Zehra Baykal - Academia.edu (original) (raw)
Papers by Zehra Baykal
Anatolian Current Medical Journal, Jul 28, 2023
Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective periphe... more Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective peripheral anesthesia methods applied in upper extremity surgery. We aimed to compare these methods in terms of duration of the block and action, first analgesic requirement and side effects. Methods: This prospective, randomized study was conducted for upper extremity surgery. 100 patients were included to perform infraclavicular block (Group 1, n=51) and axillary block (Group 2, n=49) USG guided. Patients are between 19 and 85 years old. Both groups were premedicated with 0.3 mg/kg midazolam or 0.5-1 μg/kg fentanyl. Both groups were treated with a mixture of local anesthetics in a total volume of 30 mL [7.5 mL 0.5% bupivacaine (Bustesin®, 56.25 mg), 7.5 mL 2% prilocaine (Priloc®, 225 mg) and 5 mL saline] was injected. Block placement time, motor and sensory tests, postoperative 2nd, 4th, 8th, 12th. and analgesic requirement at the 24th hour, Bromage scale, Verbal Rating scale, nausea vomiting, patient satisfaction, and block adequacy data were recorded. Results: In this study, 60% of the participants included were male and 40% were female. The systolic, diastolic and mean arterial pressures were higher in group of axillary blockade than those with blockade of infraclavicular blocks. Radial, median, ulnar and musculocutaneous nerve pin-prick test loss and loss of touch test was more frequent in infraclavicular block patients. According to the Bromage scale, the partial block was seen more frequently in patients who had a close block and a full block infraclavicular block. In patients with the axillary blockade, sedoanalgesia and general anesthesia needs after postoperative intraoperative 20 min and postoperative sedoanalgesia was needed. According to the postoperative Bromage scale; complete and close to the thumb and more frequent in infraclavicular block patients. In Postop VRS, it was observed that the patients with the axillary block group had mild, moderate, and severe pain complaints. Patient satisfaction in the postoperative period was similar in both groups. Conclusion: There is no significant difference between these techniques regarding surgical adequacy and subjective postoperative analgesia and dysesthesia. Complete and near-complete block rates in the infraclavicular block approach are minimally higher than in the axillary block approach.
Anatolian Current Medical Journal, Jul 28, 2023
Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective periphe... more Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective peripheral anesthesia methods applied in upper extremity surgery. We aimed to compare these methods in terms of duration of the block and action, first analgesic requirement and side effects. Methods: This prospective, randomized study was conducted for upper extremity surgery. 100 patients were included to perform infraclavicular block (Group 1, n=51) and axillary block (Group 2, n=49) USG guided. Patients are between 19 and 85 years old. Both groups were premedicated with 0.3 mg/kg midazolam or 0.5-1 μg/kg fentanyl. Both groups were treated with a mixture of local anesthetics in a total volume of 30 mL [7.5 mL 0.5% bupivacaine (Bustesin®, 56.25 mg), 7.5 mL 2% prilocaine (Priloc®, 225 mg) and 5 mL saline] was injected. Block placement time, motor and sensory tests, postoperative 2nd, 4th, 8th, 12th. and analgesic requirement at the 24th hour, Bromage scale, Verbal Rating scale, nausea vomiting, patient satisfaction, and block adequacy data were recorded. Results: In this study, 60% of the participants included were male and 40% were female. The systolic, diastolic and mean arterial pressures were higher in group of axillary blockade than those with blockade of infraclavicular blocks. Radial, median, ulnar and musculocutaneous nerve pin-prick test loss and loss of touch test was more frequent in infraclavicular block patients. According to the Bromage scale, the partial block was seen more frequently in patients who had a close block and a full block infraclavicular block. In patients with the axillary blockade, sedoanalgesia and general anesthesia needs after postoperative intraoperative 20 min and postoperative sedoanalgesia was needed. According to the postoperative Bromage scale; complete and close to the thumb and more frequent in infraclavicular block patients. In Postop VRS, it was observed that the patients with the axillary block group had mild, moderate, and severe pain complaints. Patient satisfaction in the postoperative period was similar in both groups. Conclusion: There is no significant difference between these techniques regarding surgical adequacy and subjective postoperative analgesia and dysesthesia. Complete and near-complete block rates in the infraclavicular block approach are minimally higher than in the axillary block approach.
