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Papers by Youjin Han (Student)
The Journal of Humanities and Social sciences 21
The Journal of Humanities and Social sciences 21
Baltic Journal of Management
PurposeDrawing from a resource-based perspective in the work–family interface literature, the cur... more PurposeDrawing from a resource-based perspective in the work–family interface literature, the current study examines how emotional exhaustion, as a resource depletion mechanism, mediates the relationship between family–work conflict and job satisfaction. The authors also considered the content and nature of coworker support to investigate whether there were differential moderating effects of the two distinct types of coworker support: emotional and instrumental support.Design/methodology/approachThe authors surveyed 321 kindergarten employees across multiple sites located in South Korea. Using this sample, the authors performed random coefficient modeling to test the proposed research model.FindingsThe results showed a significant negative indirect relationship between family–work conflict and job satisfaction through emotional exhaustion. Furthermore, the findings suggested differential effects of the two coworker support types, such that the positive relationship between family–wo...
The Journal of Humanities and Social sciences 21
Korean Journal of Child Psychotherapy
Journal of Families and Better Life, 2021
Journal of Families and Better Life, 2021
Korean Journal of Human Ecology, 2020
The Journal of Play Therapy, 2020
The Journal of Humanities and Social sciences 21, 2020
Journal of Korean Home Management Association, 2019
Journal of Korean Home Management Association, 2019
Current Psychology, 2019
In this study, the authors examined how perceived supervisor incivility negatively affected the p... more In this study, the authors examined how perceived supervisor incivility negatively affected the performance of childcare workers, focusing on emotional exhaustion and intrinsic motivation as underlying mediators. Data were collected from 321 childcare workers at 43 daycare centers in South Korea. A two-stage mediation model using multilevel structural equation modeling (MSEM) indicated that emotional exhaustion and intrinsic motivation fully and sequentially mediated the relationship. Perceived supervisor incivility emotionally exhausted childcare workers, decreased their intrinsic motivation, and reduced their overall performance. The findings highlight the need to manage workplace incivility in the child care sector. Finally, implications for organizational practice and interventions were discussed.
Journal of Digital Contents Society, 2017
Recently, consumer who has a desire to spend less money want to buy a cheap and good product beca... more Recently, consumer who has a desire to spend less money want to buy a cheap and good product because of long economy recession. Secondhand trading is regarded as a good method which allows people to buy cheap and good product. Activation of secondhand trading reduces the psychological distance among customers. Especially, in the case of expensive books such as major books, each university has community only for used book trading. However, existing used book community is hard to find current real-time trading state at a look, and it is impossible to purchase reasonably because of a one-way pricing of the seller. In this paper, we design and implement a used book trading web service using an auction system which can help anyone to trade used book easily. It is designed web based system and it provides convenience to user through efficient book registration function and book search function.
Marine Drugs, 2017
We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal abso... more We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted) with taurocholate supplementation (60 mg/kg). Consistent with the increased absorption in the presence of bile salts, rat intestinal permeability of Jaspine B also increased in the presence of 10 mM taurocholate or 20% bile. Further studies demonstrated that the enhanced intestinal permeability with bile salts was due to increased lipophilicity and decreased membrane integrity. Jaspine B was designated as a highly tissue-distributed compound, because it showed large tissue to plasma ratios in the brain, kidney, heart, and spleen. Moreover, the recovery of Jaspine B from the feces and urine after an intravenous administration was about 6.3%, suggesting a substantial metabolism of Jaspine B. Consistent with this observation, 80% of the administered Jaspine B was degraded after 1 h incubation with rat liver microsomes. In conclusion, the facilitated intestinal permeability in the presence of bile salts could significantly increase the bioavailability of Jaspine B and could lead to the development of oral formulations of Jaspine B with bile salts. Moreover, the highly distributed features of Jaspine B in the brain, kidney, heart, and spleen should be carefully considered in the therapeutic effect and toxicity of this compound.
