Yijie Wang - Academia.edu (original) (raw)

Papers by Yijie Wang

3 Abbreviations used in this paper: ITAM, immunoreceptor tyrosine-based activation motif; ITIM, i... more 3 Abbreviations used in this paper: ITAM, immunoreceptor tyrosine-based activation motif; ITIM, immunoreceptor tyrosine-based inhibition motif; SH, Src homology; GAM, goat anti-mouse Ig; SHIP, SH2 domain-containing inositol polyphosphate phosphatase; Erk, extracellular signal-regulated kinase; BMM, bone marrow-derived macrophage.

Phagocytosis in Murine Macrophages Independently of SHIP-1

World Journal of Gastroenterology, Dec 1, 2010

AIM: To assess the benefits and limits of surgery for primary hepatic lymphoma (PHL), and probabi... more AIM: To assess the benefits and limits of surgery for primary hepatic lymphoma (PHL), and probability of survival after postoperative chemotherapy.

The Everyday Implications of Ethnic-Racial Identity Processes: Exploring Variability in Ethnic-Racial Identity Salience Across Situations

Journal of youth and adolescence, Jan 10, 2015

Given the social and developmental relevance of ethnicity-race during adolescence, it is importan... more Given the social and developmental relevance of ethnicity-race during adolescence, it is important to understand the meaning of ethnic-racial identity in adolescents' everyday lives. The current study considered how individual differences in ethnic-racial identity exploration (i.e., the extent to which individuals have explored their ethnicity-race), and commitment (i.e., the extent which they have a clear sense of what it means to them) influenced variability versus stability in the awareness of ethnicity-race in a given situation (i.e., salience), and how this variability is related to mood in that situation. Within an ethnic/racially diverse sample of 395 adolescents (M age = 15; 63 % female; 12 % Black, 26 % Latino, 34 % Asian, 23 % White), results indicated that ethnic-racial identity exploration was unrelated to variability in salience, while commitment promoted stability in salience across situations. Further, among adolescents who were generally very aware of their ethni...

Parental Acculturative Stressors and Adolescent Adjustment Through Interparental and Parent-Child Relationships in Chinese American Families

Journal of youth and adolescence, Jan 17, 2016

Perpetual foreigner stereotype and bicultural management difficulty are two understudied accultur... more Perpetual foreigner stereotype and bicultural management difficulty are two understudied acculturative stressors frequently experienced by Asian Americans. This study expanded the family stress model to examine how parental experiences of these two acculturative stressors relate to measures of adolescent adjustment (depressive symptoms, delinquent behaviors, and academic performance) during high school and emerging adulthood through interparental and parent-child relationship processes. Participants were 350 Chinese American adolescents (M age = 17.04, 58 % female) and their parents in Northern California. Path models showed that parental acculturative stressors positively related to parent-child conflict, either directly (for both mother-adolescent and father-adolescent dyads) or indirectly through interparental conflict (for mother-adolescent dyads only). Subsequently, both interparental and parent-child conflict positively related to a sense of alienation between parents and ado...

Development of an Asian American Parental Racial-Ethnic Socialization Scale

Cultural diversity & ethnic minority psychology, Jan 11, 2016

To develop a measure of parental racial-ethnic socialization that is appropriate for Asian Americ... more To develop a measure of parental racial-ethnic socialization that is appropriate for Asian American families. To test the reliability and validity of this new measure, we surveyed 575 Asian American emerging adults (49% female, 79% U.S. born). Using exploratory and confirmatory factor analyses, the results show 7 reliable subscales: maintenance of heritage culture, becoming American, awareness of discrimination, avoidance of other groups, minimization of race, promotion of equality, and cultural pluralism. Tests of factorial invariance show that overall, the subscales demonstrate, at minimum, partial metric invariance across gender, age, nativity, educational attainment, parent educational attainment, geographic region of residence, and Asian-heritage region. Thus, the relations among the subscales with other variables can be compared across these different subgroups. The subscales also correlated with ethnic identity, ethnic centrality, perceptions of discrimination, and pluralisti...