Journal of Contemporary Medicine, 2013
Anatolian Current Medical Journal
Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective periphe... more Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective peripheral anesthesia methods applied in upper extremity surgery. We aimed to compare these methods in terms of duration of the block and action, first analgesic requirement and side effects. Methods: This prospective, randomized study was conducted for upper extremity surgery. 100 patients were included to perform infraclavicular block (Group 1, n=51) and axillary block (Group 2, n=49) USG guided. Patients are between 19 and 85 years old. Both groups were premedicated with 0.3 mg/kg midazolam or 0.5-1 μg/kg fentanyl. Both groups were treated with a mixture of local anesthetics in a total volume of 30 mL [7.5 mL 0.5% bupivacaine (Bustesin®, 56.25 mg), 7.5 mL 2% prilocaine (Priloc®, 225 mg) and 5 mL saline] was injected. Block placement time, motor and sensory tests, postoperative 2nd, 4th, 8th, 12th. and analgesic requirement at the 24th hour, Bromage scale, Verbal Rating scale, nausea vomiting...
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Times; color: #6b6a6a} p.p2 {margin: 0.0px 0.0... more p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Times; color: #6b6a6a} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Helvetica; color: #6b6a6a} span.s1 {font: 8.0px Times} Amac Bu calismada yetiskin yogun bakim unitesindeki (YBU) hastalarda akut bobrek yetmezligi, santral ve periferik venoz basinc olcumleri arasinda herhangi bir iliski olup olmadigini analiz etmeyi amacladik. Gerec ve Yontem Herhangi bir nedenle YBU’de en az 6 gun yatmis 39 hasta (16 K, 73.6 ± 13.9 yas) dahil edildi. Bazal ve gunluk kreatinin degerleri, gunluk sistolik, diyastolik ve ortalama kan basinclari ile santral venoz basinc / periferik venoz basinc (CVP/ PVP) olcumleri kaydedildi. Izlem sirasinda kreatinin duzeylerinde %50’den fazla artis gorulen hastalar, akut bobrek hasari (AKI, n: 12) grubunda, stabil kreatinin degerleri olan hastalar ise no-AKI (n: 27) grup olarak kabul edildi. Bulgular Tum hastalar goz onune alindiginda, PVP ve CVP olcumlerinin pozitif yonde (r: .882, p: 0.0001) korel...
Asian Pacific journal of cancer prevention : APJCP, 2011
Smoking, the most important preventable cause of death overall, is also the leading cause of canc... more Smoking, the most important preventable cause of death overall, is also the leading cause of cancer-related mortality. Tobacco consumption has a direct or indirect relationship with most types of cancer. In Turkey, the second leading cause of death is cancer, with lung cancer the most prevalent. The aim of this study was to determine the level of cigarette dependence among men and women aged 50+, living in Izmir. This research is a descriptive and cross-sectional field study, carried out with the participation of a total of 2,497 subjects. It was found that 48.8% of the participants used to be smokers, and 95.5% of the smoking participants had been smoking for at least 11 years at the time of study. 36.1% of the participants were being exposed to secondhand smoke at home, and almost one third of the smokers (29%) had a moderate level of dependence. Continuing education may help high-risk groups develop good habits for a healthier lifestyle such as smoking less and quitting smoking, ...
Purpose: We aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analge... more Purpose: We aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analgesic requirements, postroperative cortisol and prolactin levels. Material and Methods: Sixty patients have been included. Study groups were as follows; 1: Esmolol infusion was added to propofol and remifentanil, 2: Only propofol and remifentanil, 3: Esmolol infusion was added to desflurane and remifentanil, 4: Only desflurane and remifentanil was used. Preoperative and postoperative cortisol and prolactin levels were measured. Results: Analgesic requirements were significantly lower in group 1 and was lower in group 3 compared to group 4. Heart rates were significantly lower in esmolol groups (group 1 and 3) compared to their controls. Prolactin levels significantly increased postoperatively in all groups compared to preoperative levels. We observed a significant decrease in cortisol levels postoperatively in group 1 compared to preoperative levels. Conclusion: Using adjuvant esmolol duri...
