Young-min Kim - Academia.edu (original) (raw)

Papers by Young-min Kim

Research paper thumbnail of Automatic annotation of incomplete and scattered bibliographical references in Digital Humanities papers

In this paper, we deal with the problem of extracting and processing useful information from bibl... more In this paper, we deal with the problem of extracting and processing useful information from bibliographic references in Digital Humanities (DH) data. We present our ongoing project BILBO, supported by Google Grant for Digital Humanities that includes the constitution of proper reference corpora and construction of efficient annotation model using several appropriate machine learning techniques. Conditional Random Field is used as a basic approach to automatic annotation of reference fields and Support Vector Machine with a set of newly proposed features is applied for sequence classification. A number of experiments are conducted to find one of the best feature settings for CRF model on these corpora.

Research paper thumbnail of Une Méthode Contextuelle d'Extension de Requête avec des Groupements de Mots pour le Résumé Automatique

Research paper thumbnail of poster booksonline11

Research paper thumbnail of Quality-of-service scheduler for next generation network services

Flows have different characteristics depending on the type of application, and this leads to cons... more Flows have different characteristics depending on the type of application, and this leads to consideration of the QoS needed to guarantee that the application will work satisfactorily. However, the scheduling algorithms such as WFQ, DRR, or hierarchical scheduling algorithms are complex to guarantee QoS in per-flow level because of buffer management. Calendar queue is appropriate to service per-flow based scheduling

Research paper thumbnail of Quadruple-junction lattice coherency and phase separation in a binary-phase system

Nature communications, 2015

If each phase has an identical crystal structure and small misfit in the lattice parameters in a ... more If each phase has an identical crystal structure and small misfit in the lattice parameters in a binary-phase crystalline system, coherent phase boundaries usually form during separation. Although there have been numerous studies on the effect of coherency elastic energy, no attempt has been made to demonstrate how the phase-separation behaviour varies when multiple interfaces meet at a junction. Here we show that a comprehensively different phase-separation morphology is induced, to release the high coherency strain confined to quadruple junctions. High-temperature in-situ transmission electron microscopy reveals that phase boundaries with a new crystallographic orientation emerge over twinned crystals to provide strain relaxation at quadruple junctions. The high coherency strain and the formation of different phase boundaries can be understood in terms of the force equilibrium between interface tensions at a junction point. Visualizing the quadruple points at atomic resolution, ou...

Research paper thumbnail of Practical Approaches to Mitigation of Specimen Charging in High-Resolution Transmission Electron Microscopy

Journal of Analytical Science and Technology, 2010

Research paper thumbnail of Effect of Second Phase on Mechanical Properties of Bainite-Base Steels

Advanced Materials Research, 2006

Effects of acicular ferrite and retained austenite on the mechanical properties of bainite-base s... more Effects of acicular ferrite and retained austenite on the mechanical properties of bainite-base steels were investigated. Various morphology and volume fraction of constituent phases have been obtained by control of hot rolling conditions and alloy compositions. It has been shown that the steels containing retained austenite have better combinations of strength and ductility than the ones with no retained austenite. However, there is no noticeable change in DBTT by the incorporation of retained austenite in the microstructure since retained austenite exists as fine particles. On the other hand, DBTT of the steels are largely affected by the presence of acicular ferrite in the microstructure. EBSD analyses of fractured Charpy specimens show that cracks are deflected within the morphological packet of acicular ferrite, indicating its role in reducing the effective grain size of the steels.

