Yu-Lan Peng - Academia.edu (original) (raw)
Papers by Yu-Lan Peng
TAXON, 2019
The taxonomy of the cliff fern family Woodsiaceae has been controversial with 22-59 species in 1-... more The taxonomy of the cliff fern family Woodsiaceae has been controversial with 22-59 species in 1-7 genera recognized in various classifications. This is mainly due to limited taxon sampling (up to 33 accessions representing up to 21 species) and poor resolution in molecular studies so far. In the present study, DNA sequences of five plastid markers (atpA, matK, rbcL, rps4 + rps4-trnS, trnL + trnL-F) of 152 accessions representing ca. 43 out of ca. 65 species estimated of Woodsiaceae (122 accessions), and 30 non-Woodsiaceae accessions from the most closely related four families (Athyriaceae, Blechnaceae, Onocleaceae, Thelypteridaceae) were used to infer a phylogeny. Our major results include: (1) Woodsiaceae are strongly supported as monophyletic; (2) Two major clades representing the deepest split in Woodsiaceae are identified, corresponding to the two recently proposed subfamilies, Woodsioideae and Protowoodsioideae; (3) Within Woodsioideae and Protowoodsioideae, two and three well-supported subclades, respectively, are determined; (4) Cheilanthopsis is resolved as paraphyletic in relation to Hymenocystis (sampled for the first time) and Protowoodsia; (5) Physematium and Woodsiopsis are paraphyletic in relation to a clade containing Cheilanthopsis, Hymenocystis, and Protowoodsia; (6) Evolution of 13 morphological characters is inferred in a phylogenetic context, and morphological synapomorphies of each of the five major subclades are identified; (7) We propose to recognize two genera in Woodsiaceae based on deep divergence (ca. 45 Ma), morphology, chromosome number, and geographic distribution: Physematium (syn.: Cheilanthopsis, Hymenocystis, Protowoodsia, Woodsiopsis) and Woodsia (syn.: Eriosoriopsis), and Physematium is further divided into three subgenera and Woodsia into two subgenera; (8) we describe ×Woodsimatium, a hybrid genus (nothogen. nov.) between the two genera recognized. A taxonomic synopsis of the family is provided, and 15 new combinations are made.
World Journal of Gastroenterology
To investigate the value of clinical manifestations and ultrasound examination in the differentia... more To investigate the value of clinical manifestations and ultrasound examination in the differential diagnosis of pancreatic lymphoma and pancreatic cancer.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2006
To evaluate the effectiveness of ultrasonography in detecting Rheumatoid Arthritis through ultras... more To evaluate the effectiveness of ultrasonography in detecting Rheumatoid Arthritis through ultrasonographic image of suprapatellar bursa' fluid, synovium, and femoral condylar cartilage in the knee joints. The ultrasonographic image of suprapatellar bursa' fluid, synovium and femoral condylar cartilage was compared between people with and without Rheumatoid Arthritis. The changes of suprapatellar bursa' fluid and thickness, color flow grading, RI of synovium and femoral condylar cartilage in the patient with Rheumatoid Arthritis before and after therapy were measured. The correlations between suprapatellar bursa' fluid, thickness, color flow grading, RI of synovium and CRP/ESR were analyzed. The suprapatellar bursa' fluid and synovium in the patients with Rheumatoid Arthritis before treatments were thicker than those without Rheumatoid Arthritis. After treatments for the patients with Rheumatoid Arthritis, the thickness of suprapatellar bursa' fluid and synov...
