Young Whan Choi - Academia.edu (original) (raw)

Papers by Young Whan Choi

Research paper thumbnail of Surgical Treatment of Primary True Aneurysm on the Dorsalis Pedis Vein

The Korean Journal of Thoracic and Cardiovascular Surgery, 2010

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Bone health and its correlates in Korean prostate cancer patients receiving androgen deprivation therapy

European journal of oncology nursing : the official journal of European Oncology Nursing Society, Jan 27, 2015

This study aimed to examine bone health status, identify factors associated with bone mineral den... more This study aimed to examine bone health status, identify factors associated with bone mineral density (BMD), and determine potential risk factors for osteoporosis in Korean prostate cancer patients receiving androgen deprivation therapy (ADT). Using a cross-sectional descriptive design, we recruited 139 men with prostate cancer receiving ADT at two university-based hospitals in South Korea. Participants completed a self-reported questionnaire and underwent dual energy X-ray absorptiometry testing. BMD (gm/cm(2)), bone health status (normal BMD, osteopenia, and osteoporosis), and lifestyle variables (physical activity, smoking, and alcohol consumption) were measured. The prevalence in our sample was 49.6% for osteopenia and 17.3% for osteoporosis. In multivariate linear regression analyses, BMD was positively associated with body mass index, number of comorbidities, and level of physical activity and negatively associated with being unemployed or retired, having a lower monthly incom...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The temporal association of excessive health expenditure with suicidal ideation among primary income earners: a cross-sectional design using the Korean Welfare Panel Survey (KoWePS)

BMJ open, 2015

Excessive health expenditure (EHE) is a global issue for households suffering from high-cost medi... more Excessive health expenditure (EHE) is a global issue for households suffering from high-cost medical conditions, low incomes and limited insurance coverage. After the international financial crisis of 2008, EHE became a social problem in developed countries. Such economic crisis might induce severe mental stress, resulting in suicidal ideation. We used the Korean Welfare Panel Study (KoWePS) from 2011 to 2013 and selected primary income earners, who were defined as practical and economic representatives of households; the total number of analysed samples was 4247 of 5717 households in the database. We only included households that had never experienced EHE before 2011. To examine the temporal relationship between EHE and suicidal ideation, we conducted a logistic regression analysis. Among 4247 participants, 146 (3.4%) experienced suicidal ideation, whereas 4101 (96.6%) did not. One scale of depression score (OR=1.28, CI 1.23 to 1.34, p<0.001) was associated with increased suicid...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Reasonable efforts? Implementation of the reunification bypass provision of ASFA

Child welfare, 2008

The Adoption and Safe Families Act (ASFA) of 1997 includes provisions to deny reunification servi... more The Adoption and Safe Families Act (ASFA) of 1997 includes provisions to deny reunification services under specified conditions and gives states latitude to develop any number of additional "aggravated circumstances" in which parents need not be offered services. California legislators have developed a relatively large number of conditions enabling agencies to bypass reunification services. Based upon a case record review involving 1,055 parents, this study attempts to identify the proportion of parents eligible for a reunification bypass, the proportion recommended to the courts, and the proportion of parents who were denied reunification services, and examines the characteristics of parents associated with reunification bypass recommendations. Based upon focus groups and interviews with child welfare and judicial personnel in six counties, the study also examines the implementation of reunification bypass provisions. Implications for public policy and practice are provided.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The Thermal Analysis of Brake Disc with 3-D Coupled Analysis

Key Engineering Materials, 2005

ABSTRACT As the automobile industry develops, the demand for automobiles that provide more comfor... more ABSTRACT As the automobile industry develops, the demand for automobiles that provide more comfortable ride and safety is also increasing. In the conventional braking analysis, frictional heat generation is only related to wheel speed, friction material, and the interface pressure. However, under the dynamic braking conditions, the frictional heat causes the thermo-elastic distortion that leads to more concentrated distribution of contact pressure and hence more and more non-uniform temperature. This paper describes the thermo-elastic instability arising from friction heat generation in braking and proposes the finite element methods to predict the variation of temperature and thermal deformation.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Finite Element Analysis of the Repeated Braking with 3-D Coupled Model