American Journal of Respiratory and Critical Care Medicine, Jan 10, 2013

Rationale: Idiopathic pulmonary fibrosis (IPF) is a disease of progressive lung fibrosis with a h... more Rationale: Idiopathic pulmonary fibrosis (IPF) is a disease of progressive lung fibrosis with a high mortality rate. In organ repair and remodeling, epigenetic events are important. MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and can target epigenetic molecules important in DNA methylation. The miR-17z92 miRNA cluster is critical for lung development and lung epithelial cell homeostasis and is predicted to target fibrotic genes and DNA methyltransferase (DNMT)-1 expression. Objectives: We investigated the miR-17z92 cluster expression and its role in regulating DNA methylation events in IPF lung tissue. Methods: Expression and DNA methylation patterns of miR-17z92 were determined in human IPF lung tissue and fibroblasts and fibrotic mouse lung tissue. The relationship between the miR-17z92 cluster and DNMT-1 expression was examined in vitro. Using a murine model of pulmonary fibrosis, we examined the therapeutic potential of the demethylating agent, 59-aza-29-deoxycytidine. Measurements and Main Results: Compared with control samples, miR-17z92 expression was reduced in lung biopsies and lung fibroblasts from patients with IPF, whereas DNMT-1 expression and methylation of the miR-17z92 promoter was increased. Several miRNAs from the miR-17z92 cluster targeted DNMT-1 expression resulting in a negative feedback loop. Similarly, miR-17z92 expression was reduced in the lungs of bleomycin-treated mice. Treatment with 59aza-29-deoxycytidine in a murine bleomycin-induced pulmonary fibrosis model reduced fibrotic gene and DNMT-1 expression, enhanced miR-17z92 cluster expression, and attenuated pulmonary fibrosis.

A Single-Stage LED Driver Based on Interleaved Buck–Boost Circuit and LLC Resonant Converter

IEEE Journal of Emerging and Selected Topics in Power Electronics, 2015

ABSTRACT A single-stage LED driver based on an interleaved buck–boost circuit and an LLC resonant... more ABSTRACT A single-stage LED driver based on an interleaved buck–boost circuit and an LLC resonant converter is proposed. The buck–boost circuit and the LLC resonant converter are integrated by sharing switches, which can decrease the system cost and improve the system efficiency. The input voltage of the buck–boost circuit is half of the rectified voltage, and two buck–boost circuits are formed with the two half-bridge switches and corresponding diodes. The two buck–boost circuits work in interleaved mode and the inductor current is in discontinuous conduction mode, both helping to achieve the power factor (PF) correction. A half-bridge LLC resonant converter is adopted here, and the soft switching characteristic of the LLC resonant converter is not changed by the switch integration. The primary-side switches still work in zero voltage switching (ZVS) mode, and the secondary diodes still work in ZCS mode, which both reduce the switching losses and improve the efficiency of the system. The design process is described in detail this paper, and a 100-W LED street lighting prototype is proposed, with a PF of 0.995, a total harmonic distortion of 5.7%, and an efficiency of 91.6% at full load.

A Novel Single-stage AC/DC Converter with ZVS Characteristic

A novel single-stage AC/DC converter is proposed in this letter. The converter is designed by int... more A novel single-stage AC/DC converter is proposed in this letter. The converter is designed by integrating a sepic circuit and a flyback circuit, the circuit work in the quasi-resonance state, and the switch is turned on in the zero voltage switching (ZVS) state, which decreased the switching losses of the converter Streszczenie. Opisano nowy konwerter AC/DC. Układ pracuje w stanie quasi-rezonansu z przełączaniem przy zerowym napięciu. (Nowy konwerter AC/DC z przełączaniem przy zerowym napięciu) Keywords: AC-DC converter. Słowa kluczowe: konwerter AC-DC. Introduction Usually a PFC (power-factor-correction) must be added to an AC/DC converter to satisfy the standards such as IEEE 519 and IEC 61000-3-2[1]-[2]. But the costs of the two-stage AC/DC converter are very high, and the reliability is very low. So the single-stage AC/DC converter becomes a choice, but most single-stage converters cannot work with soft switching state, which increases the switching losses of the converter [3]-[...