Chinese medical journal, Jan 20, 2009
On May 12, 2008, a major earthquake hit Wenchuan County in Sichuan Province of China. The number ... more On May 12, 2008, a major earthquake hit Wenchuan County in Sichuan Province of China. The number of cases of crush injury following this event was high. Ultrasonic appearance of rhabdomyolysis (RM) caused by crush injury in the Wenchuan earthquake was observed to evaluate the diagnostic value of ultrasound for detection of rhabdomyolysis. We analyzed clinical and ultrasonic manifestations of 50 cases of RM and 18 cases of RM with osteofascial compartment syndrome (OCS). All cases were caused by crush injury in the Wenchuan earthquake. For these RM patients, we also evaluated the correlations between creatine kinase (CK) and the scope of the muscle lesions as observed by ultrasound. There were differences in clinical symptoms, physical signs and ultrasonic appearance between the two groups of patients. The ultrasonic characteristics of the RM were as follows: the striated muscle in the lesions thickened with good overall continuity, and the muscle texture was vague; the strength of t...
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2014
To determine the perfusion pattern of lymphadenopathy in contrast-enhanced ultrasonography (CEUS)... more To determine the perfusion pattern of lymphadenopathy in contrast-enhanced ultrasonography (CEUS) under different reference conditions. The CEUS perfusion patterns of 78 superficial lymph node lesions were compared with their pathology results. Time-intensity curves were used for comparison between benign and malignant lymph nodes. Inhomogeneous hyperenhancement was the main perfusion pattern (7/17, 41. 2%) in metastatic lymph nodes; compared with homogeneous hyperenhancement (2/4, 50. 0%) in lymphoma, homogeneous hyperenhancement and isoenhancement (6/52, 11. 5%) in reactive lymph nodes, and circle enhancement (2/4,50. 0%) in tuberculosis. Benign lymph nodes showed different mean value, peak intensity and area under the curve compared with their surrounding arteries (P<0. 05). But the differences in mean value, rise time, time to peak, peak intensity and the area under the curve between benign lymphadenopathy and their surrounding tissues were not statistically significant (P>...
World Journal of Gastroenterology, 2008
To investigate the value of clinical manifestations and ultrasound examination in the differentia... more To investigate the value of clinical manifestations and ultrasound examination in the differential diagnosis of pancreatic lymphoma and pancreatic cancer.
PloS one, 2016
This study aimed to confirm whether strain ratio should be added after evaluation of lesions with... more This study aimed to confirm whether strain ratio should be added after evaluation of lesions with 5-point elasticity scoring for differentiating benign and malignant breast lesions on ultrasonographic elastography(UE). From June 2010 to March 2012, 1080 consecutive female patients with breast lesions were recruited into a multicenter retrospective study, which involved 8 centers across China. Each institutional ethic review board approved the study, and all the patients gave written informed consent. All the patients underwent the UE procedure and the strain ratios were calculated and the final diagnosis was made by histological findings. The sensitivity, specificity, accuracy, PPV and NPV were calculated for each of the two evaluation systems and the areas under the ROC curve were compared. The strain ratios of benign lesions (mean, 2.6±2.0) and malignant lesions (mean,7.9±5.8) were significantly different (p <0.01). When the cutoff point was 3.01, strain ratio method had 79.8% ...
World Journal of Gastroenterology
... Clin Transplant 2000; 14: 235-241 17 Lu MQ, Chen GH, Yang Y, Cai CJ, Wang GD, Zhu XF, He XS. ... more ... Clin Transplant 2000; 14: 235-241 17 Lu MQ, Chen GH, Yang Y, Cai CJ, Wang GD, Zhu XF, He XS. ... Transplant Proc 2006; 38: 1438-1439 23 Kok T, Slooff MJ, Thijn CJ, Peeters PM, Verwer R, Bijleveld CM, van den Berg AP, Haagsma EB, Klompmaker IJ. ...
BMC Gastroenterology, 2011
Background Hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are respectively the first an... more Background Hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are respectively the first and the second most common pediatric malignant liver tumors. The purpose of this study was to evaluate the combined use of the ultrasound examination and the assessment of the patients' clinical features for differentiating HBL from HCC in children. Methods Thirty cases of the confirmed HBL and 12 cases of the
Asian Pacific journal of cancer prevention : APJCP, 2015
To evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in differentiatin... more To evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in differentiating between benign and malignant enlarged lymph nodes using meta-analysis. Pubmed, Embase, SCI and Cochrane databases were searched for studies (up to September 1, 2014) reporting the diagnostic performance of CEUS in discriminating between benign and malignant lymph nodes. Inclusion criteria were: prospective study; histopathology as the reference standard; and sufficient data to construct 2?2 contingency tables. Methodological quality was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Patient clinical characteristics, sensitivity and specificity were extracted. The summary receiver operating characteristic curve was used to examine the accuracy of CEUS. A meta-analysis was performed to evaluate the clinical utility in identification of benign and malignant lymph nodes. Sensitivity analysis was performed after omitting outliers identified in a bivariate box...