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Times; color: #6b6a6a} p.p2 {margin: 0.0px 0.0... more p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Times; color: #6b6a6a} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Helvetica; color: #6b6a6a} span.s1 {font: 8.0px Times} Amac Bu calismada yetiskin yogun bakim unitesindeki (YBU) hastalarda akut bobrek yetmezligi, santral ve periferik venoz basinc olcumleri arasinda herhangi bir iliski olup olmadigini analiz etmeyi amacladik. Gerec ve Yontem Herhangi bir nedenle YBU’de en az 6 gun yatmis 39 hasta (16 K, 73.6 ± 13.9 yas) dahil edildi. Bazal ve gunluk kreatinin degerleri, gunluk sistolik, diyastolik ve ortalama kan basinclari ile santral venoz basinc / periferik venoz basinc (CVP/ PVP) olcumleri kaydedildi. Izlem sirasinda kreatinin duzeylerinde %50’den fazla artis gorulen hastalar, akut bobrek hasari (AKI, n: 12) grubunda, stabil kreatinin degerleri olan hastalar ise no-AKI (n: 27) grup olarak kabul edildi. Bulgular Tum hastalar goz onune alindiginda, PVP ve CVP olcumlerinin pozitif yonde (r: .882, p: 0.0001) korel...
Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi), 2017
We aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analgesic requi... more We aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analgesic requirements, postroperative cortisol and prolactin levels. Material and Methods: Sixty patients have been included. Study groups were as follows; 1: Esmolol infusion was added to propofol and remifentanil, 2: Only propofol and remifentanil, 3: Esmolol infusion was added to desflurane and remifentanil, 4: Only desflurane and remifentanil was used. Preoperative and postoperative cortisol and prolactin levels were measured. Results: Analgesic requirements were significantly lower in group 1 and was lower in group 3 compared to group 4. Heart rates were significantly lower in esmolol groups (group 1 and 3) compared to their controls. Prolactin levels significantly increased postoperatively in all groups compared to preoperative levels. We observed a significant decrease in cortisol levels postoperatively in group 1 compared to preoperative levels. Conclusion: Using adjuvant esmolol during anesthetic maintenance of laparoscopic cholecystectomy patients decreases anesthetic-analgesic requirements without causing any hemodynamic instability, and supresses postoperative cortisol response but does not have any significant effect on postoperative prolactin response. Amaç: Çalışmada esmololün intraoperatif anestezikpostoperatif analjezik gereksinimi, postoperatif kortizol ve prolaktin düzeylerine etkisini araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya 60 hasta dahil edilmiştir. Çalışma grupları şu şekilde dizayn edildi; 1: Esmolol infüzyonuna propofol ve remifentanil eklendi, 2: Sadece propofol ve remifentanil, 3: Esmolol infüzyonuna desfluran ve remifentanil eklendi, 4: Sadece desfluran ve remifentanil kullanıldı. Ameliyat öncesi ve sonrası kortizol ve prolaktin seviyeleri ölçüldü. Bulgular: Analjezik gereksinimi tüm gruplar içinde grup 1'de anlamlı olarak düşüktü ve grup 4 ile karşılaştırıldığında grup 3'te düşük bulundu. Kalp hızı esmolol gruplarında (grup 1 ve 3) kontrol gruplarına göre anlamlı olarak daha düşüktü. Prolaktin düzeyleri bütün gruplarda preoperatif değerlere göre postoperatif dönemde anlamlı yüksek bulundu. Ameliyat öncesi seviyelere ile karşılaştırıldığında postoperatif kortizol düzeylerinde grup 1de anlamlı bir azalma gözlendi. Sonuç: Laparoskopik kolesistektomi hastalarında anestezi yönetiminde adjuvan esmolol kullanımı herhangi bir hemodinamik instabiliteye neden olmadan anestezikanaljezik gereksinimini azaltıp postoperatif kortizol yanıtı baskılarken ameliyat sonrası prolaktin yanıtı üzerinde önemli bir etkisi yoktur.
