Zaid Zoumot - Academia.edu (original) (raw)

Papers by Zaid Zoumot

Research paper thumbnail of Faculty of 1000 evaluation for A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies

F1000 - Post-publication peer review of the biomedical literature, 2012

Research paper thumbnail of Faculty of 1000 evaluation for Morbidity and mortality in children with obstructive sleep apnoea: a controlled national study

F1000 - Post-publication peer review of the biomedical literature, 2013

Research paper thumbnail of Faculty of 1000 evaluation for Tiotropium Respimat Inhaler and the Risk of Death in COPD

F1000 - Post-publication peer review of the biomedical literature, 2000

Research paper thumbnail of Diagnosing heparin induced thrombocytopenia in critically ill patients

European Journal of Intensive Care Medicine, Mar 1, 2010

Research paper thumbnail of An Analysis of the 4T's Score in Diagnosing Heparin Induced Thrombocytopenia in Critically Ill Patients

B44. ORGANIZATION AND GUIDELINES IN THE ICU, 2009

Research paper thumbnail of A severe case of multisystem sarcoidosis complicated by aspergillosis and aspergillomas

Research paper thumbnail of Radiological resolution of cavitating Aspergillus fumigatus infection following treatment with oral voriconazole in two lung transplant recipients

Transplant International, 2006

Research paper thumbnail of Panton–Valentine leukocidin pneumonia: an emerging threat

The Clinical Respiratory Journal, 2000

Al-Hadithy et al.

Research paper thumbnail of Diagnosing heparin induced thrombocytopenia in critically ill patients

Intensive Care Medicine, 2010

Research paper thumbnail of 003. Association between dynamic hyperinflation and emphysema distribution in chronic obstructive pulmonary disease (COPD) patients

Journal of Thoracic Disease, Nov 2, 2015

Research paper thumbnail of Twitch Transdiaphragmatic Pressure Morphology Can Distinguish Diaphragm Paralysis from a Diaphragm Defect

American Journal of Respiratory and Critical Care Medicine, Jul 15, 2013

Research paper thumbnail of A randomised controlled study of Bronchoscopic Lung Volume Reduction with endobronchial valves for patients with Heterogeneous emphysema and Intact interlobar Fissures: the BeLieVeR-HIFi study

Efficacy and Mechanism Evaluation, 2015

Research paper thumbnail of Mortality data following lung volume reductionsurgery at the Royal Brompton Hospital

Research paper thumbnail of The Impact of Homogeneous Versus Heterogeneous Emphysema on Dynamic Hyperinflation in Patients With Severe COPD Assessed for Lung Volume Reduction

COPD, Jan 23, 2015

Dynamic hyperinflation (DH) is a pathophysiologic hallmark of Chronic Obstructive Pulmonary Disea... more Dynamic hyperinflation (DH) is a pathophysiologic hallmark of Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to investigate the impact of emphysema distribution on DH during a maximal cardiopulmonary exercise test (CPET) in patients with severe COPD. This was a retrospective analysis of prospectively collected data among severe COPD patients who underwent thoracic high-resolution computed tomography, full lung function measurements and maximal CPET with inspiratory manouvers as assessment for a lung volume reduction procedure. ΔIC was calculated by subtracting the end-exercise inspiratory capacity (eIC) from resting IC (rIC) and expressed as a percentage of rIC (ΔIC %). Emphysema quantification was conducted at 3 predefined levels using the syngo PULMO-CT (Siemens AG); a difference >25% between best and worse slice was defined as heterogeneous emphysema. Fifty patients with heterogeneous (62.7% male; 60.9 ± 7.5 years old; FEV1% = 32.4 ± 11.4) and 14 with ...

Research paper thumbnail of Bronchoscopic intrabullous endobronchial autologous blood instillation (BIABI) for the treatment of giant bullae

Background: At present, surgical bullectomy is the standard of care for the treatment of patients... more Background: At present, surgical bullectomy is the standard of care for the treatment of patients with giant bullae. However, a significant proportion of patients are not suitable for surgical treatment due to high operative risk and co-morbidities. There is also limited availability to bullectomy, a high cost, and a significant morbidity associated with the surgical approach. Autologous blood instilled endobronchially can induce an inflammatory reaction leading to scarring, fibrosis, and ultimately volume loss.Methods: We recruited 5 subjects with giant bullae (2 not fit for surgery, 2 had previous pleurodeses, 1 refused surgery). They were treated with fluoroscopically guided bronchoscopically instilled unaltered autologous blood directly into their bullae. All treatments were performed using moderate sedation as day-case procedures. Measures of exercise capacity, quality of life, lung function, and computerised tomography (CT) scans of the chest were performed before and three mo...

