Yong Xu - Academia.edu (original) (raw)
Papers by Yong Xu
Innate immunity, 2016
NK cells participate in the development of human multiple sclerosis (MS) and mouse experimental a... more NK cells participate in the development of human multiple sclerosis (MS) and mouse experimental autoimmune encephalomyelitis (EAE), but the roles of different NK cell subsets in disease onset remain poorly understood. In this study, murine NK cells were divided into CD27(high) and CD27(low/-) subsets. The CD27(high) subset was decreased and the CD27(low/-) subset was increased in lymphoid organs during the pre-onset stage of EAE. Compared with the counterpart in naïve mice, the CD27(high) subset showed lower expression of Ly49D, Ly49H and NKG2D, and less production of IFN-γ, whereas the CD27(low/-) subset showed similar expression of the above mentioned surface receptors but higher cytotoxic activity in EAE mice. Compared with the CD27(high) subset, the CD27(low/-) subset exhibited increased promotion of DC maturation and no significant inhibition of T cells proliferation and Th17 cells differentiation in vitro Additionally, adoptive transfer of the CD27(low/-) subset, but not the C...
Molecular immunology, Jan 4, 2016
A large number of recipients are in a compromised immune defense condition because of the routine... more A large number of recipients are in a compromised immune defense condition because of the routine application of immunosuppressive regimens after heart transplantation. Our previous work demonstrated that blockade of high-mobility group box 1 (HMGB1) prolongs the graft survival. Whether and how HMGB1 blockade impacts respiratory responses against pathogen-like challenge in organ transplant recipients when it improves cardiac graft are not elucidated. At the present study, after abdominal heterotopic heart transplantation, the recipient mice were treated with HMGB1 mAb, and then challenged with poly(I:C) or LPS intratracheally on day 7 post transplantation. We found that the level of bronchoalveolar lavage (BAL) HMGB1 was elevated after heart transplantation, and aggravated responses to respiratory tract poly(I:C)/LPS challenge were observed. HMGB1 neutralizing mAb treatment in poly(I:C)-challenged recipient mice alleviated pulmonary histopathological changes, neutrophil infiltration...
Cytokines secreted by infiltrating immune cells during atherogenesis modulate vascular remodel- i... more Cytokines secreted by infiltrating immune cells during atherogenesis modulate vascular remodel- ing. One exemplary event is the antagonism between transformed growth factor (TGF-b) and interferon gamma (IFN-c) on the transcriptional con- trol of type I collagen gene (COL1A2). Previously we have reported that IFN-c up-regulates regulatory factor for X-box B (RFXB) to repress collagen tran- scription while down-regulates the expression
Physical Review B, 1994
The addition of suitable dopants to ZrO[sub 2] can induce dramatic phase stabilization, and this ... more The addition of suitable dopants to ZrO[sub 2] can induce dramatic phase stabilization, and this dopant-induced phase stabilization is the basis of transformation toughening of zirconia-based structural ceramics. We have determined the electronic structure of three phases of ZrO[sub 2], cubic, tetragonal, and monoclinic, using vacuum-ultraviolet and x-ray-photoemission spectroscopies, coupled with [ital ab] [ital initio] band-structure and optical property calculations
International Journal of High Performance Computing and Networking, 2006
Smart antennas are suggested to be used in future generation wireless and mobile networks to prov... more Smart antennas are suggested to be used in future generation wireless and mobile networks to provide the service with high capacity and service quality. In this paper, we propose a novel multimedia wireless and mobile network using smart antennas. The smart antenna in the proposed system provides a Space Division Multiple Access (SDMA) scheme to improve system capacity dramatically. In the proposed system, the Quality of Service (QoS) is guaranteed for real-time service at the cost of the tolerable quality decrease for non-real- ...
