Zbigniew Bartuzi - Academia.edu (original) (raw)

Papers by Zbigniew Bartuzi

Postepy Dermatologii I Alergologii, 2021

Introduction: Interleukin 25 (IL-25) is a cytokine with proinflammatory and anti-inflammatory eff... more Introduction: Interleukin 25 (IL-25) is a cytokine with proinflammatory and anti-inflammatory effects, and its biological function of reciprocal epidermal hyperplasia and of inhibiting the filaggrin synthesis points to an essential role connecting the inflammatory process with damage to the epidermal barrier in the course of atopic dermatitis (AD). Aim: To assess the IL-25 in serum concentration in AD patients and to analyse its possible correlation with the disease intensity and selected epidermal barrier parameters such as transepidermal water loss (TEWL). Material and methods: The study involved 43 patients with AD and 22 healthy volunteers. The IL-25 concentration was measured using the ELISA method. The intensity of disease symptoms was investigated using W-AZS and EASI indicators. The epidermal barrier was evaluated using a Tewameter TM300 and Corneometer CM825. Results: The concentration of IL-25 in serum was higher in the study group than in the control group. IL-25 serum concentration correlates with W-AZS/EASI in patients with a severe and moderate course of AD. The concentration of IL-25 affects the TEWL within the affected, evaluated skin surface. Conclusions: An elevated IL-25 concentration in serum is characteristic for patients with moderate and severe AD intensity. The IL-25 concentration in serum correlates with TEWL and with the moisture level in the affected area. However, further studies are necessary to determine the role played by IL-25 in the course of the disease and how it affects the functional parameters of the epidermal barrier.

W ostatnich 10-15 latach mamy do czynienia z "drugą falą" epidemii chorób alergicznych wywołaną u... more W ostatnich 10-15 latach mamy do czynienia z "drugą falą" epidemii chorób alergicznych wywołaną uczuleniem na pokarmy. 60% przypadków alergii pokarmowej u osób dorosłych i dzieci związane jest z współwystępowaniem alergii wziewnej. Strukturalne podobieństwo białek, nawet tych o odmiennym pochodzeniu, jest głównym czynnikiem determinującym występowanie reakcji krzyżowych. W artykule dokonano przeglądu istotnych klinicznych aspektów alergii pokarmowej związanych z zespołami klinicznymi alergii krzyżowej.

International Journal of Immunopathology and Pharmacology, 2020

Shrimp tropomyosin has a similar structure to house dust mite (HDM) tropomyosin. In this research... more Shrimp tropomyosin has a similar structure to house dust mite (HDM) tropomyosin. In this research, 232 adult patients with symptoms of persistent allergic rhinitis were randomly selected. In the group, 59% were sensitized to Dermatophagoides pteronyssinus and 57.8% to Dermatophagoides farinae. In total, 128 (55.2%) patients were sensitized to both HDM species and 143 (61.6%) to at least one. Slightly over a quarter (25.4%) of patients were sensitized to shrimp. Of the 35 shrimp-sensitized patients, the sensitization to Der p 10 and Pen a 1 was found in 11 cases (31.4%). There was a strong correlation between IgE Pen a 1 and IgE Der p 10 concentrations. The results indicate that there are other allergens responsible for a high incidence of shrimp sensitization in HDM-sensitized patients. A high convergence of Der p 10 and Pen a 1 levels may indicate that the determination of just one of the above is reasonable.

Postepy Dermatologii I Alergologii, 2016

This paper presents current views on the role of immunoglobulin G (IgG) antibodies in the reactio... more This paper presents current views on the role of immunoglobulin G (IgG) antibodies in the reactions with food antigens in the digestive tract and their role in the diagnosis of food allergy based on the assays of specific IgG class antibodies, with a special focus on contemporary practice guidelines. In the light of current scientific knowledge, the IgG-specific antibody-mediated reactions are a body's natural and normal defensive reactions to infiltrating food antigens, which are considered as pathogens. On the other hand, specific IgG antibodies against food allergens play a crucial role in the induction and maintaining of immunological tolerance to food antigens. The statements of many scientific societies stress that sIgG are of no significant importance in the diagnosis of food allergy since their presence is associated with a normal immune response to food allergens and attests to a protracted exposure to food antigens.