Research paper thumbnail of Association between dynamic hyperinflation and emphysema distribution in COPD patients

IntroductionDynamic hyperinflation (DH) is a major contributor of both dyspnea and reduced exerci... more IntroductionDynamic hyperinflation (DH) is a major contributor of both dyspnea and reduced exercise capacity among patients with Chronic Obstructive Pulmonary Disease (COPD). The relationship between the pattern of distribution of emphysema (homogeneous versus heterogeneous) and DH has not been previously studied.AimTo compare the impact of emphysema distribution on DH during a maximal cardiopulmonary exercise testing (CPET) in severe COPD.Material-MethodsData on COPD patients who underwent thorax high-resolution computed tomography, full lung function measurements and maximal CPET were retrospectively analysed. Resting inspiratory capacity (rIC) was calculated by averaging 4 resting IC manouvers. ΔIC was calculated by subtracting the peak IC (pIC), that is the IC measured during the last 30 seconds of maximum exercise, from rIC and was expressed as ratio of rIC (ΔICratio). Emphysema quantification was conducted at 3 predefined levels for each patient using the syngo PULMO-CT (Sieme...

Research paper thumbnail of Bronchoscopic Coil Treatment for Patients with Severe Emphysema: A Meta-Analysis

Respiration, 2015

Bronchoscopic coil treatment has been shown to improve pulmonary function, exercise capacity, and... more Bronchoscopic coil treatment has been shown to improve pulmonary function, exercise capacity, and quality of life in patients with severe emphysema. To perform a meta-analysis of the results of four independent European clinical trials investigating this coil therapy for emphysema. Data on all patients included in the four European clinical trials were analyzed for efficacy and safety outcomes. A total of 2,536 coils were placed during 259 procedures in 140 patients. A total of 37 chronic obstructive pulmonary disease exacerbations and 27 pneumonias were recorded as serious adverse events up to 1 year after treatment. The pneumothorax rate was 6.4%. Both 6 and 12 months after treatment, significant (all p < 0.001) improvements were observed for: forced expiratory volume in 1 s [+0.08 liters (±0.19) and +0.08 liters (±0.21)], residual volume [RV; -510 ml (±850) and -430 ml (±720)], 6-min walking distance [6MWD; +44.1 m (±69.8) and +38.1 m (±71.9)], and St. George's Respiratory Questionnaire score [SGRQ; -9.5 points (±14.3) and -7.7 points (±14.2)]. No differences in any outcome measures were observed between heterogeneous and homogeneous emphysema patients. Only a high baseline RV was found to be an independent predictor of successful treatment. Bronchoscopic coil treatment improves pulmonary function, 6MWD, and quality of life in patients with severe emphysema up to 1 year after treatment, independent of the distribution of the disease. © 2015 S. Karger AG, Basel.

Research paper thumbnail of Effective Bronchoscopic Lung Volume Reduction Accelerates Exercise Oxygen Uptake Kinetics in Emphysema

Chest, Jan 25, 2015

The impact of bronchoscopic lung volume reduction (BLVR) on physiological responses to exercise i... more The impact of bronchoscopic lung volume reduction (BLVR) on physiological responses to exercise in patients with advanced emphysema remains incompletely understood. We hypothesised that effective BLVR (e-BLVR), defined as a reduction in residual volume >350mL, would improve cardiovascular responses to exercise and accelerate oxygen uptake (V.O2) kinetics. Thirty-one patients (FEV1: 36±9% predicted; residual volume: 219±57% predicted) underwent a constant intensity exercise test at 70% peak work-rate to the limit of tolerance before and after treatment bronchoscopy (n=24) or sham bronchoscopy (n=7). Physiological responses in e-BLVR patients (n=16) were compared with controls (ineffective BLVR or sham bronchoscopy; n=15). e-BLVR reduced residual volume (-1.1±0.5L, p=0.001), improved lung diffusing capacity by 12±13% (p=0.001) and increased exercise tolerance by 181±214s (p=0.004). V.O2 kinetics were accelerated in the e-BLVR group but remained unchanged in controls (∆ mean respons...

