Zbigniew Podgajny - Academia.edu (original) (raw)
Papers by Zbigniew Podgajny
Poster: "ECR 2017 / C-2863 / Hodgkin’s lymphoma: Hounsfield units in 18F-FDG-PET/CT are usef... more Poster: "ECR 2017 / C-2863 / Hodgkin’s lymphoma: Hounsfield units in 18F-FDG-PET/CT are useful in evaluating of lymph nodes in children, adolescents with cHL" by: "R. Chaber1, M. Lasecki2, C. M. Olchowy2, O. Koptiuk2, Z. Podgajny2, U. Zaleska-Dorobisz2; 1Rzeszow/PL, 2Wroclaw/PL"
Purpose: We aimed to nd the minimum feasible dose of uorodeoxyglucose (18F-FDG) in positron emiss... more Purpose: We aimed to nd the minimum feasible dose of uorodeoxyglucose (18F-FDG) in positron emission tomography/computed tomography (PET/CT) of Hodgkin lymphoma patients performed on a camera with bismuth germanate (BGO) crystals. Methods: Ninety-one 18F-FDG PET/CT scans with decreasing time per bed position (2 min, 1.5 min, 1 min, 50 sec, 40 sec, 30 sec and 20 sec) were assessed to evaluate image quality. Mean administered dose was 3.0±0.1 MBq/kg and mean uptake time was 54.0±8.7 min. The series quality was subjectively marked in 1-10 scale and then ranked 1-7 based on the mean mark. Interobserver rank correlation and intraclass correlation within each series were calculated. Phantom studies were also performed to determine if reduced acquisition time can be directly translated into a reduced dose. Results: We show the longer the time of acquisition the higher the mark and rank. The interobserver agreement in ranking was 100% with kappa coe cient of 1.00 (95% CI [0.83-1.0]). The general intraclass correlation coe cient was 0.945 (95% CI [0,936-0,952]). Only the series with 2 min and 1.5 min acquisition time were appropriate for assessment (mean mark ≥7). In phantom studies there was a linear correlation between time per bed, administered activity and number of total prompts detected by a scanner. Hence, reduction of acquisition time of 25% (from 2 min to 1.5 min) could be directly translated into a 25% dose reduction (from 3.0 to 2.25 MBq/kg). Conclusions: In patients with HL, 18F-FDG dose can be reduced by up to 25% when using a BGO crystal camera, without substantial impact on image quality.
![Research paper thumbnail of Optimal activity of [18F]FDG for Hodgkin lymphoma imaging performed on PET/CT camera with BGO crystals](https://attachments.academia-assets.com/90277649/thumbnails/1.jpg)
](Nuclear Medicine Review, 2022
Background: We aimed to find the minimum feasible activity of fluorodeoxyglucose ([ 18 F]FDG) in ... more Background: We aimed to find the minimum feasible activity of fluorodeoxyglucose ([ 18 F]FDG) in positron emission tomography/computed tomography (PET/CT) of Hodgkin lymphoma patients performed on a camera with bismuth germanate (BGO) crystals. Material and methods: Ninety-one [ 18 F]FDG PET/CT scans (each in seven Bayesian Penalized Likelihood [BPL] reconstructions with varying acquisition time per bed position-2 min, 1.5 min, 1 min, 50 s, 40 s, 30 s, and 20 s) were independently assessed by three physicians to evaluate image quality. Mean administered activity was 3.0 ± 0.1 MBq/kg and mean uptake time was 54.0 ± 8.7 min. The series quality was subjectively marked on a 1-10 scale and then ranked 1-7 based on the mean mark. Interobserver rank correlation and intraclass correlation within each series for the three observers were calculated. Phantom studies were also performed to determine if reduced acquisition time can be directly translated into a reduced activity. Results: Time series were marked and ranked unanimously-the longer the time of acquisition the higher the mark and rank. The interobserver agreement in the ranking was excellent (100%) with a kappa coefficient of 1.00 (95% CI [0.83-1.0]). The general intraclass correlation coefficient (agreement between the marks observers gave each time series) was very high (0.945, 95% CI [0.936-0.952]) and was higher the shorter the time per bed. According to all three observers only the series with 2 min and 1.5 min acquisition time were appropriate for assessment (mean mark ≥ 7). In phantom studies there was a linear correlation between time per bed, administered activity, and number of total prompts detected by a scanner. Hence, a reduction of acquisition time of 25% (from 2 min to 1.5 min) could be directly translated into a 25% activity reduction (from 3.0 to 2.25 MBq/kg). Conclusions: In patients with HL, [ 18 F]FDG activity can be reduced by up to 25% when using a BGO crystal camera, without substantial impact on image quality.
