Zhenduo Yang - Academia.edu (original) (raw)

Papers by Zhenduo Yang

Research paper thumbnail of DeepFundus: A flow-cytometry-like image quality classifier for boosting the whole life cycle of medical artificial intelligence

Research paper thumbnail of Tracer study of curcumin nanoparticles on human retinal pigment epithelial cells

DOAJ (DOAJ: Directory of Open Access Journals), Mar 1, 2022

Research paper thumbnail of Long-Term Clinical Outcomes of Small-Incision Femtosecond Laser-Assisted Intracorneal Concave Lenticule Implantation in Patients with Keratoconus

Journal of Ophthalmology, 2022

Purpose. The purpose of this study was to evaluate the long-term prognosis of small-incision femt... more Purpose. The purpose of this study was to evaluate the long-term prognosis of small-incision femtosecond laser-assisted intracorneal concave lenticule implantation (SFII) in correction of human keratoconus. Methods. This was a prospective study for 11 patients who received SFII after being diagnosed as progressive keratoconus based on the Amsler–Krumeich classification system. Clinical assessment was performed for all the patients prior to and postsurgically at different time points for 5 years. These included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), biomechanically corrected intraocular pressure (bIOP), corneal topography, anterior segment optical coherence tomography (AS-OCT), confocal microscopy, and biomechanical assessment with Corvis ST. Results. Comparison of preoperative and 60-month postoperative UDVA and CDVA ( P 60 months = 0.081 and 0.001, respectively), all eyes showed an improvement in CDVA. Corneal topography showed no signif...

Research paper thumbnail of Comparison of corneal biological parameters between transepithelial and epithelium-off corneal cross-linking in keratoconus

International journal of ophthalmology, 2021

AIM To evaluate the differences in corneal biological parameters between transepithelial and epit... more AIM To evaluate the differences in corneal biological parameters between transepithelial and epithelium-off corneal cross-linking in keratoconus. METHODS In our prospective clinical trial, 40 patients (60 eyes) with progressive keratoconus were randomized to undergo corneal cross-linking with transepithelial (TE group, n=30) or epithelium-off (EO group, n=30) keratoconus. Examinations comprised topography, corneal biomechanical analysis and specular microscopy at 6mo postoperatively. RESULTS The keratometer values were not significantly different between the TE and EO corneal cross-linked groups in different periods (each P>0.05). The corneal thickness of the EO group was greater than that of the TE group at 1wk after the operation (each P<0.05). Regarding corneal biomechanical responses, the EO group showed a longer second applanation length than TE group (P=0.003). Regarding the corneal endothelial function, standard deviation of the endothelial cell size, and coefficient of...

Research paper thumbnail of Comparison of Short-Term Changes in Dry Eye Indexes between Femtosecond Lenticule Extraction and Small Incision Lenticule Extraction

Chinese Journal of Optometry & Ophthalmology, 2018

Objective: To compare early changes in dry eye after femtosecond lenticule extraction (FLEx) and ... more Objective: To compare early changes in dry eye after femtosecond lenticule extraction (FLEx) and small incision lenticule extraction (SMILE). Methods: Twenty-eight subjects (56 eyes) underwent FLEx and 33 subjects (66 eyes) underwent SMILE in this prospective non-randomized study at the Refractive Center of Hainan Eye Hospital and Key Laboratory of Ophthalmology from February to October 2014. Ocular surface disease index (OSDI), Schirmer Ⅰ test (SⅠT), noninvasive tear breakup time (NIBUT), and tear meniscus height (TMH) were evaluated at 1 day, 1 week and 1 month after surgery but corneal fluorescein staining (FL) was measured only at 1 week and 1 month postoperatively in all patients. Concentrations of interleukin-1α (IL-1α) and tumor necrosis factor-α (TNF-α) in collected tears were assessed by multiplex antibody microarray at 1 day, 1 week and 1 month after surgery in both groups. Data were analyzed using repented measured ANOVA. Results: The NIBUT of the FLEx group was shorter t...

Research paper thumbnail of Effect of corneal stromal pocket irrigation in small-incision lenticule extraction

Eye, 2020

Objectives To investigate the effect of corneal stromal pocket irrigation after small-incision le... more Objectives To investigate the effect of corneal stromal pocket irrigation after small-incision lenticule extraction (SMILE) on visual acuity, intraocular pressure (IOP), corneal parameters and complications after surgery. Methods A total of 242 eyes of 121 patients undergoing SMILE were enrolled in this prospective controlled study, and it was designed for one eye to randomly undergo SMILE with balanced salt solution irrigation of the corneal stromal pocket, while the other eye was not. The uncorrected distance visual acuity (UDVA) and slit lamp examination were recorded at 1 hour, 1 day, 1 week, and 1 month. Postoperative corneal density, corneal biomechanical, corneal endothelial cell number, and anterior OCT images were compared at 1 day, 1 week, and 1 month. Results Compared with the nonirrigation group, the irrigation group showed significantly higher UDVA at 1 day postoperatively (P < 0.05), but there was no significant difference during the rest of the postoperative period...