IEEE Wireless Communications and Networking Conference, 2005, 2000
Abstract In this paper, we propose an analytical model for novel multimedia wireless and mobile n... more Abstract In this paper, we propose an analytical model for novel multimedia wireless and mobile networks using smart antennas. In the proposed networks, several beams having the same physical channel (eg, frequency in FDMA, time slot in TDMA, spreading code in CDMA, or any combination of them) are formed in a cell. System capacity is increased dramatically by reusing the channels in the same cell. In this paper, we consider two types of multimedia services, real-time services and non-real-time services. Quality of service (QoS ...
Third International Symposium on Multispectral Image Processing and Pattern Recognition, 2003
In this paper some properties of Foley-Sammon optimal discriminant vector (FSODV), by contrast wi... more In this paper some properties of Foley-Sammon optimal discriminant vector (FSODV), by contrast with uncorrelated optimal discriminant vector (UODV), are discussed. Firstly the Fisher ratio of every FSODV must be not less than that of corresponding UODV and consequently sole FSODV will be superior to corresponding UODV. Secondly the correlation between feature components extracted by FSODV is an important factor.
2013 IEEE Asian Solid-State Circuits Conference (A-SSCC), 2013
ABSTRACT A wireless power management and data telemetry circuit module for high compliance voltag... more ABSTRACT A wireless power management and data telemetry circuit module for high compliance voltage electrical stimulation applications is presented in this paper. The system consists of rectifier, LDOs, DC-DC step-up charge pump and power monitoring circuit for closed loop wireless power management. The system also consists of a clock and data recovery (CDR) circuit and load shift keying (LSK) modulator for bidirectional data telemetry. The system operates at 13.56MHz. The wireless power management block receives AC power through an implantable coil and outputs three DC levels: 1V, 1.8V and 10V. The CDR circuit recovers clock and data from the 13.56MHz RF carrier through the same coil. The power efficiency of the wireless power management system is measured as 42% with 100μA current load connected on each supply output. The forward and backward data rate of the data telemetry achieves 61.5 kbps and 33.3 kbps, respectively. The system is implemented in 0.18μm CMOS process with 24V HV LDMOS option, occupying a core area of 1.8 mm × 1.8 mm.
Proceedings IEEE Thirteenth Annual International Conference on Micro Electro Mechanical Systems (Cat. No.00CH36308), 2000
Packaging for a large distributed sensing system is a challenging topic. Using flexible skin tech... more Packaging for a large distributed sensing system is a challenging topic. Using flexible skin technology solves many of these problems. Combining with the newly developed backside contact technique, sensor packaging is made even easier by completely avoiding the fragile bonding wires. This paper describes the improved flexible MEMS technology and its application to the fabrication and packaging of practical shear stress sensor skins. An airflow separation detection system including these skins, MOSIS bias circuits and a data acquisition unit has been successfully tested in windtunnel and is being used for the aerodynamic study of a MEMS controlled super-maneuverable low-altitude unmanned aerial vehicle (UAV) . B J J J J J J J J
2005 International Conference on Machine Learning and Cybernetics, 2005
... Guangzhou, 18-21 August 2005 AN EFFICIENT KERNEL-BASED NONLINEAR REGRESSION METHOD FOR TWO-CL... more ... Guangzhou, 18-21 August 2005 AN EFFICIENT KERNEL-BASED NONLINEAR REGRESSION METHOD FOR TWO-CLASS CLASSIFICATION YONG XU,JING-YU YANG, JIAN-FENG LU Department of Computer Science & ...
