus, the balance between the HA and NA activities is critical for influenza virus replication in a different host system. The HA or NA changes that increased A/Fujian/411/02 virus replication in embryonated chicken eggs were found to have no significant impact on antigenicity of these recombinant viruses. This study demonstrated that the reverse genetics technology could be used to improve the manufacture of the influenza vaccines.

Journal of Virology, 2008

Influenza pandemic preparedness has focused on influenza virus H5 and H7 subtypes. However, it is... more Influenza pandemic preparedness has focused on influenza virus H5 and H7 subtypes. However, it is not possible to predict with certainty which subtype of avian influenza virus will cause the next pandemic, and it is prudent to include other avian influenza virus subtypes in pandemic preparedness efforts. An H6 influenza virus was identified as a potential progenitor of the H5N1 viruses that emerged in Hong Kong in 1997. This virus continues to circulate in the bird population in Asia, and other H6 viruses are prevalent in birds in North America and Asia. The high rate of reassortment observed in influenza viruses and the prevalence of H6 viruses in birds suggest that this subtype may pose a pandemic risk. Very little is known about the replicative capacity, immunogenicity, and correlates of protective immunity for low-pathogenicity H6 influenza viruses in mammals. We evaluated the antigenic and genetic relatedness of 14 H6 influenza viruses and their abilities to replicate and induce a cross-reactive immune response in two animal models: mice and ferrets. The different H6 viruses replicated to different levels in the respiratory tracts of mice and ferrets, causing varied degrees of morbidity and mortality in these two models. H6 virus infection induced similar patterns of neutralizing antibody responses in mice and ferrets; however, species-specific differences in the cross-reactivity of the antibody responses were observed. Overall, cross-reactivity of neutralizing antibodies in H6 virus-infected mice did not correlate well with protection against heterologous wild-type H6 viruses. However, we have identified an H6 virus that induces protective immunity against viruses in the North American and Eurasian lineages.

This paper deals with the problem of flight tracking control against actuator faults based on lin... more This paper deals with the problem of flight tracking control against actuator faults based on linear matrix inequality (LMI) method and adaptive method. The type of faults under consideration is loss of actuator effectiveness. An adaptive fault-tolerant flight controller design method is developed based on the on-line estimation of an eventual fault and the addition of a new control law to the normal control law in order to reduce the fault effect on the system without the need for an FDI (fault detection and isolation) mechanism. In the framework of linear matrix inequality (LMI) approach, the normal tracking performance of the resultant closed-loop system is optimized without any conservativeness and the states of fault modes asymptotically track those of the normal mode. A numerical example of an F-16 aircraft model and its simulation results are given

International Journal of Systems Science, 2008

This article deals with the problem of adaptive fault-tolerant control against unknown actuator f... more This article deals with the problem of adaptive fault-tolerant control against unknown actuator faults for a class of nonlinear time delay systems with disturbance. The actuator faults are types of loss of effectiveness. The aim is to find an adaptive fault tolerant controller, such that the system is not only stabilized, but also the state vectors of normal and fault cases with disturbance track that of the normal case without disturbance, which has the designed performance. A new delay-dependent adaptive law is proposed to design the adaptive reconfigurable controller, which is excited to offset the effect of faults and disturbance automatically. Numerical and simulation results are provided to demonstrate the effectiveness of the proposed controller.

This paper is concerned with the adaptive reliable H∞ filtering problem against sensor failures f... more This paper is concerned with the adaptive reliable H∞ filtering problem against sensor failures for continuous-time linear systems. An adaptive H∞ performance index is defined to describe the disturbance attenuation performance of systems with time-varying parameter estimations. By combining the linear matrix inequality (LMI) approach for H∞ filter design and adaptive method, a method of designing adaptive reliable H∞ filters is proposed, where the filter parameter matrices are updating automatically to compensate the sensor fault effects on systems based on the on-line estimations of eventual faults. It is shown that the design condition for the newly proposed adaptive H∞ filtering is more relaxed than that for the traditional fixed gain filter design based on LMI approach. A numerical example and its simulations are given to illustrate the effectiveness of the results

International Journal of Robust and Nonlinear Control, 2009

This paper considers the problem of delay-dependent adaptive reliable H∞ controller design agains... more This paper considers the problem of delay-dependent adaptive reliable H∞ controller design against actuator faults for linear time-varying delay systems. Based on the online estimation of eventual faults, the parameters of adaptive reliable H∞ controller are updating automatically to compensate the fault effects on the system. A new delay-dependent reliable H∞ controller is established using a linear matrix inequality technique and an adaptive method, which guarantees the stability and adaptive H∞ performance of closed-loop systems in normal and faulty cases. A numerical example and its simulation results illustrate the effectiveness of the proposed method. Copyright © 2008 John Wiley & Sons, Ltd.

In this paper, a new indirect adaptive fault-tolerant controller design methods dynamic output fe... more In this paper, a new indirect adaptive fault-tolerant controller design methods dynamic output feedback is presented to tolerate actuator faults for linear time-invariant systems. Based on the on-line estimation of eventual faults, the adaptive fault-tolerant controller parameters are updating automatically to compensate the fault effect on system. A notion of adaptive H∞ performance index is proposed to describe the disturbance attenuation performances of closed-loop systems. The designs are developed in the framework of linear matrix inequality (LMI) approach, which can guaranteed the asymptotic stability and adaptive H∞ performances of closed-loop systems even in the presence of actuator faults. Benefits of the proposed design are demonstrated by a numerical example and its simulation results

$Research paper thumbnail of Reliable <math xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><msub><mi>H</mi><mi mathvariant="normal">∞</mi></msub></mrow><annotation encoding="application/x-tex">H_{\infty}</annotation></semantics></math>H∞ Control of Linear Systems With Adaptive Mechanism$

IEEE Transactions on Automatic Control, 2010