Ultrasound in medicine & biology, 2011
The objective was to determine whether contrast-enhanced ultrasound (CEUS) could improve the diag... more The objective was to determine whether contrast-enhanced ultrasound (CEUS) could improve the diagnostic confidence of solid renal masses. CEUS examinations were performed on 51 patients with renal tumors. Histologic findings from surgical specimens (n = 24) or magnetic resonance imaging follow-up (n = 27) were used as reference procedures for definitive diagnosis. Diffuse heterogeneous/homogeneous enhancement and quick peripheralnodularenhancement were found to be characteristic patterns in renal cell carcinoma (RCC). Dotlike or diffuse heterogeneous/homogeneous enhancement and slow peripheral nodular enhancement were observed as typical enhancement patterns in angiomyolipoma. The results show that CEUS combined with conventional ultrasound significantly improves diagnostic confidence. The sensitivity for RCC diagnosis with this imaging approach was 86% and the specificity was 93%. Both positive and negative predictive values of detection were 90% and the overall accuracy was 90%.
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery, 2012
To study the related factors of central lymph node (CLN) metastasis in papillary thyroid carcinom... more To study the related factors of central lymph node (CLN) metastasis in papillary thyroid carcinoma (PTC),the indications and the extent of central neck dissection (CND). A total of 153 cases treated between Jan. 2009 and Dec. 2010 was analysed retrospectively. Of the cases 28 males and 125 cases females, with a mean age of (44 ± 14) years. T1, T2, and T3 diseases accounted for 51, 10 and 81 cases, respectively; I, II, III and IV diseases for 88, 3, 26 and 36 cases, respectively. Multifocal tumors were found in 63 cases. The related clinicopathologic factors were analyzed, including sex, age, tumor size, extrathyroidal extension, and multifocal tumor. All the cases had total/near total thyroidectomy and CND, of them 64 cases had unilateral neck dissection and 18 cases had bilateral neck dissection. CLN metastases existed in 68.6% (105/153) cases, 37.2% (57/153) for unilateral and 31.4% (48/153) for bilateral respectively. The rates of CLN metastasis were 86.6% (71/82) in cN1 cases an...
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery, 2012
To study the pattern of lymph node spread in papillary thyroid carcinoma (PTC) with clinically ne... more To study the pattern of lymph node spread in papillary thyroid carcinoma (PTC) with clinically negative node (cN0). A total of 106 patients with cN0 PTC who underwent total or subtotal thyroidectomy plus unilateral or bilateral lateral neck dissection (LND, level II-V or level I-V) at West China Hospital of Sichuan University between April 2004 and August 2010 were analyzed retrospectively. The lateral neck lymph node metastasis in cN0 PTC was significantly associated with sex (male, P = 0.007), tumor stage (T3/T4, P = 0.006), tumor size (> 1 cm, P = 0.014) and the number of positive central lymph nodes (≥ 2, P < 0.001), but not with age and multifocal tumor. Level III (47/116, 40.5%) was the most prevalent metastatic site, followed by level IV (41/116, 35.3%), level II (18/116, 15.5%) and level V (2/29, 6.9%). Of the cases with lymph node metastases in level III and IV, 89.8% (79/88) of primary thyroid tumors existed in the lower and middle sites of the thyroid lobes, while i...