Arthritis Research & Therapy, 2008
INTRODUCTION: Conflicting findings on the association of single nucleotide polymorphisms (SNPs) i... more INTRODUCTION: Conflicting findings on the association of single nucleotide polymorphisms (SNPs) in RHOB and TXNDC3 with susceptibility to knee osteoarthritis (OA) have been reported in European Caucasians. To examine the associations of these SNPs with OA in East Asian populations and to evaluate their global significance, we conducted two case-control studies in 955 Chinese and 750 Japanese patients. METHODS: We
The Red Soils of China, 2004
2010 IEEE Sensors, 2010
This paper reports the preliminary development of a capacitive accelerometer that possesses high ... more This paper reports the preliminary development of a capacitive accelerometer that possesses high sensitivity and broad dynamic range simultaneously. Our idea of improving these two conflicting requirements is to incorporate positive and negative feedbacks into the system, inspired by the operation mechanisms of the inner ear hair cells. The positive feedback selectively amplifies small inputs but stops functioning for large
Neurocomputing, 2010
We propose a linear discriminant analysis method. In this method, every discriminant vector, exce... more We propose a linear discriminant analysis method. In this method, every discriminant vector, except for the first one, is worked out by maximizing a Fisher criterion defined in a transformed space which is the null space of the previously obtained discriminant vectors. All of these discriminant vectors are used for dimension reduction. We also propose two algorithms to implement the model. Based on the algorithms, we prove that the discriminant vectors will be orthogonal if the within-class scatter matrix is not singular. The experimental results show that the proposed method is effective and efficient.
Urologic oncology
RNA interference (RNAi) has the potential to be developed into therapeutics for prostate cancer, ... more RNA interference (RNAi) has the potential to be developed into therapeutics for prostate cancer, but the lack of cellular targets limits its application. In the present study we attempt to develop a prostate cancer-specific RNAi system using the human prostate specific membrane antigen (PSMA) promoter/enhancer; furthermore, we analyzed its inhibitive effect on STAT3 expression. The adenoviral vectors containing a small hairpin RNA (shRNA) to target exogenous reporters enhance green fluorescent protein (EGFP) and endogenous gene signal transducers and activators of transcription 3 (STAT3) were constructed. After prostate cancer and other cells were transfected, reverse transcription-polymerase chain reaction (RT-PCR), fluorescence microscopy, and Western blotting were used to measure EGFP expression. Inhibition of STAT3 was evaluated by Western blotting. Cell proliferation and viability were measured by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assa...
IEEE Asian Solid-State Circuits Conference 2011, 2011
This paper presents a single-channel programmable muscle stimulator. The charge balance of the pr... more This paper presents a single-channel programmable muscle stimulator. The charge balance of the proposed stimulator is achieved using the concept of the dual-slope analog-to-digital converter (ADC). This approach negates the need for precise current matching between cathodic and anodic current, which is usually required in order to achieve good charge balance. In the dual-slope concept, the charge on the integrating
Journal of Plant Registrations, 2007
2011 5th International IEEE/EMBS Conference on Neural Engineering, 2011
programmable 0.35 output digital required cathodic and anodic currents circuit to control the ope... more programmable 0.35 output digital required cathodic and anodic currents circuit to control the operation of the sti programmab stimulator produce programmable amplitude, frequency and pulse experimental cathodic current 10mA clock of designed to be half of the cathodic current to facilitate charge balance. This paper presents a nerve/muscle m CMOS technology. og converter required cathodic and anodic currents circuit to control the operation of the sti le stimulation parameters balanced biphasic current programmable amplitude, frequency and pulse results show that the stimulator can provide amplitude pulse amplitude of the designed to be half of the cathodic current to facilitate measured
Arthritis Research & Therapy, 2008
Introduction Congenital dysplasia of the hip is an abnormal seating of the femoral head in the a... more Introduction Congenital dysplasia of the hip is an abnormal seating of the femoral head in the acetabulum, mainly caused by shallow acetabulum and lax joint capsule. Genetic factors play a considerable role in the pathogenesis of congenital dysplasia of the hip. The gene growth differentiate factor 5 (GDF5) has been implicated in skeletal development and joint morphogenesis in humans and mice.
Solar Energy, 1987
The transient methods for collector performance testing are significant in those areas where the ... more The transient methods for collector performance testing are significant in those areas where the weather is often unsuitable for steady outdoor tests. A new filter method is proposed for transient testing of solar collectors. A second order model is used to describe the dynamic characteristics of a collector in the present study. According to the impulse response function of the collector, a recursive digital filter is constructed for transient test data processing. It is found that the filter method is simple, fast acting, and is valid in real-time applications. The experimental results with a filter have shown good agreement with those of standard steady-state method.