Research paper thumbnail of DeepFundus: A flow-cytometry-like image quality classifier for boosting the whole life cycle of medical artificial intelligence

Research paper thumbnail of Tracer study of curcumin nanoparticles on human retinal pigment epithelial cells

DOAJ (DOAJ: Directory of Open Access Journals), Mar 1, 2022

Research paper thumbnail of Long-Term Clinical Outcomes of Small-Incision Femtosecond Laser-Assisted Intracorneal Concave Lenticule Implantation in Patients with Keratoconus

Journal of Ophthalmology, 2022

Purpose. The purpose of this study was to evaluate the long-term prognosis of small-incision femt... more Purpose. The purpose of this study was to evaluate the long-term prognosis of small-incision femtosecond laser-assisted intracorneal concave lenticule implantation (SFII) in correction of human keratoconus. Methods. This was a prospective study for 11 patients who received SFII after being diagnosed as progressive keratoconus based on the Amsler–Krumeich classification system. Clinical assessment was performed for all the patients prior to and postsurgically at different time points for 5 years. These included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), biomechanically corrected intraocular pressure (bIOP), corneal topography, anterior segment optical coherence tomography (AS-OCT), confocal microscopy, and biomechanical assessment with Corvis ST. Results. Comparison of preoperative and 60-month postoperative UDVA and CDVA ( P 60 months = 0.081 and 0.001, respectively), all eyes showed an improvement in CDVA. Corneal topography showed no signif...

Research paper thumbnail of Comparison of corneal biological parameters between transepithelial and epithelium-off corneal cross-linking in keratoconus

International journal of ophthalmology, 2021

AIM To evaluate the differences in corneal biological parameters between transepithelial and epit... more AIM To evaluate the differences in corneal biological parameters between transepithelial and epithelium-off corneal cross-linking in keratoconus. METHODS In our prospective clinical trial, 40 patients (60 eyes) with progressive keratoconus were randomized to undergo corneal cross-linking with transepithelial (TE group, n=30) or epithelium-off (EO group, n=30) keratoconus. Examinations comprised topography, corneal biomechanical analysis and specular microscopy at 6mo postoperatively. RESULTS The keratometer values were not significantly different between the TE and EO corneal cross-linked groups in different periods (each P>0.05). The corneal thickness of the EO group was greater than that of the TE group at 1wk after the operation (each P<0.05). Regarding corneal biomechanical responses, the EO group showed a longer second applanation length than TE group (P=0.003). Regarding the corneal endothelial function, standard deviation of the endothelial cell size, and coefficient of...

Research paper thumbnail of Comparison of Short-Term Changes in Dry Eye Indexes between Femtosecond Lenticule Extraction and Small Incision Lenticule Extraction

Chinese Journal of Optometry & Ophthalmology, 2018

Objective: To compare early changes in dry eye after femtosecond lenticule extraction (FLEx) and ... more Objective: To compare early changes in dry eye after femtosecond lenticule extraction (FLEx) and small incision lenticule extraction (SMILE). Methods: Twenty-eight subjects (56 eyes) underwent FLEx and 33 subjects (66 eyes) underwent SMILE in this prospective non-randomized study at the Refractive Center of Hainan Eye Hospital and Key Laboratory of Ophthalmology from February to October 2014. Ocular surface disease index (OSDI), Schirmer Ⅰ test (SⅠT), noninvasive tear breakup time (NIBUT), and tear meniscus height (TMH) were evaluated at 1 day, 1 week and 1 month after surgery but corneal fluorescein staining (FL) was measured only at 1 week and 1 month postoperatively in all patients. Concentrations of interleukin-1α (IL-1α) and tumor necrosis factor-α (TNF-α) in collected tears were assessed by multiplex antibody microarray at 1 day, 1 week and 1 month after surgery in both groups. Data were analyzed using repented measured ANOVA. Results: The NIBUT of the FLEx group was shorter t...

Research paper thumbnail of Effect of corneal stromal pocket irrigation in small-incision lenticule extraction

Eye, 2020

Objectives To investigate the effect of corneal stromal pocket irrigation after small-incision le... more Objectives To investigate the effect of corneal stromal pocket irrigation after small-incision lenticule extraction (SMILE) on visual acuity, intraocular pressure (IOP), corneal parameters and complications after surgery. Methods A total of 242 eyes of 121 patients undergoing SMILE were enrolled in this prospective controlled study, and it was designed for one eye to randomly undergo SMILE with balanced salt solution irrigation of the corneal stromal pocket, while the other eye was not. The uncorrected distance visual acuity (UDVA) and slit lamp examination were recorded at 1 hour, 1 day, 1 week, and 1 month. Postoperative corneal density, corneal biomechanical, corneal endothelial cell number, and anterior OCT images were compared at 1 day, 1 week, and 1 month. Results Compared with the nonirrigation group, the irrigation group showed significantly higher UDVA at 1 day postoperatively (P < 0.05), but there was no significant difference during the rest of the postoperative period...