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, Oct 19, 2009

A Ad dr re es s d do o k ko or re es sp po on nd de en nc cj ji i: : prof. dr hab. n.

Journal of Investigational Allergology and Clinical Immunology, Jul 28, 2020

Birch pollen 2 0.25 Gray alder pollen 2 1.00 1 SPTskin prick test with native allergen-prick by p... more Birch pollen 2 0.25 Gray alder pollen 2 1.00 1 SPTskin prick test with native allergen-prick by prick method, histamine diameter-3 mm, negative control diameter-0 mm 2 asIgEallergen specific IgE assay by Polycheck (bold ≥-0.7 kUA/l, i.e. ≥ class 2) 3 asIgEallergen specific IgE assay by ImmunoCAP (bold ≥-0.7 IU/ml, i.e. ≥ class 2) 4 ALEX; MacroArrayDX, Wien, Austriaallergen extracts (kUA/L) (bold ≥ 1 kUA/l i.e. medium/high/very high) 5,6 CRDcomponent-resolved diagnosis:

Postepy Dermatologii I Alergologii, 2021

From a botanical point of view, a nut is a kind of dry, closed, unbroken, single-seeded fruit, wh... more From a botanical point of view, a nut is a kind of dry, closed, unbroken, single-seeded fruit, which has a ligneous pericarp made up of several fruiting bodies surrounded by one free semen. The term "allergy to tree nuts" includes allergies to almonds, Brazil nuts, cashew nuts, hazelnuts, chestnuts, macadamia nuts, pecan nuts, pistachios and walnuts. All tree nuts belong to five orders of plants: Rosaceae, Fagales, Sapindales, Ericales and Proteales. Allergies to tree nuts usually start in childhood, but unlike other food allergies, they rarely fade away and generally persist throughout life. They are one of the main causes of serious allergic reactions ending in death in both children and adults. The epidemiology of allergy to nuts is variable and depends mainly on the geographical zone and eating habits. In northern Europe, hazelnut allergy is prevalent, whereas in the USA the most common is allergy to peanuts and, when taking tree nuts into consideration, to walnuts. The diagnosis of allergies to nuts is difficult and requires the use of the most modern research tools including molecular diagnostic techniques.

Clinical and Translational Allergy, Mar 30, 2015

Introduction: Neutrophilic granulocytes (neutrophils) are the most important cells of the non-spe... more Introduction: Neutrophilic granulocytes (neutrophils) are the most important cells of the non-specific immune response. These cells have the capability of chemotaxis and phagocytosis and also participate in inflammatory processes. Stimulated neutrophils or reactive oxygen species (ROS) and elastase, important mediators of the inflammatory process responsible for tissue injury. Aim: To assess oxygen metabolism as one of the representatives regarding metabolic activity of neutrophilic granulocytes measured with the chemiluminescence test (CL) and analysis of concentrations of leukocyte elastase released from neutrophils and measured in the form of complexes with inhibitor (EL-α1-IP) in the serum of patients with allergic type of hypersensitivity to food. Material and methods: The study included 30 patients with diagnosed food allergy on the basis of medical history, clinical symptoms, positive prick tests and the presence of allergen-specific IgE against selected food allergens in the serum. The control group contained 10 healthy volunteers. Chemiluminescence of basal neutrophils and neutrophils stimulated for 40 min (fMLP, PMA, OZ) was assessed with the kinetic luminol-dependent method using a luminometer (Luminoscan-Labsystem) and elastase concentration was estimated in the serum with the ELISA method, using Bendermed Systems kits. Results: Mean values of obtained chemiluminescence from basal and stimulated neutrophils and elastase concentrations assessed in a complex with its inhibitor α1-IP were statistically significantly higher in patients with allergic hypersensitivity to food than values in the group of healthy persons. Conclusions: The results of performed analyses indicate that neutrophils participate and have increased activity in the process of allergic inflammation in patients with food allergy.

