Yoon-seok Chang - Academia.edu (original) (raw)

Papers by Yoon-seok Chang

The Journal of Allergy and Clinical Immunology, Feb 1, 2010

RATIONALE: We reported that IFNs could augment the adhesiveness of endothelial cells to eosinophi... more RATIONALE: We reported that IFNs could augment the adhesiveness of endothelial cells to eosinophils, mainly through the expressions of adhesion moleculers (Eur Respir J 2008; 32: 1-9). Theophylline exerts inhibitory effects on eosinophil adhesion (Int Arch Allergy Immunol. 2003;131:S40-5). In this study, we examined whether theophylline modifies adhesive interaction between eosinophil and endothelial cells in the presence of IFN-g. METHODS: Human umbilical vein endothelial cells (HUVEC) were stimulated with IFN-g for 24 hrs in the presence or absence of TNF-a. Eosinophils, preincubated in the presence or absence of theophylline (0.01-1mM) for 30 min, were placed onto the HUVEC and then incubated for 30 min. Eosinophils adhesion to HUVEC were assessed by the residual eosinophil peroxidase activity of adherent eosinophils. In the other part of study, HUVEC preincubated with theophylline (1mM) for 30 min were stimulated with IFN-g for 24 hrs in the presence or absence of TNF-a and then the expressions of ICAM-1 and VCAM-1 of HUVEC were measured by cell ELISA. RESULTS: Theophylline (1mM) significantly reduced eosinophil adhesion to HUVEC stimulated both with a combination of IFN-g and TNFa and TNF-a alone (p<0.05, respectively). Theophylline (1mM) also significantly attenuated the expression of ICAM-1 on HUVEC stimulated with IFN-g plus TNF-a and TNF-a (p<0.05), however, this drug did not inhibit the expression of VCAM-1. CONCLUSIONS: Theophylline down modulates both eosinophil adhesiveness and the expression of ICAM-1 on endothelium in the presence of IFN-g. These effects of theophylline may provide therapeutic benefits on the enhanced airway inflammation of asthma observed with severe persistent disease or during viral infections.

The Journal of Allergy and Clinical Immunology, Feb 1, 2011

Asia Pacific Allergy, 2018

Background: The basophil activation test (BAT) is a promising tool for monitoring allergenspecifi... more Background: The basophil activation test (BAT) is a promising tool for monitoring allergenspecific immunotherapy responses. Objective: We aimed to investigate the changes in basophil activation in response to the inhalant allergens of house dust mite (HDM) and mugwort pollen during immunotherapy in patients with allergic rhinitis. Methods: We enrolled patients with allergic rhinitis who were to receive subcutaneous immunotherapy for the inhalant allergens HDM or mugwort. A BAT was performed to assess CD63 upregulation in response to allergen stimulation using peripheral blood collected from the patients prior to immunotherapy and at 3, 6, 12, and 24 months after beginning immunotherapy. Rhinitis symptoms were evaluated using the rhinitis quality of life questionnaire (RQLQ) at 1-year intervals. Results: Seventeen patients (10 with HDM sensitivity, 3 with mugwort sensitivity, and 4 with sensitivity to both HDM and mugwort) were enrolled in the study. Basophil reactivity to HDM did not change significantly during 24 months of immunotherapy. However, a significant reduction in basophil reactivity to mugwort was observed at 24-month follow-up. There was no significant association between the change in clinical symptoms by RQLQ and the change in basophil reactivity to either allergen. The change in allergen-specific basophil reactivity to HDM was well correlated with the change in nonspecific basophil activation induced by anti-FcεRI antibody, although basophil reactivity to anti-FcεRI antibody was not significantly reduced during immunotherapy. Conclusion: Suppression of CD63 upregulation in the BAT was only observed with mugwort at 2-year follow-up. However, the basophil response did not reflect the clinical response to immunotherapy.

Asia Pacific Allergy, 2013

Taurine is one of most abundant free amino acids in mammalian tissue. It has been used for variou... more Taurine is one of most abundant free amino acids in mammalian tissue. It has been used for various health functional foods as a main ingredient in food industry. A 33-year-old female patient repeatedly experienced generalized itching, urticaria, dyspnea and dizziness after drinking taurine-containing drinks. The patient showed positive response to oral challenge tests with taurine-containing drinks. The patient also showed positive response with synthetic taurine but not with natural taurine. Skin prick test and basophil activation test with the synthetic taurine were negative. To our knowledge, there has been no report of taurine-induced hypersensitivity reactions. We herein report the first case of taurine-containing drink induced anaphylaxis, especially by synthetic taurine.