Electronic ballast of metal halide lamp for projector with digital control

Przeglad Elektrotechniczny

A novel digital control theory is proposed for the metal halide lamp electronic ballast used for ... more A novel digital control theory is proposed for the metal halide lamp electronic ballast used for the projector. The resonant ignition with LC S C P mode is adopted here, an adaptive digital control method for ignition is proposed to overcome the problem of the deviation for the passive components. A simple power closed loop method is proposed to make the lamp power constant without the power over shooting. In the laboratory, a 150W prototype is proposed to prove the rightness of the control theory. Streszczenie. Zaproponowano zmodyfikowany układ obciążenia lampy halogenowej. Zastosowano zapłon rezonansowy oraz układ adaptacyjnego cyfrowego sterowania. Sprzężenie zwrotne zapewnia stały pobór mocy. Zbadano prototypowy projektor o mocy 150 W. (Układ elektroniczny z cyfrowym sterowaniem w projektorze z lampą halogenową) Introduction There are three lighting sources for the projector, which are the ultra high performance (UHP) lamp, the ultra high efficiency lamp (UHE) and the metal hali...

Experimental hepatocyte xenotransplantation-a comprehensive review of the literature

Xenotransplantation, Jan 7, 2015

Hepatocyte transplantation (Tx) is a potential therapy for certain diseases of the liver, includi... more Hepatocyte transplantation (Tx) is a potential therapy for certain diseases of the liver, including hepatic failure. However, there is a limited supply of human livers as a source of cells and, after isolation, human hepatocytes can be difficult to expand in culture, limiting the number available for Tx. Hepatocytes from other species, for example, the pig, have therefore emerged as a potential alternative source. We searched the literature through the end of 2014 to assess the current status of experimental research into hepatocyte xenoTx. The literature search identified 51 reports of in vivo cross-species Tx of hepatocytes in a variety of experimental models. Most studies investigated the Tx of human (n = 23) or pig (n = 19) hepatocytes. No studies explored hepatocytes from genetically engineered pigs. The spleen was the most common site of Tx (n = 23), followed by the liver (through the portal vein [n = 6]) and peritoneal cavity (n = 19). In 47 studies (92%), there was evidence ...

Abstract 3623: Fluctuating antibody response and CD4-positive T-cells in a small-cell lung cancer mouse model

Cancer Research, 2014

Journal of youth and adolescence, Jan 29, 2015

Asian American adolescents are often depicted as academically successful but psychologically dist... more Asian American adolescents are often depicted as academically successful but psychologically distressed, a pattern known as the achievement/adjustment paradox. In a sample of 444 Chinese American adolescents (54 % females), we identified three distinct patterns of adjustment in early adolescence, middle adolescence, and emerging adulthood: the well-adjusted group, which was the largest, exhibited high achievement and low psychological distress; the poorly-adjusted group exhibited poor achievement and moderate distress; and the paradox group exhibited relatively high achievement and high distress. More than half of the adolescents remained in the same profile over time. Adolescents with supportive parents were more likely to stay well-adjusted, and those with "tiger" parents were more likely to stay in the paradox group over time. The present study focused on the critical role of parenting in early adolescence, highlighting variations in Chinese American adolescents' ad...

Journal of Youth and Adolescence, 2015

Upregulation of Caveolin-1 correlate with Akt expression and poor prognosis in NPC patients

The Laryngoscope, Jan 15, 2015

The aim of this study is to investigate the role of Caveolin-1 (Cav-1) in nasopharyngeal carcinom... more The aim of this study is to investigate the role of Caveolin-1 (Cav-1) in nasopharyngeal carcinoma (NPC) progression and correlated with clinical outcomes. We used quantitative real-time PCR (qPCR) to detect the difference in the expression of mRNA level of Cav-1 mRNA in NPC, non-NPC cell lines, and 74 NPC and 29 nontumorous nasopharyngeal mucosa biopsies. Western blotting and immunohistochemistry staining were used to detect the protein expression of Cav-1 in cell lines and biopsy tissues. We collected clinical follow-up data to investigate the association with expression of Cav-1 mRNA. Also, transfection of Cav-1 and suppression by delivery of shRNA against Cav-1 into NPC derived cell lines to analyze its influence in Akt signaling. By use of qPCR, immunohistochemical staining, and western blotting, we found that not only is Cav-1 overexpressed in human NPC tumor cells and NPC-derived cell lines but high Cav-1 mRNA expression is associated with poor overall survival time of NPC pa...