Pneumonologia I Alergologia Polska, Dec 13, 2012
Wstep. Rak p³uca jest najczestsz± przyczyn± zgonow z powodu nowotworow z³o¶liwych w krajach rozwi... more Wstep. Rak p³uca jest najczestsz± przyczyn± zgonow z powodu nowotworow z³o¶liwych w krajach rozwinietych. Metody diagnostyki obrazowej stanowi± podstawe wczesnego rozpoznania tej choroby. Klasyfikacja TNM jest bardzo wa?nym narzedziem pozwalaj±cym na optymalne postepowanie w niedrobnokomorkowym raku p³uca (NSCLC). Konwencjonalne techniki radiologiczne pozwalaj± na ocene stopnia zaawansowania tylko na podstawie zmian anatomicznych, natomiastpozytonowa tomografia emisyjna skojarzona z tomografi± komputerow± (PET-CT) dostarcza informacji o procesach biochemicznych, mog±cych poprzedzaae zmiany anatomiczne. Celem pracy by³o porownanie dok³adno¶ci i czu³o¶ci CT i PET-CT w ocenie zaawansowania NSCLC. Materia³ i metody. Badanie przeprowadzono w grupie 99 chorych na NSCLC diagnozowanych w Instytucie Gru¼licy i Chorob P³uc w okresie od stycznia 2008 rou do maja 2010 roku. U wszystkich chorych wykonywano badania CT i PET-CT. Testem referencyjnym by³o badanie histologiczne lub cytologiczne materia³u uzyskanego z oligobiopsji, bronchoskopii, mediastinoskopii oraz ¶rodoperacyjnie. Klasyfikacji TNM dokonano niezale?nie po badaniu CT i PET-CT. Wyniki i wnioski. Wykazano, ?e badanie PET-CT jest metod± bardziej dok³adn± i czu³± od CT w ocenie stopnia zaawansowania NSCLC. Badanie PET-CT pozwala na w³a¶ciw± klasyfikacje cech T, N, M i ³±cznie TNM, odpowiednio w: 97%, 95%, 99%, 89% przypadkow; natomiast badanie CT odpowiednio w: 95%, 84%, 84%, 68% (p = 0,0002).
Assessment of recurrence of non-small cell lung cancer after therapy using CT and Integrated PET/... more Assessment of recurrence of non-small cell lung cancer after therapy using CT and Integrated PET/CT Ocena wznowy po leczeniu NDRP przy użyciu TK i PET/CT The authors declare no financial support. Introduction: Non-small cell lung cancer (NSCLC) has become the leading cause of cancer-related deaths in Poland. Follow-up of patients with NSCLC is aimed at early detection of local recurrence, metastatic process, treatment-related complications or second primary lung cancer. We investigated the diagnostic accuracy of FDG-PET-CT in the detection of recurrence of NSCLC after treatment. Material and methods: Seventy-two NSCLC patients (19 females, 56 males), stage I to IV, who had undergone surgery and/ /or radiation therapy, occasionally associated with chemotherapy, were retrospectively included in our study.