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2009
To study the ultrasonographic (US) features of labral plicae entrapment syndrome of hip (LPEH) in... more To study the ultrasonographic (US) features of labral plicae entrapment syndrome of hip (LPEH) in children and to evaluate the value of US in diagnosing LPEH. (1) Twenty six LPEH models and 38 sham LPEH hips were established surgically from 32 children cadavers [15 male and 17 female, age from 2 to 8 years, mean age of (6.12 +/- 2.13) years]. US was performed on these hips double-blindly. The sensitivity, specificity, positive and negative predictive values were calculated. (2) A total of 21 children (17 male and 4 female, mean age (5.95 +/- 2.67) years) with unilateral LPEH and 21 age and gender matched children with normal hips were consecutively recruited. The 21 symptomatic hips, 21 asymptomatic hips and 42 normal hips were examined by the US (ATL 5000) using the high-frequency (7.5-12 MHz) linear array transducer. (1) The sensitivity, specificity, positive and negative predictive values of the US for the LPEH model were 88%, 84%, 79%, and 91%, respectively. (2) Fluids in hip jo...
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2013
To investigate the monitoring of renal microcirculation perfusion alteration with contrast-enhanc... more To investigate the monitoring of renal microcirculation perfusion alteration with contrast-enhanced ultrasound (CEU) during cardiopulmonary bypass (CPB). Renal microcirculation perfusion before and during CPB was assessed by CEU. Time-intensity curve (TIC) were derived from three region of interest (ROI) using QLAB post-analysis software. Parameters such as TIC curve wash in slope (A), area under curve (AUC), peak intensity (DPI) as well as time to peak intensity (TTP) were then calculated. Contrast-enhanced ultrasound showed a significant reduction (or elongation) of perfusion parameter (A, AUC, DPI, TTP) in all three regions (superficial cortex, deep cortex and medulla) during cardiopulmonary bypass in comparison with normal cardiac cycle. Cardiopulmonary bypass (CPB) has a dramatic impact on renal microcirculation in pediatric patients which manifest as global reduction in renal perfusion as well as significant region perfusion difference. Contrast-enhanced ultrasound (CEU) could...
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2014
To examine the characteristics of carotid arteriosclerotic plaques in contrast-enhanced ultrasono... more To examine the characteristics of carotid arteriosclerotic plaques in contrast-enhanced ultrasonography (CEUS) of neovascularization. Seventy-eight patients with carotid atherosclerotic plaques were examined with real-time CEUS. The perfusion modes of neovascularization in relation to the carotid arteriosclerotic plaques were identified. Patients were categorized into four groups according to their plaque echo. Five patients with serious atherosclerotic carotid artery disease received carotid endarterectomy. The intra-plaque neovascularization recorded by CEUS were validated by post-surgery pathology examinations of the tissues. In routing ultrasound examinations, 23 (29. 49%) plaques were identified with low-echo, 30 (38.46%) with mixed echo, 20 (25. 64%) with equal-echo, and 5 (6. 41%) with high-echo. The CEUS imaging revealed 60 carotid atherosclerotic plaques (76. 9%) with various degrees of enhancement in intra-plaque neovascularization. The thickness of plaques was correlated ...
Clinical breast cancer, 2013
Through analysis, the elastograms characteristics of breast lesions of Chinese women, a suitable ... more Through analysis, the elastograms characteristics of breast lesions of Chinese women, a suitable diagnostic standard of quasistatic ultrasound elastography (UE) for Chinese women was proposed. From June 2010 to March 2012, 1036 consecutive female patients (mean age, 44 years old) with breast lesions were recruited into a multicenter retrospective study, which involved 8 centers across China. Each institutional ethic review board approved the study, and all the patients gave written informed consent. All breast lesions underwent ultrasound and UE examination. Two radiologists analyzed the elastograms and separated the elastograms into 10 types. A final diagnosis was made on the basis of histologic findings. The characteristics of the elastograms were analyzed. Receiver operating characteristic curves were plotted for evaluating the diagnostic performance. Sensitivity, specificity, and accuracy were calculated. Differences in sensitivity, specificity, and accuracy were tested by using...