Asia Pacific Allergy, Jul 1, 2016

Background: Asthma patients may experience acute episodic exacerbation. The guidelines recommend ... more Background: Asthma patients may experience acute episodic exacerbation. The guidelines recommend that written action plan should be given to asthma patients. However, no one can predict when and where acute exacerbation will happen. As people carry smart phone almost anytime and anywhere, smartphone application could be a useful tool in asthma care. We evaluated the feasibility of the ubiquitous healthcare system of asthma care using a smartphone application (snuCare) based on the selfmanagement guideline or action plan. Methods: Forty-four patients including fragile asthmatics were enrolled from Seoul National University Bundang Hospital between December 2011 and February 2012. They were randomly assigned into application user (n = 22) or application nonuser group (n = 22). We evaluated user-satisfaction, and clinical parameters such as asthma control, Quality of Life Questionnaire for Adult Korean Asthmatics, and the adherence of patients. Results: The characteristics were similar at baseline between the 2 groups except those who treated with short-term systemic steroid or increased dose of systemic steroid during previous 8 weeks (user vs. nonuser: 31.8% vs. 4.5%, p = 0.020). Total of 2,226 signals was generated during 8 weeks including 5 risky states. After eight weeks, the users answered that it was very easy to use the application, which was shown in highest scores in terms of satisfaction (mean ± standard deviation, 4.3 ± 0.56). Seventy-three percent of patients answered that the application was very useful for asthma care. User group showed improved the adherence scores (p = 0.017). One patient in application user group could avoid Emergency Department visit owing to the application while a patient in nonuser group visited Emergency Department. Conclusion: The ubiquitous healthcare system using a smartphone application (snuCare) based on the self-management guideline or action plan could be helpful in the monitoring and the management of asthma.

Immune Network, 2021

Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are ... more Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are characterized by eosinophil and/or neutrophil cell dominant airway inflammation that represent distinct clinical features. Upper and lower airways constitute a unique system and their interaction shows functional complementarity. Although human upper airway contains various indigenous commensals and opportunistic pathogenic microbiome, imbalance of this interactions lead to pathogen overgrowth and increased inflammation and airway remodeling. Competition for epithelial cell attachment, different susceptibilities to host defense molecules and antimicrobial peptides, and the production of proinflammatory cytokine and pattern recognition receptors possibly determine the pattern of this inflammation. Exposure to environmental factors, including infection, air pollution, smoking is commonly associated with asthma comorbidity, severity, exacerbation and resistance to anti-microbial and steroid treatment, and these effects may also be modulated by host and microbial genetics. Administration of probiotic, antibiotic and corticosteroid treatment for asthma may modify the composition of resident microbiota and clinical features. This review summarizes the effect of some environmental factors on the upper respiratory microbiome, the interaction between host-microbiome, and potential impact of asthma treatment on the composition of the upper airway microbiome.

Asia Pacific allergy, 2016

Asthma patients may experience acute episodic exacerbation. The guidelines recommend that written... more Asthma patients may experience acute episodic exacerbation. The guidelines recommend that written action plan should be given to asthma patients. However, no one can predict when and where acute exacerbation will happen. As people carry smart phone almost anytime and anywhere, smartphone application could be a useful tool in asthma care. We evaluated the feasibility of the ubiquitous healthcare system of asthma care using a smartphone application (snuCare) based on the self-management guideline or action plan. Forty-four patients including fragile asthmatics were enrolled from Seoul National University Bundang Hospital between December 2011 and February 2012. They were randomly assigned into application user (n = 22) or application nonuser group (n = 22). We evaluated user-satisfaction, and clinical parameters such as asthma control, Quality of Life Questionnaire for Adult Korean Asthmatics, and the adherence of patients. The characteristics were similar at baseline between the 2 gr...