IASTED Technology Conferences / 696:MS / 697:CA / 698: WC / 699: EME / 700: SOE, 2010
In the study in [1], a novel spectrum sensing scheme has been proposed and the performance charac... more In the study in [1], a novel spectrum sensing scheme has been proposed and the performance characteristics of the proposed scheme have been analyzed in Gaussian noise environment. The test statistic of the proposed scheme is the sum of one or more order statistics of the log-likelihood ratios obtained at the branches of a receiver. In this paper, the performance characteristics of the proposed scheme are addressed in impulsive noise environment. It is demonstrated that the proposed scheme provides significant performance gain and higher level of performance stability over the conventional schemes in non-Gaussian impulsive noise environment.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
To investigate the biological behavior including survival and proliferation of CD34 + CD38--Lin--... more To investigate the biological behavior including survival and proliferation of CD34 + CD38--Lin--cells when they are cultured at single cell level. Purified umbilical cord blood CD34 + CD38--Lin--cells were separated at single cell level in 96-well plates using flow cytometry for four groups: control group (CD34 + CD38--Lin--cell plus stem cell medium) , Shh group (CD34 + CD38--Lin--cell plus stem cell medium and Shh), BMP-4 group (CD34 + CD38--Lin--cell plus stem cell medium and BMP-4), Jagged-1 group (CD34 + CD38--Lin--cell plus stem cell medium and Jagged-1). Methylcellulose medium was used in the colony-forming experiment which was also in four groups as previously. The number of cells and colony-forming units in each well for the four groups was evaluated at different time points (day 1, 3, 7) with fluorescence microscopy counting method. Division of single cell was observed to be amplified in all of these groups from day 3. And meanwhile, after 1-week culture, the survival rates for the treated groups were all higher than the control group (Jagged-1 group > BMP-4 group > Shh group > control), while the cell number in each well was also highest in the Jagged-1 group (Jagged-1 group > BMP-4 group > control). The number of wells with a cell number of zero was significantly fewer in all treated groups (especially the Jagged-1 group) than in the control group; meanwhile, the number of wells with a cell number higher than 17 was evidently higher in all the treated groups (especially the BMP-4 group) more than controls. Colony-forming units for erythroid (BFU-E), granulocyte (CFU-G), macrophage (CFU-M), and granulocyte macrophage (CFU-GM) were observed for all of these experimental groups, and there was no significant difference between the four experimental groups. CD34 + CD38 - Lin - cell can achieve the survival, self-renewal and proliferation when cultured at single cell level, and the adding of Shh, BMP-4, and Jagged-1 can enhance such capabilities. However, CD34 + CD38 - Lin - cell can only maintain cell totipotency in its niche.
Leukemia & Lymphoma, 2011
Despite unsurpassed anti-tumor activity of bortezomib for multiple myeloma (MM), drug resistance ... more Despite unsurpassed anti-tumor activity of bortezomib for multiple myeloma (MM), drug resistance has emerged as a challenge, especially when MM cells adhere to the stroma. This study aimed to determine whether bone marrow stromal cells (BMSCs) have a role in the development of chemoresistance in MM. Our data demonstrate that the secretion of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and cell-to-cell contact with microenvironment-derived stromal cells from patients with multiple myeloma (MM-BMSCs) significantly decreased the sensitivity of myeloma cells to bortezomib treatment. Mechanistically, we found that microRNA (miRNA)- 15a expression was up-regulated in U266 and NCI-H929 cells treated by bortezomib, which was inhibited by MM-BMSCs. miRNA-15a transfected myeloma cells were arrested in G1/S checkpoint and secreted less VEGF compared to control transfected cells, although no significant difference was found in VEGF mRNA levels. In conclusion, our data suggest that via suppressing miRNA-15a expression, BMSCs provide survival support and protect myeloma cells from bortezomib induced apoptosis.
The Journal of Humanities and Social sciences 21
The Journal of Humanities and Social sciences 21
Baltic Journal of Management
PurposeDrawing from a resource-based perspective in the work–family interface literature, the cur... more PurposeDrawing from a resource-based perspective in the work–family interface literature, the current study examines how emotional exhaustion, as a resource depletion mechanism, mediates the relationship between family–work conflict and job satisfaction. The authors also considered the content and nature of coworker support to investigate whether there were differential moderating effects of the two distinct types of coworker support: emotional and instrumental support.Design/methodology/approachThe authors surveyed 321 kindergarten employees across multiple sites located in South Korea. Using this sample, the authors performed random coefficient modeling to test the proposed research model.FindingsThe results showed a significant negative indirect relationship between family–work conflict and job satisfaction through emotional exhaustion. Furthermore, the findings suggested differential effects of the two coworker support types, such that the positive relationship between family–wo...
The Journal of Humanities and Social sciences 21
Korean Journal of Child Psychotherapy
Journal of Families and Better Life, 2021
Journal of Families and Better Life, 2021
Korean Journal of Human Ecology, 2020
The Journal of Play Therapy, 2020
The Journal of Humanities and Social sciences 21, 2020
Journal of Korean Home Management Association, 2019
Journal of Korean Home Management Association, 2019
Current Psychology, 2019
In this study, the authors examined how perceived supervisor incivility negatively affected the p... more In this study, the authors examined how perceived supervisor incivility negatively affected the performance of childcare workers, focusing on emotional exhaustion and intrinsic motivation as underlying mediators. Data were collected from 321 childcare workers at 43 daycare centers in South Korea. A two-stage mediation model using multilevel structural equation modeling (MSEM) indicated that emotional exhaustion and intrinsic motivation fully and sequentially mediated the relationship. Perceived supervisor incivility emotionally exhausted childcare workers, decreased their intrinsic motivation, and reduced their overall performance. The findings highlight the need to manage workplace incivility in the child care sector. Finally, implications for organizational practice and interventions were discussed.
Journal of Digital Contents Society, 2017
Recently, consumer who has a desire to spend less money want to buy a cheap and good product beca... more Recently, consumer who has a desire to spend less money want to buy a cheap and good product because of long economy recession. Secondhand trading is regarded as a good method which allows people to buy cheap and good product. Activation of secondhand trading reduces the psychological distance among customers. Especially, in the case of expensive books such as major books, each university has community only for used book trading. However, existing used book community is hard to find current real-time trading state at a look, and it is impossible to purchase reasonably because of a one-way pricing of the seller. In this paper, we design and implement a used book trading web service using an auction system which can help anyone to trade used book easily. It is designed web based system and it provides convenience to user through efficient book registration function and book search function.