Przeglad Gastroenterologiczny, 2023

Eosinophilic gastroenteritis (EGE) is a relatively rare disease, but it should be considered when... more Eosinophilic gastroenteritis (EGE) is a relatively rare disease, but it should be considered whenever a patient presents with unexplained gastrointestinal symptoms that cannot be explained by parasitic infection or other gastrointestinal diseases characterized by eosinophilic infiltration. A high coexistence of EGE and allergic diseases has been documented. Diagnosis of EGE is based primarily on clinical, endoscopic, and histopathological findings. Glucocorticosteroids and other immunomodulatory drugs are the mainstay of treatment, but currently the greatest hope lies in biological drugs, which are undergoing intensive research. This disease is troublesome for the patient and significantly reduces the quality of life.

Antioxidants, Jun 28, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Popularność cytrusów zarówno jako produktów spożywczych jak i dodatków do kosmetyków i środków cz... more Popularność cytrusów zarówno jako produktów spożywczych jak i dodatków do kosmetyków i środków czystości przyczynia się do wzrostu liczby osób uczulonych na cytrusy. Alergeny owoców cytrusowych mogą powodować objawy ze strony przewodu pokarmowego i układu oddechowego, a także objawy w postaci zmian skórnych. Liczne reakcje krzyżowe alergenów cytrusów z alergenami z innych źródeł utrudniają diagnostykę oraz określenie źródła alergenów odpowiedzialnych za powstawanie objawów alergii. Niniejsza praca ma na celu zebranie i usystematyzowanie informacji dostępnych w literaturze na temat alergenów cytrusów, objawów klinicznych alergii na cytrusy oraz diagnostyki i związanych z nią problemów.

Annals of Agricultural and Environmental Medicine, Sep 21, 2017

Introduction. Numerous publications indicate that the prevalence of some infectious, neoplastic a... more Introduction. Numerous publications indicate that the prevalence of some infectious, neoplastic and immunological diseases are associated with ABO blood groups. Objective. The aim of this study was to verify whether ABO and Rh blood groups are associated with severe anaphylactic reactions after Hymenoptera stings. Materials and Method. A study was undertaken of 71,441 Caucasian subjects living in the same geographic area. The study group included 353 patients with diagnosed systemic anaphylaxis to Hymenoptera venom. Control group included 71,088 healthy blood donors. Frequencies of ABO and Rhesus groups in the study and control groups were compared using univariate and multivariate analyses. Results. No statistically significant interactions were observed between the ABO blood group and anaphylactic reactions to Hymenoptera.

The increasing prevalence of food allergy is a growing problem. This review examines recent devel... more The increasing prevalence of food allergy is a growing problem. This review examines recent developments in the genetic factors of food allergy. The use of genomic information, accelerated by the sequencing of the human genome and the advent of new tools and technologies, has raised widespread hope that food allergy genetics can significantly contribute to the prediction, prevention, and treatment of food allergy.

The food protein triggering the allergic response is termed a food allergen. Six to eight percent... more The food protein triggering the allergic response is termed a food allergen. Six to eight percent of children under the age of three have food allergies and nearly four percent of adults have them. The most common food allergies in adults are shellfish, peanuts, tree nuts, fish, and eggsand the most common food allergies in children are milk, eggs, peanuts, and tree nus. Conditions caused by food allergies are classified into 3 groups according to the mechanism of the allergic response. The reaction may progress to anaphylactic shock: a systemic reaction involving several different bodily systems including hypotension (low blood pressure), loss of consciousness, and possibly death. Allergens most frequently associated with this type of reaction are peanuts, nuts, milk, egg, and seafood, though many food allergens have been reported as triggers for anaphylaxis. Food allergy is thought to develop more easily in patients with the atopic syndrome, a very common combination of diseases: ...