Innate immunity, 2016
NK cells participate in the development of human multiple sclerosis (MS) and mouse experimental a... more NK cells participate in the development of human multiple sclerosis (MS) and mouse experimental autoimmune encephalomyelitis (EAE), but the roles of different NK cell subsets in disease onset remain poorly understood. In this study, murine NK cells were divided into CD27(high) and CD27(low/-) subsets. The CD27(high) subset was decreased and the CD27(low/-) subset was increased in lymphoid organs during the pre-onset stage of EAE. Compared with the counterpart in naïve mice, the CD27(high) subset showed lower expression of Ly49D, Ly49H and NKG2D, and less production of IFN-γ, whereas the CD27(low/-) subset showed similar expression of the above mentioned surface receptors but higher cytotoxic activity in EAE mice. Compared with the CD27(high) subset, the CD27(low/-) subset exhibited increased promotion of DC maturation and no significant inhibition of T cells proliferation and Th17 cells differentiation in vitro Additionally, adoptive transfer of the CD27(low/-) subset, but not the C...
Molecular immunology, Jan 4, 2016
A large number of recipients are in a compromised immune defense condition because of the routine... more A large number of recipients are in a compromised immune defense condition because of the routine application of immunosuppressive regimens after heart transplantation. Our previous work demonstrated that blockade of high-mobility group box 1 (HMGB1) prolongs the graft survival. Whether and how HMGB1 blockade impacts respiratory responses against pathogen-like challenge in organ transplant recipients when it improves cardiac graft are not elucidated. At the present study, after abdominal heterotopic heart transplantation, the recipient mice were treated with HMGB1 mAb, and then challenged with poly(I:C) or LPS intratracheally on day 7 post transplantation. We found that the level of bronchoalveolar lavage (BAL) HMGB1 was elevated after heart transplantation, and aggravated responses to respiratory tract poly(I:C)/LPS challenge were observed. HMGB1 neutralizing mAb treatment in poly(I:C)-challenged recipient mice alleviated pulmonary histopathological changes, neutrophil infiltration...
Cytokines secreted by infiltrating immune cells during atherogenesis modulate vascular remodel- i... more Cytokines secreted by infiltrating immune cells during atherogenesis modulate vascular remodel- ing. One exemplary event is the antagonism between transformed growth factor (TGF-b) and interferon gamma (IFN-c) on the transcriptional con- trol of type I collagen gene (COL1A2). Previously we have reported that IFN-c up-regulates regulatory factor for X-box B (RFXB) to repress collagen tran- scription while down-regulates the expression
Physical Review B, 1994
The addition of suitable dopants to ZrO[sub 2] can induce dramatic phase stabilization, and this ... more The addition of suitable dopants to ZrO[sub 2] can induce dramatic phase stabilization, and this dopant-induced phase stabilization is the basis of transformation toughening of zirconia-based structural ceramics. We have determined the electronic structure of three phases of ZrO[sub 2], cubic, tetragonal, and monoclinic, using vacuum-ultraviolet and x-ray-photoemission spectroscopies, coupled with [ital ab] [ital initio] band-structure and optical property calculations
International Journal of High Performance Computing and Networking, 2006
Smart antennas are suggested to be used in future generation wireless and mobile networks to prov... more Smart antennas are suggested to be used in future generation wireless and mobile networks to provide the service with high capacity and service quality. In this paper, we propose a novel multimedia wireless and mobile network using smart antennas. The smart antenna in the proposed system provides a Space Division Multiple Access (SDMA) scheme to improve system capacity dramatically. In the proposed system, the Quality of Service (QoS) is guaranteed for real-time service at the cost of the tolerable quality decrease for non-real- ...