Anatolian Current Medical Journal, Jul 28, 2023
Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective periphe... more Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective peripheral anesthesia methods applied in upper extremity surgery. We aimed to compare these methods in terms of duration of the block and action, first analgesic requirement and side effects. Methods: This prospective, randomized study was conducted for upper extremity surgery. 100 patients were included to perform infraclavicular block (Group 1, n=51) and axillary block (Group 2, n=49) USG guided. Patients are between 19 and 85 years old. Both groups were premedicated with 0.3 mg/kg midazolam or 0.5-1 μg/kg fentanyl. Both groups were treated with a mixture of local anesthetics in a total volume of 30 mL [7.5 mL 0.5% bupivacaine (Bustesin®, 56.25 mg), 7.5 mL 2% prilocaine (Priloc®, 225 mg) and 5 mL saline] was injected. Block placement time, motor and sensory tests, postoperative 2nd, 4th, 8th, 12th. and analgesic requirement at the 24th hour, Bromage scale, Verbal Rating scale, nausea vomiting, patient satisfaction, and block adequacy data were recorded. Results: In this study, 60% of the participants included were male and 40% were female. The systolic, diastolic and mean arterial pressures were higher in group of axillary blockade than those with blockade of infraclavicular blocks. Radial, median, ulnar and musculocutaneous nerve pin-prick test loss and loss of touch test was more frequent in infraclavicular block patients. According to the Bromage scale, the partial block was seen more frequently in patients who had a close block and a full block infraclavicular block. In patients with the axillary blockade, sedoanalgesia and general anesthesia needs after postoperative intraoperative 20 min and postoperative sedoanalgesia was needed. According to the postoperative Bromage scale; complete and close to the thumb and more frequent in infraclavicular block patients. In Postop VRS, it was observed that the patients with the axillary block group had mild, moderate, and severe pain complaints. Patient satisfaction in the postoperative period was similar in both groups. Conclusion: There is no significant difference between these techniques regarding surgical adequacy and subjective postoperative analgesia and dysesthesia. Complete and near-complete block rates in the infraclavicular block approach are minimally higher than in the axillary block approach.
Anatolian Current Medical Journal, Jul 28, 2023
Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective periphe... more Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective peripheral anesthesia methods applied in upper extremity surgery. We aimed to compare these methods in terms of duration of the block and action, first analgesic requirement and side effects. Methods: This prospective, randomized study was conducted for upper extremity surgery. 100 patients were included to perform infraclavicular block (Group 1, n=51) and axillary block (Group 2, n=49) USG guided. Patients are between 19 and 85 years old. Both groups were premedicated with 0.3 mg/kg midazolam or 0.5-1 μg/kg fentanyl. Both groups were treated with a mixture of local anesthetics in a total volume of 30 mL [7.5 mL 0.5% bupivacaine (Bustesin®, 56.25 mg), 7.5 mL 2% prilocaine (Priloc®, 225 mg) and 5 mL saline] was injected. Block placement time, motor and sensory tests, postoperative 2nd, 4th, 8th, 12th. and analgesic requirement at the 24th hour, Bromage scale, Verbal Rating scale, nausea vomiting, patient satisfaction, and block adequacy data were recorded. Results: In this study, 60% of the participants included were male and 40% were female. The systolic, diastolic and mean arterial pressures were higher in group of axillary blockade than those with blockade of infraclavicular blocks. Radial, median, ulnar and musculocutaneous nerve pin-prick test loss and loss of touch test was more frequent in infraclavicular block patients. According to the Bromage scale, the partial block was seen more frequently in patients who had a close block and a full block infraclavicular block. In patients with the axillary blockade, sedoanalgesia and general anesthesia needs after postoperative intraoperative 20 min and postoperative sedoanalgesia was needed. According to the postoperative Bromage scale; complete and close to the thumb and more frequent in infraclavicular block patients. In Postop VRS, it was observed that the patients with the axillary block group had mild, moderate, and severe pain complaints. Patient satisfaction in the postoperative period was similar in both groups. Conclusion: There is no significant difference between these techniques regarding surgical adequacy and subjective postoperative analgesia and dysesthesia. Complete and near-complete block rates in the infraclavicular block approach are minimally higher than in the axillary block approach.