Research paper thumbnail of Bronchoscopic and Percutaneous Approaches to Lung Volume Reduction

Clinical Pulmonary Medicine, 2013

ABSTRACT Lung hyperinflation in chronic obstructive pulmonary disease is a major cause of breathl... more ABSTRACT Lung hyperinflation in chronic obstructive pulmonary disease is a major cause of breathlessness that responds poorly to medication. Lung volume reduction surgery provides relief of breathlessness, improved lung function, and exercise capacity and in some patients improves survival. However, it comes at a cost of surgical complications and mortality. Bronchoscopic lung volume reduction offers patients a less invasive and potentially safer alternative. This article reviews some of the techniques available and the most up-to-date evidence for them.

Research paper thumbnail of Endobronchial Coils for Severe Emphysema Are Effective Up to 12 Months following Treatment: Medium Term and Cross-Over Results from a Randomised Controlled Trial

PloS one, 2015

There is a clinical need for therapeutic options to reduce hyperinflation associated with severe ... more There is a clinical need for therapeutic options to reduce hyperinflation associated with severe emphysema. Endobronchial Coils (coils) are nitinol devices implanted bronchoscopically under fluoroscopic guidance to re-tension the lung. We report the medium term effectiveness and safety of coils in a study of patients with emphysema. Forty five subjects with severe airflow obstruction and hyperinflation received bilateral sequential treatment with coils (30 day interval between treatments) as part of a randomised controlled trial with a primary endpoint 90 days after the final treatment (Clinicaltrials.gov NCT01334307). Further assessments were made at 180 and 360 days and in this study the primary outcome was the effect of coil treatment on the St. George's Respiratory Questionnaire (SGRQ) 360 days following treatment. At 360 days following treatment, there was an improvement in the SGRQ score of -6.1±14.0 points (p = 0.01) compared to baseline. Improvements in secondary outcome...

Research paper thumbnail of Faculty of 1000 evaluation for A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies

F1000 - Post-publication peer review of the biomedical literature, 2012

Research paper thumbnail of Faculty of 1000 evaluation for Morbidity and mortality in children with obstructive sleep apnoea: a controlled national study

F1000 - Post-publication peer review of the biomedical literature, 2013

Research paper thumbnail of Faculty of 1000 evaluation for Tiotropium Respimat Inhaler and the Risk of Death in COPD

F1000 - Post-publication peer review of the biomedical literature, 2000

Research paper thumbnail of Diagnosing heparin induced thrombocytopenia in critically ill patients

European Journal of Intensive Care Medicine, Mar 1, 2010

Research paper thumbnail of An Analysis of the 4T's Score in Diagnosing Heparin Induced Thrombocytopenia in Critically Ill Patients

B44. ORGANIZATION AND GUIDELINES IN THE ICU, 2009

Research paper thumbnail of A severe case of multisystem sarcoidosis complicated by aspergillosis and aspergillomas

Research paper thumbnail of Radiological resolution of cavitating Aspergillus fumigatus infection following treatment with oral voriconazole in two lung transplant recipients

Transplant International, 2006

Research paper thumbnail of Panton–Valentine leukocidin pneumonia: an emerging threat

The Clinical Respiratory Journal, 2000

Al-Hadithy et al.

Research paper thumbnail of Diagnosing heparin induced thrombocytopenia in critically ill patients

Intensive Care Medicine, 2010

Research paper thumbnail of 003. Association between dynamic hyperinflation and emphysema distribution in chronic obstructive pulmonary disease (COPD) patients

Journal of Thoracic Disease, Nov 2, 2015

Research paper thumbnail of Twitch Transdiaphragmatic Pressure Morphology Can Distinguish Diaphragm Paralysis from a Diaphragm Defect

American Journal of Respiratory and Critical Care Medicine, Jul 15, 2013

Research paper thumbnail of A randomised controlled study of Bronchoscopic Lung Volume Reduction with endobronchial valves for patients with Heterogeneous emphysema and Intact interlobar Fissures: the BeLieVeR-HIFi study