Clinical and Translational Allergy, 2015

Cough is an intrinsic protective reflex. However, chronic cough affects a considerable proportion... more Cough is an intrinsic protective reflex. However, chronic cough affects a considerable proportion of general population and has a major impact on quality of life. A recent paradigm shift to ‘cough hypersensitivity syndrome’ suggests that chronic cough arises from hypersensitivity of the airway sensory nerves. As cough reflex is determined by interaction of the nervous system with immune system, persistent dysregulation of one or both of these systems may lead to chronic cough hypersensitivity. Here we review the current evidence for the neuro‐immune interactions that underlie cough hypersensitivity and discuss future therapeutic strategies.

Asia Pacific allergy, 2015

Eosinophilic myocarditis is a condition resulting from various eosinophilic diseases, including h... more Eosinophilic myocarditis is a condition resulting from various eosinophilic diseases, including helminth infection, drug hypersensitivity, systemic vasculitis or idiopathic hypereosinophilic syndromes. Clinical manifestations of eosinophilic myocarditis may vary from early necrosis to endomyocardial fibrosis. Eosinophilic myocarditis is one of the most fatal complications of hypereosinophilia. However, eosinophilic myocarditis has been rarely reported in the literature, particularly in Asia Pacific regions, reflecting the under-recognition of the disease among clinicians. Early recognition is crucial for improving clinical outcomes of eosinophilic myocarditis. Early administration of systemic corticosteroid is necessary in eosinophilic myocarditis regardless of underlying causes, as delayed treatment may result in fatal outcomes. In addition, differential diagnoses of underlying causes for eosinophilia are necessary to improve long-term outcomes.

B31. COMPLICATING INFECTIONS: INFLUENZA AND RHINOVIRUS, 2011

/ Thematic Poster Session / Monday, May 16/8:15 AM-4:30 ... PM / Area J, Hall B (Upper Level), Co... more / Thematic Poster Session / Monday, May 16/8:15 AM-4:30 ... PM / Area J, Hall B (Upper Level), Colorado Convention Center ... Clinical Course Of Asthma Patients With H1n1 Influenza Infection ... , W. Song , J. Jung , J. Kwon , T. Kim , S. Lee , S. Kim , H. Kang , H. Park , S. ...

Wheat is a major staple of the diet worldwide and wheat allergy is defined as an adverse immunolo... more Wheat is a major staple of the diet worldwide and wheat allergy is defined as an adverse immunologic reaction to wheat protein [1]. Depending on the route of exposure and the underlying immunologic mechanisms, wheat allergy are diagnosed as different forms of allergic diseases such as classic food allergy, food-dependent exercise-induced anaphylaxis (FDEIA), occupational asthma, rhinitis or contact urticaria [2]. IgE mediated allergy to wheat may be presented with various severity from simple urticaria to anaphylaxis. In Korea, only a few studies on wheat-induced anaphylaxis (WIA) have been performed [3,4]. We herein report six cases of severe wheat allergy including WIA and wheat-dependent exercise-induced anaphylaxis (WDEIA). Case We reviewed three cases of WIA and three cases of WDEIA. All the patients visited our allergy clinic for the evaluation

Asia Pacific Allergy, 2013

Background: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk... more Background: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma. Objective: To investigate the associations between Staphylococcal enterotoxin sensitization and asthma. Methods: A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization. Results: A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82). Conclusion: Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.

Allergy, Asthma & Immunology Research, 2014

Prior studies have reported an association between the specific aeroallergen sensitization and th... more Prior studies have reported an association between the specific aeroallergen sensitization and the development of asthma or AHR. Sensitization to house dust mite or mold was associated with increasing asthma. 8 Cockroach allergy also has been reported as an important cause of asthma. 9 There was also a trend in increasing AHR with increased cat allergen exposure. 10 However, sensitization to pollen was not significantly associated with the presence of asthma symptoms or AHR. 11 Previous studies have generally focused on the prevalence of