Alergologia Polska - Polish Journal of Allergology, 2020

Przewodniczący Sekcji PTA "Mikrobiom, infekcje a alergia" StReSzczenie Celem dokumentu jest dosta... more Przewodniczący Sekcji PTA "Mikrobiom, infekcje a alergia" StReSzczenie Celem dokumentu jest dostarczenie lekarzom alergologom wskazówek dotyczących właściwego postępowania u pacjentów z astmą oskrzelową i chorobami alergicznymi w czasie trwania pandemii SARS-CoV-2. Postępowanie takie powinno prowadzić do zmniejszenia prawdopodobieństwa infekcji SARS-CoV-2 poprzez ograniczenie społecznych kontaktów pacjenta-równolegle alergolog powinien zapewnić właściwe leczenie chorób podstawowych. Eksperci przestawiają osiemnaście zaleceń dotyczących postępowania w okresie pandemii (w tym kontynuacji swoistej immunoterapii i leczenia biologicznego), rekomendując ograniczenie wizyt i zastąpienie ich kontaktem z pacjentem drogą telefoniczną lub internetową. U większości chorych dotychczasowe leczenie przeciwastmatyczne i przeciwalergiczne powinno być kontynuowane, ale w indywidualnych przypadkach decyzja co do postępowania należy do lekarza prowadzącego, który ma bezpośrednią i pełną wiedzę o stanie zdrowia i oczekiwaniach chorego, jak również o realnych możliwościach działania.

Advances in Dermatology and Allergology, 2019

Severe asthma requires at least high doses of inhaled corticosteroids (ICS) in combination with a... more Severe asthma requires at least high doses of inhaled corticosteroids (ICS) in combination with a long-acting β-agonist (LABA) or systemic corticosteroids (SCS) for more than 50% of days/year to avoid loss of control, or remains uncontrolled despite the treatment described above. The diagnosis of severe asthma should be confirmed in a reference centre as it requires careful differential diagnosis and the exclusion of factors hindering the achievement of optimal control. Severe asthma represents a significant burden for the patient, their family and the healthcare system. This is due to the severity of the symptoms, drug costs, significant impairment of everyday functioning and life quality, and limitation in the professional work. In the case of ineffectiveness of the step 4 GINA treatment, the patient should be referred to a specialist centre to consider additional treatment, including anti-IgE receptor (omalizumab), anti-IL-5 receptor (mepolizumab), or an antibody directed against the α-subunit of receptor for IL-5 (benralizumab). In the case of severe asthma, intensification of therapy should first of all include biological therapy and not the use of SCS. Biological drugs are available in Poland as a part of the therapeutic programme for the treatment of severe asthma. In practice, the therapeutic programme may change with subsequent notices of the Ministry of Health and does not have to be consistent with the Summary of Product Characteristics for individual preparations. The current review presents the basic principles of differential diagnosis of severe asthma and the selection of the optimal biological therapy in Polish conditions.

Rheumatology, 2019

Antibody determination is routinely used in everyday rheumatological practice. Its result repeate... more Antibody determination is routinely used in everyday rheumatological practice. Its result repeatedly determines the diagnosis or exclusion of a particular disease. Antibodies are immunoglobulins, i.e. some of the most important proteins in the immune system, and have specific properties that we should know. In addition, there are a number of factors that can affect their concentration, including drugs commonly used in the treatment of rheumatic diseases. There are definite indications, when the total concentrations of individual classes of immunoglobulins should be initially determined and it should be evaluated whether the patient produces them at all or their production is impaired. In some cases, we should evaluate the levels of specific antibodies along with the total protein concentration and the -globulin fraction, in which the antibodies are contained. The article presents information on the most common mistakes made when performing these tests.

Clinical and Translational Allergy, 2013

Nowadays in countries all over Europe more and more people consume shrimps and other types of sea... more Nowadays in countries all over Europe more and more people consume shrimps and other types of sea food. Consumption of even one or two shrimps can induce anaphylactic reaction in patient with allergy. In this work our aim is to present a case of patient admitted to the Department and Clinic of Allergy, Clinical Immunology and Internal Diseases to diagnose and confirm allergy to shrimp.

