Yen-Chien Lee - Academia.edu (original) (raw)

Papers by Yen-Chien Lee

Distribution of colorectal adenocarcinoma among the different sites.</p

adjust for sex, race (white, black and others), age;*p</i... more adjust for sex, race (white, black and others), age;*p<0.05.</p

*p<0.05.</p

Survival and cumulative hazard in Cox regression model of stage IIIC colon and rectal ca... more Survival and cumulative hazard in Cox regression model of stage IIIC colon and rectal cancer patients.</p

Survival and cumulative hazard for stage IIB colon and rectal cancer patients (1, colon ... more Survival and cumulative hazard for stage IIB colon and rectal cancer patients (1, colon cancer; 2, rectal cancer).</p

All values are median (interquartile range) or N (%).</p

Survival and cumulative hazard in Cox regression model of stage IIB colon and rectal can... more Survival and cumulative hazard in Cox regression model of stage IIB colon and rectal cancer patients.</p

Survival and cumulative hazard of stage IV colon and rectal cancer patients (1, colon ca... more Survival and cumulative hazard of stage IV colon and rectal cancer patients (1, colon cancer; 2, rectal cancer).</p

All values are median (interquartile range) or N (%),*p</... more All values are median (interquartile range) or N (%),*p<0.05.</p

Survival and cumulative hazard of stage IIIC colon and rectal cancer patients (1, colon ... more Survival and cumulative hazard of stage IIIC colon and rectal cancer patients (1, colon cancer; 2, rectal cancer).</p

Medicina, 2021

Background and Objectives:BRCA1 and BRCA2 are genes located in different chromosomes that are dis... more Background and Objectives:BRCA1 and BRCA2 are genes located in different chromosomes that are disproportionately associated with hereditary breast and ovarian cancer syndrome. Their association with other cancers remains to be explored. Materials and Methods: We systematically reviewed cohort studies to explore the association of BRCA 1 and BRCA2 with various cancers except lung cancer. We searched PubMed, Medline (EBSCOhost) and relevant articles published up to 10 May 2021. The odds ratio, standardised morbidity rate and cancer-specific standardised incidence ratio were pooled together as relative risk (RR) estimates. Results: Twelve studies were included for analysis. BRCA mutation increased pancreatic and uterine cancers by around 3–5- and 1.5-fold, respectively. BRCA mutation did not increase brain cancer; colorectal cancer; prostate, bladder and kidney cancer; cervical cancer; or malignant melanoma. BRCA2 increased gastric cancer with RR = 2.15 (1.98–2.33). Conclusion: The met...

Formosan Journal of Surgery, 2007

Dermatofibrosarcoma protuberans (DFSP), a rare indolent cutaneous tumor, arises from the rearrang... more Dermatofibrosarcoma protuberans (DFSP), a rare indolent cutaneous tumor, arises from the rearrangement of chromosomes 17 and 22. The optimal treatment for DFSP is resection with wide margins. DFSP is radiosensitive. Adjuvant radiotherapy may be considered in case of a positive resection margin or close margin. We report a 69-year-old Taiwanese man with DFSP. The lesion began to grow in the front part of the chest wall about 3 years previously. In the past 6 months, the lesion became larger and harder. Surgical resection was performed and the pathology report showed dermatofibrosarcoma with a close margin (about 0.2 cm). For fear of cardiovascular complications, and due to the old age of the patient and the location of the tumor in the front part of the chest wall, radiation therapy was not performed. Eight months after the operation, the patient remained free from recurrence. He is still under close follow up, as the median time of recurrence is around 38 months after surgery.

After the radiation leak from Japan's quake-stricken Fukushima Daiichi nuclear plant, concern... more After the radiation leak from Japan's quake-stricken Fukushima Daiichi nuclear plant, concern about radiation exposure arose. There are a variety of radiation-related health problems, including acute exposure toxicities, radiotherapy-related malignancy, and malignancies from imaging, environmental, and occupation-related radiation. As medical staff, we should be aware of radiation-related problems. A discussion of radiation-related malignancies is presented. This review is not intended to discuss the mechanisms of radiation, the tissue effects or other acute effects.

We report a 65-year-old male with rectal cancer who received three hepatic operations and chemoth... more We report a 65-year-old male with rectal cancer who received three hepatic operations and chemotherapy at Tainan Hospital, and the recent advances in hepatic colorectal metastases are also reviewed. Neoadjuvant chemotherapy includes FOLFOX or FOLFIRI with either bevacizumab or cetuximab. There may be a role for adjuvant chemotherapy, but further study is needed. Other options, such as hepatic arterial infusion, have been studied in clinical trials. Preoperative PET/CT is indicated only in the presence of potentially surgically curable M1 disease.

Medicina, 2019

Background and objectives: Targeted therapy is widely used in the era of precision medicine. Whet... more Background and objectives: Targeted therapy is widely used in the era of precision medicine. Whether the sequence in which targeted therapy and chemotherapy are performed matters, is however not known. We examined the impact of the sequential treatment of targeted therapy and chemotherapy among advanced anaplastic lymphoma kinase (ALK), non-small cell lung cancer (NSCLC) patients. Materials and Methods: Randomized controlled trials comparing the use of ALK inhibitors with chemotherapy were included in this meta-analysis. We estimated the hazard ratios (HRs) and 95% confidence intervals (CI), for progression-free survival (PFS) and overall survival (OS) from a random effects model. Two-sided statistical tests were used to determine the significance of these estimates. Results: In five eligible studies (1404 patients), ALK targeted therapy, in comparison with chemotherapy, had a significantly higher PFS (HR = 0.48; 95% CI, 0.42–0.55), but not significantly higher OS (HR = 0.88; 95% CI...