Neuro - endocrinology letters, 2015
Ectopic adrenocorticotropic hormone secretion (EAS) is responsible for approximately 10-15% cases... more Ectopic adrenocorticotropic hormone secretion (EAS) is responsible for approximately 10-15% cases of Cushing's syndrome. EAS is associated with various tumors such as small cell lung cancer and well-differentiated bronchial or gastrointestinal neuroendocrine tumors. Hormonal diagnostics include assessments in basic conditions as well as dynamic tests, such as the high-dose dexamethasone suppression test and corticotrophin releasing hormone (CRH) stimulation test. Treatment selection depends on the type of tumor and its extent. In the case of neuroendocrine tumors, the main treatments are surgery and administration of somatostatin analogs that may be additionally radiolabeled for targeted radiotherapy. The tumor histology and the presence and control of hypercortisolemia and metastases are of major importance in prognosis. In this article we presented the principles of modern hormonal and imaging diagnostics techniques as well as the key issues associated with treatment of ACTH-d...
The use of 90Y-PET imaging in evaluation of 90Y-microspheres distribution in the liver: initial r... more The use of 90Y-PET imaging in evaluation of 90Y-microspheres distribution in the liver: initial results
Pneumonologia i alergologia polska, 2013
INTRODUCTION Non-small cell lung cancer (NSCLC) has become the leading cause of cancer-related de... more INTRODUCTION Non-small cell lung cancer (NSCLC) has become the leading cause of cancer-related deaths in Poland. Follow-up of patients with NSCLC is aimed at early detection of local recurrence, metastatic process, treatment-related complications or second primary lung cancer. We investigated the diagnostic accuracy of FDG-PET-CT in the detection of recurrence of NSCLC after treatment. MATERIAL AND METHODS Seventy-two NSCLC patients (19 females, 56 males), stage I to IV, who had undergone surgery and/ /or radiation therapy, occasionally associated with chemotherapy, were retrospectively included in our study. Chest radiographs and thoracic computed tomography (CT) were performed to localize the abnormality prior to PET-CT. All the patients underwent CT and PET-CT in the period from January 2008 until January 2012. All PET images were interpreted in conjunction with thoracic CT. PET-CT and CT diagnoses were correlated with pathological diagnoses. RESULTS Forty-five patients had recur...
Neuro endocrinology letters, 2015
Ectopic adrenocorticotropic hormone secretion (EAS) is responsible for approximately 10-15% cases... more Ectopic adrenocorticotropic hormone secretion (EAS) is responsible for approximately 10-15% cases of Cushing's syndrome. EAS is associated with various tumors such as small cell lung cancer and well-differentiated bronchial or gastrointestinal neuroendocrine tumors. Hormonal diagnostics include assessments in basic conditions as well as dynamic tests, such as the high-dose dexamethasone suppression test and corticotrophin releasing hormone (CRH) stimulation test. Treatment selection depends on the type of tumor and its extent. In the case of neuroendocrine tumors, the main treatments are surgery and administration of somatostatin analogs that may be additionally radiolabeled for targeted radiotherapy. The tumor histology and the presence and control of hypercortisolemia and metastases are of major importance in prognosis. In this article we presented the principles of modern hormonal and imaging diagnostics techniques as well as the key issues associated with treatment of ACTH-d...
![Research paper thumbnail of [Staging of non-small cell lung cancer using CT and integrated PET-CT]](https://attachments.academia-assets.com/77021723/thumbnails/1.jpg)
](Pneumonologia i alergologia polska, 2013
INTRODUCTION Lung cancer is the leading cause of death from cancer in developed countries. Radiol... more INTRODUCTION Lung cancer is the leading cause of death from cancer in developed countries. Radiological imaging methods are the basic methods in early diagnosis of this disease. TNM classification is a very important tool for optimal treatment in non-small lung cancer (NSCLC). Conventional radiological techniques allow the evaluation of the stage on the basis of anatomical changes only, while PET-CT provides information about the biochemical processes that may precede anatomical changes. The aim of this study was to compare the accuracy and sensitivity of CT and PET-CT in the staging of NSCLC. MATERIAL AND METHODS The study was conducted on a group of 99 patients with NSCLC diagnosed at the Institute of Tuberculosis and Lung Diseases in the period from January 2008 to May 2010. CT and PET-CT were performed in all patients. Histological or cytological examination of the material obtained from biopsy, bronchoscopy, mediastinoscopy, and intraoperatively was the reference test. TNM clas...