Asia Pacific Allergy, 2015

Background: Standardized questionnaire is one of key instruments for general population surveys. ... more Background: Standardized questionnaire is one of key instruments for general population surveys. Objective: The present study aimed to develop and validate the Korean version of the European Community Respiratory Health Survey (ECRHS) screening questionnaire for adult asthma surveys. Methods: The ECRHS screening questionnaire was translated into Korean language according to the international criteria. Study participants were prospectively recruited from six referral hospitals and one health checkup center. Comprehensibility of the translation was tested in a pilot study of 10 patients. The reliability was evaluated by internal consistency and test-retest repeatability. Validity was assess with regard to physician-diagnosed asthma. Results: A total of 100 adult asthma patients and 134 volunteers were recruited. Reliability was examined for 10 items in 100 asthmatics; Cronbach α coefficients were 0.84, and test-retest repeatability was good (Cohen κ coefficient, 0.71-1.00). Validity was assessed for 8 items in 234 participants; in particular, 'recent wheeze' showed a high sensitivity (0.89) for physician-diagnosed asthma. 'Recent asthma attack' and 'current asthma medication' showed high specificity (0.96-0.98). Conclusion: The present study demonstrated that the Korean version of the ECRHS screening questionnaire was comprehensible, reliable and valid. We suggest the questionnaire to be utilized in further epidemiological studies for asthma in Korean adult populations.

Asia Pacific allergy, 2013

Immediate-type drug hypersensitivity is an increasingly significant clinical issue; however, the ... more Immediate-type drug hypersensitivity is an increasingly significant clinical issue; however, the diagnosis is frequently hindered due to lack of safe and precise diagnostic tests. Flow cytometry-assisted basophil activation test is a safe in vitro diagnostic tool for assessing basophil activation upon allergen stimulation. In this review, we have summarized current literature on the diagnostic utilities, new indications, and methodological aspects of the basophil activation test for the diagnosis of drug hypersensitivity.

Asia Pacific allergy, 2014

Radiocontrast media (RCM) is a major cause of drug hypersensitivity reactions as the medical appl... more Radiocontrast media (RCM) is a major cause of drug hypersensitivity reactions as the medical application of RCM is increasing recently. RCM induced hypersensitivity reactions are considered as unpredictable type B reactions. Underlying mechanism of RCM induced hypersensitivity was previously regarded as nonimmunological mechanisms but recent studies suggest that immunological mechanisms could also be involved. As a result, the roles of skin tests and premedication are revisiting. As there has been no report that comprehensively summarized and analyzed the results of the studies on RCM hypersensitivity in the Asia Pacific region, we aimed to review the literatures on hypersensitivity reactions to RCM in terms of prevalence clinical manifestations, diagnostic approach, and preventive measures in the Asia Pacific region.

World Allergy Organization Journal, 2012

Clinical & Experimental Allergy, 2014

Song et al. 2 Take home message Staphylococcal enterotoxin sensitization was highly prevalent and... more Song et al. 2 Take home message Staphylococcal enterotoxin sensitization was highly prevalent and independently associated with late-onset asthma.

Allergy, Asthma & Respiratory Disease, 2015

Chronic urticaria (CU) is defined by the presence of urticaria that has been continuously or inte... more Chronic urticaria (CU) is defined by the presence of urticaria that has been continuously or intermittently for a period of 6 weeks or longer. The prevalence of CU in the general population has been estimated to range from 0.5% to 5%. Correct diagnosis and proper management for CU is essential to improve the quality of care. To date, several practical guidelines have been available for practitioners. In this article, we reviewed and summarized the epidemiology, pathogenesis, diagnosis, and management based on case reports and studies of CU from Korea and the other part of world, and recently published guidelines. Although there are many controversies, this report for CU would provide a clinical guidance for healthcare professionals in Korea.

The role of food additives in chronic urticaria (CU) is still under investigation. In this study,... more The role of food additives in chronic urticaria (CU) is still under investigation. In this study, we aimed to explore the association between food additives and CU by using the basophil activation test (BAT). The BAT using 15 common food additives was performed for 15 patients with CU who had a history of recurrent urticarial aggravation following intake of various foods without a definite food-specific IgE. Of the 15 patients studied, two (13.3%) showed positive BAT results for one of the tested food additives. One patient responded to monosodium glutamate, showing 18.7% of CD203c-positive basophils. Another patient showed a positive BAT result to sodium benzoate. Both patients had clinical correlations with the agents, which were partly determined by elimination diets. The present study suggested that at least a small proportion of patients with CU had symptoms associated with food additives. The results may suggest the potential utility of the BAT to identity the role of food additives in CU.