Key Engineering Materials, 2006

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The Applications of Human Factors Associated with Hearing Impairments: Issues and Recent Technological Developments in Telecommunications

... Young B. Choi, Joshua S. Krause, and Kathleen E. Capitan James Madison University, Harrisonbu... more ... Young B. Choi, Joshua S. Krause, and Kathleen E. Capitan James Madison University, Harrisonburg, Virginia 22807-0001, USA ... A mixed hearing loss refers to a combination of both conductive and sensorineural hearing loss (Schow & Nerbonne, 2002). ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The state-of-the-art of mobile payment architecture and emerging issues

International Journal of Electronic Finance, 2006

... (Karnouskos and Fraunhofer, 2004). In pre-paid accounts, the payment is deducted from the air... more ... (Karnouskos and Fraunhofer, 2004). In pre-paid accounts, the payment is deducted from the airtime credit, where as with post-paid accounts, the payment is charged to the mobilephone bill (Herzberg, 2003). 2 The state-of-the-art of mobile payment ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Reeling in Cognitive Radio: The Issues of Regulations and Policies Affecting Spectrum Management

Communications in Computer and Information Science, 2009

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Feasibility of virtual security laboratory for three-tiered distance education

Proceedings of the 2010 ACM conference on Information technology education - SIGITE '10, 2010

Today, a number of universities and colleges offering security education has been growing rapidly... more Today, a number of universities and colleges offering security education has been growing rapidly for last couple of years. Most universities have adequate facilities and labs to provide hand-on experience in security courses, but some universities and colleges that initiated security courses do not have equipments and space to offer hand-on experience for the students. This is challenge for distance

Bookmarks Related papers MentionsView impact

Research paper thumbnail of RFID Implementation and Security Issues

Communications in Computer and Information Science, 2011

... RFID: Improved Patient Safety, http://clearcount.com/rfid-improved-patient-safety 26. Fuqua, ... more ... RFID: Improved Patient Safety, http://clearcount.com/rfid-improved-patient-safety 26. Fuqua, M.: Is RFID Getting Primed To Change Digital Marketing?, http://fifthgearanalytics.com/ 2010/11/is-rfid-getting-primed-to-change-digital-marketing/ 27. ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of A quantification model using P3P in privacy control for telecommunications service management

International Journal of Services and Standards, 2005

426 Int. J. Services and Standards, Vol. 1, No. 4, 2005 ... A quantification model using P3P in p... more 426 Int. J. Services and Standards, Vol. 1, No. 4, 2005 ... A quantification model using P3P in privacy control for telecommunications service management ... Department of Computer Information Systems and Management Science College of Business, James Madison University 800 ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of MicroRNA alteration and putative target genes in high-grade prostatic intraepithelial neoplasia and prostate cancer: STAT3 and ZEB1 are upregulated during prostate carcinogenesis

The Prostate, Jan 28, 2016

We aimed to identify alteration of cancer-related miRNAs in HGPIN and PCa, and to investigate the... more We aimed to identify alteration of cancer-related miRNAs in HGPIN and PCa, and to investigate the clinical implications of HGPIN as a precancerous lesion of PCa. Clinicopathologic analysis based on the status of HGPIN was performed in 388 patients who received radical prostatectomy between January 2005 and December 2008 in Severance Hospital. Among them, 10 paired HGPIN and PCa were prepared to perform miRNA microarray and quantitative real-time PCR. Fifty-two prostatectomy specimens were used to further validation of protein expression that was assessed by immunohistochemical staining (IHC) in matched non-neoplastic prostatic tissue (NPT), HGPIN, and PCa. Functional analysis was performed using a prostate normal cell line (RWPE-1) and two prostate cancer cell lines (LNCaP, PC-3) for comparison of expression of miR-155 and STAT3 mRNA before and after treatment of miR-155 mimetics/antagomir into each cell line. Patients with HGPIN had significantly less lymphovascular invasion, less ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Differences in cognitive ability and hippocampal volume between Alzheimer's disease, amnestic mild cognitive impairment, and healthy control groups, and their correlation