Southern Medical Journal, 2010
TAXON, 2019
The taxonomy of the cliff fern family Woodsiaceae has been controversial with 22-59 species in 1-... more The taxonomy of the cliff fern family Woodsiaceae has been controversial with 22-59 species in 1-7 genera recognized in various classifications. This is mainly due to limited taxon sampling (up to 33 accessions representing up to 21 species) and poor resolution in molecular studies so far. In the present study, DNA sequences of five plastid markers (atpA, matK, rbcL, rps4 + rps4-trnS, trnL + trnL-F) of 152 accessions representing ca. 43 out of ca. 65 species estimated of Woodsiaceae (122 accessions), and 30 non-Woodsiaceae accessions from the most closely related four families (Athyriaceae, Blechnaceae, Onocleaceae, Thelypteridaceae) were used to infer a phylogeny. Our major results include: (1) Woodsiaceae are strongly supported as monophyletic; (2) Two major clades representing the deepest split in Woodsiaceae are identified, corresponding to the two recently proposed subfamilies, Woodsioideae and Protowoodsioideae; (3) Within Woodsioideae and Protowoodsioideae, two and three well-supported subclades, respectively, are determined; (4) Cheilanthopsis is resolved as paraphyletic in relation to Hymenocystis (sampled for the first time) and Protowoodsia; (5) Physematium and Woodsiopsis are paraphyletic in relation to a clade containing Cheilanthopsis, Hymenocystis, and Protowoodsia; (6) Evolution of 13 morphological characters is inferred in a phylogenetic context, and morphological synapomorphies of each of the five major subclades are identified; (7) We propose to recognize two genera in Woodsiaceae based on deep divergence (ca. 45 Ma), morphology, chromosome number, and geographic distribution: Physematium (syn.: Cheilanthopsis, Hymenocystis, Protowoodsia, Woodsiopsis) and Woodsia (syn.: Eriosoriopsis), and Physematium is further divided into three subgenera and Woodsia into two subgenera; (8) we describe ×Woodsimatium, a hybrid genus (nothogen. nov.) between the two genera recognized. A taxonomic synopsis of the family is provided, and 15 new combinations are made.
World Journal of Gastroenterology
To investigate the value of clinical manifestations and ultrasound examination in the differentia... more To investigate the value of clinical manifestations and ultrasound examination in the differential diagnosis of pancreatic lymphoma and pancreatic cancer.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2006
To evaluate the effectiveness of ultrasonography in detecting Rheumatoid Arthritis through ultras... more To evaluate the effectiveness of ultrasonography in detecting Rheumatoid Arthritis through ultrasonographic image of suprapatellar bursa' fluid, synovium, and femoral condylar cartilage in the knee joints. The ultrasonographic image of suprapatellar bursa' fluid, synovium and femoral condylar cartilage was compared between people with and without Rheumatoid Arthritis. The changes of suprapatellar bursa' fluid and thickness, color flow grading, RI of synovium and femoral condylar cartilage in the patient with Rheumatoid Arthritis before and after therapy were measured. The correlations between suprapatellar bursa' fluid, thickness, color flow grading, RI of synovium and CRP/ESR were analyzed. The suprapatellar bursa' fluid and synovium in the patients with Rheumatoid Arthritis before treatments were thicker than those without Rheumatoid Arthritis. After treatments for the patients with Rheumatoid Arthritis, the thickness of suprapatellar bursa' fluid and synov...
Chinese medical journal, Jan 20, 2009
On May 12, 2008, a major earthquake hit Wenchuan County in Sichuan Province of China. The number ... more On May 12, 2008, a major earthquake hit Wenchuan County in Sichuan Province of China. The number of cases of crush injury following this event was high. Ultrasonic appearance of rhabdomyolysis (RM) caused by crush injury in the Wenchuan earthquake was observed to evaluate the diagnostic value of ultrasound for detection of rhabdomyolysis. We analyzed clinical and ultrasonic manifestations of 50 cases of RM and 18 cases of RM with osteofascial compartment syndrome (OCS). All cases were caused by crush injury in the Wenchuan earthquake. For these RM patients, we also evaluated the correlations between creatine kinase (CK) and the scope of the muscle lesions as observed by ultrasound. There were differences in clinical symptoms, physical signs and ultrasonic appearance between the two groups of patients. The ultrasonic characteristics of the RM were as follows: the striated muscle in the lesions thickened with good overall continuity, and the muscle texture was vague; the strength of t...