Research paper thumbnail of Continuous Amplitude-Integrated Electroencephalographic Monitoring is a Useful Prognostic Tool for Hypothermia-Treated Cardiac Arrest Patients

Circulation, Jan 12, 2015

Following transient cerebral ischemia, a complex series of pathophysiological events associated w... more Following transient cerebral ischemia, a complex series of pathophysiological events associated with neuronal recovery can be observed via continuous electroencephalographic (EEG; cEEG) monitoring over time. The evolution of EEG patterns may provide clinically relevant information regarding the recovery from postanoxic coma. In 2010, the American Heart Association published guidelines for the care of these survivors Background-Modern treatments have improved the survival rate following cardiac arrest, but prognostication remains a challenge. We examined the prognostic value of continuous electroencephalography according to time by performing amplitude-integrated electroencephalography on patients with cardiac arrest receiving therapeutic hypothermia. Methods and Results-We prospectively studied 130 comatose patients treated with hypothermia from September 2010 to April 2013. We evaluated the time to normal trace (TTNT) as a neurological outcome predictor and determined the prognostic value of burst suppression and status epilepticus, with a particular focus on their time of occurrence. Fifty-five patients exhibited a cerebral performance category score of 1 to 2. The area under the curve for TTNT was 0.97 (95% confidence interval, 0.92-0.99), and the sensitivity and specificity of TTNT<24 hours after resuscitation as a threshold for predicting good neurological outcome were 94.6% (95% confidence interval, 84.9%-98.9%) and 90.7% (95% confidence interval, 81.7%-96.2%), respectively. The threshold displaying 100% specificity for predicting poor neurological outcome was TTNT>36 hours. Burst suppression and status epilepticus predicted poor neurological outcome (positive predictive value of 98.3% and 96.4%, respectively). The combination of these factors predicted a negative outcome at a median of 6.2 hours after resuscitation (sensitivity and specificity of 92.0% and 96.4%, respectively). Conclusions-A TTNT<24 hours was associated with good neurological outcome. The lack of normal trace development within 36 hours, status epilepticus, and burst suppression were predictors of poor outcome. The combination of these negative predictors may improve their prognostic performance at an earlier stage. The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/

Research paper thumbnail of GlideScope video laryngoscopy versus direct laryngoscopy in the emergency department: a propensity score-matched analysis

BMJ open, 2015

To evaluate whether the use of a GlideScope video laryngoscope (GVL) improves first-attempt intub... more To evaluate whether the use of a GlideScope video laryngoscope (GVL) improves first-attempt intubation success compared with the Macintosh laryngoscope (MAC) in the emergency department (ED). A propensity score-matched analysis of data from a prospective multicentre ED airway registry-the Korean Emergency Airway Management Registry (KEAMR). 4 academic EDs located in a metropolitan city and a province in South Korea. A total of 4041 adult patients without cardiac arrest who underwent emergency intubation from January 2007 to December 2010. The primary and secondary outcomes were successful first intubation attempt and intubation failure, respectively. To reduce the selection bias and potential confounding effects, we rigorously adjusted for the baseline differences between two groups using a propensity score matching. Of the 4041 eligible patients, a GVL was initially used in 540 patients (13.4%). Using 1:2 propensity score matching, 363 and 726 patients were assigned to the GVL and ...

Research paper thumbnail of Recommending the Meanings of Newly Coined Words

Procedia - Social and Behavioral Sciences, 2011

We live in the age of information deluge. While people can access information through these web s... more We live in the age of information deluge. While people can access information through these web services, at the very same time they used to face unknown words, which they do not know their meaning. A part of these kind words could be newly coined words, such as ...

Research paper thumbnail of A new COF bonding technique using Sn bumps and a non-conductive adhesive (NCA) for image sensor packaging

2009 59th Electronic Components and Technology Conference, 2009

Abstract A chip-on-flex (COF) bonding technology using Sn bumps and a non-conductive adhesive (NC... more Abstract A chip-on-flex (COF) bonding technology using Sn bumps and a non-conductive adhesive (NCA) was investigated. Two types of Sn bumps, square bumps and hemispherical bumps, were fabricated. The COF bonding was performed at 180°C for 5 s at 90 MPa after the NCA ...