Postepy Dermatologii I Alergologii, 2021

Introduction: Interleukin 25 (IL-25) is a cytokine with proinflammatory and anti-inflammatory eff... more Introduction: Interleukin 25 (IL-25) is a cytokine with proinflammatory and anti-inflammatory effects, and its biological function of reciprocal epidermal hyperplasia and of inhibiting the filaggrin synthesis points to an essential role connecting the inflammatory process with damage to the epidermal barrier in the course of atopic dermatitis (AD). Aim: To assess the IL-25 in serum concentration in AD patients and to analyse its possible correlation with the disease intensity and selected epidermal barrier parameters such as transepidermal water loss (TEWL). Material and methods: The study involved 43 patients with AD and 22 healthy volunteers. The IL-25 concentration was measured using the ELISA method. The intensity of disease symptoms was investigated using W-AZS and EASI indicators. The epidermal barrier was evaluated using a Tewameter TM300 and Corneometer CM825. Results: The concentration of IL-25 in serum was higher in the study group than in the control group. IL-25 serum concentration correlates with W-AZS/EASI in patients with a severe and moderate course of AD. The concentration of IL-25 affects the TEWL within the affected, evaluated skin surface. Conclusions: An elevated IL-25 concentration in serum is characteristic for patients with moderate and severe AD intensity. The IL-25 concentration in serum correlates with TEWL and with the moisture level in the affected area. However, further studies are necessary to determine the role played by IL-25 in the course of the disease and how it affects the functional parameters of the epidermal barrier.

W ostatnich 10-15 latach mamy do czynienia z "drugą falą" epidemii chorób alergicznych wywołaną u... more W ostatnich 10-15 latach mamy do czynienia z "drugą falą" epidemii chorób alergicznych wywołaną uczuleniem na pokarmy. 60% przypadków alergii pokarmowej u osób dorosłych i dzieci związane jest z współwystępowaniem alergii wziewnej. Strukturalne podobieństwo białek, nawet tych o odmiennym pochodzeniu, jest głównym czynnikiem determinującym występowanie reakcji krzyżowych. W artykule dokonano przeglądu istotnych klinicznych aspektów alergii pokarmowej związanych z zespołami klinicznymi alergii krzyżowej.

International Journal of Immunopathology and Pharmacology, 2020

Shrimp tropomyosin has a similar structure to house dust mite (HDM) tropomyosin. In this research... more Shrimp tropomyosin has a similar structure to house dust mite (HDM) tropomyosin. In this research, 232 adult patients with symptoms of persistent allergic rhinitis were randomly selected. In the group, 59% were sensitized to Dermatophagoides pteronyssinus and 57.8% to Dermatophagoides farinae. In total, 128 (55.2%) patients were sensitized to both HDM species and 143 (61.6%) to at least one. Slightly over a quarter (25.4%) of patients were sensitized to shrimp. Of the 35 shrimp-sensitized patients, the sensitization to Der p 10 and Pen a 1 was found in 11 cases (31.4%). There was a strong correlation between IgE Pen a 1 and IgE Der p 10 concentrations. The results indicate that there are other allergens responsible for a high incidence of shrimp sensitization in HDM-sensitized patients. A high convergence of Der p 10 and Pen a 1 levels may indicate that the determination of just one of the above is reasonable.

Postepy Dermatologii I Alergologii, 2016

This paper presents current views on the role of immunoglobulin G (IgG) antibodies in the reactio... more This paper presents current views on the role of immunoglobulin G (IgG) antibodies in the reactions with food antigens in the digestive tract and their role in the diagnosis of food allergy based on the assays of specific IgG class antibodies, with a special focus on contemporary practice guidelines. In the light of current scientific knowledge, the IgG-specific antibody-mediated reactions are a body's natural and normal defensive reactions to infiltrating food antigens, which are considered as pathogens. On the other hand, specific IgG antibodies against food allergens play a crucial role in the induction and maintaining of immunological tolerance to food antigens. The statements of many scientific societies stress that sIgG are of no significant importance in the diagnosis of food allergy since their presence is associated with a normal immune response to food allergens and attests to a protracted exposure to food antigens.