Supernatants from stored red blood cell (RBC) units, but not RBC-derived microvesicles, suppress monocyte function in vitro

Transfusion, Jan 27, 2015

We have previously shown that critically ill children transfused with red blood cells (RBCs) of l... more We have previously shown that critically ill children transfused with red blood cells (RBCs) of longer storage durations have more suppressed monocyte function after transfusion compared to children transfused with fresher RBCs and that older stored RBCs directly suppress monocyte function in vitro, through unknown mechanisms. We hypothesized that RBC-derived microvesicles (MVs) were responsible for monocyte suppression. To determine the role of stored RBC unit-derived MVs, we cocultured monocytes with supernatants, isolated MVs, or supernatants that had been depleted of MVs from prestorage leukoreduced RBCs that had been stored for either 7 or 30 days. Isolated MVs were characterized by electron microscopy and flow cytometry. Monocyte function after coculture experiments was measured by cytokine production after stimulation with lipopolysaccharide (LPS). Monocyte function was suppressed after exposure to supernatants from 30-day RBC units compared to monocytes cultured in medium al...

The inositol phosphatase SHIP2 down-regulates FcR-mediated phagocytosis in murine macrophages independently of SHIP1

FcR-mediated phagocytosis of IgG- coated particles is a complex process involving the activation ... more FcR-mediated phagocytosis of IgG- coated particles is a complex process involving the activation of multiple signal- ing enzymes and is regulated by the inosi- tol phosphatases PTEN (phosphatase and tensin homolog deleted on chromosome 10) and SHIP-1 (Src homology (SH2) do- main-containing inositol phosphatase). In a recent study we have demonstrated that SHIP-2, an inositol phosphatase with high-level homology to

Asian American journal of psychology, 2013

Language Brokering and Adjustment among Chinese and Korean American Adolescents: A Moderated Mediation Model of Perceived Maternal Sacrifice, Respect for the Mother, and Mother-Child Open Communication

Asian American journal of psychology, 2014

Asian American adolescents often language broker for their immigrant parents. Using a two-wave sa... more Asian American adolescents often language broker for their immigrant parents. Using a two-wave sample of Chinese American (n = 237; average age at W1 = 14.65, SD = .68) and Korean American (n = 262; average age at W1 = 14.72, SD = .69) adolescents, this study examined a culturally relevant conditional mechanism through which language brokering may contribute to lower levels of internalizing/externalizing problems. Results suggested that language brokering for the mother was associated with perceived maternal sacrifice, which was in turn associated with respect for the mother, which was eventually associated with lower levels of externalizing problems (but not internalizing problems) in the adolescents. Moreover, the indirect effect was conditional on the level of mother-child open communication. With a lower level of open communication, the indirect effect of language brokering on externalizing problems became stronger. Results indicate that interventions designed to reduce Asian Am...

Chinese American Parents' Acculturation and Enculturation, Bicultural Management Difficulty, Depressive Symptoms, and Parenting

Asian American journal of psychology, 2014

This study examined whether Chinese American parents' acculturation and enculturation were re... more This study examined whether Chinese American parents' acculturation and enculturation were related to parenting practices (punitive parenting, democratic child participation, and inductive reasoning) indirectly through the mediation of parents' bicultural management difficulty and parental depressed mood. Data came from a two-wave study of Chinese American families in Northern California. Mothers and fathers were assessed when their children were in early adolescence and then again in middle adolescence (407 mothers and 381 fathers at Wave 1; 308 mothers and 281 fathers at Wave 2). For both waves, we examined cross-sectional models encompassing both direct and indirect links from parental cultural orientations to parenting practices. We also used individual fixed-effects techniques to account for selection bias in testing model relationships at Wave 2. At Wave 1, via bicultural management difficulty and depressive symptoms, American orientation was related to less punitive p...