Journal of Contemporary Medicine, 2013
Anatolian Current Medical Journal
Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective periphe... more Aims: Infraclavicular and axillary block performed with ultrasound guidance are effective peripheral anesthesia methods applied in upper extremity surgery. We aimed to compare these methods in terms of duration of the block and action, first analgesic requirement and side effects. Methods: This prospective, randomized study was conducted for upper extremity surgery. 100 patients were included to perform infraclavicular block (Group 1, n=51) and axillary block (Group 2, n=49) USG guided. Patients are between 19 and 85 years old. Both groups were premedicated with 0.3 mg/kg midazolam or 0.5-1 μg/kg fentanyl. Both groups were treated with a mixture of local anesthetics in a total volume of 30 mL [7.5 mL 0.5% bupivacaine (Bustesin®, 56.25 mg), 7.5 mL 2% prilocaine (Priloc®, 225 mg) and 5 mL saline] was injected. Block placement time, motor and sensory tests, postoperative 2nd, 4th, 8th, 12th. and analgesic requirement at the 24th hour, Bromage scale, Verbal Rating scale, nausea vomiting...
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Times; color: #6b6a6a} p.p2 {margin: 0.0px 0.0... more p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Times; color: #6b6a6a} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Helvetica; color: #6b6a6a} span.s1 {font: 8.0px Times} Amac Bu calismada yetiskin yogun bakim unitesindeki (YBU) hastalarda akut bobrek yetmezligi, santral ve periferik venoz basinc olcumleri arasinda herhangi bir iliski olup olmadigini analiz etmeyi amacladik. Gerec ve Yontem Herhangi bir nedenle YBU’de en az 6 gun yatmis 39 hasta (16 K, 73.6 ± 13.9 yas) dahil edildi. Bazal ve gunluk kreatinin degerleri, gunluk sistolik, diyastolik ve ortalama kan basinclari ile santral venoz basinc / periferik venoz basinc (CVP/ PVP) olcumleri kaydedildi. Izlem sirasinda kreatinin duzeylerinde %50’den fazla artis gorulen hastalar, akut bobrek hasari (AKI, n: 12) grubunda, stabil kreatinin degerleri olan hastalar ise no-AKI (n: 27) grup olarak kabul edildi. Bulgular Tum hastalar goz onune alindiginda, PVP ve CVP olcumlerinin pozitif yonde (r: .882, p: 0.0001) korel...
Asian Pacific journal of cancer prevention : APJCP, 2011
Smoking, the most important preventable cause of death overall, is also the leading cause of canc... more Smoking, the most important preventable cause of death overall, is also the leading cause of cancer-related mortality. Tobacco consumption has a direct or indirect relationship with most types of cancer. In Turkey, the second leading cause of death is cancer, with lung cancer the most prevalent. The aim of this study was to determine the level of cigarette dependence among men and women aged 50+, living in Izmir. This research is a descriptive and cross-sectional field study, carried out with the participation of a total of 2,497 subjects. It was found that 48.8% of the participants used to be smokers, and 95.5% of the smoking participants had been smoking for at least 11 years at the time of study. 36.1% of the participants were being exposed to secondhand smoke at home, and almost one third of the smokers (29%) had a moderate level of dependence. Continuing education may help high-risk groups develop good habits for a healthier lifestyle such as smoking less and quitting smoking, ...
Purpose: We aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analge... more Purpose: We aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analgesic requirements, postroperative cortisol and prolactin levels. Material and Methods: Sixty patients have been included. Study groups were as follows; 1: Esmolol infusion was added to propofol and remifentanil, 2: Only propofol and remifentanil, 3: Esmolol infusion was added to desflurane and remifentanil, 4: Only desflurane and remifentanil was used. Preoperative and postoperative cortisol and prolactin levels were measured. Results: Analgesic requirements were significantly lower in group 1 and was lower in group 3 compared to group 4. Heart rates were significantly lower in esmolol groups (group 1 and 3) compared to their controls. Prolactin levels significantly increased postoperatively in all groups compared to preoperative levels. We observed a significant decrease in cortisol levels postoperatively in group 1 compared to preoperative levels. Conclusion: Using adjuvant esmolol duri...
