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Papers by Gerd Zimmermann

Research paper thumbnail of Pyridine and pyridazine derivatives, processes for the production thereof and pharmaceutical agents containing these compounds

Research paper thumbnail of A Wireless Communications System with Detection of Foreign Radiation Sources

Research paper thumbnail of Phospholipid derivatives of phosphono-carboxylic acids, the production of said derivatives and the use of said derivatives as antiviral medicaments

Research paper thumbnail of N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents

Research paper thumbnail of Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments

Research paper thumbnail of New Derivatives of Pyridil Piperazine or Pyridazinyl Piperazyl, Process for Production Thereof and Medicaments Containing These Compounds

Research paper thumbnail of Method and apparatus for selection of frequency reusage in cellular communication systems

Research paper thumbnail of Interference Measurements in a Wireless Communications System

Research paper thumbnail of System for accessing information and for communication in a vehicle having a plurality of coupled units

Research paper thumbnail of Crank-Angle Resolved Temperature in SI Engines Measured by Emission-Absorption Spectroscopy

SAE Technical Paper Series, 1999

... Date Published: 1999-10-25. Paper Number: 1999-01-3542. DOI: 10.4271/1999-01-3542. Author(s):... more ... Date Published: 1999-10-25. Paper Number: 1999-01-3542. DOI: 10.4271/1999-01-3542. Author(s): Volker Aust - Fraunhofer EMI Gerd Zimmermann - Fraunhofer EMI Peter-Wolfgang Manz - Volkswagen AG Werner Hentschel - Volkswagen AG. Abstract. ...

Research paper thumbnail of The Development of the Regulatory Process in Europe for Biological Medicines: How it Affects Gene Therapy Products

Gene Therapy Technologies, Applications and Regulations, 1999

ABSTRACT

Research paper thumbnail of Quality assurance of biologics and conclusions to be drawn for gene therapy products

The Quality Assurance Journal, 1997

Research paper thumbnail of Research on MMP Inhibitors with Unusual Scaffolds

Matrix Metalloproteinase Inhibitors in Cancer Therapy, 2000

Research paper thumbnail of Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Journal of Medicinal Chemistry, 2002

A computer-based method was developed for rapid and automatic identification of potential &am... more A computer-based method was developed for rapid and automatic identification of potential "frequent hitters". These compounds show up as hits in many different biological assays covering a wide range of targets. A scoring scheme was elaborated from substructure analysis, multivariate linear and nonlinear statistical methods applied to several sets of one and two-dimensional molecular descriptors. The final model is based on a three-layered neural network, yielding a predictive Matthews correlation coefficient of 0.81. This system was able to correctly classify 90% of the test set molecules in a 10-times cross-validation study. The method was applied to database filtering, yielding between 8% (compilation of trade drugs) and 35% (Available Chemicals Directory) potential frequent hitters. This filter will be a valuable tool for the prioritization of compounds from large databases, for compound purchase and biological testing, and for building new virtual libraries.

Research paper thumbnail of Agile resource management for 5G: A METIS-II perspective

2015 IEEE Conference on Standards for Communications and Networking (CSCN), 2015

Research paper thumbnail of Method and communication system for optimizing the throughput of a TCP flow in a wireless network

Research paper thumbnail of Internet Traffic Performance in High Speed Trains

Abstract:Internet is increasingly important to our work and daily life. With the fast development... more Abstract:Internet is increasingly important to our work and daily life. With the fast development,of wireless technologies Internet can now be accessed anywhere,and anytime. This paper investigates the Internet traffic performance in high speed trains, considering various wireless channels to connect the high speed train and wireless access network. Wireless link parameters such as bandwidth, propagation delay and error rate have

Research paper thumbnail of The METIS 5G Architecture: A Summary of METIS Work on 5G Architectures

2015 IEEE 81st Vehicular Technology Conference (VTC Spring), 2015

During the last two years, the METIS project ("Mobile and wireless communications Enablers for th... more During the last two years, the METIS project ("Mobile and wireless communications Enablers for the Twentytwenty Information Society") has been conducting research on 5G-enabling technology components. This paper provides a summary of METIS work on 5G architectures. The architecture description is presented from different viewpoints. First, a functional architecture is presented that may lay a foundation for development of first novel 5G network functions. It is based on functional decomposition of most relevant 5G technology components provided by METIS. The logical orchestration & control architecture depicts the realization of flexibility, scalability and service orientation needed to fulfil diverse 5G requirements. Finally, a third viewpoint reveals deployment aspects and function placement options for 5G.

Research paper thumbnail of METIS research advances towards the 5G mobile and wireless system definition

EURASIP Journal on Wireless Communications and Networking, 2015

The Mobile and wireless communications Enablers for the Twenty-twenty Information Society (METIS)... more The Mobile and wireless communications Enablers for the Twenty-twenty Information Society (METIS) project is laying the foundations of Fifth Generation (5G) mobile and wireless communication system putting together the point of view of vendors, operators, vertical players, and academia. METIS envisions a 5G system concept that efficiently integrates new applications developed in the METIS horizontal topics and evolved versions of existing services and systems. This article provides a first view on the METIS system concept, highlights the main features including architecture, and addresses the challenges while discussing perspectives for the further research work.