Research paper thumbnail of Pyrolysis and catalytic upgrading of citrus unshiu peel

Bioresource Technology, 2015

Ex situ catalytic pyrolysis of Citrus unshiu (C. unshiu) peel was performed using a tandem μ-reac... more Ex situ catalytic pyrolysis of Citrus unshiu (C. unshiu) peel was performed using a tandem μ-reactor-GC/MS consisting of two sequential furnaces. The pyrolyzates of C. unshiu peel, composed mainly of alcohols, ketones and furans produced in the 1st furnace of the reactor, were upgraded to aromatics by the use of catalysts in the 2nd furnace. Compared to wood powder, C. unshiu peel produced larger amounts of aromatics over HZSM-5(23). Among the various catalysts, HZSM-5(23) and HBETA(25) showed high aromatic yields, 6.78 C% and 9.69 C%, respectively. HBETA(25) produced large amounts of undesirable PAHs (3.59 C%). During the sequential catalytic upgrading test, the yield of BTEXs (benzene, toluene, ethylbenzene, xylenes) over HZSM-5(23) was reduced more slowly than that over HBETA(25) because of the slower deactivation of HZSM-5(23), which suggests that HZSM-5(23) is a more stable catalyst than the other catalysts used in this study during the sequential catalytic upgrading of C. unshiu peel pyrolyzates.

Research paper thumbnail of Adaptive coded-modulation in multipath fading channels

Gateway to 21st Century Communications Village. VTC 1999-Fall. IEEE VTS 50th Vehicular Technology Conference (Cat. No.99CH36324), 1999

We have seen an explosive expansion and growth in wireless communications and a vision of communi... more We have seen an explosive expansion and growth in wireless communications and a vision of communicating; any-where any-time is becoming reality. Future mobile radio systems are projected to support a data rate of up to a few Mbps. Considering current digital mobile radio systems are being operated at a spectral efficiency less than 1 bit/sec/Hz, the spectral efficiency of future wireless systems must be increased substantially to maximize the utilization of scarce radio spectrum and to make such high data rate services economically feasible. Adaptive coded modulation (ACM) is a promising way to provide a substantial improvement in spectral efficiency for slow fading channels. The basic idea is to adapt system functionality such as modulation, coding, information rate, and transmission power to varying channel conditions. In this work the potential of adaptive coded modulation was investigated using cut-off rate analysis in multipath fading channels. It was shown that the adaptive coded modulation can provide several folds of increase in spectral efficiency compared to a fixed modulation system employing QPSK when the channel varies slowly

Research paper thumbnail of The anti-obesity effects of a tuna peptide on 3T3-L1 adipocytes are mediated by the inhibition of the expression of lipogenic and adipogenic genes and by the activation of the Wnt/β-catenin signaling pathway

International journal of molecular medicine, 2015

The differentiation of 3T3-L1 cells into adipocytes involves the activation of an organized syste... more The differentiation of 3T3-L1 cells into adipocytes involves the activation of an organized system of obesity-related genes, of which those encoding CCAAT/enhancer‑binding proteins (C/EBPs) and the Wnt-10b protein may play integral roles. In a previous study of ours, we found that a specific peptide found in tuna (sequence D‑I‑V‑D‑K‑I‑E‑I; termed TP‑D) inhibited 3T3‑L1 cell differentiation. In the present study, we observed that the expression of expression of C/EBPs and Wnt‑10b was associated with obesity. The initial step of 3T3‑L1 cell differentiation involved the upregulation of C/EBP‑α expression, which in turn activated various subfactors. An upstream effector of glycogen synthase kinase-3β (GSK‑3β) inhibited Wnt‑10b expression in 3T3‑L1 adipocytes. In a previous study of ours, we sequenced the tuna peptide via sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS‑PAGE) and quadrupole time-of-flight mass spectrometry (Q-TOF MS/MS) and confirmed the anti‑obesity effect...

