Ron Zimmern - Academia.edu (original) (raw)

Papers by Ron Zimmern

Research paper thumbnail of Differences in the neural basis of human amblyopia: The distribution of the anomaly across the visual field

Research paper thumbnail of Public Health Genomics

Elsevier eBooks, 2010

Page 1. 23 Public Health Genomics SUZANNE C. O'NEILL This volume has provided a ... more Page 1. 23 Public Health Genomics SUZANNE C. O'NEILL This volume has provided a broad and comprehensive review of psy-chosocial and behavioral concerns of children, adolescents, and their families in the context of genomic medicine and health care. ...

Research paper thumbnail of High “population attributable fraction” for coronary heart disease mortality among relatives in monogenic familial hypercholesterolemia

Genetics in Medicine, Jul 1, 2002

Research paper thumbnail of Genomics and public health

Oxford University Press eBooks, Feb 1, 2015

Research paper thumbnail of Public health and genetics

Research paper thumbnail of The Arguments Could Be Extended

Research paper thumbnail of Genomic medicine: the future is now. Lessons for Hong Kong from the House of Lords Report on Genomic Medicine

Research paper thumbnail of Quality Issues in the Evaluation and Regulation of Genetic Testing Services: A Public Health Approach

Springer eBooks, 2010

• The evaluation of genetic testing services is essential for ensuring quality, and determining w... more • The evaluation of genetic testing services is essential for ensuring quality, and determining whether genetic tests offer a health benefit to the population. However, this is complex process, because any given test may be used in different contexts and for different purposes. • It is therefore useful to distinguish between: an assay, the measurement of a genetic sequence; a test, the use of an assay in a particular context; and a service, which embraces performing, processing, and interpreting the test, in addition to informing and supporting the patient. • This distinction has important practical implications for both evaluation and regulation of medical testing services. • Quality standards may be set for all three aspects of genetic testing, relating to the testing process itself, the possible outcome(s) and structure of the service, then monitored and improved using a formal audit cycle. • Different regulatory models may be appropriate for the three aspects of genetic testing services, including statutory legislation, professional self-governance and voluntary guidance.

Research paper thumbnail of Genetic testing: a conceptual exploration

Journal of Medical Ethics, Apr 1, 1999

Research paper thumbnail of Next-generation sequencing in the clinic: are we ready?

Nature Reviews Genetics, Oct 18, 2012

Research paper thumbnail of Even detailed analysis of wide variations in surgical rates did not produce convincing explanations that could be easily used by purchasers

Evidence-based Healthcare, 1997

Research paper thumbnail of A collaboratively-derived science-policy research agenda

PloS one, 2012

The need for policy makers to understand science and for scientists to understand policy processe... more The need for policy makers to understand science and for scientists to understand policy processes is widely recognised. However, the science-policy relationship is sometimes difficult and occasionally dysfunctional; it is also increasingly visible, because it must deal with contentious issues, or itself becomes a matter of public controversy, or both. We suggest that identifying key unanswered questions on the relationship between science and policy will catalyse and focus research in this field. To identify these questions, a collaborative procedure was employed with 52 participants selected to cover a wide range of experience in both science and policy, including people from government, non-governmental organisations, academia and industry. These participants consulted with colleagues and submitted 239 questions. An initial round of voting was followed by a workshop in which 40 of the most important questions were identified by further discussion and voting. The resulting list in...

Research paper thumbnail of Genomics and Public Health

Springer eBooks, 2015

This chapter addresses the crucial question of how genomics knowledge and technologies can curren... more This chapter addresses the crucial question of how genomics knowledge and technologies can currently be integrated into public health practice. There has been an astonishing rate of technological advance in genomic science over the last decade since the public health genomics movement was first conceived in the 1990s, though the arrival of genomics into health-care practice represents only the beginning of the translational highway. For some, this exponential growth in knowledge promises a future in which health care is focused much more effectively at the level of the individual. In this chapter, we examine the emerging areas where public health and genomics intersect, the criteria for population screening programmes involving genomic knowledge, and the use of genomics for evidence-based approaches to forecast and manage disease prevention and prognosis, as well as health intervention outcomes. We discuss challenges and barriers for implementing evidence-based genomic applications in the public health practice. We provide a three-tiered approach to group public health genomics applications based on their readiness for practice. We conclude that coordinated efforts are essential to guide development in genomic medicine, towards an impact on population health.

