Yoichi Ogushi - Academia.edu (original) (raw)

Papers by Yoichi Ogushi

Journal of Lipid Nutrition, 2018

An open-label, randomized controlled trial in type 2 diabetics with hypertension, dyslipidemia, o... more An open-label, randomized controlled trial in type 2 diabetics with hypertension, dyslipidemia, or both was reported (J-DOIT3 study) ．The participants were randomly assigned to receive conventional or intensive therapy with respect to HbA1c, blood pressure and LDL-C (n=1,271 in each group) ，and were followed for 8.5 years at 81 clinical sites. Both the participants and doctors in charge were aware of the group assigned. The experimental design was essentially as recommended in the [Comprehensive risk management chart for the prevention of cerebro-and cardiovascular diseases 2015] from the Joint Committee consisted of 13 internal medicine-related societies in Japan, and the Japan Atherosclerotic Society Guidelines 2017. Therefore, the conclusion from the J-DOIT3 study is expected in medical field to affect the current and future medications for the prevention of atherosclerotic cerebro-and cardiovascular diseases (ASCVD) ．While analyzing the results of this study，we encountered serious problems associated with the methodology, logics and its interpretations, which were summarized in this review. The follow-up study appears to be in progress as described in the Discussion, but we interpret that the intensive therapy used in the J-DOIT3 study is risky in view of currently available evidence. We propose the authors of the study to let the participants know of the results on its objective endpoint, and newly obtain Informed Consents including the potential risks of the intensive intervention based on the progress in this field after the start of this study.

Journal of Medical Informatics, 2002

Journal of Lipid Nutrition, 2009

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ANTI-AGING MEDICINE, 2010

In the "Brain Aging and Nutrition" symposium at the 2010 10th Scientific Meeting of the Japanese ... more In the "Brain Aging and Nutrition" symposium at the 2010 10th Scientific Meeting of the Japanese Society of Anti-Aging Medicine, three experts were invited to report recent findings on maintenance of brain health. Speaking on "The association of postural instability with brain atrophy/cognitive impairment", Dr.

The Tokai journal of experimental and clinical medicine, Jan 20, 2007

We evaluated the usefulness of radiological reporting that combines continuous speech recognition... more We evaluated the usefulness of radiological reporting that combines continuous speech recognition (CSR) and error correction by transcriptionists. Four transcriptionists (two with more than 10 years' and two with less than 3 months' transcription experience) listened to the same 100 dictation files and created radiological reports using conventional transcription and a method that combined CSR with manual error correction by the transcriptionists. We compared the 2 groups using the 2 methods for accuracy and report creation time and evaluated the transcriptionists' inter-personal dependence on accuracy rate and report creation time. We used a CSR system that did not require the training of the system to recognize the user's voice. We observed no significant difference in accuracy between the 2 groups and 2 methods that we tested, though transcriptionists with greater experience transcribed faster than those with less experience using conventional transcription. Using...

The Tokai journal of experimental and clinical medicine, 2005

A retrospective evaluation was made concerning thrombolytic therapy for ultra-acute ischemic stro... more A retrospective evaluation was made concerning thrombolytic therapy for ultra-acute ischemic stroke patients, using a recombinant tissue plasminogen activator (rt-PA), which is not yet approved as a drug for brain infarction in Japan. The evaluation was implemented using the database of patients that suffered acute strokes as collected by the Japanese Standard Stroke Registry Study (JSSRS). The thrombolytic therapy group, selected from among the registered 6,090 cases of brain infarction patients, was divided into two groups, namely, a group of patients who were admitted in the hospital within 3 hours of the onset (86 cases, average age 69.6) and the other group who were admitted after 3 hours from the onset (28 cases, average age 66.8). Using a Multiple Logistic Regression Analysis adapted for modified Rankin scale (mRS) regarding each group, the clinical effects of thrombolytic therapy for functional outcome and presence or absence of dementia at the time of hospital discharge wer...