3 Abbreviations used in this paper: ITAM, immunoreceptor tyrosine-based activation motif; ITIM, i... more 3 Abbreviations used in this paper: ITAM, immunoreceptor tyrosine-based activation motif; ITIM, immunoreceptor tyrosine-based inhibition motif; SH, Src homology; GAM, goat anti-mouse Ig; SHIP, SH2 domain-containing inositol polyphosphate phosphatase; Erk, extracellular signal-regulated kinase; BMM, bone marrow-derived macrophage.

Phagocytosis in Murine Macrophages Independently of SHIP-1

World Journal of Gastroenterology, Dec 1, 2010

AIM: To assess the benefits and limits of surgery for primary hepatic lymphoma (PHL), and probabi... more AIM: To assess the benefits and limits of surgery for primary hepatic lymphoma (PHL), and probability of survival after postoperative chemotherapy.

The Everyday Implications of Ethnic-Racial Identity Processes: Exploring Variability in Ethnic-Racial Identity Salience Across Situations

Journal of youth and adolescence, Jan 10, 2015

Given the social and developmental relevance of ethnicity-race during adolescence, it is importan... more Given the social and developmental relevance of ethnicity-race during adolescence, it is important to understand the meaning of ethnic-racial identity in adolescents' everyday lives. The current study considered how individual differences in ethnic-racial identity exploration (i.e., the extent to which individuals have explored their ethnicity-race), and commitment (i.e., the extent which they have a clear sense of what it means to them) influenced variability versus stability in the awareness of ethnicity-race in a given situation (i.e., salience), and how this variability is related to mood in that situation. Within an ethnic/racially diverse sample of 395 adolescents (M age = 15; 63 % female; 12 % Black, 26 % Latino, 34 % Asian, 23 % White), results indicated that ethnic-racial identity exploration was unrelated to variability in salience, while commitment promoted stability in salience across situations. Further, among adolescents who were generally very aware of their ethni...

Parental Acculturative Stressors and Adolescent Adjustment Through Interparental and Parent-Child Relationships in Chinese American Families

Journal of youth and adolescence, Jan 17, 2016

Perpetual foreigner stereotype and bicultural management difficulty are two understudied accultur... more Perpetual foreigner stereotype and bicultural management difficulty are two understudied acculturative stressors frequently experienced by Asian Americans. This study expanded the family stress model to examine how parental experiences of these two acculturative stressors relate to measures of adolescent adjustment (depressive symptoms, delinquent behaviors, and academic performance) during high school and emerging adulthood through interparental and parent-child relationship processes. Participants were 350 Chinese American adolescents (M age = 17.04, 58 % female) and their parents in Northern California. Path models showed that parental acculturative stressors positively related to parent-child conflict, either directly (for both mother-adolescent and father-adolescent dyads) or indirectly through interparental conflict (for mother-adolescent dyads only). Subsequently, both interparental and parent-child conflict positively related to a sense of alienation between parents and ado...

Development of an Asian American Parental Racial-Ethnic Socialization Scale

Cultural diversity & ethnic minority psychology, Jan 11, 2016

To develop a measure of parental racial-ethnic socialization that is appropriate for Asian Americ... more To develop a measure of parental racial-ethnic socialization that is appropriate for Asian American families. To test the reliability and validity of this new measure, we surveyed 575 Asian American emerging adults (49% female, 79% U.S. born). Using exploratory and confirmatory factor analyses, the results show 7 reliable subscales: maintenance of heritage culture, becoming American, awareness of discrimination, avoidance of other groups, minimization of race, promotion of equality, and cultural pluralism. Tests of factorial invariance show that overall, the subscales demonstrate, at minimum, partial metric invariance across gender, age, nativity, educational attainment, parent educational attainment, geographic region of residence, and Asian-heritage region. Thus, the relations among the subscales with other variables can be compared across these different subgroups. The subscales also correlated with ethnic identity, ethnic centrality, perceptions of discrimination, and pluralisti...