Research paper thumbnail of Direct-to-consumer genetic testing for health-related purposes in the European Union

Research paper thumbnail of Role of next of kin in accessing health records of deceased relatives

Research paper thumbnail of Genetics services. Briefing encounters

PubMed, Apr 29, 1999

Developments in genetic science have huge implications for NHS services. Demand for genetic testi... more Developments in genetic science have huge implications for NHS services. Demand for genetic testing is set to increase. The Public Health Genetics Unit aims to link academic research, policy making and clinical practice, and stimulate debate about the provision of genetic services.

Research paper thumbnail of How can genetic tests be evaluated for clinical use? Experience of the UK Genetic Testing Network

European Journal of Human Genetics, May 30, 2007

Research paper thumbnail of A framework for new practice in public health genomics

European journal of public health, Oct 1, 2015

Research paper thumbnail of HER2 status in breast cancer--an example of pharmacogenetic testing

Journal of the Royal Society of Medicine, Jul 1, 2007

Research paper thumbnail of The Impact of Genomics on Public Health Practice: The Case for Change

Public Health Genomics, 2012

Public health practice will not be able in the 21st century to ignore the impact of genomics, cel... more Public health practice will not be able in the 21st century to ignore the impact of genomics, cell and molecular biology. It will need to take into consideration issues that include, among others: the complementary nature of social and biological models of disease, genetic exceptionalism, the readiness of public and patient to respond to genomic information, the relationship between individuals and populations, and concepts of population stratification. Health systems will need to adapt their practice and organisation to include new sequencing technologies, bioinformatic expertise and proper evaluation of genetic and molecular tests. Links with the commercial sector will increase in importance. The impact on developing countries cannot be ignored and will require special attention.

Research paper thumbnail of Differences in the neural basis of human amblyopia: The distribution of the anomaly across the visual field

Research paper thumbnail of Public Health Genomics

Elsevier eBooks, 2010

Page 1. 23 Public Health Genomics SUZANNE C. O'NEILL This volume has provided a ... more Page 1. 23 Public Health Genomics SUZANNE C. O'NEILL This volume has provided a broad and comprehensive review of psy-chosocial and behavioral concerns of children, adolescents, and their families in the context of genomic medicine and health care. ...

Research paper thumbnail of High “population attributable fraction” for coronary heart disease mortality among relatives in monogenic familial hypercholesterolemia

Genetics in Medicine, Jul 1, 2002

Research paper thumbnail of Genomics and public health

Oxford University Press eBooks, Feb 1, 2015

Research paper thumbnail of Public health and genetics

Research paper thumbnail of The Arguments Could Be Extended

Research paper thumbnail of Genomic medicine: the future is now. Lessons for Hong Kong from the House of Lords Report on Genomic Medicine

Research paper thumbnail of Quality Issues in the Evaluation and Regulation of Genetic Testing Services: A Public Health Approach

Springer eBooks, 2010

• The evaluation of genetic testing services is essential for ensuring quality, and determining w... more • The evaluation of genetic testing services is essential for ensuring quality, and determining whether genetic tests offer a health benefit to the population. However, this is complex process, because any given test may be used in different contexts and for different purposes. • It is therefore useful to distinguish between: an assay, the measurement of a genetic sequence; a test, the use of an assay in a particular context; and a service, which embraces performing, processing, and interpreting the test, in addition to informing and supporting the patient. • This distinction has important practical implications for both evaluation and regulation of medical testing services. • Quality standards may be set for all three aspects of genetic testing, relating to the testing process itself, the possible outcome(s) and structure of the service, then monitored and improved using a formal audit cycle. • Different regulatory models may be appropriate for the three aspects of genetic testing services, including statutory legislation, professional self-governance and voluntary guidance.