The Journal of Allergy and Clinical Immunology, Feb 1, 2010

RATIONALE: We reported that IFNs could augment the adhesiveness of endothelial cells to eosinophi... more RATIONALE: We reported that IFNs could augment the adhesiveness of endothelial cells to eosinophils, mainly through the expressions of adhesion moleculers (Eur Respir J 2008; 32: 1-9). Theophylline exerts inhibitory effects on eosinophil adhesion (Int Arch Allergy Immunol. 2003;131:S40-5). In this study, we examined whether theophylline modifies adhesive interaction between eosinophil and endothelial cells in the presence of IFN-g. METHODS: Human umbilical vein endothelial cells (HUVEC) were stimulated with IFN-g for 24 hrs in the presence or absence of TNF-a. Eosinophils, preincubated in the presence or absence of theophylline (0.01-1mM) for 30 min, were placed onto the HUVEC and then incubated for 30 min. Eosinophils adhesion to HUVEC were assessed by the residual eosinophil peroxidase activity of adherent eosinophils. In the other part of study, HUVEC preincubated with theophylline (1mM) for 30 min were stimulated with IFN-g for 24 hrs in the presence or absence of TNF-a and then the expressions of ICAM-1 and VCAM-1 of HUVEC were measured by cell ELISA. RESULTS: Theophylline (1mM) significantly reduced eosinophil adhesion to HUVEC stimulated both with a combination of IFN-g and TNFa and TNF-a alone (p<0.05, respectively). Theophylline (1mM) also significantly attenuated the expression of ICAM-1 on HUVEC stimulated with IFN-g plus TNF-a and TNF-a (p<0.05), however, this drug did not inhibit the expression of VCAM-1. CONCLUSIONS: Theophylline down modulates both eosinophil adhesiveness and the expression of ICAM-1 on endothelium in the presence of IFN-g. These effects of theophylline may provide therapeutic benefits on the enhanced airway inflammation of asthma observed with severe persistent disease or during viral infections.

The Journal of Allergy and Clinical Immunology, Feb 1, 2011

Asia Pacific Allergy, 2018

Background: The basophil activation test (BAT) is a promising tool for monitoring allergenspecifi... more Background: The basophil activation test (BAT) is a promising tool for monitoring allergenspecific immunotherapy responses. Objective: We aimed to investigate the changes in basophil activation in response to the inhalant allergens of house dust mite (HDM) and mugwort pollen during immunotherapy in patients with allergic rhinitis. Methods: We enrolled patients with allergic rhinitis who were to receive subcutaneous immunotherapy for the inhalant allergens HDM or mugwort. A BAT was performed to assess CD63 upregulation in response to allergen stimulation using peripheral blood collected from the patients prior to immunotherapy and at 3, 6, 12, and 24 months after beginning immunotherapy. Rhinitis symptoms were evaluated using the rhinitis quality of life questionnaire (RQLQ) at 1-year intervals. Results: Seventeen patients (10 with HDM sensitivity, 3 with mugwort sensitivity, and 4 with sensitivity to both HDM and mugwort) were enrolled in the study. Basophil reactivity to HDM did not change significantly during 24 months of immunotherapy. However, a significant reduction in basophil reactivity to mugwort was observed at 24-month follow-up. There was no significant association between the change in clinical symptoms by RQLQ and the change in basophil reactivity to either allergen. The change in allergen-specific basophil reactivity to HDM was well correlated with the change in nonspecific basophil activation induced by anti-FcεRI antibody, although basophil reactivity to anti-FcεRI antibody was not significantly reduced during immunotherapy. Conclusion: Suppression of CD63 upregulation in the BAT was only observed with mugwort at 2-year follow-up. However, the basophil response did not reflect the clinical response to immunotherapy.

Asia Pacific Allergy, 2013

Taurine is one of most abundant free amino acids in mammalian tissue. It has been used for variou... more Taurine is one of most abundant free amino acids in mammalian tissue. It has been used for various health functional foods as a main ingredient in food industry. A 33-year-old female patient repeatedly experienced generalized itching, urticaria, dyspnea and dizziness after drinking taurine-containing drinks. The patient showed positive response to oral challenge tests with taurine-containing drinks. The patient also showed positive response with synthetic taurine but not with natural taurine. Skin prick test and basophil activation test with the synthetic taurine were negative. To our knowledge, there has been no report of taurine-induced hypersensitivity reactions. We herein report the first case of taurine-containing drink induced anaphylaxis, especially by synthetic taurine.