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, Oct 19, 2009

A Ad dr re es s d do o k ko or re es sp po on nd de en nc cj ji i: : prof. dr hab. n.

Journal of Investigational Allergology and Clinical Immunology, Jul 28, 2020

Birch pollen 2 0.25 Gray alder pollen 2 1.00 1 SPTskin prick test with native allergen-prick by p... more Birch pollen 2 0.25 Gray alder pollen 2 1.00 1 SPTskin prick test with native allergen-prick by prick method, histamine diameter-3 mm, negative control diameter-0 mm 2 asIgEallergen specific IgE assay by Polycheck (bold ≥-0.7 kUA/l, i.e. ≥ class 2) 3 asIgEallergen specific IgE assay by ImmunoCAP (bold ≥-0.7 IU/ml, i.e. ≥ class 2) 4 ALEX; MacroArrayDX, Wien, Austriaallergen extracts (kUA/L) (bold ≥ 1 kUA/l i.e. medium/high/very high) 5,6 CRDcomponent-resolved diagnosis:

Postepy Dermatologii I Alergologii, 2021

From a botanical point of view, a nut is a kind of dry, closed, unbroken, single-seeded fruit, wh... more From a botanical point of view, a nut is a kind of dry, closed, unbroken, single-seeded fruit, which has a ligneous pericarp made up of several fruiting bodies surrounded by one free semen. The term "allergy to tree nuts" includes allergies to almonds, Brazil nuts, cashew nuts, hazelnuts, chestnuts, macadamia nuts, pecan nuts, pistachios and walnuts. All tree nuts belong to five orders of plants: Rosaceae, Fagales, Sapindales, Ericales and Proteales. Allergies to tree nuts usually start in childhood, but unlike other food allergies, they rarely fade away and generally persist throughout life. They are one of the main causes of serious allergic reactions ending in death in both children and adults. The epidemiology of allergy to nuts is variable and depends mainly on the geographical zone and eating habits. In northern Europe, hazelnut allergy is prevalent, whereas in the USA the most common is allergy to peanuts and, when taking tree nuts into consideration, to walnuts. The diagnosis of allergies to nuts is difficult and requires the use of the most modern research tools including molecular diagnostic techniques.

Clinical and Translational Allergy, Mar 30, 2015

Introduction: Neutrophilic granulocytes (neutrophils) are the most important cells of the non-spe... more Introduction: Neutrophilic granulocytes (neutrophils) are the most important cells of the non-specific immune response. These cells have the capability of chemotaxis and phagocytosis and also participate in inflammatory processes. Stimulated neutrophils or reactive oxygen species (ROS) and elastase, important mediators of the inflammatory process responsible for tissue injury. Aim: To assess oxygen metabolism as one of the representatives regarding metabolic activity of neutrophilic granulocytes measured with the chemiluminescence test (CL) and analysis of concentrations of leukocyte elastase released from neutrophils and measured in the form of complexes with inhibitor (EL-α1-IP) in the serum of patients with allergic type of hypersensitivity to food. Material and methods: The study included 30 patients with diagnosed food allergy on the basis of medical history, clinical symptoms, positive prick tests and the presence of allergen-specific IgE against selected food allergens in the serum. The control group contained 10 healthy volunteers. Chemiluminescence of basal neutrophils and neutrophils stimulated for 40 min (fMLP, PMA, OZ) was assessed with the kinetic luminol-dependent method using a luminometer (Luminoscan-Labsystem) and elastase concentration was estimated in the serum with the ELISA method, using Bendermed Systems kits. Results: Mean values of obtained chemiluminescence from basal and stimulated neutrophils and elastase concentrations assessed in a complex with its inhibitor α1-IP were statistically significantly higher in patients with allergic hypersensitivity to food than values in the group of healthy persons. Conclusions: The results of performed analyses indicate that neutrophils participate and have increased activity in the process of allergic inflammation in patients with food allergy.