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Times; color: #6b6a6a} p.p2 {margin: 0.0px 0.0... more p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Times; color: #6b6a6a} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; font: 8.0px Helvetica; color: #6b6a6a} span.s1 {font: 8.0px Times} Amac Bu calismada yetiskin yogun bakim unitesindeki (YBU) hastalarda akut bobrek yetmezligi, santral ve periferik venoz basinc olcumleri arasinda herhangi bir iliski olup olmadigini analiz etmeyi amacladik. Gerec ve Yontem Herhangi bir nedenle YBU’de en az 6 gun yatmis 39 hasta (16 K, 73.6 ± 13.9 yas) dahil edildi. Bazal ve gunluk kreatinin degerleri, gunluk sistolik, diyastolik ve ortalama kan basinclari ile santral venoz basinc / periferik venoz basinc (CVP/ PVP) olcumleri kaydedildi. Izlem sirasinda kreatinin duzeylerinde %50’den fazla artis gorulen hastalar, akut bobrek hasari (AKI, n: 12) grubunda, stabil kreatinin degerleri olan hastalar ise no-AKI (n: 27) grup olarak kabul edildi. Bulgular Tum hastalar goz onune alindiginda, PVP ve CVP olcumlerinin pozitif yonde (r: .882, p: 0.0001) korel...
Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi), 2017
We aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analgesic requi... more We aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analgesic requirements, postroperative cortisol and prolactin levels. Material and Methods: Sixty patients have been included. Study groups were as follows; 1: Esmolol infusion was added to propofol and remifentanil, 2: Only propofol and remifentanil, 3: Esmolol infusion was added to desflurane and remifentanil, 4: Only desflurane and remifentanil was used. Preoperative and postoperative cortisol and prolactin levels were measured. Results: Analgesic requirements were significantly lower in group 1 and was lower in group 3 compared to group 4. Heart rates were significantly lower in esmolol groups (group 1 and 3) compared to their controls. Prolactin levels significantly increased postoperatively in all groups compared to preoperative levels. We observed a significant decrease in cortisol levels postoperatively in group 1 compared to preoperative levels. Conclusion: Using adjuvant esmolol during anesthetic maintenance of laparoscopic cholecystectomy patients decreases anesthetic-analgesic requirements without causing any hemodynamic instability, and supresses postoperative cortisol response but does not have any significant effect on postoperative prolactin response. Amaç: Çalışmada esmololün intraoperatif anestezikpostoperatif analjezik gereksinimi, postoperatif kortizol ve prolaktin düzeylerine etkisini araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya 60 hasta dahil edilmiştir. Çalışma grupları şu şekilde dizayn edildi; 1: Esmolol infüzyonuna propofol ve remifentanil eklendi, 2: Sadece propofol ve remifentanil, 3: Esmolol infüzyonuna desfluran ve remifentanil eklendi, 4: Sadece desfluran ve remifentanil kullanıldı. Ameliyat öncesi ve sonrası kortizol ve prolaktin seviyeleri ölçüldü. Bulgular: Analjezik gereksinimi tüm gruplar içinde grup 1'de anlamlı olarak düşüktü ve grup 4 ile karşılaştırıldığında grup 3'te düşük bulundu. Kalp hızı esmolol gruplarında (grup 1 ve 3) kontrol gruplarına göre anlamlı olarak daha düşüktü. Prolaktin düzeyleri bütün gruplarda preoperatif değerlere göre postoperatif dönemde anlamlı yüksek bulundu. Ameliyat öncesi seviyelere ile karşılaştırıldığında postoperatif kortizol düzeylerinde grup 1de anlamlı bir azalma gözlendi. Sonuç: Laparoskopik kolesistektomi hastalarında anestezi yönetiminde adjuvan esmolol kullanımı herhangi bir hemodinamik instabiliteye neden olmadan anestezikanaljezik gereksinimini azaltıp postoperatif kortizol yanıtı baskılarken ameliyat sonrası prolaktin yanıtı üzerinde önemli bir etkisi yoktur.