Neuroscience letters, Jan 24, 2016

The study investigated differences in cognitive ability and hippocampal volume between groups of ... more The study investigated differences in cognitive ability and hippocampal volume between groups of patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), and healthy control (HC) subjects, and explored the relationship between cognitive ability and hippocampal volume. Among the sub-tests of Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), the Boston naming test score decreased in the order HC, aMCI, and AD. The hippocampal volumes of subjects with AD and aMCI were relatively smaller than those of HC individuals. There were strongly positive correlations between hippocampal volume and the scores for the Boston naming test. Discriminant analysis identified the Boston naming test as having the highest level of discrimination among the variables used to differentiate the three groups (89.9%). In conclusion, the Boston naming test accurately differentiated the three groups and was correlated with hippocampal ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The Epidemiology of Myasthenia Gravis in Korea

Yonsei medical journal, 2016

An epidemiological study of myasthenia gravis (MG) has not been performed in Korea. The purpose o... more An epidemiological study of myasthenia gravis (MG) has not been performed in Korea. The purpose of this study was to estimate the prevalence and incidence of MG in Korea. Health Insurance Review and Assessment (HIRA) data from 2010 to 2014 were searched for MG codes as defined by the International Classification of Diseases, 10th revision. After identifying MG cases, we estimated the prevalence and annual incidence of MG based on the HIRA database and Korean population data. During the study period, 10138 MG cases were identified. The prevalence of MG was 10.42 cases per 100000 people in 2010 and this increased every year to 12.99 cases per 100000 people in 2014. The average incidence of MG between 2011 and 2014 was 0.69 cases per 100000 person-years. The prevalence and incidence were higher in the older (≥50 years) age group than in the younger (<50 years) age group [prevalence: 9.26 vs. 19.24 per 100000, relative risk 2.077, 95% confidence interval (CI) 1.976-2.183, p<0.001;...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Differences in and correlations between cognitive abilities and brain volumes in healthy control, mild cognitive impairment, and Alzheimer disease groups

Clinical anatomy (New York, N.Y.), Jan 28, 2015

The purpose of this study is to investigate differences in and correlations between cognitive abi... more The purpose of this study is to investigate differences in and correlations between cognitive abilities and brain volumes in healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) groups. The Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), which is used to diagnose AD, was used to measure the cognitive abilities of the study subjects, and the volumes of typical brain components related to AD diagnosis - cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM) - were acquired. Of the CERAD-K subtests, the Boston Naming Test distinguished significantly among the HC, MCI, and AD groups. GM and WM volumes differed significantly among the three groups. There was a significant positive correlation between Boston Naming Test scores and GM and WM volumes. In conclusion, the Boston Naming Test and GM and WM brain volumes differentiated the three tested groups accurately, and there were strong correlati...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of TCT-381 Worsening renal function is strongly associated with long-term mortality in stable post-myocardial infarction 1-year survivors

Journal of the American College of Cardiology, 2015

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Whole-Body Muscle MRI in Patients with Hyperkalemic Periodic Paralysis Carrying the SCN4A Mutation T704M: Evidence for Chronic Progressive Myopathy with Selective Muscle Involvement