Marine Drugs, 2017
We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal abso... more We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted) with taurocholate supplementation (60 mg/kg). Consistent with the increased absorption in the presence of bile salts, rat intestinal permeability of Jaspine B also increased in the presence of 10 mM taurocholate or 20% bile. Further studies demonstrated that the enhanced intestinal permeability with bile salts was due to increased lipophilicity and decreased membrane integrity. Jaspine B was designated as a highly tissue-distributed compound, because it showed large tissue to plasma ratios in the brain, kidney, heart, and spleen. Moreover, the recovery of Jaspine B from the feces and urine after an intravenous administration was about 6.3%, suggesting a substantial metabolism of Jaspine B. Consistent with this observation, 80% of the administered Jaspine B was degraded after 1 h incubation with rat liver microsomes. In conclusion, the facilitated intestinal permeability in the presence of bile salts could significantly increase the bioavailability of Jaspine B and could lead to the development of oral formulations of Jaspine B with bile salts. Moreover, the highly distributed features of Jaspine B in the brain, kidney, heart, and spleen should be carefully considered in the therapeutic effect and toxicity of this compound.
IASTED Technology Conferences / 696:MS / 697:CA / 698: WC / 699: EME / 700: SOE, 2010
In the study in [1], a novel spectrum sensing scheme has been proposed and the performance charac... more In the study in [1], a novel spectrum sensing scheme has been proposed and the performance characteristics of the proposed scheme have been analyzed in Gaussian noise environment. The test statistic of the proposed scheme is the sum of one or more order statistics of the log-likelihood ratios obtained at the branches of a receiver. In this paper, the performance characteristics of the proposed scheme are addressed in impulsive noise environment. It is demonstrated that the proposed scheme provides significant performance gain and higher level of performance stability over the conventional schemes in non-Gaussian impulsive noise environment.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
To investigate the biological behavior including survival and proliferation of CD34 + CD38--Lin--... more To investigate the biological behavior including survival and proliferation of CD34 + CD38--Lin--cells when they are cultured at single cell level. Purified umbilical cord blood CD34 + CD38--Lin--cells were separated at single cell level in 96-well plates using flow cytometry for four groups: control group (CD34 + CD38--Lin--cell plus stem cell medium) , Shh group (CD34 + CD38--Lin--cell plus stem cell medium and Shh), BMP-4 group (CD34 + CD38--Lin--cell plus stem cell medium and BMP-4), Jagged-1 group (CD34 + CD38--Lin--cell plus stem cell medium and Jagged-1). Methylcellulose medium was used in the colony-forming experiment which was also in four groups as previously. The number of cells and colony-forming units in each well for the four groups was evaluated at different time points (day 1, 3, 7) with fluorescence microscopy counting method. Division of single cell was observed to be amplified in all of these groups from day 3. And meanwhile, after 1-week culture, the survival rates for the treated groups were all higher than the control group (Jagged-1 group > BMP-4 group > Shh group > control), while the cell number in each well was also highest in the Jagged-1 group (Jagged-1 group > BMP-4 group > control). The number of wells with a cell number of zero was significantly fewer in all treated groups (especially the Jagged-1 group) than in the control group; meanwhile, the number of wells with a cell number higher than 17 was evidently higher in all the treated groups (especially the BMP-4 group) more than controls. Colony-forming units for erythroid (BFU-E), granulocyte (CFU-G), macrophage (CFU-M), and granulocyte macrophage (CFU-GM) were observed for all of these experimental groups, and there was no significant difference between the four experimental groups. CD34 + CD38 - Lin - cell can achieve the survival, self-renewal and proliferation when cultured at single cell level, and the adding of Shh, BMP-4, and Jagged-1 can enhance such capabilities. However, CD34 + CD38 - Lin - cell can only maintain cell totipotency in its niche.
Leukemia & Lymphoma, 2011
Despite unsurpassed anti-tumor activity of bortezomib for multiple myeloma (MM), drug resistance ... more Despite unsurpassed anti-tumor activity of bortezomib for multiple myeloma (MM), drug resistance has emerged as a challenge, especially when MM cells adhere to the stroma. This study aimed to determine whether bone marrow stromal cells (BMSCs) have a role in the development of chemoresistance in MM. Our data demonstrate that the secretion of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and cell-to-cell contact with microenvironment-derived stromal cells from patients with multiple myeloma (MM-BMSCs) significantly decreased the sensitivity of myeloma cells to bortezomib treatment. Mechanistically, we found that microRNA (miRNA)- 15a expression was up-regulated in U266 and NCI-H929 cells treated by bortezomib, which was inhibited by MM-BMSCs. miRNA-15a transfected myeloma cells were arrested in G1/S checkpoint and secreted less VEGF compared to control transfected cells, although no significant difference was found in VEGF mRNA levels. In conclusion, our data suggest that via suppressing miRNA-15a expression, BMSCs provide survival support and protect myeloma cells from bortezomib induced apoptosis.