Efficacy and Mechanism Evaluation, 2015

Research paper thumbnail of Mortality data following lung volume reductionsurgery at the Royal Brompton Hospital

Research paper thumbnail of The Impact of Homogeneous Versus Heterogeneous Emphysema on Dynamic Hyperinflation in Patients With Severe COPD Assessed for Lung Volume Reduction

COPD, Jan 23, 2015

Dynamic hyperinflation (DH) is a pathophysiologic hallmark of Chronic Obstructive Pulmonary Disea... more Dynamic hyperinflation (DH) is a pathophysiologic hallmark of Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to investigate the impact of emphysema distribution on DH during a maximal cardiopulmonary exercise test (CPET) in patients with severe COPD. This was a retrospective analysis of prospectively collected data among severe COPD patients who underwent thoracic high-resolution computed tomography, full lung function measurements and maximal CPET with inspiratory manouvers as assessment for a lung volume reduction procedure. ΔIC was calculated by subtracting the end-exercise inspiratory capacity (eIC) from resting IC (rIC) and expressed as a percentage of rIC (ΔIC %). Emphysema quantification was conducted at 3 predefined levels using the syngo PULMO-CT (Siemens AG); a difference >25% between best and worse slice was defined as heterogeneous emphysema. Fifty patients with heterogeneous (62.7% male; 60.9 ± 7.5 years old; FEV1% = 32.4 ± 11.4) and 14 with ...

Research paper thumbnail of Bronchoscopic intrabullous endobronchial autologous blood instillation (BIABI) for the treatment of giant bullae

Background: At present, surgical bullectomy is the standard of care for the treatment of patients... more Background: At present, surgical bullectomy is the standard of care for the treatment of patients with giant bullae. However, a significant proportion of patients are not suitable for surgical treatment due to high operative risk and co-morbidities. There is also limited availability to bullectomy, a high cost, and a significant morbidity associated with the surgical approach. Autologous blood instilled endobronchially can induce an inflammatory reaction leading to scarring, fibrosis, and ultimately volume loss.Methods: We recruited 5 subjects with giant bullae (2 not fit for surgery, 2 had previous pleurodeses, 1 refused surgery). They were treated with fluoroscopically guided bronchoscopically instilled unaltered autologous blood directly into their bullae. All treatments were performed using moderate sedation as day-case procedures. Measures of exercise capacity, quality of life, lung function, and computerised tomography (CT) scans of the chest were performed before and three mo...

Research paper thumbnail of Association between dynamic hyperinflation and emphysema distribution in COPD patients

IntroductionDynamic hyperinflation (DH) is a major contributor of both dyspnea and reduced exerci... more IntroductionDynamic hyperinflation (DH) is a major contributor of both dyspnea and reduced exercise capacity among patients with Chronic Obstructive Pulmonary Disease (COPD). The relationship between the pattern of distribution of emphysema (homogeneous versus heterogeneous) and DH has not been previously studied.AimTo compare the impact of emphysema distribution on DH during a maximal cardiopulmonary exercise testing (CPET) in severe COPD.Material-MethodsData on COPD patients who underwent thorax high-resolution computed tomography, full lung function measurements and maximal CPET were retrospectively analysed. Resting inspiratory capacity (rIC) was calculated by averaging 4 resting IC manouvers. ΔIC was calculated by subtracting the peak IC (pIC), that is the IC measured during the last 30 seconds of maximum exercise, from rIC and was expressed as ratio of rIC (ΔICratio). Emphysema quantification was conducted at 3 predefined levels for each patient using the syngo PULMO-CT (Sieme...

