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Papers by abdul sayeed

International journal of pharma and bio sciences, 2010

Der Pharmacia Lettre, 2010

ORIGINAL RESEARCH ARTICLE ABSTRACT ARTICLE INFORMATION Background: According to World Health Orga... more ORIGINAL RESEARCH ARTICLE ABSTRACT ARTICLE INFORMATION Background: According to World Health Organization, about 80% of the world population relies on traditional systems of medicine for primary health care. The objective of the present study was to evaluate antihyperglycemic activity of aqueous and alcoholic extract of Girardinia diversifolia (AQGD and ALGD respectively). Material and methods: In the present study, the leaves of Girardinia diversifolia were subjected to successive extraction by using petroleum ether, chloroform, acetone, alcohol and water. Animals were divided into seven groups (n=6). Group I served as normal control (normal saline); group II served as alloxan diabetic control (120 mg/kg, i.p.); group III served as positive control, glibenclamide (10 mg/kg, p.o.); group IV and VII served as test groups, two doses of alcoholic extracts of Girardinia diversifolia (200 & 400 mg/kg p.o.), and two doses of aqueous extract of Girardinia diversifolia (200 and 400 mg/kg p....

ORIGINAL RESEARCH ARTICLE ABSTRACT ARTICLE INFORMATION Background: Correct prescription writing h... more ORIGINAL RESEARCH ARTICLE ABSTRACT ARTICLE INFORMATION Background: Correct prescription writing habits could have a great influence on the fate of drug therapy as well as the health of patients. The aim of the study was to determine the prescription writing errors from the outpatient department of pediatrics in a teaching Hospital. Subject and methods: A nine month hospital based prospective study was carried out after obtaining ethical clearance certificate. A total of 220 prescriptions were randomly collected and analyzed. Results: Among them 279 errors of omission related to prescriber and 236 errors of omission related to drugs with an average of 1.26 and1.07 error per prescription were reported respectively. Among errors of omission related to the prescriber, prescribers name was not written in 215 (97.72%) followed by weight18 (8.18%) and illegible prescriptions were 18(8.18%). Regarding errors omission related to the drugs, duration/no. of doses was not mentioned in124 (53.36...

The present study in the development of Hydro dynamically Balanced Systems (HBS) of fenofibrate, ... more The present study in the development of Hydro dynamically Balanced Systems (HBS) of fenofibrate, a lipid regulating drug which are designed to increase the gastric residence time, thus prolonging the drug release. Hydroxy propyl methyl cellulose (HPMC) of different viscosity grades at three different drug to polymer ratios were used to prepare HBS by wet granulation technique. The prepared HBS tablets were evaluated in terms of their pre-compression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, drug polymer interaction studies, invitro floating studies, invitro drug release and short term stability studies. The drug polymer ratio, viscosity grades of HPMC, different diluents and gas generating agents were found to influence the drug release and floating properties of the prepared HBS. The floating properties and drug release characteristics were determined for the prepared HBS in 0.1 N HCl dissolutio...

Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the rig... more Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like capsular systems, osmotic systems, singleand multiple-unit systems based on the use of soluble or erodible polymer coating and use of rupturable membranes have been dealt with in the article. It summarizes the latest technological developments, formulation parameters, and release profiles of these systems. These systems are beneficial for the drugs having chronopharmacological behavior where night time dosing is required, such as anti-arh...

This study presents the results of in vitro dissolution of sustained release propranolol hydrochl... more This study presents the results of in vitro dissolution of sustained release propranolol hydrochloride (PPN) matrix tablets using hydroxypropyl methyl cellulose K100M as a rate retarding polymer. The effects of the proportion of the polymer and the influence of excipient like microcrystalline cellulose on the release rate of drug was investigated. The results of the present study point out that the rate of propranolol hydrochloride release from HPMC K100M matrices are mainly controlled by the drug –HPMC ratio. When the influence of excipients on the release of drug was examined, the excipient microcrystalline cellulose enhanced the release rate of propranolol hydrochlroid.