Research paper thumbnail of Novel chimeric peptide with enhanced cell specificity and anti-inflammatory activity

Biochemical and biophysical research communications, Jan 29, 2015

An antimicrobial peptide (AMP), Hn-Mc, was designed by combining the N-terminus of HPA3NT3 and th... more An antimicrobial peptide (AMP), Hn-Mc, was designed by combining the N-terminus of HPA3NT3 and the C-terminus of melittin. This chimeric AMP exhibited potent antibacterial activity with low minimal inhibitory concentrations (MICs), ranging from 1 to 2 μM against four drug-susceptible bacteria and ten drug-resistant bacteria. Moreover, the hemolysis and cytotoxicity was reduced significantly compared to those of the parent peptides, highlighting its high cell selectivity. The morphological changes in the giant unilamellar vesicles and bacterial cell surfaces caused by the Hn-Mc peptide suggested that it killed the microbial cells by damaging the membrane envelope. An in vivo study also demonstrated the antibacterial activity of the Hn-Mc peptide in a mouse model infected with drug-resistant bacteria. In addition, the chimeric peptide inhibited the expression of lipopolysaccharide (LPS)-induced cytokines in RAW 264.7 cells by preventing the interaction between LPS and Toll-like recept...

Research paper thumbnail of Frenkel-Defect-Mediated Chemical Ordering Transition in a Li-Mn-Ni Spinel Oxide

Angewandte Chemie, 2015

Using spinel-type Li(Mn1.5 Ni0.5 )O4 with two different cations, Mn and Ni, in the oxygen octahed... more Using spinel-type Li(Mn1.5 Ni0.5 )O4 with two different cations, Mn and Ni, in the oxygen octahedra as a model system, we show that a cation ordering transition takes place through the formation of Frenkel-type point defects. A series of experimental results based on atomic-scale observations and in situ powder diffractions along with ab initio calculations consistently support such defect-mediated transition behavior. In addition to providing a precise suggestion of the intermediate transient states and the resulting kinetic pathway during the transition between two phases, our findings emphasize the significant role of point defects in ordering transformation of complex oxides.

Research paper thumbnail of An extension of PLSA for document clustering

Proceeding of the 17th ACM conference on Information and knowledge mining - CIKM '08, 2008

ABSTRACT In this paper we propose an extension of the PLSA model in which an extra latent variabl... more ABSTRACT In this paper we propose an extension of the PLSA model in which an extra latent variable allows the model to co-cluster documents and terms simultaneously. We show on three datasets that our extended model produces statisti-cally significant improvements with ...

Research paper thumbnail of Multi-view clustering of multilingual documents

Proceeding of the 33rd international ACM SIGIR conference on Research and development in information retrieval - SIGIR '10, 2010

We propose a new multi-view clustering method which uses clustering results obtained on each view... more We propose a new multi-view clustering method which uses clustering results obtained on each view as a voting pattern in order to construct a new set of multi-view clusters. Our experiments on a multilingual corpus of documents show that performance increases significantly over simple concatenation and another multi-view clustering technique.

Research paper thumbnail of An observational study of surface versus endovascular cooling techniques in cardiac arrest patients: a propensity-matched analysis

Critical care (London, England), 2015

Various methods and devices have been described for cooling after cardiac arrest, but the ideal c... more Various methods and devices have been described for cooling after cardiac arrest, but the ideal cooling method remains unclear. The aim of this study was to compare the neurological outcomes, efficacies and adverse events of surface and endovascular cooling techniques in cardiac arrest patients. We performed a multicenter, retrospective, registry-based study of adult cardiac arrest patients treated with therapeutic hypothermia presenting to 24 hospitals across South Korea from 2007 to 2012. We included patients who received therapeutic hypothermia using overall surface or endovascular cooling devices and compared the neurological outcomes, efficacies and adverse events of both cooling techniques. To adjust for differences in the baseline characteristics of each cooling method, we performed one-to-one matching by the propensity score. In total, 803 patients were included in the analysis. Of these patients, 559 underwent surface cooling, and the remaining 244 patients underwent endova...