American Journal of Respiratory and Critical Care Medicine, Jan 10, 2013

Rationale: Idiopathic pulmonary fibrosis (IPF) is a disease of progressive lung fibrosis with a h... more Rationale: Idiopathic pulmonary fibrosis (IPF) is a disease of progressive lung fibrosis with a high mortality rate. In organ repair and remodeling, epigenetic events are important. MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and can target epigenetic molecules important in DNA methylation. The miR-17z92 miRNA cluster is critical for lung development and lung epithelial cell homeostasis and is predicted to target fibrotic genes and DNA methyltransferase (DNMT)-1 expression. Objectives: We investigated the miR-17z92 cluster expression and its role in regulating DNA methylation events in IPF lung tissue. Methods: Expression and DNA methylation patterns of miR-17z92 were determined in human IPF lung tissue and fibroblasts and fibrotic mouse lung tissue. The relationship between the miR-17z92 cluster and DNMT-1 expression was examined in vitro. Using a murine model of pulmonary fibrosis, we examined the therapeutic potential of the demethylating agent, 59-aza-29-deoxycytidine. Measurements and Main Results: Compared with control samples, miR-17z92 expression was reduced in lung biopsies and lung fibroblasts from patients with IPF, whereas DNMT-1 expression and methylation of the miR-17z92 promoter was increased. Several miRNAs from the miR-17z92 cluster targeted DNMT-1 expression resulting in a negative feedback loop. Similarly, miR-17z92 expression was reduced in the lungs of bleomycin-treated mice. Treatment with 59aza-29-deoxycytidine in a murine bleomycin-induced pulmonary fibrosis model reduced fibrotic gene and DNMT-1 expression, enhanced miR-17z92 cluster expression, and attenuated pulmonary fibrosis.

A Single-Stage LED Driver Based on Interleaved Buck–Boost Circuit and LLC Resonant Converter

IEEE Journal of Emerging and Selected Topics in Power Electronics, 2015

ABSTRACT A single-stage LED driver based on an interleaved buck–boost circuit and an LLC resonant... more ABSTRACT A single-stage LED driver based on an interleaved buck–boost circuit and an LLC resonant converter is proposed. The buck–boost circuit and the LLC resonant converter are integrated by sharing switches, which can decrease the system cost and improve the system efficiency. The input voltage of the buck–boost circuit is half of the rectified voltage, and two buck–boost circuits are formed with the two half-bridge switches and corresponding diodes. The two buck–boost circuits work in interleaved mode and the inductor current is in discontinuous conduction mode, both helping to achieve the power factor (PF) correction. A half-bridge LLC resonant converter is adopted here, and the soft switching characteristic of the LLC resonant converter is not changed by the switch integration. The primary-side switches still work in zero voltage switching (ZVS) mode, and the secondary diodes still work in ZCS mode, which both reduce the switching losses and improve the efficiency of the system. The design process is described in detail this paper, and a 100-W LED street lighting prototype is proposed, with a PF of 0.995, a total harmonic distortion of 5.7%, and an efficiency of 91.6% at full load.

A Novel Single-stage AC/DC Converter with ZVS Characteristic

A novel single-stage AC/DC converter is proposed in this letter. The converter is designed by int... more A novel single-stage AC/DC converter is proposed in this letter. The converter is designed by integrating a sepic circuit and a flyback circuit, the circuit work in the quasi-resonance state, and the switch is turned on in the zero voltage switching (ZVS) state, which decreased the switching losses of the converter Streszczenie. Opisano nowy konwerter AC/DC. Układ pracuje w stanie quasi-rezonansu z przełączaniem przy zerowym napięciu. (Nowy konwerter AC/DC z przełączaniem przy zerowym napięciu) Keywords: AC-DC converter. Słowa kluczowe: konwerter AC-DC. Introduction Usually a PFC (power-factor-correction) must be added to an AC/DC converter to satisfy the standards such as IEEE 519 and IEC 61000-3-2[1]-[2]. But the costs of the two-stage AC/DC converter are very high, and the reliability is very low. So the single-stage AC/DC converter becomes a choice, but most single-stage converters cannot work with soft switching state, which increases the switching losses of the converter [3]-[...

