Zachary Schaaf - Academia.edu (original) (raw)

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Papers by Zachary Schaaf

Research paper thumbnail of Correction: WDFY3 mutation alters laminar position and morphology of cortical neurons

Molecular Autism, Jan 31, 2023

Research paper thumbnail of Wntless expression promotes lineage plasticity and is associated with neuroendocrine prostate cancer

American journal of clinical and experimental urology, 2022

Research paper thumbnail of MP20-04  ARHGEF2 Regulates Lineage Plasticity Promoting Neuroendocrine Differentiation and Treatment Resistance in Advanced Prostate Cancer

Research paper thumbnail of WDFY3 mutation alters laminar position and morphology of cortical neurons

Molecular Autism

Background Proper cerebral cortical development depends on the tightly orchestrated migration of ... more Background Proper cerebral cortical development depends on the tightly orchestrated migration of newly born neurons from the inner ventricular and subventricular zones to the outer cortical plate. Any disturbance in this process during prenatal stages may lead to neuronal migration disorders (NMDs), which can vary in extent from focal to global. Furthermore, NMDs show a substantial comorbidity with other neurodevelopmental disorders, notably autism spectrum disorders (ASDs). Our previous work demonstrated focal neuronal migration defects in mice carrying loss-of-function alleles of the recognized autism risk gene WDFY3. However, the cellular origins of these defects in Wdfy3 mutant mice remain elusive and uncovering it will provide critical insight into WDFY3-dependent disease pathology. Methods Here, in an effort to untangle the origins of NMDs in Wdfy3lacZ mice, we employed mosaic analysis with double markers (MADM). MADM technology enabled us to genetically distinctly track and p...

Research paper thumbnail of WDFY3 cell autonomously controls neuronal migration

Research paper thumbnail of Deficient or Excess Folic Acid Supply During Pregnancy Alter Cortical Neurodevelopment in Mouse Offspring

Folate is an essential micronutrient required for both cellular proliferation through de novo nuc... more Folate is an essential micronutrient required for both cellular proliferation through de novo nucleotide synthesis and epigenetic regulation of gene expression through methylation. This dual requirement places a particular demand on folate availability during pregnancy when both rapid cell generation and programmed differentiation of maternal, extraembryonic, and embryonic/fetal tissues are required. Accordingly, prenatal neurodevelopment is particularly susceptible to folate deficiency, which can predispose to neural tube defects, or when effective transport into the brain is impaired, cerebral folate deficiency. Consequently, adequate folate consumption, in the form of folic acid (FA) fortification and supplement use, is widely recommended and has led to a substantial increase in the amount of FA intake during pregnancy in some populations. Here, we show that either maternal folate deficiency or FA excess in mice results in disruptions in folate metabolism of the offspring, sugges...

Research paper thumbnail of Correction: WDFY3 mutation alters laminar position and morphology of cortical neurons

Molecular Autism, Jan 31, 2023

Research paper thumbnail of Wntless expression promotes lineage plasticity and is associated with neuroendocrine prostate cancer

American journal of clinical and experimental urology, 2022

Research paper thumbnail of MP20-04  ARHGEF2 Regulates Lineage Plasticity Promoting Neuroendocrine Differentiation and Treatment Resistance in Advanced Prostate Cancer

Research paper thumbnail of WDFY3 mutation alters laminar position and morphology of cortical neurons

Molecular Autism

Background Proper cerebral cortical development depends on the tightly orchestrated migration of ... more Background Proper cerebral cortical development depends on the tightly orchestrated migration of newly born neurons from the inner ventricular and subventricular zones to the outer cortical plate. Any disturbance in this process during prenatal stages may lead to neuronal migration disorders (NMDs), which can vary in extent from focal to global. Furthermore, NMDs show a substantial comorbidity with other neurodevelopmental disorders, notably autism spectrum disorders (ASDs). Our previous work demonstrated focal neuronal migration defects in mice carrying loss-of-function alleles of the recognized autism risk gene WDFY3. However, the cellular origins of these defects in Wdfy3 mutant mice remain elusive and uncovering it will provide critical insight into WDFY3-dependent disease pathology. Methods Here, in an effort to untangle the origins of NMDs in Wdfy3lacZ mice, we employed mosaic analysis with double markers (MADM). MADM technology enabled us to genetically distinctly track and p...

Research paper thumbnail of WDFY3 cell autonomously controls neuronal migration

Research paper thumbnail of Deficient or Excess Folic Acid Supply During Pregnancy Alter Cortical Neurodevelopment in Mouse Offspring

Folate is an essential micronutrient required for both cellular proliferation through de novo nuc... more Folate is an essential micronutrient required for both cellular proliferation through de novo nucleotide synthesis and epigenetic regulation of gene expression through methylation. This dual requirement places a particular demand on folate availability during pregnancy when both rapid cell generation and programmed differentiation of maternal, extraembryonic, and embryonic/fetal tissues are required. Accordingly, prenatal neurodevelopment is particularly susceptible to folate deficiency, which can predispose to neural tube defects, or when effective transport into the brain is impaired, cerebral folate deficiency. Consequently, adequate folate consumption, in the form of folic acid (FA) fortification and supplement use, is widely recommended and has led to a substantial increase in the amount of FA intake during pregnancy in some populations. Here, we show that either maternal folate deficiency or FA excess in mice results in disruptions in folate metabolism of the offspring, sugges...

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