Z. Niculescu - Academia.edu (original) (raw)

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Papers by Z. Niculescu

Research paper thumbnail of Gaucher Disease Type I

Infomedica, 2008

Rezumat Boala Gaucher este cea mai frecventã boalã lizo-zomalã produsã prin deficitul unei enzime... more Rezumat Boala Gaucher este cea mai frecventã boalã lizo-zomalã produsã prin deficitul unei enzime numitã β-glucocerebrozidazã. Se descriu trei tipuri de boalã Gaucher. Boala Gaucher tip I beneficiazã de tratament substitutiv enzimatic cronic cu imiglucerazã. Se prezintã ...

Research paper thumbnail of Clinical manifestations of pulmonary thromboembolism in cardiac failure

European Journal of Internal Medicine, 2013

Research paper thumbnail of Etiopathogenic aspects of autoimmune hemolytic anemias

European Journal of Internal Medicine, 2013

Research paper thumbnail of Polycythemia vera — Baseline thrombotic and hemorrhagic complications and patient evolution under therapy

European Journal of Internal Medicine, 2013

Research paper thumbnail of Clinical manifestations of hepatopulmonary syndrome

European Journal of Internal Medicine, 2013

Research paper thumbnail of Physio-Pathological Aspects of Bronchial Asthma in Children

Infomedica, 2008

Rezumat: Scopul articolului îl reprezintã cunoaºterea aspec-telor fiziopatologice ale astmului br... more Rezumat: Scopul articolului îl reprezintã cunoaºterea aspec-telor fiziopatologice ale astmului bronºic la copil în zona geograficã menþionatã, acestea putând contribui la ameliorarea rezultatelor programelor prevenþional terapeutice. Material ºi metodã. Lotul de studiu: 100 de copii (7 ...

Research paper thumbnail of Evaluation of Antioxidant Status in Passive Smokers

Chronic exposure of human body to tobacco smoke environment induces oxidative stress in cells as ... more Chronic exposure of human body to tobacco smoke environment induces oxidative stress in cells as a consequence of oxidative reactions by increasing the production of oxygen-free radicals. The aim of this study is to evaluate the influence of passive smoking on antioxidant status in adults. in accordance with their physiological role, erythrocytes are continuously exposed to oxidative stress. Analysis of oxidative susceptibility in the exposed erythrocytes to tobacco smoke was assessed by measurement of erythrocytic superoxide dismutase (sod) and glutathione-peroxidase, in 50 adult passive smokers, compared with non-smokers. in case of chronic exposures (more than 15 years) in environment with tobacco smoke, the results of erythrocytic superoxide dismutase indicates an adaptive response of the organism to the oxidative stress, which is considered to be antioxidantdefense response, induced by altering the gene expression of SOD from the stem cells. Significantly increasing of erythrocyte sod is associated with lower-level glutathione peroxidase activity in passive smokers compared to non-smokers. our research results reveal the fact that chronic exposure to tobacco smoke environment generates biochemical imbalance in erythrocytic antioxidant defense, providing a protective adaptive mechanism at cellular and sub-cellular levels.

Research paper thumbnail of Gaucher Disease Type I

Infomedica, 2008

Rezumat Boala Gaucher este cea mai frecventã boalã lizo-zomalã produsã prin deficitul unei enzime... more Rezumat Boala Gaucher este cea mai frecventã boalã lizo-zomalã produsã prin deficitul unei enzime numitã β-glucocerebrozidazã. Se descriu trei tipuri de boalã Gaucher. Boala Gaucher tip I beneficiazã de tratament substitutiv enzimatic cronic cu imiglucerazã. Se prezintã ...

Research paper thumbnail of Clinical manifestations of pulmonary thromboembolism in cardiac failure

European Journal of Internal Medicine, 2013

Research paper thumbnail of Etiopathogenic aspects of autoimmune hemolytic anemias

European Journal of Internal Medicine, 2013

Research paper thumbnail of Polycythemia vera — Baseline thrombotic and hemorrhagic complications and patient evolution under therapy

European Journal of Internal Medicine, 2013

Research paper thumbnail of Clinical manifestations of hepatopulmonary syndrome

European Journal of Internal Medicine, 2013

Research paper thumbnail of Physio-Pathological Aspects of Bronchial Asthma in Children

Infomedica, 2008

Rezumat: Scopul articolului îl reprezintã cunoaºterea aspec-telor fiziopatologice ale astmului br... more Rezumat: Scopul articolului îl reprezintã cunoaºterea aspec-telor fiziopatologice ale astmului bronºic la copil în zona geograficã menþionatã, acestea putând contribui la ameliorarea rezultatelor programelor prevenþional terapeutice. Material ºi metodã. Lotul de studiu: 100 de copii (7 ...

Research paper thumbnail of Evaluation of Antioxidant Status in Passive Smokers

Chronic exposure of human body to tobacco smoke environment induces oxidative stress in cells as ... more Chronic exposure of human body to tobacco smoke environment induces oxidative stress in cells as a consequence of oxidative reactions by increasing the production of oxygen-free radicals. The aim of this study is to evaluate the influence of passive smoking on antioxidant status in adults. in accordance with their physiological role, erythrocytes are continuously exposed to oxidative stress. Analysis of oxidative susceptibility in the exposed erythrocytes to tobacco smoke was assessed by measurement of erythrocytic superoxide dismutase (sod) and glutathione-peroxidase, in 50 adult passive smokers, compared with non-smokers. in case of chronic exposures (more than 15 years) in environment with tobacco smoke, the results of erythrocytic superoxide dismutase indicates an adaptive response of the organism to the oxidative stress, which is considered to be antioxidantdefense response, induced by altering the gene expression of SOD from the stem cells. Significantly increasing of erythrocyte sod is associated with lower-level glutathione peroxidase activity in passive smokers compared to non-smokers. our research results reveal the fact that chronic exposure to tobacco smoke environment generates biochemical imbalance in erythrocytic antioxidant defense, providing a protective adaptive mechanism at cellular and sub-cellular levels.

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