4-thiazolidinones are a mo n g t h e mo st exten s ive ly i n v e s t ig a te d cla ss of organic... more 4-thiazolidinones are a mo n g t h e mo st exten s ive ly i n v e s t ig a te d cla ss of organic compounds. Thiazolidin-4-one has been considered as magic moiety, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities.They are widely used as anti-inflammatory, anticonvulsant, analgesic, antimicrobial,anti-HIV,CNS depressant, carcinostatic, antihypertensive and cytotoxic. In view of the wide spectrum activities of condensed 4-thiazolidinones, itwas thought worthwhile to undertake the synthesis of heterocyclic systems in which 4-thiazolidinone nucleus is linked to another biologically active moiety.Semicarbazide/Thiosemicarbazide was reacted with b e n z o y l chloride to obtain N-hydrazinocarbonyl benzene-1-carboxamide/N-hydrazinocarbothioyl benzene-1 carboxamide respectively.These were then condensed with various aldehydes to yield the intermediate Schiff bases. Thiazolidin-4-ones were prepared by the reaction of Schiff b...

Quinazolinone derivatives are the versatile nitrogen containing heterocyclic compounds displaying... more Quinazolinone derivatives are the versatile nitrogen containing heterocyclic compounds displaying a wide variety of biological and pharmacological activities like antibacterial, anthelmintic,neuroleptic,antitubercular,platelet,antiaggregating,antifungal,anticancer,anti-inflammatory,antiviral,CNSdepressant activity,antiparkinson,bronchodilator etc. Recently several scientists have elucidated that Quinazolinone system possesses variable sites like position 2 and 3 which can be suitably modified to yield new potent chemotherapeutic and pharmacotherapeutic agents. Further, Schiff bases are use as substrate in the preparation of number of industrial and biologically Active compound via ring closure, cyclo addition and replacement reactions.Morever,Schiff b a s es d e r i v e d from various heterocycles have been reported to posses cytotoxic, anticonvulsant, antiproliferative,antimicrobial, anticancer and antifungal activities. In view of the above mentioned facts and in continuation of o...

4-thiazolidinones are among t he most extensively investigated class of organic compounds. Thiazo... more 4-thiazolidinones are among t he most extensively investigated class of organic compounds. Thiazolidin-4-one has been considered as magic moiety, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities.They are widely used as anti-inflammatory, anticonvulsant, analgesic, antimicrobial,anti-HIV,CNS depressant, carcinostatic, antihypertensive and cytotoxic. In view of the wide spectrum activities of condensed 4-thiazolidinones, itwas thought worthwhile to undertake the synthesis of heterocyclic systems in which 4-thiazolidinone nucleus is linked to another biologically active moiety.Semicarbazide/Thiosemicarbazide was reacted with b e n z o y l chloride to obtain N-hydrazinocarbonyl benzene-1-carboxamide/N-hydrazinocarbothioyl benzene-1 carboxamide respectively.These were then condensed with various aldehydes to yield the intermediate Schiff bases. Thiazolidin-4-ones were prepared by the reaction of Schiff bases with mercapto...

Surgical management cannot be completed without the use of antimicrobial and analgesic drugs. Pha... more Surgical management cannot be completed without the use of antimicrobial and analgesic drugs. Pharmacotherapy with multiple agents before, during and after surgery is marked in present day indoor hospital settings.Irrational prescription may lead to severe postoperative complications.The present prospective observational study aims to evaluate the drug utilization patterns using WHO core indicators and to assess how much it confirms to standard treatment guidelines in the inpatient ward of surgery in a tertiary care hospital, by collecting the admitted cases of surgery as per the study criteria. A total of 104 cases were enrolled into the study for a period of 9 months.The results shown that, majority (43.26%) of the surgery cases were in the age group of 21-40 years. The majority of patients were males (67.30%) compared to females (32.70%). Majority of them were from rural area (74.03%) and the remaining is from urban area (25.97%). The majority of surgeries performed were clean- c...