Journal of clinical neurology (Seoul, Korea), Jan 6, 2015

Hyperkalemic periodic paralysis (hyperKPP) is a muscle sodium-ion channelopathy characterized by ... more Hyperkalemic periodic paralysis (hyperKPP) is a muscle sodium-ion channelopathy characterized by recurrent paralytic attacks. A proportion of affected individuals develop fixed or chronic progressive weakness that results in significant disability. However, little is known about the pathology of hyperKPP-induced fixed weakness, including the pattern of muscle involvement. The aim of this study was to characterize the patterns of muscle involvement in hyperKPP by whole-body magnetic resonance imaging (MRI). We performed whole-body muscle MRI in seven hyperKPP patients carrying the T704M mutation in the SCN4A skeletal sodium-channel gene. Muscle fat infiltration, suggestive of chronic progressive myopathy, was analyzed qualitatively using a grading system and was quantified by the two-point Dixon technique. Whole-body muscle MRI analysis revealed muscle atrophy and fatty infiltration in hyperKPP patients, especially in older individuals. Muscle involvement followed a selective pattern...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Feasibility Study of Pulsatile Left Ventricular Assist Device for Prolonged Ex Vivo Lung Perfusion

The Annals of Thoracic Surgery, 2015

Ex vivo lung perfusion (EVLP) has the potential to increase the donor pool for lung transplantati... more Ex vivo lung perfusion (EVLP) has the potential to increase the donor pool for lung transplantation by facilitating resuscitation and extended evaluation of marginal organs. Current EVLP methodology employs continuous flow (CF) pumps that produce non-pulsatile EVLP hemodynamics. In this feasibility study, we tested the hypothesis that a pulsatile flow (PF) pump will provide better EVLP support than a CF pump through delivery of physiologic hemodynamics. Porcine lungs were supported in an EVLP model by centrifugal CF (n = 3) or PF (n = 4) left ventricular assist devices. Lungs were ventilated at 4 to 5 mL/kg, 0.21 fraction of inspired oxygen (FiO2), and perfused with an acellular, albumin-based solution corrected for osmolarity, acid-base balance, and carbon dioxide pressure (≤20 hours at 30°C) for a minimum of 12 hours support. Prostaglandin E1 and 30% albumin were infused continuously. Hemodynamic, respiratory, and blood gas parameters were continuously monitored and digitally recorded hourly. Parenchymal biopsies were used for quantification of wet to dry weight ratio. All lungs maintained function in the EVLP circuit for a minimum of 12 hours (mean 14.7 ± 1 hours) and demonstrated minimal edema formation. The PF EVLP produced higher pulsatility as demonstrated by greater energy equivalent pressure and surplus hemodynamic energy compared with CF EVLP (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). There were no statistically significant differences in pulmonary impedance, arterial partial pressure of oxygen/fraction of inspired oxygen, wet to dry weight ratio, and peak airway pressure between CF and PF EVLP. The CF and PF EVLP systems successfully maintained lungs 12+ hours using a modified Steen perfusate (XVIVO Perfusion, Inc, Goteborg, Sweden); however, there were no statistically significant differences between CF and PF groups despite higher pulsatility, suggesting that PF may not offer immediate benefits over CF for prolonged ex vivo lung preservation.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Effect of backwashing on perchlorate removal in fixed bed biofilm reactors

Water research, 2007

The influence of backwashing on biological perchlorate reduction was evaluated in two laboratory ... more The influence of backwashing on biological perchlorate reduction was evaluated in two laboratory scale fixed bed biofilm reactors using 1- or 3-mm glass beads as support media. Influent perchlorate concentrations were 50 microg/L and acetate was added as the electron donor at a concentration of 2 mg C/L. Perchlorate removal was evaluated at various influent dissolved oxygen (DO) concentrations. Complete perchlorate removal was achieved with an influent DO concentration of 1mg/L resulting in bulk phase DO concentrations below the detection limit of 0.01 mg/L. The influence of increasing influent DO concentrations for 12 h periods was evaluated before and after individual backwash events. Partial perchlorate removal was achieved with an influent DO concentration of 3.5 mg/L before a strong backwash (bulk phase DO concentrations of approximately 0.2mg/L), while no perchlorate removal was observed after the strong backwash at the same influent DO level (bulk phase DO concentrations of a...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Surgical Treatment of Primary True Aneurysm on the Dorsalis Pedis Vein