Przeglad Gastroenterologiczny, 2023

Eosinophilic gastroenteritis (EGE) is a relatively rare disease, but it should be considered when... more Eosinophilic gastroenteritis (EGE) is a relatively rare disease, but it should be considered whenever a patient presents with unexplained gastrointestinal symptoms that cannot be explained by parasitic infection or other gastrointestinal diseases characterized by eosinophilic infiltration. A high coexistence of EGE and allergic diseases has been documented. Diagnosis of EGE is based primarily on clinical, endoscopic, and histopathological findings. Glucocorticosteroids and other immunomodulatory drugs are the mainstay of treatment, but currently the greatest hope lies in biological drugs, which are undergoing intensive research. This disease is troublesome for the patient and significantly reduces the quality of life.

Antioxidants, Jun 28, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Popularność cytrusów zarówno jako produktów spożywczych jak i dodatków do kosmetyków i środków cz... more Popularność cytrusów zarówno jako produktów spożywczych jak i dodatków do kosmetyków i środków czystości przyczynia się do wzrostu liczby osób uczulonych na cytrusy. Alergeny owoców cytrusowych mogą powodować objawy ze strony przewodu pokarmowego i układu oddechowego, a także objawy w postaci zmian skórnych. Liczne reakcje krzyżowe alergenów cytrusów z alergenami z innych źródeł utrudniają diagnostykę oraz określenie źródła alergenów odpowiedzialnych za powstawanie objawów alergii. Niniejsza praca ma na celu zebranie i usystematyzowanie informacji dostępnych w literaturze na temat alergenów cytrusów, objawów klinicznych alergii na cytrusy oraz diagnostyki i związanych z nią problemów.

Annals of Agricultural and Environmental Medicine, Sep 21, 2017

Introduction. Numerous publications indicate that the prevalence of some infectious, neoplastic a... more Introduction. Numerous publications indicate that the prevalence of some infectious, neoplastic and immunological diseases are associated with ABO blood groups. Objective. The aim of this study was to verify whether ABO and Rh blood groups are associated with severe anaphylactic reactions after Hymenoptera stings. Materials and Method. A study was undertaken of 71,441 Caucasian subjects living in the same geographic area. The study group included 353 patients with diagnosed systemic anaphylaxis to Hymenoptera venom. Control group included 71,088 healthy blood donors. Frequencies of ABO and Rhesus groups in the study and control groups were compared using univariate and multivariate analyses. Results. No statistically significant interactions were observed between the ABO blood group and anaphylactic reactions to Hymenoptera.

The increasing prevalence of food allergy is a growing problem. This review examines recent devel... more The increasing prevalence of food allergy is a growing problem. This review examines recent developments in the genetic factors of food allergy. The use of genomic information, accelerated by the sequencing of the human genome and the advent of new tools and technologies, has raised widespread hope that food allergy genetics can significantly contribute to the prediction, prevention, and treatment of food allergy.

The food protein triggering the allergic response is termed a food allergen. Six to eight percent... more The food protein triggering the allergic response is termed a food allergen. Six to eight percent of children under the age of three have food allergies and nearly four percent of adults have them. The most common food allergies in adults are shellfish, peanuts, tree nuts, fish, and eggsand the most common food allergies in children are milk, eggs, peanuts, and tree nus. Conditions caused by food allergies are classified into 3 groups according to the mechanism of the allergic response. The reaction may progress to anaphylactic shock: a systemic reaction involving several different bodily systems including hypotension (low blood pressure), loss of consciousness, and possibly death. Allergens most frequently associated with this type of reaction are peanuts, nuts, milk, egg, and seafood, though many food allergens have been reported as triggers for anaphylaxis. Food allergy is thought to develop more easily in patients with the atopic syndrome, a very common combination of diseases: ...