IEEE Wireless Communications and Networking Conference, 2005, 2000
Abstract In this paper, we propose an analytical model for novel multimedia wireless and mobile n... more Abstract In this paper, we propose an analytical model for novel multimedia wireless and mobile networks using smart antennas. In the proposed networks, several beams having the same physical channel (eg, frequency in FDMA, time slot in TDMA, spreading code in CDMA, or any combination of them) are formed in a cell. System capacity is increased dramatically by reusing the channels in the same cell. In this paper, we consider two types of multimedia services, real-time services and non-real-time services. Quality of service (QoS ...
Third International Symposium on Multispectral Image Processing and Pattern Recognition, 2003
In this paper some properties of Foley-Sammon optimal discriminant vector (FSODV), by contrast wi... more In this paper some properties of Foley-Sammon optimal discriminant vector (FSODV), by contrast with uncorrelated optimal discriminant vector (UODV), are discussed. Firstly the Fisher ratio of every FSODV must be not less than that of corresponding UODV and consequently sole FSODV will be superior to corresponding UODV. Secondly the correlation between feature components extracted by FSODV is an important factor.
2013 IEEE Asian Solid-State Circuits Conference (A-SSCC), 2013
ABSTRACT A wireless power management and data telemetry circuit module for high compliance voltag... more ABSTRACT A wireless power management and data telemetry circuit module for high compliance voltage electrical stimulation applications is presented in this paper. The system consists of rectifier, LDOs, DC-DC step-up charge pump and power monitoring circuit for closed loop wireless power management. The system also consists of a clock and data recovery (CDR) circuit and load shift keying (LSK) modulator for bidirectional data telemetry. The system operates at 13.56MHz. The wireless power management block receives AC power through an implantable coil and outputs three DC levels: 1V, 1.8V and 10V. The CDR circuit recovers clock and data from the 13.56MHz RF carrier through the same coil. The power efficiency of the wireless power management system is measured as 42% with 100μA current load connected on each supply output. The forward and backward data rate of the data telemetry achieves 61.5 kbps and 33.3 kbps, respectively. The system is implemented in 0.18μm CMOS process with 24V HV LDMOS option, occupying a core area of 1.8 mm × 1.8 mm.
Proceedings IEEE Thirteenth Annual International Conference on Micro Electro Mechanical Systems (Cat. No.00CH36308), 2000
Packaging for a large distributed sensing system is a challenging topic. Using flexible skin tech... more Packaging for a large distributed sensing system is a challenging topic. Using flexible skin technology solves many of these problems. Combining with the newly developed backside contact technique, sensor packaging is made even easier by completely avoiding the fragile bonding wires. This paper describes the improved flexible MEMS technology and its application to the fabrication and packaging of practical shear stress sensor skins. An airflow separation detection system including these skins, MOSIS bias circuits and a data acquisition unit has been successfully tested in windtunnel and is being used for the aerodynamic study of a MEMS controlled super-maneuverable low-altitude unmanned aerial vehicle (UAV) . B J J J J J J J J
2005 International Conference on Machine Learning and Cybernetics, 2005
... Guangzhou, 18-21 August 2005 AN EFFICIENT KERNEL-BASED NONLINEAR REGRESSION METHOD FOR TWO-CL... more ... Guangzhou, 18-21 August 2005 AN EFFICIENT KERNEL-BASED NONLINEAR REGRESSION METHOD FOR TWO-CLASS CLASSIFICATION YONG XU,JING-YU YANG, JIAN-FENG LU Department of Computer Science & ...