Polish Archives of Internal Medicine
A 60 years-old male patient with no past medical history and 30 pack-year of smoking reported to ... more A 60 years-old male patient with no past medical history and 30 pack-year of smoking reported to surgical clinic with a result of a routine chest radiograph followed by chest computed tomography (CT) imaging presenting a left lung tumor measuring 25x15mm. Patient noticed neither weight loss nor elevated body temperature in previous months, further physical examination revealed no abnormalities. Positron emission tomography with CT Supplementary material Supplementary material is available at www.mp.pl/paim. Article information Conflict of interest None declared.
Advances in Clinical and Experimental Medicine
Background. The precise identification of the primarily-affected nodal regions in Hodgkin's lymph... more Background. The precise identification of the primarily-affected nodal regions in Hodgkin's lymphoma (HL) is essential in determining the stage of the disease and the intensity of chemotherapy and radiotherapy. Objectives. The aim of this study was to use the degree of X-ray attenuation (XRA) in Hounsfield units (HU) and the lymph node-to-muscle attenuation ratio (LN/M) in computed tomography (CT) unenhanced imaging, routinely performed with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET), to distinguish HL-affected supradiaphragmatic lymph nodes. Material and methods. The study included 52 patients with classical HL treated according to the Eu-roNet-PHL-C1 protocol. Patients received 2 chemotherapy cycles after 18F-FDG-PET/CT testing, followed by re-examination. The lymph nodes were evaluated according to the Society for Pediatric Oncology and Hematology's GPOH-HD-2002 study and Lugano criteria as not-involved (NI-LN) and involved (I-LN). Results. A significant difference (p < 0.001) was found in the XRA and LN/M values between NI-LN and I-LN before treatment and after the 2 chemotherapy cycles. The optimal cutoff point for XRA (44.7 HU) and LN/M (0.79) values distinguishing I-LN from NI-LN nodes was determined by receiver operating characteristic (ROC) analysis. After 2 cycles of chemotherapy, higher XRA (p = 0.002) and LN/M (p = 0.001) values in the group with inadequate early CTx response were found. Conclusions. The use of XRA in HU and LN/M, together with the existing standard, can improve the qualification of supradiaphragmatic lymph nodes in HL.
Poster: "ECR 2017 / C-2863 / Hodgkin’s lymphoma: Hounsfield units in 18F-FDG-PET/CT are usef... more Poster: "ECR 2017 / C-2863 / Hodgkin’s lymphoma: Hounsfield units in 18F-FDG-PET/CT are useful in evaluating of lymph nodes in children, adolescents with cHL" by: "R. Chaber1, M. Lasecki2, C. M. Olchowy2, O. Koptiuk2, Z. Podgajny2, U. Zaleska-Dorobisz2; 1Rzeszow/PL, 2Wroclaw/PL"
Purpose: We aimed to nd the minimum feasible dose of uorodeoxyglucose (18F-FDG) in positron emiss... more Purpose: We aimed to nd the minimum feasible dose of uorodeoxyglucose (18F-FDG) in positron emission tomography/computed tomography (PET/CT) of Hodgkin lymphoma patients performed on a camera with bismuth germanate (BGO) crystals. Methods: Ninety-one 18F-FDG PET/CT scans with decreasing time per bed position (2 min, 1.5 min, 1 min, 50 sec, 40 sec, 30 sec and 20 sec) were assessed to evaluate image quality. Mean administered dose was 3.0±0.1 MBq/kg and mean uptake time was 54.0±8.7 min. The series quality was subjectively marked in 1-10 scale and then ranked 1-7 based on the mean mark. Interobserver rank correlation and intraclass correlation within each series were calculated. Phantom studies were also performed to determine if reduced acquisition time can be directly translated into a reduced dose. Results: We show the longer the time of acquisition the higher the mark and rank. The interobserver agreement in ranking was 100% with kappa coe cient of 1.00 (95% CI [0.83-1.0]). The general intraclass correlation coe cient was 0.945 (95% CI [0,936-0,952]). Only the series with 2 min and 1.5 min acquisition time were appropriate for assessment (mean mark ≥7). In phantom studies there was a linear correlation between time per bed, administered activity and number of total prompts detected by a scanner. Hence, reduction of acquisition time of 25% (from 2 min to 1.5 min) could be directly translated into a 25% dose reduction (from 3.0 to 2.25 MBq/kg). Conclusions: In patients with HL, 18F-FDG dose can be reduced by up to 25% when using a BGO crystal camera, without substantial impact on image quality.