Asia Pacific Allergy, Jul 1, 2016

Background: Asthma patients may experience acute episodic exacerbation. The guidelines recommend ... more Background: Asthma patients may experience acute episodic exacerbation. The guidelines recommend that written action plan should be given to asthma patients. However, no one can predict when and where acute exacerbation will happen. As people carry smart phone almost anytime and anywhere, smartphone application could be a useful tool in asthma care. We evaluated the feasibility of the ubiquitous healthcare system of asthma care using a smartphone application (snuCare) based on the selfmanagement guideline or action plan. Methods: Forty-four patients including fragile asthmatics were enrolled from Seoul National University Bundang Hospital between December 2011 and February 2012. They were randomly assigned into application user (n = 22) or application nonuser group (n = 22). We evaluated user-satisfaction, and clinical parameters such as asthma control, Quality of Life Questionnaire for Adult Korean Asthmatics, and the adherence of patients. Results: The characteristics were similar at baseline between the 2 groups except those who treated with short-term systemic steroid or increased dose of systemic steroid during previous 8 weeks (user vs. nonuser: 31.8% vs. 4.5%, p = 0.020). Total of 2,226 signals was generated during 8 weeks including 5 risky states. After eight weeks, the users answered that it was very easy to use the application, which was shown in highest scores in terms of satisfaction (mean ± standard deviation, 4.3 ± 0.56). Seventy-three percent of patients answered that the application was very useful for asthma care. User group showed improved the adherence scores (p = 0.017). One patient in application user group could avoid Emergency Department visit owing to the application while a patient in nonuser group visited Emergency Department. Conclusion: The ubiquitous healthcare system using a smartphone application (snuCare) based on the self-management guideline or action plan could be helpful in the monitoring and the management of asthma.

Immune Network, 2021

Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are ... more Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are characterized by eosinophil and/or neutrophil cell dominant airway inflammation that represent distinct clinical features. Upper and lower airways constitute a unique system and their interaction shows functional complementarity. Although human upper airway contains various indigenous commensals and opportunistic pathogenic microbiome, imbalance of this interactions lead to pathogen overgrowth and increased inflammation and airway remodeling. Competition for epithelial cell attachment, different susceptibilities to host defense molecules and antimicrobial peptides, and the production of proinflammatory cytokine and pattern recognition receptors possibly determine the pattern of this inflammation. Exposure to environmental factors, including infection, air pollution, smoking is commonly associated with asthma comorbidity, severity, exacerbation and resistance to anti-microbial and steroid treatment, and these effects may also be modulated by host and microbial genetics. Administration of probiotic, antibiotic and corticosteroid treatment for asthma may modify the composition of resident microbiota and clinical features. This review summarizes the effect of some environmental factors on the upper respiratory microbiome, the interaction between host-microbiome, and potential impact of asthma treatment on the composition of the upper airway microbiome.

Asia Pacific allergy, 2016

Asthma patients may experience acute episodic exacerbation. The guidelines recommend that written... more Asthma patients may experience acute episodic exacerbation. The guidelines recommend that written action plan should be given to asthma patients. However, no one can predict when and where acute exacerbation will happen. As people carry smart phone almost anytime and anywhere, smartphone application could be a useful tool in asthma care. We evaluated the feasibility of the ubiquitous healthcare system of asthma care using a smartphone application (snuCare) based on the self-management guideline or action plan. Forty-four patients including fragile asthmatics were enrolled from Seoul National University Bundang Hospital between December 2011 and February 2012. They were randomly assigned into application user (n = 22) or application nonuser group (n = 22). We evaluated user-satisfaction, and clinical parameters such as asthma control, Quality of Life Questionnaire for Adult Korean Asthmatics, and the adherence of patients. The characteristics were similar at baseline between the 2 gr...

Clinical and Translational Allergy, 2015

Cough is an intrinsic protective reflex. However, chronic cough affects a considerable proportion... more Cough is an intrinsic protective reflex. However, chronic cough affects a considerable proportion of general population and has a major impact on quality of life. A recent paradigm shift to ‘cough hypersensitivity syndrome’ suggests that chronic cough arises from hypersensitivity of the airway sensory nerves. As cough reflex is determined by interaction of the nervous system with immune system, persistent dysregulation of one or both of these systems may lead to chronic cough hypersensitivity. Here we review the current evidence for the neuro‐immune interactions that underlie cough hypersensitivity and discuss future therapeutic strategies.