Research paper thumbnail of A Novel Protection Architecture for WDM-PON

COIN-NGNCON 2006 - The Joint International Conference on Optical Internet and Next Generation Network, 2006

ABSTRACT

Research paper thumbnail of Automatic annotation of incomplete and scattered bibliographical references in Digital Humanities papers

In this paper, we deal with the problem of extracting and processing useful information from bibl... more In this paper, we deal with the problem of extracting and processing useful information from bibliographic references in Digital Humanities (DH) data. We present our ongoing project BILBO, supported by Google Grant for Digital Humanities that includes the constitution of proper reference corpora and construction of efficient annotation model using several appropriate machine learning techniques. Conditional Random Field is used as a basic approach to automatic annotation of reference fields and Support Vector Machine with a set of newly proposed features is applied for sequence classification. A number of experiments are conducted to find one of the best feature settings for CRF model on these corpora.

Research paper thumbnail of Une Méthode Contextuelle d'Extension de Requête avec des Groupements de Mots pour le Résumé Automatique

Research paper thumbnail of poster booksonline11

Research paper thumbnail of Quality-of-service scheduler for next generation network services

Flows have different characteristics depending on the type of application, and this leads to cons... more Flows have different characteristics depending on the type of application, and this leads to consideration of the QoS needed to guarantee that the application will work satisfactorily. However, the scheduling algorithms such as WFQ, DRR, or hierarchical scheduling algorithms are complex to guarantee QoS in per-flow level because of buffer management. Calendar queue is appropriate to service per-flow based scheduling

Research paper thumbnail of Quadruple-junction lattice coherency and phase separation in a binary-phase system

Nature communications, 2015

If each phase has an identical crystal structure and small misfit in the lattice parameters in a ... more If each phase has an identical crystal structure and small misfit in the lattice parameters in a binary-phase crystalline system, coherent phase boundaries usually form during separation. Although there have been numerous studies on the effect of coherency elastic energy, no attempt has been made to demonstrate how the phase-separation behaviour varies when multiple interfaces meet at a junction. Here we show that a comprehensively different phase-separation morphology is induced, to release the high coherency strain confined to quadruple junctions. High-temperature in-situ transmission electron microscopy reveals that phase boundaries with a new crystallographic orientation emerge over twinned crystals to provide strain relaxation at quadruple junctions. The high coherency strain and the formation of different phase boundaries can be understood in terms of the force equilibrium between interface tensions at a junction point. Visualizing the quadruple points at atomic resolution, ou...

Research paper thumbnail of Practical Approaches to Mitigation of Specimen Charging in High-Resolution Transmission Electron Microscopy

Journal of Analytical Science and Technology, 2010

Research paper thumbnail of Effect of Second Phase on Mechanical Properties of Bainite-Base Steels

Advanced Materials Research, 2006

Effects of acicular ferrite and retained austenite on the mechanical properties of bainite-base s... more Effects of acicular ferrite and retained austenite on the mechanical properties of bainite-base steels were investigated. Various morphology and volume fraction of constituent phases have been obtained by control of hot rolling conditions and alloy compositions. It has been shown that the steels containing retained austenite have better combinations of strength and ductility than the ones with no retained austenite. However, there is no noticeable change in DBTT by the incorporation of retained austenite in the microstructure since retained austenite exists as fine particles. On the other hand, DBTT of the steels are largely affected by the presence of acicular ferrite in the microstructure. EBSD analyses of fractured Charpy specimens show that cracks are deflected within the morphological packet of acicular ferrite, indicating its role in reducing the effective grain size of the steels.