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2014
To determine the perfusion pattern of lymphadenopathy in contrast-enhanced ultrasonography (CEUS)... more To determine the perfusion pattern of lymphadenopathy in contrast-enhanced ultrasonography (CEUS) under different reference conditions. The CEUS perfusion patterns of 78 superficial lymph node lesions were compared with their pathology results. Time-intensity curves were used for comparison between benign and malignant lymph nodes. Inhomogeneous hyperenhancement was the main perfusion pattern (7/17, 41. 2%) in metastatic lymph nodes; compared with homogeneous hyperenhancement (2/4, 50. 0%) in lymphoma, homogeneous hyperenhancement and isoenhancement (6/52, 11. 5%) in reactive lymph nodes, and circle enhancement (2/4,50. 0%) in tuberculosis. Benign lymph nodes showed different mean value, peak intensity and area under the curve compared with their surrounding arteries (P<0. 05). But the differences in mean value, rise time, time to peak, peak intensity and the area under the curve between benign lymphadenopathy and their surrounding tissues were not statistically significant (P>...
World Journal of Gastroenterology, 2008
To investigate the value of clinical manifestations and ultrasound examination in the differentia... more To investigate the value of clinical manifestations and ultrasound examination in the differential diagnosis of pancreatic lymphoma and pancreatic cancer.
PloS one, 2016
This study aimed to confirm whether strain ratio should be added after evaluation of lesions with... more This study aimed to confirm whether strain ratio should be added after evaluation of lesions with 5-point elasticity scoring for differentiating benign and malignant breast lesions on ultrasonographic elastography(UE). From June 2010 to March 2012, 1080 consecutive female patients with breast lesions were recruited into a multicenter retrospective study, which involved 8 centers across China. Each institutional ethic review board approved the study, and all the patients gave written informed consent. All the patients underwent the UE procedure and the strain ratios were calculated and the final diagnosis was made by histological findings. The sensitivity, specificity, accuracy, PPV and NPV were calculated for each of the two evaluation systems and the areas under the ROC curve were compared. The strain ratios of benign lesions (mean, 2.6±2.0) and malignant lesions (mean,7.9±5.8) were significantly different (p <0.01). When the cutoff point was 3.01, strain ratio method had 79.8% ...
World Journal of Gastroenterology
... Clin Transplant 2000; 14: 235-241 17 Lu MQ, Chen GH, Yang Y, Cai CJ, Wang GD, Zhu XF, He XS. ... more ... Clin Transplant 2000; 14: 235-241 17 Lu MQ, Chen GH, Yang Y, Cai CJ, Wang GD, Zhu XF, He XS. ... Transplant Proc 2006; 38: 1438-1439 23 Kok T, Slooff MJ, Thijn CJ, Peeters PM, Verwer R, Bijleveld CM, van den Berg AP, Haagsma EB, Klompmaker IJ. ...
BMC Gastroenterology, 2011
Background Hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are respectively the first an... more Background Hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are respectively the first and the second most common pediatric malignant liver tumors. The purpose of this study was to evaluate the combined use of the ultrasound examination and the assessment of the patients' clinical features for differentiating HBL from HCC in children. Methods Thirty cases of the confirmed HBL and 12 cases of the
Asian Pacific journal of cancer prevention : APJCP, 2015
To evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in differentiatin... more To evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in differentiating between benign and malignant enlarged lymph nodes using meta-analysis. Pubmed, Embase, SCI and Cochrane databases were searched for studies (up to September 1, 2014) reporting the diagnostic performance of CEUS in discriminating between benign and malignant lymph nodes. Inclusion criteria were: prospective study; histopathology as the reference standard; and sufficient data to construct 2?2 contingency tables. Methodological quality was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Patient clinical characteristics, sensitivity and specificity were extracted. The summary receiver operating characteristic curve was used to examine the accuracy of CEUS. A meta-analysis was performed to evaluate the clinical utility in identification of benign and malignant lymph nodes. Sensitivity analysis was performed after omitting outliers identified in a bivariate box...