Asia Pacific allergy, 2015

Eosinophilic myocarditis is a condition resulting from various eosinophilic diseases, including h... more Eosinophilic myocarditis is a condition resulting from various eosinophilic diseases, including helminth infection, drug hypersensitivity, systemic vasculitis or idiopathic hypereosinophilic syndromes. Clinical manifestations of eosinophilic myocarditis may vary from early necrosis to endomyocardial fibrosis. Eosinophilic myocarditis is one of the most fatal complications of hypereosinophilia. However, eosinophilic myocarditis has been rarely reported in the literature, particularly in Asia Pacific regions, reflecting the under-recognition of the disease among clinicians. Early recognition is crucial for improving clinical outcomes of eosinophilic myocarditis. Early administration of systemic corticosteroid is necessary in eosinophilic myocarditis regardless of underlying causes, as delayed treatment may result in fatal outcomes. In addition, differential diagnoses of underlying causes for eosinophilia are necessary to improve long-term outcomes.

B31. COMPLICATING INFECTIONS: INFLUENZA AND RHINOVIRUS, 2011

/ Thematic Poster Session / Monday, May 16/8:15 AM-4:30 ... PM / Area J, Hall B (Upper Level), Co... more / Thematic Poster Session / Monday, May 16/8:15 AM-4:30 ... PM / Area J, Hall B (Upper Level), Colorado Convention Center ... Clinical Course Of Asthma Patients With H1n1 Influenza Infection ... , W. Song , J. Jung , J. Kwon , T. Kim , S. Lee , S. Kim , H. Kang , H. Park , S. ...

Wheat is a major staple of the diet worldwide and wheat allergy is defined as an adverse immunolo... more Wheat is a major staple of the diet worldwide and wheat allergy is defined as an adverse immunologic reaction to wheat protein [1]. Depending on the route of exposure and the underlying immunologic mechanisms, wheat allergy are diagnosed as different forms of allergic diseases such as classic food allergy, food-dependent exercise-induced anaphylaxis (FDEIA), occupational asthma, rhinitis or contact urticaria [2]. IgE mediated allergy to wheat may be presented with various severity from simple urticaria to anaphylaxis. In Korea, only a few studies on wheat-induced anaphylaxis (WIA) have been performed [3,4]. We herein report six cases of severe wheat allergy including WIA and wheat-dependent exercise-induced anaphylaxis (WDEIA). Case We reviewed three cases of WIA and three cases of WDEIA. All the patients visited our allergy clinic for the evaluation

Asia Pacific Allergy, 2013

Background: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk... more Background: Recent literature suggests that Staphylococcal enterotoxin specific IgE may be a risk factor for asthma. Objective: To investigate the associations between Staphylococcal enterotoxin sensitization and asthma. Methods: A systematic review and meta-analysis was performed for relevant case-control or population-based studies, published in the peer-reviewed journals until February 2013. Data were extracted on study designs, subjects, definitions and the prevalence of Staphylococcal enterotoxin sensitization. Results: A total of 683 studies were initially identified, of which 7 studies finally met the inclusion criteria (5 case-control and 2 population-based studies). All the included studies reported higher prevalence of the sensitization in asthmatics than in controls, despite clinical and methodological heterogeneity. In a meta-analysis, the pooled odds ratio of the sensitization for asthma was 2.95 (95% confidence intervals 2.28-3.82). Conclusion: Staphylococcal enterotoxin sensitization was significantly associated with asthma. The mechanisms of associations warrant further elucidation.

Allergy, Asthma & Immunology Research, 2014

Prior studies have reported an association between the specific aeroallergen sensitization and th... more Prior studies have reported an association between the specific aeroallergen sensitization and the development of asthma or AHR. Sensitization to house dust mite or mold was associated with increasing asthma. 8 Cockroach allergy also has been reported as an important cause of asthma. 9 There was also a trend in increasing AHR with increased cat allergen exposure. 10 However, sensitization to pollen was not significantly associated with the presence of asthma symptoms or AHR. 11 Previous studies have generally focused on the prevalence of