Electronic ballast of metal halide lamp for projector with digital control

Przeglad Elektrotechniczny

A novel digital control theory is proposed for the metal halide lamp electronic ballast used for ... more A novel digital control theory is proposed for the metal halide lamp electronic ballast used for the projector. The resonant ignition with LC S C P mode is adopted here, an adaptive digital control method for ignition is proposed to overcome the problem of the deviation for the passive components. A simple power closed loop method is proposed to make the lamp power constant without the power over shooting. In the laboratory, a 150W prototype is proposed to prove the rightness of the control theory. Streszczenie. Zaproponowano zmodyfikowany układ obciążenia lampy halogenowej. Zastosowano zapłon rezonansowy oraz układ adaptacyjnego cyfrowego sterowania. Sprzężenie zwrotne zapewnia stały pobór mocy. Zbadano prototypowy projektor o mocy 150 W. (Układ elektroniczny z cyfrowym sterowaniem w projektorze z lampą halogenową) Introduction There are three lighting sources for the projector, which are the ultra high performance (UHP) lamp, the ultra high efficiency lamp (UHE) and the metal hali...

Experimental hepatocyte xenotransplantation-a comprehensive review of the literature

Xenotransplantation, Jan 7, 2015

Hepatocyte transplantation (Tx) is a potential therapy for certain diseases of the liver, includi... more Hepatocyte transplantation (Tx) is a potential therapy for certain diseases of the liver, including hepatic failure. However, there is a limited supply of human livers as a source of cells and, after isolation, human hepatocytes can be difficult to expand in culture, limiting the number available for Tx. Hepatocytes from other species, for example, the pig, have therefore emerged as a potential alternative source. We searched the literature through the end of 2014 to assess the current status of experimental research into hepatocyte xenoTx. The literature search identified 51 reports of in vivo cross-species Tx of hepatocytes in a variety of experimental models. Most studies investigated the Tx of human (n = 23) or pig (n = 19) hepatocytes. No studies explored hepatocytes from genetically engineered pigs. The spleen was the most common site of Tx (n = 23), followed by the liver (through the portal vein [n = 6]) and peritoneal cavity (n = 19). In 47 studies (92%), there was evidence ...

Abstract 3623: Fluctuating antibody response and CD4-positive T-cells in a small-cell lung cancer mouse model

Cancer Research, 2014

Journal of youth and adolescence, Jan 29, 2015

Asian American adolescents are often depicted as academically successful but psychologically dist... more Asian American adolescents are often depicted as academically successful but psychologically distressed, a pattern known as the achievement/adjustment paradox. In a sample of 444 Chinese American adolescents (54 % females), we identified three distinct patterns of adjustment in early adolescence, middle adolescence, and emerging adulthood: the well-adjusted group, which was the largest, exhibited high achievement and low psychological distress; the poorly-adjusted group exhibited poor achievement and moderate distress; and the paradox group exhibited relatively high achievement and high distress. More than half of the adolescents remained in the same profile over time. Adolescents with supportive parents were more likely to stay well-adjusted, and those with "tiger" parents were more likely to stay in the paradox group over time. The present study focused on the critical role of parenting in early adolescence, highlighting variations in Chinese American adolescents' ad...

Journal of Youth and Adolescence, 2015

Upregulation of Caveolin-1 correlate with Akt expression and poor prognosis in NPC patients

The Laryngoscope, Jan 15, 2015

The aim of this study is to investigate the role of Caveolin-1 (Cav-1) in nasopharyngeal carcinom... more The aim of this study is to investigate the role of Caveolin-1 (Cav-1) in nasopharyngeal carcinoma (NPC) progression and correlated with clinical outcomes. We used quantitative real-time PCR (qPCR) to detect the difference in the expression of mRNA level of Cav-1 mRNA in NPC, non-NPC cell lines, and 74 NPC and 29 nontumorous nasopharyngeal mucosa biopsies. Western blotting and immunohistochemistry staining were used to detect the protein expression of Cav-1 in cell lines and biopsy tissues. We collected clinical follow-up data to investigate the association with expression of Cav-1 mRNA. Also, transfection of Cav-1 and suppression by delivery of shRNA against Cav-1 into NPC derived cell lines to analyze its influence in Akt signaling. By use of qPCR, immunohistochemical staining, and western blotting, we found that not only is Cav-1 overexpressed in human NPC tumor cells and NPC-derived cell lines but high Cav-1 mRNA expression is associated with poor overall survival time of NPC pa...