Nuclear Medicine Review, 2022
Background: We aimed to find the minimum feasible activity of fluorodeoxyglucose ([ 18 F]FDG) in ... more Background: We aimed to find the minimum feasible activity of fluorodeoxyglucose ([ 18 F]FDG) in positron emission tomography/computed tomography (PET/CT) of Hodgkin lymphoma patients performed on a camera with bismuth germanate (BGO) crystals. Material and methods: Ninety-one [ 18 F]FDG PET/CT scans (each in seven Bayesian Penalized Likelihood [BPL] reconstructions with varying acquisition time per bed position-2 min, 1.5 min, 1 min, 50 s, 40 s, 30 s, and 20 s) were independently assessed by three physicians to evaluate image quality. Mean administered activity was 3.0 ± 0.1 MBq/kg and mean uptake time was 54.0 ± 8.7 min. The series quality was subjectively marked on a 1-10 scale and then ranked 1-7 based on the mean mark. Interobserver rank correlation and intraclass correlation within each series for the three observers were calculated. Phantom studies were also performed to determine if reduced acquisition time can be directly translated into a reduced activity. Results: Time series were marked and ranked unanimously-the longer the time of acquisition the higher the mark and rank. The interobserver agreement in the ranking was excellent (100%) with a kappa coefficient of 1.00 (95% CI [0.83-1.0]). The general intraclass correlation coefficient (agreement between the marks observers gave each time series) was very high (0.945, 95% CI [0.936-0.952]) and was higher the shorter the time per bed. According to all three observers only the series with 2 min and 1.5 min acquisition time were appropriate for assessment (mean mark ≥ 7). In phantom studies there was a linear correlation between time per bed, administered activity, and number of total prompts detected by a scanner. Hence, a reduction of acquisition time of 25% (from 2 min to 1.5 min) could be directly translated into a 25% activity reduction (from 3.0 to 2.25 MBq/kg). Conclusions: In patients with HL, [ 18 F]FDG activity can be reduced by up to 25% when using a BGO crystal camera, without substantial impact on image quality.
Pneumonologia I Alergologia Polska, Dec 13, 2012
Wstep. Rak p³uca jest najczestsz± przyczyn± zgonow z powodu nowotworow z³o¶liwych w krajach rozwi... more Wstep. Rak p³uca jest najczestsz± przyczyn± zgonow z powodu nowotworow z³o¶liwych w krajach rozwinietych. Metody diagnostyki obrazowej stanowi± podstawe wczesnego rozpoznania tej choroby. Klasyfikacja TNM jest bardzo wa?nym narzedziem pozwalaj±cym na optymalne postepowanie w niedrobnokomorkowym raku p³uca (NSCLC). Konwencjonalne techniki radiologiczne pozwalaj± na ocene stopnia zaawansowania tylko na podstawie zmian anatomicznych, natomiastpozytonowa tomografia emisyjna skojarzona z tomografi± komputerow± (PET-CT) dostarcza informacji o procesach biochemicznych, mog±cych poprzedzaae zmiany anatomiczne. Celem pracy by³o porownanie dok³adno¶ci i czu³o¶ci CT i PET-CT w ocenie zaawansowania NSCLC. Materia³ i metody. Badanie przeprowadzono w grupie 99 chorych na NSCLC diagnozowanych w Instytucie Gru¼licy i Chorob P³uc w okresie od stycznia 2008 rou do maja 2010 roku. U wszystkich chorych wykonywano badania CT i PET-CT. Testem referencyjnym by³o badanie histologiczne lub cytologiczne materia³u uzyskanego z oligobiopsji, bronchoskopii, mediastinoskopii oraz ¶rodoperacyjnie. Klasyfikacji TNM dokonano niezale?nie po badaniu CT i PET-CT. Wyniki i wnioski. Wykazano, ?e badanie PET-CT jest metod± bardziej dok³adn± i czu³± od CT w ocenie stopnia zaawansowania NSCLC. Badanie PET-CT pozwala na w³a¶ciw± klasyfikacje cech T, N, M i ³±cznie TNM, odpowiednio w: 97%, 95%, 99%, 89% przypadkow; natomiast badanie CT odpowiednio w: 95%, 84%, 84%, 68% (p = 0,0002).