Arthritis Research & Therapy, 2008
INTRODUCTION: Conflicting findings on the association of single nucleotide polymorphisms (SNPs) i... more INTRODUCTION: Conflicting findings on the association of single nucleotide polymorphisms (SNPs) in RHOB and TXNDC3 with susceptibility to knee osteoarthritis (OA) have been reported in European Caucasians. To examine the associations of these SNPs with OA in East Asian populations and to evaluate their global significance, we conducted two case-control studies in 955 Chinese and 750 Japanese patients. METHODS: We
The Red Soils of China, 2004
2010 IEEE Sensors, 2010
This paper reports the preliminary development of a capacitive accelerometer that possesses high ... more This paper reports the preliminary development of a capacitive accelerometer that possesses high sensitivity and broad dynamic range simultaneously. Our idea of improving these two conflicting requirements is to incorporate positive and negative feedbacks into the system, inspired by the operation mechanisms of the inner ear hair cells. The positive feedback selectively amplifies small inputs but stops functioning for large
Neurocomputing, 2010
We propose a linear discriminant analysis method. In this method, every discriminant vector, exce... more We propose a linear discriminant analysis method. In this method, every discriminant vector, except for the first one, is worked out by maximizing a Fisher criterion defined in a transformed space which is the null space of the previously obtained discriminant vectors. All of these discriminant vectors are used for dimension reduction. We also propose two algorithms to implement the model. Based on the algorithms, we prove that the discriminant vectors will be orthogonal if the within-class scatter matrix is not singular. The experimental results show that the proposed method is effective and efficient.
Urologic oncology
RNA interference (RNAi) has the potential to be developed into therapeutics for prostate cancer, ... more RNA interference (RNAi) has the potential to be developed into therapeutics for prostate cancer, but the lack of cellular targets limits its application. In the present study we attempt to develop a prostate cancer-specific RNAi system using the human prostate specific membrane antigen (PSMA) promoter/enhancer; furthermore, we analyzed its inhibitive effect on STAT3 expression. The adenoviral vectors containing a small hairpin RNA (shRNA) to target exogenous reporters enhance green fluorescent protein (EGFP) and endogenous gene signal transducers and activators of transcription 3 (STAT3) were constructed. After prostate cancer and other cells were transfected, reverse transcription-polymerase chain reaction (RT-PCR), fluorescence microscopy, and Western blotting were used to measure EGFP expression. Inhibition of STAT3 was evaluated by Western blotting. Cell proliferation and viability were measured by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assa...
IEEE Asian Solid-State Circuits Conference 2011, 2011
This paper presents a single-channel programmable muscle stimulator. The charge balance of the pr... more This paper presents a single-channel programmable muscle stimulator. The charge balance of the proposed stimulator is achieved using the concept of the dual-slope analog-to-digital converter (ADC). This approach negates the need for precise current matching between cathodic and anodic current, which is usually required in order to achieve good charge balance. In the dual-slope concept, the charge on the integrating
Journal of Plant Registrations, 2007
2011 5th International IEEE/EMBS Conference on Neural Engineering, 2011
programmable 0.35 output digital required cathodic and anodic currents circuit to control the ope... more programmable 0.35 output digital required cathodic and anodic currents circuit to control the operation of the sti programmab stimulator produce programmable amplitude, frequency and pulse experimental cathodic current 10mA clock of designed to be half of the cathodic current to facilitate charge balance. This paper presents a nerve/muscle m CMOS technology. og converter required cathodic and anodic currents circuit to control the operation of the sti le stimulation parameters balanced biphasic current programmable amplitude, frequency and pulse results show that the stimulator can provide amplitude pulse amplitude of the designed to be half of the cathodic current to facilitate measured
Arthritis Research & Therapy, 2008
Introduction Congenital dysplasia of the hip is an abnormal seating of the femoral head in the a... more Introduction Congenital dysplasia of the hip is an abnormal seating of the femoral head in the acetabulum, mainly caused by shallow acetabulum and lax joint capsule. Genetic factors play a considerable role in the pathogenesis of congenital dysplasia of the hip. The gene growth differentiate factor 5 (GDF5) has been implicated in skeletal development and joint morphogenesis in humans and mice.
Solar Energy, 1987
The transient methods for collector performance testing are significant in those areas where the ... more The transient methods for collector performance testing are significant in those areas where the weather is often unsuitable for steady outdoor tests. A new filter method is proposed for transient testing of solar collectors. A second order model is used to describe the dynamic characteristics of a collector in the present study. According to the impulse response function of the collector, a recursive digital filter is constructed for transient test data processing. It is found that the filter method is simple, fast acting, and is valid in real-time applications. The experimental results with a filter have shown good agreement with those of standard steady-state method.