Ultrasound in medicine & biology, 2011
The objective was to determine whether contrast-enhanced ultrasound (CEUS) could improve the diag... more The objective was to determine whether contrast-enhanced ultrasound (CEUS) could improve the diagnostic confidence of solid renal masses. CEUS examinations were performed on 51 patients with renal tumors. Histologic findings from surgical specimens (n = 24) or magnetic resonance imaging follow-up (n = 27) were used as reference procedures for definitive diagnosis. Diffuse heterogeneous/homogeneous enhancement and quick peripheralnodularenhancement were found to be characteristic patterns in renal cell carcinoma (RCC). Dotlike or diffuse heterogeneous/homogeneous enhancement and slow peripheral nodular enhancement were observed as typical enhancement patterns in angiomyolipoma. The results show that CEUS combined with conventional ultrasound significantly improves diagnostic confidence. The sensitivity for RCC diagnosis with this imaging approach was 86% and the specificity was 93%. Both positive and negative predictive values of detection were 90% and the overall accuracy was 90%.
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery, 2012
To study the related factors of central lymph node (CLN) metastasis in papillary thyroid carcinom... more To study the related factors of central lymph node (CLN) metastasis in papillary thyroid carcinoma (PTC),the indications and the extent of central neck dissection (CND). A total of 153 cases treated between Jan. 2009 and Dec. 2010 was analysed retrospectively. Of the cases 28 males and 125 cases females, with a mean age of (44 ± 14) years. T1, T2, and T3 diseases accounted for 51, 10 and 81 cases, respectively; I, II, III and IV diseases for 88, 3, 26 and 36 cases, respectively. Multifocal tumors were found in 63 cases. The related clinicopathologic factors were analyzed, including sex, age, tumor size, extrathyroidal extension, and multifocal tumor. All the cases had total/near total thyroidectomy and CND, of them 64 cases had unilateral neck dissection and 18 cases had bilateral neck dissection. CLN metastases existed in 68.6% (105/153) cases, 37.2% (57/153) for unilateral and 31.4% (48/153) for bilateral respectively. The rates of CLN metastasis were 86.6% (71/82) in cN1 cases an...
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery, 2012
To study the pattern of lymph node spread in papillary thyroid carcinoma (PTC) with clinically ne... more To study the pattern of lymph node spread in papillary thyroid carcinoma (PTC) with clinically negative node (cN0). A total of 106 patients with cN0 PTC who underwent total or subtotal thyroidectomy plus unilateral or bilateral lateral neck dissection (LND, level II-V or level I-V) at West China Hospital of Sichuan University between April 2004 and August 2010 were analyzed retrospectively. The lateral neck lymph node metastasis in cN0 PTC was significantly associated with sex (male, P = 0.007), tumor stage (T3/T4, P = 0.006), tumor size (> 1 cm, P = 0.014) and the number of positive central lymph nodes (≥ 2, P < 0.001), but not with age and multifocal tumor. Level III (47/116, 40.5%) was the most prevalent metastatic site, followed by level IV (41/116, 35.3%), level II (18/116, 15.5%) and level V (2/29, 6.9%). Of the cases with lymph node metastases in level III and IV, 89.8% (79/88) of primary thyroid tumors existed in the lower and middle sites of the thyroid lobes, while i...