The Korean Journal of Thoracic and Cardiovascular Surgery, 2010

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Bone health and its correlates in Korean prostate cancer patients receiving androgen deprivation therapy

European journal of oncology nursing : the official journal of European Oncology Nursing Society, Jan 27, 2015

This study aimed to examine bone health status, identify factors associated with bone mineral den... more This study aimed to examine bone health status, identify factors associated with bone mineral density (BMD), and determine potential risk factors for osteoporosis in Korean prostate cancer patients receiving androgen deprivation therapy (ADT). Using a cross-sectional descriptive design, we recruited 139 men with prostate cancer receiving ADT at two university-based hospitals in South Korea. Participants completed a self-reported questionnaire and underwent dual energy X-ray absorptiometry testing. BMD (gm/cm(2)), bone health status (normal BMD, osteopenia, and osteoporosis), and lifestyle variables (physical activity, smoking, and alcohol consumption) were measured. The prevalence in our sample was 49.6% for osteopenia and 17.3% for osteoporosis. In multivariate linear regression analyses, BMD was positively associated with body mass index, number of comorbidities, and level of physical activity and negatively associated with being unemployed or retired, having a lower monthly incom...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The temporal association of excessive health expenditure with suicidal ideation among primary income earners: a cross-sectional design using the Korean Welfare Panel Survey (KoWePS)

BMJ open, 2015

Excessive health expenditure (EHE) is a global issue for households suffering from high-cost medi... more Excessive health expenditure (EHE) is a global issue for households suffering from high-cost medical conditions, low incomes and limited insurance coverage. After the international financial crisis of 2008, EHE became a social problem in developed countries. Such economic crisis might induce severe mental stress, resulting in suicidal ideation. We used the Korean Welfare Panel Study (KoWePS) from 2011 to 2013 and selected primary income earners, who were defined as practical and economic representatives of households; the total number of analysed samples was 4247 of 5717 households in the database. We only included households that had never experienced EHE before 2011. To examine the temporal relationship between EHE and suicidal ideation, we conducted a logistic regression analysis. Among 4247 participants, 146 (3.4%) experienced suicidal ideation, whereas 4101 (96.6%) did not. One scale of depression score (OR=1.28, CI 1.23 to 1.34, p<0.001) was associated with increased suicid...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Reasonable efforts? Implementation of the reunification bypass provision of ASFA

Child welfare, 2008

The Adoption and Safe Families Act (ASFA) of 1997 includes provisions to deny reunification servi... more The Adoption and Safe Families Act (ASFA) of 1997 includes provisions to deny reunification services under specified conditions and gives states latitude to develop any number of additional "aggravated circumstances" in which parents need not be offered services. California legislators have developed a relatively large number of conditions enabling agencies to bypass reunification services. Based upon a case record review involving 1,055 parents, this study attempts to identify the proportion of parents eligible for a reunification bypass, the proportion recommended to the courts, and the proportion of parents who were denied reunification services, and examines the characteristics of parents associated with reunification bypass recommendations. Based upon focus groups and interviews with child welfare and judicial personnel in six counties, the study also examines the implementation of reunification bypass provisions. Implications for public policy and practice are provided.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The Thermal Analysis of Brake Disc with 3-D Coupled Analysis

Key Engineering Materials, 2005

ABSTRACT As the automobile industry develops, the demand for automobiles that provide more comfor... more ABSTRACT As the automobile industry develops, the demand for automobiles that provide more comfortable ride and safety is also increasing. In the conventional braking analysis, frictional heat generation is only related to wheel speed, friction material, and the interface pressure. However, under the dynamic braking conditions, the frictional heat causes the thermo-elastic distortion that leads to more concentrated distribution of contact pressure and hence more and more non-uniform temperature. This paper describes the thermo-elastic instability arising from friction heat generation in braking and proposes the finite element methods to predict the variation of temperature and thermal deformation.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Finite Element Analysis of the Repeated Braking with 3-D Coupled Model