Asia Pacific Allergy, 2015

Background: Standardized questionnaire is one of key instruments for general population surveys. ... more Background: Standardized questionnaire is one of key instruments for general population surveys. Objective: The present study aimed to develop and validate the Korean version of the European Community Respiratory Health Survey (ECRHS) screening questionnaire for adult asthma surveys. Methods: The ECRHS screening questionnaire was translated into Korean language according to the international criteria. Study participants were prospectively recruited from six referral hospitals and one health checkup center. Comprehensibility of the translation was tested in a pilot study of 10 patients. The reliability was evaluated by internal consistency and test-retest repeatability. Validity was assess with regard to physician-diagnosed asthma. Results: A total of 100 adult asthma patients and 134 volunteers were recruited. Reliability was examined for 10 items in 100 asthmatics; Cronbach α coefficients were 0.84, and test-retest repeatability was good (Cohen κ coefficient, 0.71-1.00). Validity was assessed for 8 items in 234 participants; in particular, 'recent wheeze' showed a high sensitivity (0.89) for physician-diagnosed asthma. 'Recent asthma attack' and 'current asthma medication' showed high specificity (0.96-0.98). Conclusion: The present study demonstrated that the Korean version of the ECRHS screening questionnaire was comprehensible, reliable and valid. We suggest the questionnaire to be utilized in further epidemiological studies for asthma in Korean adult populations.

Asia Pacific allergy, 2013

Immediate-type drug hypersensitivity is an increasingly significant clinical issue; however, the ... more Immediate-type drug hypersensitivity is an increasingly significant clinical issue; however, the diagnosis is frequently hindered due to lack of safe and precise diagnostic tests. Flow cytometry-assisted basophil activation test is a safe in vitro diagnostic tool for assessing basophil activation upon allergen stimulation. In this review, we have summarized current literature on the diagnostic utilities, new indications, and methodological aspects of the basophil activation test for the diagnosis of drug hypersensitivity.

Asia Pacific allergy, 2014

Radiocontrast media (RCM) is a major cause of drug hypersensitivity reactions as the medical appl... more Radiocontrast media (RCM) is a major cause of drug hypersensitivity reactions as the medical application of RCM is increasing recently. RCM induced hypersensitivity reactions are considered as unpredictable type B reactions. Underlying mechanism of RCM induced hypersensitivity was previously regarded as nonimmunological mechanisms but recent studies suggest that immunological mechanisms could also be involved. As a result, the roles of skin tests and premedication are revisiting. As there has been no report that comprehensively summarized and analyzed the results of the studies on RCM hypersensitivity in the Asia Pacific region, we aimed to review the literatures on hypersensitivity reactions to RCM in terms of prevalence clinical manifestations, diagnostic approach, and preventive measures in the Asia Pacific region.

World Allergy Organization Journal, 2012

Clinical & Experimental Allergy, 2014

Song et al. 2 Take home message Staphylococcal enterotoxin sensitization was highly prevalent and... more Song et al. 2 Take home message Staphylococcal enterotoxin sensitization was highly prevalent and independently associated with late-onset asthma.

Allergy, Asthma & Respiratory Disease, 2015

Chronic urticaria (CU) is defined by the presence of urticaria that has been continuously or inte... more Chronic urticaria (CU) is defined by the presence of urticaria that has been continuously or intermittently for a period of 6 weeks or longer. The prevalence of CU in the general population has been estimated to range from 0.5% to 5%. Correct diagnosis and proper management for CU is essential to improve the quality of care. To date, several practical guidelines have been available for practitioners. In this article, we reviewed and summarized the epidemiology, pathogenesis, diagnosis, and management based on case reports and studies of CU from Korea and the other part of world, and recently published guidelines. Although there are many controversies, this report for CU would provide a clinical guidance for healthcare professionals in Korea.

The role of food additives in chronic urticaria (CU) is still under investigation. In this study,... more The role of food additives in chronic urticaria (CU) is still under investigation. In this study, we aimed to explore the association between food additives and CU by using the basophil activation test (BAT). The BAT using 15 common food additives was performed for 15 patients with CU who had a history of recurrent urticarial aggravation following intake of various foods without a definite food-specific IgE. Of the 15 patients studied, two (13.3%) showed positive BAT results for one of the tested food additives. One patient responded to monosodium glutamate, showing 18.7% of CD203c-positive basophils. Another patient showed a positive BAT result to sodium benzoate. Both patients had clinical correlations with the agents, which were partly determined by elimination diets. The present study suggested that at least a small proportion of patients with CU had symptoms associated with food additives. The results may suggest the potential utility of the BAT to identity the role of food additives in CU.