Supernatants from stored red blood cell (RBC) units, but not RBC-derived microvesicles, suppress monocyte function in vitro

Transfusion, Jan 27, 2015

We have previously shown that critically ill children transfused with red blood cells (RBCs) of l... more We have previously shown that critically ill children transfused with red blood cells (RBCs) of longer storage durations have more suppressed monocyte function after transfusion compared to children transfused with fresher RBCs and that older stored RBCs directly suppress monocyte function in vitro, through unknown mechanisms. We hypothesized that RBC-derived microvesicles (MVs) were responsible for monocyte suppression. To determine the role of stored RBC unit-derived MVs, we cocultured monocytes with supernatants, isolated MVs, or supernatants that had been depleted of MVs from prestorage leukoreduced RBCs that had been stored for either 7 or 30 days. Isolated MVs were characterized by electron microscopy and flow cytometry. Monocyte function after coculture experiments was measured by cytokine production after stimulation with lipopolysaccharide (LPS). Monocyte function was suppressed after exposure to supernatants from 30-day RBC units compared to monocytes cultured in medium al...

The inositol phosphatase SHIP2 down-regulates FcR-mediated phagocytosis in murine macrophages independently of SHIP1

FcR-mediated phagocytosis of IgG- coated particles is a complex process involving the activation ... more FcR-mediated phagocytosis of IgG- coated particles is a complex process involving the activation of multiple signal- ing enzymes and is regulated by the inosi- tol phosphatases PTEN (phosphatase and tensin homolog deleted on chromosome 10) and SHIP-1 (Src homology (SH2) do- main-containing inositol phosphatase). In a recent study we have demonstrated that SHIP-2, an inositol phosphatase with high-level homology to

Asian American journal of psychology, 2013

Language Brokering and Adjustment among Chinese and Korean American Adolescents: A Moderated Mediation Model of Perceived Maternal Sacrifice, Respect for the Mother, and Mother-Child Open Communication

Asian American journal of psychology, 2014

Asian American adolescents often language broker for their immigrant parents. Using a two-wave sa... more Asian American adolescents often language broker for their immigrant parents. Using a two-wave sample of Chinese American (n = 237; average age at W1 = 14.65, SD = .68) and Korean American (n = 262; average age at W1 = 14.72, SD = .69) adolescents, this study examined a culturally relevant conditional mechanism through which language brokering may contribute to lower levels of internalizing/externalizing problems. Results suggested that language brokering for the mother was associated with perceived maternal sacrifice, which was in turn associated with respect for the mother, which was eventually associated with lower levels of externalizing problems (but not internalizing problems) in the adolescents. Moreover, the indirect effect was conditional on the level of mother-child open communication. With a lower level of open communication, the indirect effect of language brokering on externalizing problems became stronger. Results indicate that interventions designed to reduce Asian Am...

Chinese American Parents' Acculturation and Enculturation, Bicultural Management Difficulty, Depressive Symptoms, and Parenting

Asian American journal of psychology, 2014

This study examined whether Chinese American parents' acculturation and enculturation were re... more This study examined whether Chinese American parents' acculturation and enculturation were related to parenting practices (punitive parenting, democratic child participation, and inductive reasoning) indirectly through the mediation of parents' bicultural management difficulty and parental depressed mood. Data came from a two-wave study of Chinese American families in Northern California. Mothers and fathers were assessed when their children were in early adolescence and then again in middle adolescence (407 mothers and 381 fathers at Wave 1; 308 mothers and 281 fathers at Wave 2). For both waves, we examined cross-sectional models encompassing both direct and indirect links from parental cultural orientations to parenting practices. We also used individual fixed-effects techniques to account for selection bias in testing model relationships at Wave 2. At Wave 1, via bicultural management difficulty and depressive symptoms, American orientation was related to less punitive p...