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2009
To study the ultrasonographic (US) features of labral plicae entrapment syndrome of hip (LPEH) in... more To study the ultrasonographic (US) features of labral plicae entrapment syndrome of hip (LPEH) in children and to evaluate the value of US in diagnosing LPEH. (1) Twenty six LPEH models and 38 sham LPEH hips were established surgically from 32 children cadavers [15 male and 17 female, age from 2 to 8 years, mean age of (6.12 +/- 2.13) years]. US was performed on these hips double-blindly. The sensitivity, specificity, positive and negative predictive values were calculated. (2) A total of 21 children (17 male and 4 female, mean age (5.95 +/- 2.67) years) with unilateral LPEH and 21 age and gender matched children with normal hips were consecutively recruited. The 21 symptomatic hips, 21 asymptomatic hips and 42 normal hips were examined by the US (ATL 5000) using the high-frequency (7.5-12 MHz) linear array transducer. (1) The sensitivity, specificity, positive and negative predictive values of the US for the LPEH model were 88%, 84%, 79%, and 91%, respectively. (2) Fluids in hip jo...
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2013
To investigate the monitoring of renal microcirculation perfusion alteration with contrast-enhanc... more To investigate the monitoring of renal microcirculation perfusion alteration with contrast-enhanced ultrasound (CEU) during cardiopulmonary bypass (CPB). Renal microcirculation perfusion before and during CPB was assessed by CEU. Time-intensity curve (TIC) were derived from three region of interest (ROI) using QLAB post-analysis software. Parameters such as TIC curve wash in slope (A), area under curve (AUC), peak intensity (DPI) as well as time to peak intensity (TTP) were then calculated. Contrast-enhanced ultrasound showed a significant reduction (or elongation) of perfusion parameter (A, AUC, DPI, TTP) in all three regions (superficial cortex, deep cortex and medulla) during cardiopulmonary bypass in comparison with normal cardiac cycle. Cardiopulmonary bypass (CPB) has a dramatic impact on renal microcirculation in pediatric patients which manifest as global reduction in renal perfusion as well as significant region perfusion difference. Contrast-enhanced ultrasound (CEU) could...
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2014
To examine the characteristics of carotid arteriosclerotic plaques in contrast-enhanced ultrasono... more To examine the characteristics of carotid arteriosclerotic plaques in contrast-enhanced ultrasonography (CEUS) of neovascularization. Seventy-eight patients with carotid atherosclerotic plaques were examined with real-time CEUS. The perfusion modes of neovascularization in relation to the carotid arteriosclerotic plaques were identified. Patients were categorized into four groups according to their plaque echo. Five patients with serious atherosclerotic carotid artery disease received carotid endarterectomy. The intra-plaque neovascularization recorded by CEUS were validated by post-surgery pathology examinations of the tissues. In routing ultrasound examinations, 23 (29. 49%) plaques were identified with low-echo, 30 (38.46%) with mixed echo, 20 (25. 64%) with equal-echo, and 5 (6. 41%) with high-echo. The CEUS imaging revealed 60 carotid atherosclerotic plaques (76. 9%) with various degrees of enhancement in intra-plaque neovascularization. The thickness of plaques was correlated ...
Clinical breast cancer, 2013
Through analysis, the elastograms characteristics of breast lesions of Chinese women, a suitable ... more Through analysis, the elastograms characteristics of breast lesions of Chinese women, a suitable diagnostic standard of quasistatic ultrasound elastography (UE) for Chinese women was proposed. From June 2010 to March 2012, 1036 consecutive female patients (mean age, 44 years old) with breast lesions were recruited into a multicenter retrospective study, which involved 8 centers across China. Each institutional ethic review board approved the study, and all the patients gave written informed consent. All breast lesions underwent ultrasound and UE examination. Two radiologists analyzed the elastograms and separated the elastograms into 10 types. A final diagnosis was made on the basis of histologic findings. The characteristics of the elastograms were analyzed. Receiver operating characteristic curves were plotted for evaluating the diagnostic performance. Sensitivity, specificity, and accuracy were calculated. Differences in sensitivity, specificity, and accuracy were tested by using...
Southern Medical Journal, 2010