Research paper thumbnail of Continuous Amplitude-Integrated Electroencephalographic Monitoring is a Useful Prognostic Tool for Hypothermia-Treated Cardiac Arrest Patients

Circulation, Jan 12, 2015

Following transient cerebral ischemia, a complex series of pathophysiological events associated w... more Following transient cerebral ischemia, a complex series of pathophysiological events associated with neuronal recovery can be observed via continuous electroencephalographic (EEG; cEEG) monitoring over time. The evolution of EEG patterns may provide clinically relevant information regarding the recovery from postanoxic coma. In 2010, the American Heart Association published guidelines for the care of these survivors Background-Modern treatments have improved the survival rate following cardiac arrest, but prognostication remains a challenge. We examined the prognostic value of continuous electroencephalography according to time by performing amplitude-integrated electroencephalography on patients with cardiac arrest receiving therapeutic hypothermia. Methods and Results-We prospectively studied 130 comatose patients treated with hypothermia from September 2010 to April 2013. We evaluated the time to normal trace (TTNT) as a neurological outcome predictor and determined the prognostic value of burst suppression and status epilepticus, with a particular focus on their time of occurrence. Fifty-five patients exhibited a cerebral performance category score of 1 to 2. The area under the curve for TTNT was 0.97 (95% confidence interval, 0.92-0.99), and the sensitivity and specificity of TTNT<24 hours after resuscitation as a threshold for predicting good neurological outcome were 94.6% (95% confidence interval, 84.9%-98.9%) and 90.7% (95% confidence interval, 81.7%-96.2%), respectively. The threshold displaying 100% specificity for predicting poor neurological outcome was TTNT>36 hours. Burst suppression and status epilepticus predicted poor neurological outcome (positive predictive value of 98.3% and 96.4%, respectively). The combination of these factors predicted a negative outcome at a median of 6.2 hours after resuscitation (sensitivity and specificity of 92.0% and 96.4%, respectively). Conclusions-A TTNT<24 hours was associated with good neurological outcome. The lack of normal trace development within 36 hours, status epilepticus, and burst suppression were predictors of poor outcome. The combination of these negative predictors may improve their prognostic performance at an earlier stage. The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/

Research paper thumbnail of GlideScope video laryngoscopy versus direct laryngoscopy in the emergency department: a propensity score-matched analysis

BMJ open, 2015

To evaluate whether the use of a GlideScope video laryngoscope (GVL) improves first-attempt intub... more To evaluate whether the use of a GlideScope video laryngoscope (GVL) improves first-attempt intubation success compared with the Macintosh laryngoscope (MAC) in the emergency department (ED). A propensity score-matched analysis of data from a prospective multicentre ED airway registry-the Korean Emergency Airway Management Registry (KEAMR). 4 academic EDs located in a metropolitan city and a province in South Korea. A total of 4041 adult patients without cardiac arrest who underwent emergency intubation from January 2007 to December 2010. The primary and secondary outcomes were successful first intubation attempt and intubation failure, respectively. To reduce the selection bias and potential confounding effects, we rigorously adjusted for the baseline differences between two groups using a propensity score matching. Of the 4041 eligible patients, a GVL was initially used in 540 patients (13.4%). Using 1:2 propensity score matching, 363 and 726 patients were assigned to the GVL and ...

Research paper thumbnail of Recommending the Meanings of Newly Coined Words

Procedia - Social and Behavioral Sciences, 2011

We live in the age of information deluge. While people can access information through these web s... more We live in the age of information deluge. While people can access information through these web services, at the very same time they used to face unknown words, which they do not know their meaning. A part of these kind words could be newly coined words, such as ...

Research paper thumbnail of A new COF bonding technique using Sn bumps and a non-conductive adhesive (NCA) for image sensor packaging

2009 59th Electronic Components and Technology Conference, 2009

Abstract A chip-on-flex (COF) bonding technology using Sn bumps and a non-conductive adhesive (NC... more Abstract A chip-on-flex (COF) bonding technology using Sn bumps and a non-conductive adhesive (NCA) was investigated. Two types of Sn bumps, square bumps and hemispherical bumps, were fabricated. The COF bonding was performed at 180°C for 5 s at 90 MPa after the NCA ...