Key Engineering Materials, 2006

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The Applications of Human Factors Associated with Hearing Impairments: Issues and Recent Technological Developments in Telecommunications

... Young B. Choi, Joshua S. Krause, and Kathleen E. Capitan James Madison University, Harrisonbu... more ... Young B. Choi, Joshua S. Krause, and Kathleen E. Capitan James Madison University, Harrisonburg, Virginia 22807-0001, USA ... A mixed hearing loss refers to a combination of both conductive and sensorineural hearing loss (Schow & Nerbonne, 2002). ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The state-of-the-art of mobile payment architecture and emerging issues

International Journal of Electronic Finance, 2006

... (Karnouskos and Fraunhofer, 2004). In pre-paid accounts, the payment is deducted from the air... more ... (Karnouskos and Fraunhofer, 2004). In pre-paid accounts, the payment is deducted from the airtime credit, where as with post-paid accounts, the payment is charged to the mobilephone bill (Herzberg, 2003). 2 The state-of-the-art of mobile payment ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Reeling in Cognitive Radio: The Issues of Regulations and Policies Affecting Spectrum Management

Communications in Computer and Information Science, 2009

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Feasibility of virtual security laboratory for three-tiered distance education

Proceedings of the 2010 ACM conference on Information technology education - SIGITE '10, 2010

Today, a number of universities and colleges offering security education has been growing rapidly... more Today, a number of universities and colleges offering security education has been growing rapidly for last couple of years. Most universities have adequate facilities and labs to provide hand-on experience in security courses, but some universities and colleges that initiated security courses do not have equipments and space to offer hand-on experience for the students. This is challenge for distance

Bookmarks Related papers MentionsView impact

Research paper thumbnail of RFID Implementation and Security Issues

Communications in Computer and Information Science, 2011

... RFID: Improved Patient Safety, http://clearcount.com/rfid-improved-patient-safety 26. Fuqua, ... more ... RFID: Improved Patient Safety, http://clearcount.com/rfid-improved-patient-safety 26. Fuqua, M.: Is RFID Getting Primed To Change Digital Marketing?, http://fifthgearanalytics.com/ 2010/11/is-rfid-getting-primed-to-change-digital-marketing/ 27. ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of A quantification model using P3P in privacy control for telecommunications service management

International Journal of Services and Standards, 2005

426 Int. J. Services and Standards, Vol. 1, No. 4, 2005 ... A quantification model using P3P in p... more 426 Int. J. Services and Standards, Vol. 1, No. 4, 2005 ... A quantification model using P3P in privacy control for telecommunications service management ... Department of Computer Information Systems and Management Science College of Business, James Madison University 800 ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of MicroRNA alteration and putative target genes in high-grade prostatic intraepithelial neoplasia and prostate cancer: STAT3 and ZEB1 are upregulated during prostate carcinogenesis

The Prostate, Jan 28, 2016

We aimed to identify alteration of cancer-related miRNAs in HGPIN and PCa, and to investigate the... more We aimed to identify alteration of cancer-related miRNAs in HGPIN and PCa, and to investigate the clinical implications of HGPIN as a precancerous lesion of PCa. Clinicopathologic analysis based on the status of HGPIN was performed in 388 patients who received radical prostatectomy between January 2005 and December 2008 in Severance Hospital. Among them, 10 paired HGPIN and PCa were prepared to perform miRNA microarray and quantitative real-time PCR. Fifty-two prostatectomy specimens were used to further validation of protein expression that was assessed by immunohistochemical staining (IHC) in matched non-neoplastic prostatic tissue (NPT), HGPIN, and PCa. Functional analysis was performed using a prostate normal cell line (RWPE-1) and two prostate cancer cell lines (LNCaP, PC-3) for comparison of expression of miR-155 and STAT3 mRNA before and after treatment of miR-155 mimetics/antagomir into each cell line. Patients with HGPIN had significantly less lymphovascular invasion, less ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Differences in cognitive ability and hippocampal volume between Alzheimer's disease, amnestic mild cognitive impairment, and healthy control groups, and their correlation