Research paper thumbnail of Bronchoscopic Coil Treatment for Patients with Severe Emphysema: A Meta-Analysis

Respiration, 2015

Bronchoscopic coil treatment has been shown to improve pulmonary function, exercise capacity, and... more Bronchoscopic coil treatment has been shown to improve pulmonary function, exercise capacity, and quality of life in patients with severe emphysema. To perform a meta-analysis of the results of four independent European clinical trials investigating this coil therapy for emphysema. Data on all patients included in the four European clinical trials were analyzed for efficacy and safety outcomes. A total of 2,536 coils were placed during 259 procedures in 140 patients. A total of 37 chronic obstructive pulmonary disease exacerbations and 27 pneumonias were recorded as serious adverse events up to 1 year after treatment. The pneumothorax rate was 6.4%. Both 6 and 12 months after treatment, significant (all p < 0.001) improvements were observed for: forced expiratory volume in 1 s [+0.08 liters (±0.19) and +0.08 liters (±0.21)], residual volume [RV; -510 ml (±850) and -430 ml (±720)], 6-min walking distance [6MWD; +44.1 m (±69.8) and +38.1 m (±71.9)], and St. George's Respiratory Questionnaire score [SGRQ; -9.5 points (±14.3) and -7.7 points (±14.2)]. No differences in any outcome measures were observed between heterogeneous and homogeneous emphysema patients. Only a high baseline RV was found to be an independent predictor of successful treatment. Bronchoscopic coil treatment improves pulmonary function, 6MWD, and quality of life in patients with severe emphysema up to 1 year after treatment, independent of the distribution of the disease. © 2015 S. Karger AG, Basel.

Research paper thumbnail of Effective Bronchoscopic Lung Volume Reduction Accelerates Exercise Oxygen Uptake Kinetics in Emphysema

Chest, Jan 25, 2015

The impact of bronchoscopic lung volume reduction (BLVR) on physiological responses to exercise i... more The impact of bronchoscopic lung volume reduction (BLVR) on physiological responses to exercise in patients with advanced emphysema remains incompletely understood. We hypothesised that effective BLVR (e-BLVR), defined as a reduction in residual volume >350mL, would improve cardiovascular responses to exercise and accelerate oxygen uptake (V.O2) kinetics. Thirty-one patients (FEV1: 36±9% predicted; residual volume: 219±57% predicted) underwent a constant intensity exercise test at 70% peak work-rate to the limit of tolerance before and after treatment bronchoscopy (n=24) or sham bronchoscopy (n=7). Physiological responses in e-BLVR patients (n=16) were compared with controls (ineffective BLVR or sham bronchoscopy; n=15). e-BLVR reduced residual volume (-1.1±0.5L, p=0.001), improved lung diffusing capacity by 12±13% (p=0.001) and increased exercise tolerance by 181±214s (p=0.004). V.O2 kinetics were accelerated in the e-BLVR group but remained unchanged in controls (∆ mean respons...

Research paper thumbnail of Bronchoscopic and Percutaneous Approaches to Lung Volume Reduction

Clinical Pulmonary Medicine, 2013

ABSTRACT Lung hyperinflation in chronic obstructive pulmonary disease is a major cause of breathl... more ABSTRACT Lung hyperinflation in chronic obstructive pulmonary disease is a major cause of breathlessness that responds poorly to medication. Lung volume reduction surgery provides relief of breathlessness, improved lung function, and exercise capacity and in some patients improves survival. However, it comes at a cost of surgical complications and mortality. Bronchoscopic lung volume reduction offers patients a less invasive and potentially safer alternative. This article reviews some of the techniques available and the most up-to-date evidence for them.

Research paper thumbnail of Endobronchial Coils for Severe Emphysema Are Effective Up to 12 Months following Treatment: Medium Term and Cross-Over Results from a Randomised Controlled Trial

PloS one, 2015

There is a clinical need for therapeutic options to reduce hyperinflation associated with severe ... more There is a clinical need for therapeutic options to reduce hyperinflation associated with severe emphysema. Endobronchial Coils (coils) are nitinol devices implanted bronchoscopically under fluoroscopic guidance to re-tension the lung. We report the medium term effectiveness and safety of coils in a study of patients with emphysema. Forty five subjects with severe airflow obstruction and hyperinflation received bilateral sequential treatment with coils (30 day interval between treatments) as part of a randomised controlled trial with a primary endpoint 90 days after the final treatment (Clinicaltrials.gov NCT01334307). Further assessments were made at 180 and 360 days and in this study the primary outcome was the effect of coil treatment on the St. George's Respiratory Questionnaire (SGRQ) 360 days following treatment. At 360 days following treatment, there was an improvement in the SGRQ score of -6.1±14.0 points (p = 0.01) compared to baseline. Improvements in secondary outcome...