Research paper thumbnail of Pyrolysis and catalytic upgrading of citrus unshiu peel

Bioresource Technology, 2015

Ex situ catalytic pyrolysis of Citrus unshiu (C. unshiu) peel was performed using a tandem μ-reac... more Ex situ catalytic pyrolysis of Citrus unshiu (C. unshiu) peel was performed using a tandem μ-reactor-GC/MS consisting of two sequential furnaces. The pyrolyzates of C. unshiu peel, composed mainly of alcohols, ketones and furans produced in the 1st furnace of the reactor, were upgraded to aromatics by the use of catalysts in the 2nd furnace. Compared to wood powder, C. unshiu peel produced larger amounts of aromatics over HZSM-5(23). Among the various catalysts, HZSM-5(23) and HBETA(25) showed high aromatic yields, 6.78 C% and 9.69 C%, respectively. HBETA(25) produced large amounts of undesirable PAHs (3.59 C%). During the sequential catalytic upgrading test, the yield of BTEXs (benzene, toluene, ethylbenzene, xylenes) over HZSM-5(23) was reduced more slowly than that over HBETA(25) because of the slower deactivation of HZSM-5(23), which suggests that HZSM-5(23) is a more stable catalyst than the other catalysts used in this study during the sequential catalytic upgrading of C. unshiu peel pyrolyzates.

Research paper thumbnail of Adaptive coded-modulation in multipath fading channels

Gateway to 21st Century Communications Village. VTC 1999-Fall. IEEE VTS 50th Vehicular Technology Conference (Cat. No.99CH36324), 1999

We have seen an explosive expansion and growth in wireless communications and a vision of communi... more We have seen an explosive expansion and growth in wireless communications and a vision of communicating; any-where any-time is becoming reality. Future mobile radio systems are projected to support a data rate of up to a few Mbps. Considering current digital mobile radio systems are being operated at a spectral efficiency less than 1 bit/sec/Hz, the spectral efficiency of future wireless systems must be increased substantially to maximize the utilization of scarce radio spectrum and to make such high data rate services economically feasible. Adaptive coded modulation (ACM) is a promising way to provide a substantial improvement in spectral efficiency for slow fading channels. The basic idea is to adapt system functionality such as modulation, coding, information rate, and transmission power to varying channel conditions. In this work the potential of adaptive coded modulation was investigated using cut-off rate analysis in multipath fading channels. It was shown that the adaptive coded modulation can provide several folds of increase in spectral efficiency compared to a fixed modulation system employing QPSK when the channel varies slowly

Research paper thumbnail of The anti-obesity effects of a tuna peptide on 3T3-L1 adipocytes are mediated by the inhibition of the expression of lipogenic and adipogenic genes and by the activation of the Wnt/β-catenin signaling pathway

International journal of molecular medicine, 2015

The differentiation of 3T3-L1 cells into adipocytes involves the activation of an organized syste... more The differentiation of 3T3-L1 cells into adipocytes involves the activation of an organized system of obesity-related genes, of which those encoding CCAAT/enhancer‑binding proteins (C/EBPs) and the Wnt-10b protein may play integral roles. In a previous study of ours, we found that a specific peptide found in tuna (sequence D‑I‑V‑D‑K‑I‑E‑I; termed TP‑D) inhibited 3T3‑L1 cell differentiation. In the present study, we observed that the expression of expression of C/EBPs and Wnt‑10b was associated with obesity. The initial step of 3T3‑L1 cell differentiation involved the upregulation of C/EBP‑α expression, which in turn activated various subfactors. An upstream effector of glycogen synthase kinase-3β (GSK‑3β) inhibited Wnt‑10b expression in 3T3‑L1 adipocytes. In a previous study of ours, we sequenced the tuna peptide via sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS‑PAGE) and quadrupole time-of-flight mass spectrometry (Q-TOF MS/MS) and confirmed the anti‑obesity effect...