Assessment of recurrence of non-small cell lung cancer after therapy using CT and Integrated PET/... more Assessment of recurrence of non-small cell lung cancer after therapy using CT and Integrated PET/CT Ocena wznowy po leczeniu NDRP przy użyciu TK i PET/CT The authors declare no financial support. Introduction: Non-small cell lung cancer (NSCLC) has become the leading cause of cancer-related deaths in Poland. Follow-up of patients with NSCLC is aimed at early detection of local recurrence, metastatic process, treatment-related complications or second primary lung cancer. We investigated the diagnostic accuracy of FDG-PET-CT in the detection of recurrence of NSCLC after treatment. Material and methods: Seventy-two NSCLC patients (19 females, 56 males), stage I to IV, who had undergone surgery and/ /or radiation therapy, occasionally associated with chemotherapy, were retrospectively included in our study.
Neuro - endocrinology letters, 2015
Ectopic adrenocorticotropic hormone secretion (EAS) is responsible for approximately 10-15% cases... more Ectopic adrenocorticotropic hormone secretion (EAS) is responsible for approximately 10-15% cases of Cushing's syndrome. EAS is associated with various tumors such as small cell lung cancer and well-differentiated bronchial or gastrointestinal neuroendocrine tumors. Hormonal diagnostics include assessments in basic conditions as well as dynamic tests, such as the high-dose dexamethasone suppression test and corticotrophin releasing hormone (CRH) stimulation test. Treatment selection depends on the type of tumor and its extent. In the case of neuroendocrine tumors, the main treatments are surgery and administration of somatostatin analogs that may be additionally radiolabeled for targeted radiotherapy. The tumor histology and the presence and control of hypercortisolemia and metastases are of major importance in prognosis. In this article we presented the principles of modern hormonal and imaging diagnostics techniques as well as the key issues associated with treatment of ACTH-d...
The use of 90Y-PET imaging in evaluation of 90Y-microspheres distribution in the liver: initial r... more The use of 90Y-PET imaging in evaluation of 90Y-microspheres distribution in the liver: initial results
Pneumonologia i alergologia polska, 2013
INTRODUCTION Non-small cell lung cancer (NSCLC) has become the leading cause of cancer-related de... more INTRODUCTION Non-small cell lung cancer (NSCLC) has become the leading cause of cancer-related deaths in Poland. Follow-up of patients with NSCLC is aimed at early detection of local recurrence, metastatic process, treatment-related complications or second primary lung cancer. We investigated the diagnostic accuracy of FDG-PET-CT in the detection of recurrence of NSCLC after treatment. MATERIAL AND METHODS Seventy-two NSCLC patients (19 females, 56 males), stage I to IV, who had undergone surgery and/ /or radiation therapy, occasionally associated with chemotherapy, were retrospectively included in our study. Chest radiographs and thoracic computed tomography (CT) were performed to localize the abnormality prior to PET-CT. All the patients underwent CT and PET-CT in the period from January 2008 until January 2012. All PET images were interpreted in conjunction with thoracic CT. PET-CT and CT diagnoses were correlated with pathological diagnoses. RESULTS Forty-five patients had recur...