Research paper thumbnail of Rethinking the mobile and wireless network architecture: The METIS research into 5G

2014 European Conference on Networks and Communications (EuCNC), 2014

Research paper thumbnail of Pyridine and pyridazine derivatives, processes for the production thereof and pharmaceutical agents containing these compounds

Research paper thumbnail of A Wireless Communications System with Detection of Foreign Radiation Sources

Research paper thumbnail of Phospholipid derivatives of phosphono-carboxylic acids, the production of said derivatives and the use of said derivatives as antiviral medicaments

Research paper thumbnail of N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents

Research paper thumbnail of Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments

Research paper thumbnail of New Derivatives of Pyridil Piperazine or Pyridazinyl Piperazyl, Process for Production Thereof and Medicaments Containing These Compounds

Research paper thumbnail of Method and apparatus for selection of frequency reusage in cellular communication systems

Research paper thumbnail of Interference Measurements in a Wireless Communications System

Research paper thumbnail of System for accessing information and for communication in a vehicle having a plurality of coupled units

Research paper thumbnail of Crank-Angle Resolved Temperature in SI Engines Measured by Emission-Absorption Spectroscopy

SAE Technical Paper Series, 1999

... Date Published: 1999-10-25. Paper Number: 1999-01-3542. DOI: 10.4271/1999-01-3542. Author(s):... more ... Date Published: 1999-10-25. Paper Number: 1999-01-3542. DOI: 10.4271/1999-01-3542. Author(s): Volker Aust - Fraunhofer EMI Gerd Zimmermann - Fraunhofer EMI Peter-Wolfgang Manz - Volkswagen AG Werner Hentschel - Volkswagen AG. Abstract. ...

Research paper thumbnail of The Development of the Regulatory Process in Europe for Biological Medicines: How it Affects Gene Therapy Products

Gene Therapy Technologies, Applications and Regulations, 1999

ABSTRACT

Research paper thumbnail of Quality assurance of biologics and conclusions to be drawn for gene therapy products

The Quality Assurance Journal, 1997

Research paper thumbnail of Research on MMP Inhibitors with Unusual Scaffolds

Matrix Metalloproteinase Inhibitors in Cancer Therapy, 2000

Research paper thumbnail of Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Journal of Medicinal Chemistry, 2002

A computer-based method was developed for rapid and automatic identification of potential &am... more A computer-based method was developed for rapid and automatic identification of potential "frequent hitters". These compounds show up as hits in many different biological assays covering a wide range of targets. A scoring scheme was elaborated from substructure analysis, multivariate linear and nonlinear statistical methods applied to several sets of one and two-dimensional molecular descriptors. The final model is based on a three-layered neural network, yielding a predictive Matthews correlation coefficient of 0.81. This system was able to correctly classify 90% of the test set molecules in a 10-times cross-validation study. The method was applied to database filtering, yielding between 8% (compilation of trade drugs) and 35% (Available Chemicals Directory) potential frequent hitters. This filter will be a valuable tool for the prioritization of compounds from large databases, for compound purchase and biological testing, and for building new virtual libraries.

Research paper thumbnail of Agile resource management for 5G: A METIS-II perspective

2015 IEEE Conference on Standards for Communications and Networking (CSCN), 2015

Research paper thumbnail of Method and communication system for optimizing the throughput of a TCP flow in a wireless network

Research paper thumbnail of Internet Traffic Performance in High Speed Trains

Abstract:Internet is increasingly important to our work and daily life. With the fast development... more Abstract:Internet is increasingly important to our work and daily life. With the fast development,of wireless technologies Internet can now be accessed anywhere,and anytime. This paper investigates the Internet traffic performance in high speed trains, considering various wireless channels to connect the high speed train and wireless access network. Wireless link parameters such as bandwidth, propagation delay and error rate have

Research paper thumbnail of The METIS 5G Architecture: A Summary of METIS Work on 5G Architectures

2015 IEEE 81st Vehicular Technology Conference (VTC Spring), 2015

During the last two years, the METIS project ("Mobile and wireless communications Enablers for th... more During the last two years, the METIS project ("Mobile and wireless communications Enablers for the Twentytwenty Information Society") has been conducting research on 5G-enabling technology components. This paper provides a summary of METIS work on 5G architectures. The architecture description is presented from different viewpoints. First, a functional architecture is presented that may lay a foundation for development of first novel 5G network functions. It is based on functional decomposition of most relevant 5G technology components provided by METIS. The logical orchestration & control architecture depicts the realization of flexibility, scalability and service orientation needed to fulfil diverse 5G requirements. Finally, a third viewpoint reveals deployment aspects and function placement options for 5G.

Research paper thumbnail of METIS research advances towards the 5G mobile and wireless system definition

EURASIP Journal on Wireless Communications and Networking, 2015

The Mobile and wireless communications Enablers for the Twenty-twenty Information Society (METIS)... more The Mobile and wireless communications Enablers for the Twenty-twenty Information Society (METIS) project is laying the foundations of Fifth Generation (5G) mobile and wireless communication system putting together the point of view of vendors, operators, vertical players, and academia. METIS envisions a 5G system concept that efficiently integrates new applications developed in the METIS horizontal topics and evolved versions of existing services and systems. This article provides a first view on the METIS system concept, highlights the main features including architecture, and addresses the challenges while discussing perspectives for the further research work.

Research paper thumbnail of Rethinking the mobile and wireless network architecture: The METIS research into 5G

2014 European Conference on Networks and Communications (EuCNC), 2014