Alergologia Polska - Polish Journal of Allergology, 2020

Przewodniczący Sekcji PTA "Mikrobiom, infekcje a alergia" StReSzczenie Celem dokumentu jest dosta... more Przewodniczący Sekcji PTA "Mikrobiom, infekcje a alergia" StReSzczenie Celem dokumentu jest dostarczenie lekarzom alergologom wskazówek dotyczących właściwego postępowania u pacjentów z astmą oskrzelową i chorobami alergicznymi w czasie trwania pandemii SARS-CoV-2. Postępowanie takie powinno prowadzić do zmniejszenia prawdopodobieństwa infekcji SARS-CoV-2 poprzez ograniczenie społecznych kontaktów pacjenta-równolegle alergolog powinien zapewnić właściwe leczenie chorób podstawowych. Eksperci przestawiają osiemnaście zaleceń dotyczących postępowania w okresie pandemii (w tym kontynuacji swoistej immunoterapii i leczenia biologicznego), rekomendując ograniczenie wizyt i zastąpienie ich kontaktem z pacjentem drogą telefoniczną lub internetową. U większości chorych dotychczasowe leczenie przeciwastmatyczne i przeciwalergiczne powinno być kontynuowane, ale w indywidualnych przypadkach decyzja co do postępowania należy do lekarza prowadzącego, który ma bezpośrednią i pełną wiedzę o stanie zdrowia i oczekiwaniach chorego, jak również o realnych możliwościach działania.

Advances in Dermatology and Allergology, 2019

Severe asthma requires at least high doses of inhaled corticosteroids (ICS) in combination with a... more Severe asthma requires at least high doses of inhaled corticosteroids (ICS) in combination with a long-acting β-agonist (LABA) or systemic corticosteroids (SCS) for more than 50% of days/year to avoid loss of control, or remains uncontrolled despite the treatment described above. The diagnosis of severe asthma should be confirmed in a reference centre as it requires careful differential diagnosis and the exclusion of factors hindering the achievement of optimal control. Severe asthma represents a significant burden for the patient, their family and the healthcare system. This is due to the severity of the symptoms, drug costs, significant impairment of everyday functioning and life quality, and limitation in the professional work. In the case of ineffectiveness of the step 4 GINA treatment, the patient should be referred to a specialist centre to consider additional treatment, including anti-IgE receptor (omalizumab), anti-IL-5 receptor (mepolizumab), or an antibody directed against the α-subunit of receptor for IL-5 (benralizumab). In the case of severe asthma, intensification of therapy should first of all include biological therapy and not the use of SCS. Biological drugs are available in Poland as a part of the therapeutic programme for the treatment of severe asthma. In practice, the therapeutic programme may change with subsequent notices of the Ministry of Health and does not have to be consistent with the Summary of Product Characteristics for individual preparations. The current review presents the basic principles of differential diagnosis of severe asthma and the selection of the optimal biological therapy in Polish conditions.

Rheumatology, 2019

Antibody determination is routinely used in everyday rheumatological practice. Its result repeate... more Antibody determination is routinely used in everyday rheumatological practice. Its result repeatedly determines the diagnosis or exclusion of a particular disease. Antibodies are immunoglobulins, i.e. some of the most important proteins in the immune system, and have specific properties that we should know. In addition, there are a number of factors that can affect their concentration, including drugs commonly used in the treatment of rheumatic diseases. There are definite indications, when the total concentrations of individual classes of immunoglobulins should be initially determined and it should be evaluated whether the patient produces them at all or their production is impaired. In some cases, we should evaluate the levels of specific antibodies along with the total protein concentration and the -globulin fraction, in which the antibodies are contained. The article presents information on the most common mistakes made when performing these tests.

Clinical and Translational Allergy, 2013

Nowadays in countries all over Europe more and more people consume shrimps and other types of sea... more Nowadays in countries all over Europe more and more people consume shrimps and other types of sea food. Consumption of even one or two shrimps can induce anaphylactic reaction in patient with allergy. In this work our aim is to present a case of patient admitted to the Department and Clinic of Allergy, Clinical Immunology and Internal Diseases to diagnose and confirm allergy to shrimp.