Neuro endocrinology letters, 2015
Ectopic adrenocorticotropic hormone secretion (EAS) is responsible for approximately 10-15% cases... more Ectopic adrenocorticotropic hormone secretion (EAS) is responsible for approximately 10-15% cases of Cushing's syndrome. EAS is associated with various tumors such as small cell lung cancer and well-differentiated bronchial or gastrointestinal neuroendocrine tumors. Hormonal diagnostics include assessments in basic conditions as well as dynamic tests, such as the high-dose dexamethasone suppression test and corticotrophin releasing hormone (CRH) stimulation test. Treatment selection depends on the type of tumor and its extent. In the case of neuroendocrine tumors, the main treatments are surgery and administration of somatostatin analogs that may be additionally radiolabeled for targeted radiotherapy. The tumor histology and the presence and control of hypercortisolemia and metastases are of major importance in prognosis. In this article we presented the principles of modern hormonal and imaging diagnostics techniques as well as the key issues associated with treatment of ACTH-d...
Pneumonologia i alergologia polska, 2013
INTRODUCTION Lung cancer is the leading cause of death from cancer in developed countries. Radiol... more INTRODUCTION Lung cancer is the leading cause of death from cancer in developed countries. Radiological imaging methods are the basic methods in early diagnosis of this disease. TNM classification is a very important tool for optimal treatment in non-small lung cancer (NSCLC). Conventional radiological techniques allow the evaluation of the stage on the basis of anatomical changes only, while PET-CT provides information about the biochemical processes that may precede anatomical changes. The aim of this study was to compare the accuracy and sensitivity of CT and PET-CT in the staging of NSCLC. MATERIAL AND METHODS The study was conducted on a group of 99 patients with NSCLC diagnosed at the Institute of Tuberculosis and Lung Diseases in the period from January 2008 to May 2010. CT and PET-CT were performed in all patients. Histological or cytological examination of the material obtained from biopsy, bronchoscopy, mediastinoscopy, and intraoperatively was the reference test. TNM clas...
Polish Archives of Internal Medicine
A 60 years-old male patient with no past medical history and 30 pack-year of smoking reported to ... more A 60 years-old male patient with no past medical history and 30 pack-year of smoking reported to surgical clinic with a result of a routine chest radiograph followed by chest computed tomography (CT) imaging presenting a left lung tumor measuring 25x15mm. Patient noticed neither weight loss nor elevated body temperature in previous months, further physical examination revealed no abnormalities. Positron emission tomography with CT Supplementary material Supplementary material is available at www.mp.pl/paim. Article information Conflict of interest None declared.
Advances in Clinical and Experimental Medicine
Background. The precise identification of the primarily-affected nodal regions in Hodgkin's lymph... more Background. The precise identification of the primarily-affected nodal regions in Hodgkin's lymphoma (HL) is essential in determining the stage of the disease and the intensity of chemotherapy and radiotherapy. Objectives. The aim of this study was to use the degree of X-ray attenuation (XRA) in Hounsfield units (HU) and the lymph node-to-muscle attenuation ratio (LN/M) in computed tomography (CT) unenhanced imaging, routinely performed with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET), to distinguish HL-affected supradiaphragmatic lymph nodes. Material and methods. The study included 52 patients with classical HL treated according to the Eu-roNet-PHL-C1 protocol. Patients received 2 chemotherapy cycles after 18F-FDG-PET/CT testing, followed by re-examination. The lymph nodes were evaluated according to the Society for Pediatric Oncology and Hematology's GPOH-HD-2002 study and Lugano criteria as not-involved (NI-LN) and involved (I-LN). Results. A significant difference (p < 0.001) was found in the XRA and LN/M values between NI-LN and I-LN before treatment and after the 2 chemotherapy cycles. The optimal cutoff point for XRA (44.7 HU) and LN/M (0.79) values distinguishing I-LN from NI-LN nodes was determined by receiver operating characteristic (ROC) analysis. After 2 cycles of chemotherapy, higher XRA (p = 0.002) and LN/M (p = 0.001) values in the group with inadequate early CTx response were found. Conclusions. The use of XRA in HU and LN/M, together with the existing standard, can improve the qualification of supradiaphragmatic lymph nodes in HL.