Research paper thumbnail of Genetic testing: a conceptual exploration

Journal of Medical Ethics, Apr 1, 1999

Research paper thumbnail of Next-generation sequencing in the clinic: are we ready?

Nature Reviews Genetics, Oct 18, 2012

Research paper thumbnail of Even detailed analysis of wide variations in surgical rates did not produce convincing explanations that could be easily used by purchasers

Evidence-based Healthcare, 1997

Research paper thumbnail of A collaboratively-derived science-policy research agenda

PloS one, 2012

The need for policy makers to understand science and for scientists to understand policy processe... more The need for policy makers to understand science and for scientists to understand policy processes is widely recognised. However, the science-policy relationship is sometimes difficult and occasionally dysfunctional; it is also increasingly visible, because it must deal with contentious issues, or itself becomes a matter of public controversy, or both. We suggest that identifying key unanswered questions on the relationship between science and policy will catalyse and focus research in this field. To identify these questions, a collaborative procedure was employed with 52 participants selected to cover a wide range of experience in both science and policy, including people from government, non-governmental organisations, academia and industry. These participants consulted with colleagues and submitted 239 questions. An initial round of voting was followed by a workshop in which 40 of the most important questions were identified by further discussion and voting. The resulting list in...

Research paper thumbnail of Genomics and Public Health

Springer eBooks, 2015

This chapter addresses the crucial question of how genomics knowledge and technologies can curren... more This chapter addresses the crucial question of how genomics knowledge and technologies can currently be integrated into public health practice. There has been an astonishing rate of technological advance in genomic science over the last decade since the public health genomics movement was first conceived in the 1990s, though the arrival of genomics into health-care practice represents only the beginning of the translational highway. For some, this exponential growth in knowledge promises a future in which health care is focused much more effectively at the level of the individual. In this chapter, we examine the emerging areas where public health and genomics intersect, the criteria for population screening programmes involving genomic knowledge, and the use of genomics for evidence-based approaches to forecast and manage disease prevention and prognosis, as well as health intervention outcomes. We discuss challenges and barriers for implementing evidence-based genomic applications in the public health practice. We provide a three-tiered approach to group public health genomics applications based on their readiness for practice. We conclude that coordinated efforts are essential to guide development in genomic medicine, towards an impact on population health.

Research paper thumbnail of Direct-to-consumer genetic testing for health-related purposes in the European Union

Research paper thumbnail of Role of next of kin in accessing health records of deceased relatives

Research paper thumbnail of Genetics services. Briefing encounters

PubMed, Apr 29, 1999

Developments in genetic science have huge implications for NHS services. Demand for genetic testi... more Developments in genetic science have huge implications for NHS services. Demand for genetic testing is set to increase. The Public Health Genetics Unit aims to link academic research, policy making and clinical practice, and stimulate debate about the provision of genetic services.

Research paper thumbnail of How can genetic tests be evaluated for clinical use? Experience of the UK Genetic Testing Network

European Journal of Human Genetics, May 30, 2007

Research paper thumbnail of A framework for new practice in public health genomics

European journal of public health, Oct 1, 2015

Research paper thumbnail of HER2 status in breast cancer--an example of pharmacogenetic testing

Journal of the Royal Society of Medicine, Jul 1, 2007

Research paper thumbnail of The Impact of Genomics on Public Health Practice: The Case for Change

Public Health Genomics, 2012

Public health practice will not be able in the 21st century to ignore the impact of genomics, cel... more Public health practice will not be able in the 21st century to ignore the impact of genomics, cell and molecular biology. It will need to take into consideration issues that include, among others: the complementary nature of social and biological models of disease, genetic exceptionalism, the readiness of public and patient to respond to genomic information, the relationship between individuals and populations, and concepts of population stratification. Health systems will need to adapt their practice and organisation to include new sequencing technologies, bioinformatic expertise and proper evaluation of genetic and molecular tests. Links with the commercial sector will increase in importance. The impact on developing countries cannot be ignored and will require special attention.