Neuroscience letters, Jan 24, 2016

The study investigated differences in cognitive ability and hippocampal volume between groups of ... more The study investigated differences in cognitive ability and hippocampal volume between groups of patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), and healthy control (HC) subjects, and explored the relationship between cognitive ability and hippocampal volume. Among the sub-tests of Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), the Boston naming test score decreased in the order HC, aMCI, and AD. The hippocampal volumes of subjects with AD and aMCI were relatively smaller than those of HC individuals. There were strongly positive correlations between hippocampal volume and the scores for the Boston naming test. Discriminant analysis identified the Boston naming test as having the highest level of discrimination among the variables used to differentiate the three groups (89.9%). In conclusion, the Boston naming test accurately differentiated the three groups and was correlated with hippocampal ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The Epidemiology of Myasthenia Gravis in Korea

Yonsei medical journal, 2016

An epidemiological study of myasthenia gravis (MG) has not been performed in Korea. The purpose o... more An epidemiological study of myasthenia gravis (MG) has not been performed in Korea. The purpose of this study was to estimate the prevalence and incidence of MG in Korea. Health Insurance Review and Assessment (HIRA) data from 2010 to 2014 were searched for MG codes as defined by the International Classification of Diseases, 10th revision. After identifying MG cases, we estimated the prevalence and annual incidence of MG based on the HIRA database and Korean population data. During the study period, 10138 MG cases were identified. The prevalence of MG was 10.42 cases per 100000 people in 2010 and this increased every year to 12.99 cases per 100000 people in 2014. The average incidence of MG between 2011 and 2014 was 0.69 cases per 100000 person-years. The prevalence and incidence were higher in the older (≥50 years) age group than in the younger (<50 years) age group [prevalence: 9.26 vs. 19.24 per 100000, relative risk 2.077, 95% confidence interval (CI) 1.976-2.183, p<0.001;...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Differences in and correlations between cognitive abilities and brain volumes in healthy control, mild cognitive impairment, and Alzheimer disease groups

Clinical anatomy (New York, N.Y.), Jan 28, 2015

The purpose of this study is to investigate differences in and correlations between cognitive abi... more The purpose of this study is to investigate differences in and correlations between cognitive abilities and brain volumes in healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) groups. The Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), which is used to diagnose AD, was used to measure the cognitive abilities of the study subjects, and the volumes of typical brain components related to AD diagnosis - cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM) - were acquired. Of the CERAD-K subtests, the Boston Naming Test distinguished significantly among the HC, MCI, and AD groups. GM and WM volumes differed significantly among the three groups. There was a significant positive correlation between Boston Naming Test scores and GM and WM volumes. In conclusion, the Boston Naming Test and GM and WM brain volumes differentiated the three tested groups accurately, and there were strong correlati...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of TCT-381 Worsening renal function is strongly associated with long-term mortality in stable post-myocardial infarction 1-year survivors

Journal of the American College of Cardiology, 2015

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Whole-Body Muscle MRI in Patients with Hyperkalemic Periodic Paralysis Carrying the SCN4A Mutation T704M: Evidence for Chronic Progressive Myopathy with Selective Muscle Involvement

