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Papers by Zhalaliddin Makhammajanov

Nephrology, dialysis, transplantation/Nephrology dialysis transplantation, May 1, 2024

Nephrology Dialysis Transplantation, Oct 2, 2023

European Journal of Public Health

Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. The seasonal autoregress... more Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. The seasonal autoregressive integrated moving average (SARIMA) model is widely used for forecasting infectious disease incidence, including TB. However, there is a lack of comprehensive research on TB epidemiology and predictions for the future in Kazakhstan. Therefore, this study adopted a time series analysis of 72 monthly observations of reported TB cases in Kazakhstan from 2014-2019. The study used monthly health data from 2014-2019 for TB cases obtained from large-scale administrative records. The methodology involved using the Augmented Dickey-Fuller test for determining stationarity, ACF and PACF for identifying model parameters, and AIC/BIC for selecting the best SARIMA model, which was evaluated based on R2 score, MAE, and MAPE. The modeling dataset comprised monthly TB notification rates from 2014 to 2018, while the forecasting dataset comprised data from 2019. The findings suggest that the SARIMA mod...

Scientific reports, Jun 18, 2024

Proteinuria poses a substantial risk for the progression of chronic kidney disease (CKD) and its ... more Proteinuria poses a substantial risk for the progression of chronic kidney disease (CKD) and its related complications. Kidneys excrete hundreds of individual proteins, some with a potential impact on CKD progression or as a marker of the disease. However, the available data on specific urinary proteins and their relationship with CKD severity remain limited. Therefore, we aimed to investigate the urinary proteome and its association with kidney function in CKD patients and healthy controls. The proteomic analysis of urine samples showed CKD stage-specific differences in the number of detected proteins and the exponentially modified protein abundance index for total protein (p = 0.007). Notably, specific urinary proteins such as B2MG, FETUA, VTDB, and AMBP exhibited robust negative associations with kidney function in CKD patients compared to controls. Also, A1AG2, CD44, CD59, CERU, KNG1, LV39, OSTP, RNAS1, SH3L3, and UROM proteins showed positive associations with kidney function in the entire cohort, while LV39, A1BG, and CERU consistently displayed positive associations in patients compared to controls. This study suggests that specific urinary proteins, which were found to be negatively or positively associated with the kidney function of CKD patients, can serve as markers of dysfunctional or functional kidneys, respectively.

Kidney International Reports, 2022

Diagnostics

Proteinuria is a risk factor for chronic kidney disease (CKD) progression and associated complica... more Proteinuria is a risk factor for chronic kidney disease (CKD) progression and associated complications. However, there is insufficient information on individual protein components in urine and the severity of CKD. We aimed to investigate urinary proteomics and its association with proteinuria and kidney function in early-stage CKD and in healthy individuals. A 24 h urine sample of 42 individuals (21-CKD and 21-healthy individuals) was used for mass spectrometry-based proteomics analysis. An exponentially modified protein abundance index (emPAI) was calculated for each protein. Data were analyzed by Mascot software using the SwissProt database and bioinformatics tools. Overall, 298 unique proteins were identified in the cohort; of them, 250 proteins belong to the control group with median (IQR) emPAI 39.1 (19–53) and 142 proteins belong to the CKD group with median (IQR) emPAI 67.8 (49–117). The level of 24 h proteinuria positively correlated with emPAI (r = 0.390, p = 0.011). The em...

Journal of Clinical Medicine of Kazakhstan

Background: According to the National infectious disease monitoring report, there is a fluctuatin... more Background: According to the National infectious disease monitoring report, there is a fluctuating pattern of incidence of chickenpox in the country, but there are no studies reporting the epidemiological situation in Kazakhstan. There is a discernable association of varicella epidemiology with climate, particularly temperature dependency. We aimed to analyze the incidence and seasonality of chickenpox in the absence of universal varicella vaccination in Kazakhstan. Material and methods: A retrospective analysis of the long-term dynamics of chickenpox was carried out, and data he state report "Sanitary and epidemiological situation in the Republic of Kazakhstan for 2020" and data from the Unified Payment System (UPS) from 2014 to 2020 were used. of registered patients between 2010 and 2020 were retrieved from the National infectious disease monitoring report and the Unified Payment System (UPS) database from 2014 to 2020, which is part of the Unified National Electronic He...

Electronic Journal of General Medicine

Background: Vaccine-preventable diseases such as pertussis, measles, and influenza remain among t... more Background: Vaccine-preventable diseases such as pertussis, measles, and influenza remain among the most significant medical and socioeconomic issues in Kazakhstan, despite significant vaccination achievements. Thus, here we aimed to analyze the long-term dynamics and provide information on the current epidemiology of pertussis, measles, and influenza in Kazakhstan. Methods: A retrospective analysis of the long-term dynamics of infectious diseases was carried out using the data from the statistical collections for 2010-2020 and the Unified Payment System from 2014 to 2020. Results: During the 2010-2020 years, the long-term dynamics show an unequal distribution of pertussis, measles, and influenza-related morbidity. In comparison with earlier years, registration of infectious disease was the highest in 2019 and 2020. The incidence cases among registered infectious diseases in 2019 were: pertussis-147, measles-13,326, and in 2020: influenza-2,678. High incidence rates have been docume...