Environmental Health and Preventive Medicine, 1998

A case-control study has been conducted to investigate the relationship between lifestyle and ris... more A case-control study has been conducted to investigate the relationship between lifestyle and risk of colorectal cancer. Cases are one hundred patients diagnosed with colon and rectal cancer in Tokai University Hospital between 1986 and 1994. Three controls per case were individually matched by age, sex, local areas and date of health checkups at the Automated Multi-phasic Health Testing and Services (AMHTS) Center of the hospital. The results were analyzed by multi-factorial logistic regression models. Positive history of maternal cancer, large consumption of alcohol, frequent consumption of potato products and white-collar job were predominant risk factors while frequent intake of seaweed was a protective factor. Frequent intakes of dairy foods and lack of exercise showed no significant tendency to increase risk of colorectal cancer. Smoking habits, intakes of meat and egg were shown not to be related to this disease. These findings suggest that family history of cancer and dietary factors play a key role in causation and prevention of colorectal cancer.

Pharmacology, 2018

Background: The Consensus Statement from the European Atherosclerosis Society (EAS) Consensus Pan... more Background: The Consensus Statement from the European Atherosclerosis Society (EAS) Consensus Panel 2017 concludes on the basis of 3 different types of clinical studies that low-density lipoprotein (LDL) causes atherosclerotic cardiovascular disease (ASCVD). In Mendelian randomization studies, rare genetic mutations affecting LDL receptor function were found to cause higher or lower LDL-C levels, which are associated with correspondingly altered ASCVD risk. In prospective cohort studies and randomized controlled trials (RCTs) of statins, a remarkably consistent log-linear association was demonstrated between the absolute magnitude of LDL-C exposure and ASCVD risk. The EAS Statement proposes that any mechanism of lowering plasma LDL concentration should reduce the risk of ASCVD events proportional to the absolute reduction in LDL-C and the cumulative duration of exposure to lower LDL-C. However, as we explain, we do not find this conclusion acceptable. Summary: Our review points out ...

BMJ open, Jun 12, 2016

It is well known that total cholesterol becomes less of a risk factor or not at all for all-cause... more It is well known that total cholesterol becomes less of a risk factor or not at all for all-cause and cardiovascular (CV) mortality with increasing age, but as little is known as to whether low-density lipoprotein cholesterol (LDL-C), one component of total cholesterol, is associated with mortality in the elderly, we decided to investigate this issue. We sought PubMed for cohort studies, where LDL-C had been investigated as a risk factor for all-cause and/or CV mortality in individuals ≥60 years from the general population. We identified 19 cohort studies including 30 cohorts with a total of 68 094 elderly people, where all-cause mortality was recorded in 28 cohorts and CV mortality in 9 cohorts. Inverse association between all-cause mortality and LDL-C was seen in 16 cohorts (in 14 with statistical significance) representing 92% of the number of participants, where this association was recorded. In the rest, no association was found. In two cohorts, CV mortality was highest in the ...

Journal of Lipid Nutrition, 2008

Journal of Lipid Nutrition, 2012

Journal of Lipid Nutrition, 2013

Statins have been recognized clinically to raise blood glucose and glycated protein (HbA1c) level... more Statins have been recognized clinically to raise blood glucose and glycated protein (HbA1c) levels enhancing the development of insulin resistance. However, most clinicians appear to adopt the interpretation that the benefit (prevention of CHD)-NTP

Expert review of clinical pharmacology, 2015

In contrast to the current belief that cholesterol reduction with statins decreases atheroscleros... more In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins may be causative in coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and 'heme A', and thereby ATP generation. Statins inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation, which in turn protects arteries from calcification. Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress. An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure, reminiscent of the dilated cardiomyopathies seen with selenium deficiency. Thus, the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs. We propos...

World review of nutrition and dietetics, 2009

Studies in health technology and informatics, 2005

Most reference ranges are not considered sex-age specific differences. We collected about 700,000... more Most reference ranges are not considered sex-age specific differences. We collected about 700,000 health examination data with 24 items to estimate sex-age specific clinical reference ranges. We proposed nonlinear optimization method as a new method compatible with NCCLS guideline. All items showed sex-age specific differences of reference ranges. Especially, hepatic functions in young aged men and all aged women, diabetic functions in young aged people, blood pressures in older people, and total cholesterol in all aged people might have serious problems. Some abnormal individuals might not be detected using established reference ranges, on the other hand, some normal individuals might be treated excessively.