Journal of clinical neurology (Seoul, Korea), Jan 6, 2015

Hyperkalemic periodic paralysis (hyperKPP) is a muscle sodium-ion channelopathy characterized by ... more Hyperkalemic periodic paralysis (hyperKPP) is a muscle sodium-ion channelopathy characterized by recurrent paralytic attacks. A proportion of affected individuals develop fixed or chronic progressive weakness that results in significant disability. However, little is known about the pathology of hyperKPP-induced fixed weakness, including the pattern of muscle involvement. The aim of this study was to characterize the patterns of muscle involvement in hyperKPP by whole-body magnetic resonance imaging (MRI). We performed whole-body muscle MRI in seven hyperKPP patients carrying the T704M mutation in the SCN4A skeletal sodium-channel gene. Muscle fat infiltration, suggestive of chronic progressive myopathy, was analyzed qualitatively using a grading system and was quantified by the two-point Dixon technique. Whole-body muscle MRI analysis revealed muscle atrophy and fatty infiltration in hyperKPP patients, especially in older individuals. Muscle involvement followed a selective pattern...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Feasibility Study of Pulsatile Left Ventricular Assist Device for Prolonged Ex Vivo Lung Perfusion

The Annals of Thoracic Surgery, 2015

Ex vivo lung perfusion (EVLP) has the potential to increase the donor pool for lung transplantati... more Ex vivo lung perfusion (EVLP) has the potential to increase the donor pool for lung transplantation by facilitating resuscitation and extended evaluation of marginal organs. Current EVLP methodology employs continuous flow (CF) pumps that produce non-pulsatile EVLP hemodynamics. In this feasibility study, we tested the hypothesis that a pulsatile flow (PF) pump will provide better EVLP support than a CF pump through delivery of physiologic hemodynamics. Porcine lungs were supported in an EVLP model by centrifugal CF (n = 3) or PF (n = 4) left ventricular assist devices. Lungs were ventilated at 4 to 5 mL/kg, 0.21 fraction of inspired oxygen (FiO2), and perfused with an acellular, albumin-based solution corrected for osmolarity, acid-base balance, and carbon dioxide pressure (≤20 hours at 30°C) for a minimum of 12 hours support. Prostaglandin E1 and 30% albumin were infused continuously. Hemodynamic, respiratory, and blood gas parameters were continuously monitored and digitally recorded hourly. Parenchymal biopsies were used for quantification of wet to dry weight ratio. All lungs maintained function in the EVLP circuit for a minimum of 12 hours (mean 14.7 ± 1 hours) and demonstrated minimal edema formation. The PF EVLP produced higher pulsatility as demonstrated by greater energy equivalent pressure and surplus hemodynamic energy compared with CF EVLP (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). There were no statistically significant differences in pulmonary impedance, arterial partial pressure of oxygen/fraction of inspired oxygen, wet to dry weight ratio, and peak airway pressure between CF and PF EVLP. The CF and PF EVLP systems successfully maintained lungs 12+ hours using a modified Steen perfusate (XVIVO Perfusion, Inc, Goteborg, Sweden); however, there were no statistically significant differences between CF and PF groups despite higher pulsatility, suggesting that PF may not offer immediate benefits over CF for prolonged ex vivo lung preservation.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Effect of backwashing on perchlorate removal in fixed bed biofilm reactors

Water research, 2007

The influence of backwashing on biological perchlorate reduction was evaluated in two laboratory ... more The influence of backwashing on biological perchlorate reduction was evaluated in two laboratory scale fixed bed biofilm reactors using 1- or 3-mm glass beads as support media. Influent perchlorate concentrations were 50 microg/L and acetate was added as the electron donor at a concentration of 2 mg C/L. Perchlorate removal was evaluated at various influent dissolved oxygen (DO) concentrations. Complete perchlorate removal was achieved with an influent DO concentration of 1mg/L resulting in bulk phase DO concentrations below the detection limit of 0.01 mg/L. The influence of increasing influent DO concentrations for 12 h periods was evaluated before and after individual backwash events. Partial perchlorate removal was achieved with an influent DO concentration of 3.5 mg/L before a strong backwash (bulk phase DO concentrations of approximately 0.2mg/L), while no perchlorate removal was observed after the strong backwash at the same influent DO level (bulk phase DO concentrations of a...

Bookmarks Related papers MentionsView impact