Research paper thumbnail of Novel chimeric peptide with enhanced cell specificity and anti-inflammatory activity

Biochemical and biophysical research communications, Jan 29, 2015

An antimicrobial peptide (AMP), Hn-Mc, was designed by combining the N-terminus of HPA3NT3 and th... more An antimicrobial peptide (AMP), Hn-Mc, was designed by combining the N-terminus of HPA3NT3 and the C-terminus of melittin. This chimeric AMP exhibited potent antibacterial activity with low minimal inhibitory concentrations (MICs), ranging from 1 to 2 μM against four drug-susceptible bacteria and ten drug-resistant bacteria. Moreover, the hemolysis and cytotoxicity was reduced significantly compared to those of the parent peptides, highlighting its high cell selectivity. The morphological changes in the giant unilamellar vesicles and bacterial cell surfaces caused by the Hn-Mc peptide suggested that it killed the microbial cells by damaging the membrane envelope. An in vivo study also demonstrated the antibacterial activity of the Hn-Mc peptide in a mouse model infected with drug-resistant bacteria. In addition, the chimeric peptide inhibited the expression of lipopolysaccharide (LPS)-induced cytokines in RAW 264.7 cells by preventing the interaction between LPS and Toll-like recept...

Research paper thumbnail of Frenkel-Defect-Mediated Chemical Ordering Transition in a Li-Mn-Ni Spinel Oxide

Angewandte Chemie, 2015

Using spinel-type Li(Mn1.5 Ni0.5 )O4 with two different cations, Mn and Ni, in the oxygen octahed... more Using spinel-type Li(Mn1.5 Ni0.5 )O4 with two different cations, Mn and Ni, in the oxygen octahedra as a model system, we show that a cation ordering transition takes place through the formation of Frenkel-type point defects. A series of experimental results based on atomic-scale observations and in situ powder diffractions along with ab initio calculations consistently support such defect-mediated transition behavior. In addition to providing a precise suggestion of the intermediate transient states and the resulting kinetic pathway during the transition between two phases, our findings emphasize the significant role of point defects in ordering transformation of complex oxides.

Research paper thumbnail of An extension of PLSA for document clustering

Proceeding of the 17th ACM conference on Information and knowledge mining - CIKM '08, 2008

ABSTRACT In this paper we propose an extension of the PLSA model in which an extra latent variabl... more ABSTRACT In this paper we propose an extension of the PLSA model in which an extra latent variable allows the model to co-cluster documents and terms simultaneously. We show on three datasets that our extended model produces statisti-cally significant improvements with ...

Research paper thumbnail of Multi-view clustering of multilingual documents

Proceeding of the 33rd international ACM SIGIR conference on Research and development in information retrieval - SIGIR '10, 2010

We propose a new multi-view clustering method which uses clustering results obtained on each view... more We propose a new multi-view clustering method which uses clustering results obtained on each view as a voting pattern in order to construct a new set of multi-view clusters. Our experiments on a multilingual corpus of documents show that performance increases significantly over simple concatenation and another multi-view clustering technique.

Research paper thumbnail of An observational study of surface versus endovascular cooling techniques in cardiac arrest patients: a propensity-matched analysis

Critical care (London, England), 2015

Various methods and devices have been described for cooling after cardiac arrest, but the ideal c... more Various methods and devices have been described for cooling after cardiac arrest, but the ideal cooling method remains unclear. The aim of this study was to compare the neurological outcomes, efficacies and adverse events of surface and endovascular cooling techniques in cardiac arrest patients. We performed a multicenter, retrospective, registry-based study of adult cardiac arrest patients treated with therapeutic hypothermia presenting to 24 hospitals across South Korea from 2007 to 2012. We included patients who received therapeutic hypothermia using overall surface or endovascular cooling devices and compared the neurological outcomes, efficacies and adverse events of both cooling techniques. To adjust for differences in the baseline characteristics of each cooling method, we performed one-to-one matching by the propensity score. In total, 803 patients were included in the analysis. Of these patients, 559 underwent surface cooling, and the remaining 244 patients underwent endova...

Research paper thumbnail of A Novel Protection Architecture for WDM-PON

COIN-NGNCON 2006 - The Joint International Conference on Optical Internet and Next Generation Network, 2006

ABSTRACT