Medicina, 2020

Background and objective: BRCA1 and BRCA2 are associated with many cancer types in addition to he... more Background and objective: BRCA1 and BRCA2 are associated with many cancer types in addition to hereditary breast and ovarian cancers. However, their relation to lung cancer remains to be explored. Materials and Methods: Observation studies were systematically reviewed to explore the association of BRCA1 or BRCA2 with lung cancer. PubMed, MEDLINE [EBSCOhost], and relevant articles published up to 7 January 2020 were searched. Odd ratio (OR), standardized morbidity rate (SMR), and cancer-specific standardized incidence ratios (SIRs) were pooled together as relative risk (RR) estimates (95% confidence interval [CI], 0.66–1.40). Results: Thirteen studies were included for analysis. Results showed that the RR of BRCA2 is 0.76 (95% CI, 0.48–1.19), the overall RR is 0.96 (95% CI, 0.66–1.40), and that of BRCA1 is 0.66 (95% CI, 0.41–1.05), indicating that it was not associated with lung cancer. Conclusion: With the limitation of the retrospective study design and severe heterogeneity, these ...

American Journal of Roentgenology, 2019

ontrast-enhanced imaging studies are widely used nowadays. Frequency of contrast medium (CM)-indu... more ontrast-enhanced imaging studies are widely used nowadays. Frequency of contrast medium (CM)-induced acute kidney injury has been reported to range from 2.1% to 14.8% [1]. Clinicians often hold CM infusion for patients with chronic kidney disease (CKD). However, imaging studies are sometimes required for patients with renal failure. For example, pembrolizumab [2] was evaluated as a second-line therapy for advanced urothelial carcinoma. In an immune therapy trial, tumor imaging was scheduled to be performed at week 9 and then every 6 weeks during the first year and every 12 weeks thereafter. Poor renal function was not a criterion for exclusion from contrast-enhanced imaging studies. The prevalence of low renal function was probably high among patients with advanced urothelial carcinoma.

Medicina, 2019

Background and objective: Risk of secondary prostate cancer after radiation therapy among patient... more Background and objective: Risk of secondary prostate cancer after radiation therapy among patients with rectal cancer remains undetermined. Given an increased incidence of rectal cancer in younger people and improved survival for rectal cancer patients who received radiation therapy, the potential risk of secondary prostate cancer needs to be further investigated. Materials and Methods: Male patients (n = 11,367) newly diagnosed rectal cancer and who underwent abdominoperineal resection (APR) or low anterior resection (LAR) from 1 January, 1998 to 31 December, 2010 were identified from Taiwan National Health Insurance Research Database. The incidence and relative risk of secondary prostate cancer in study patients with (n = 1586) and without (n = 9781) radiotherapy within one year after rectal cancer diagnosis were compared using a competing-risks analysis. Results: Rectal cancer patients with radiotherapy were at a significantly decreased risk of developing prostate cancer, with a ...

Clinical lymphoma, myeloma & leukemia, 2018

Molecular markers are important in guiding treatment and predicting outcome in the genomic era. M... more Molecular markers are important in guiding treatment and predicting outcome in the genomic era. Meta-analysis of molecular markers in myelofibrosis through a search of PubMed and Medline through October 31, 2017 was performed. Markers with more than 3 studies that compared overall survival (OS) and leukemia-free survival (LFS) were analyzed. A total of 16 studies were included. Hazard ratios (HRs) for OS were as follows: IDH 2.65 (95% confidence interval [CI], 1.66-4.21), SRSF2 2.12 (95% CI, 1.18-3.79), high-risk myeloma 2.11 (95% CI, 1.70-2.61), ASXL1 1.92 (95% CI, 1.60-2.32), EZH2 1.88 (95% CI, 1.32-2.67), JAK2 1.41 (95% CI, 1.04-1.93) in the univariate analysis and 1.49 (95% CI, 0.42-5.30) in the multivariate analysis. LFS of JAK2 and SRSF2 had HRs of 1.81 (95% CI, 0.42-5.30) and 0.36 (95% CI, 0.02-6.48), respectively. In conclusion, mutations in IDH, SRSF2, and ASXL1 had worse prognosis in OS with HRs around 2. JAK2 and SRSF2 mutation were not associated with increased leukemia ...

Current Problems in Cancer, 2017

The necessity of intrathecal chemotherapy for the treatment of breast cancer patients with leptom... more The necessity of intrathecal chemotherapy for the treatment of breast cancer patients with leptomeningeal metastasis: a systematic review and pooled analysis Names of each author's name and affiliation

Distribution of colorectal adenocarcinoma among the different sites.</p

adjust for sex, race (white, black and others), age;*p</i... more adjust for sex, race (white, black and others), age;*p<0.05.</p

*p<0.05.</p

All values are median (interquartile range) or N (%).</p

All values are median (interquartile range) or N (%),*p</... more All values are median (interquartile range) or N (%),*p<0.05.</p

Medicina, 2021

Formosan Journal of Surgery, 2007

Medicina, 2019

Medicina, 2020

American Journal of Roentgenology, 2019

Medicina, 2019

Clinical lymphoma, myeloma & leukemia, 2018

Current Problems in Cancer, 2017