In the present work, mouth dissolving tablets of Carvedilol were designed with a view to enhance ... more In the present work, mouth dissolving tablets of Carvedilol were designed with a view to enhance patient compliance, by direct compression methods. In the direct compression method, treated agar was used as disintegarnt. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio, in vitro dispersion time. The tablets prepared by direct compression method, formulation TAM3 (containing 2:1 ratio of directly compressible excipient and treated agar) were found to be promising. These formulations were tested for in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40 ± 2°C/75± 5% RH for 3 months) and drug–excipient interaction (IR spectroscopy). Among the promising formulations, the formulation TAM3 prepared by direct compression method emerged as the overall best formulation based on drug release characteristics (in vitro dispersion tome of 12 s and t50% value of 8.51 min) compare...

The sustained release system includes any drug delivery system that achieves slow and extended re... more The sustained release system includes any drug delivery system that achieves slow and extended release of drug over an extended period of time. The present study was carried out to develop and evaluate the matrix tablets of Metoprolol succinate containing cellulose derivatives as release modifying polymer. Metoprolol succinate sustained release matrix tablets were prepared successfully by wet granulation using HPMC K100M and EC as polymers in different proportion, to retard the release and achieve required dissolution profile. The results of invitro drug release studies in simulated GI fluids showed that matrix tablets containing 1:1 ratio of HPMC K100M and EC (F-5) are able tocontrol the release of water-soluble Metoprolol succinate. Therefore it was concluded that HPMCK100M and EC in the ratio of 1:1 (F-5) is suitable for the formulating matrix system of Metoprolol succinate. The data generated from in-vitro studies showed, the drug release from matrices containing HPMCK100M and E...

Research Journal of Pharmacy and Technology, 2018

The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist o... more The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist over the years mainly because they possess diverse biological properties. The literature survey on 1,2,4-triazoles revealed that they are endowed with wide variety of biological activities .During the present investigation a series of new 1,2,4-triazole derivatives N-(3-(2-(3hydrazinyl-3-oxoalkanoyl)hydrazinyl)-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide(6a6e)were synthesized by reacting withN-(5-mercapto-3-(phenoxymethyl)-4H-1,2,4-triazol-4yl)isonicotinamide (5) and aliphatic dicarboxylic acid hydrazides (a-e). The structures of the newly All the compounds synthesised 6a to 6e were evaluated for antifungal activity against Candida albicans and Aspergillus Niger was carried out and MIC values were determined synthesized compounds were estblished by FT-IR, 1H-NMR and MASS spectral analysis. The compound 6a (n=0) was found to be the most potent antifungal agent.

Research Journal of Pharmacy and Technology, 2010

The present study in the development of Hydrodynamically Balanced Systems (HBS) of Simvastatin an... more The present study in the development of Hydrodynamically Balanced Systems (HBS) of Simvastatin an hypolipidemic drug which are designed to increase the gastric residence time, thus prolonging the drug release. Hydroxy propyl methyl cellulose (HPMC) of different viscosity grades at three different drugs to polymer ratios were used to prepare HBS by direct compression technique. The prepared HBS tablets were evaluated in terms of their pre-compression parameters, post-compression parameters and short term stability studies. The drug polymer ratio, viscosity grades of HPMC, different diluents and gas generating agents were found to influence the drug release and floating properties of the prepared HBS. The floating properties and drug release characteristics were determined for the prepared HBS in 0.1 N HCl dissolution media. All the HBS formulations showed good invitro floating properties with an optimum concentration of gas generating agents sodium bicarbonate and citric acid. The rate of drug release decreased with increased polymer concentration. It was found that HPMC viscosity had significant impact on the drug release from the prepared HBS. Among the three viscosity grades of HPMC (K4M, K15M, K100M), HPMC K4M along with lactose as diluents was found to be beneficial in improving the drug release rate and floating properties The short term stability study indicated that there was no much differences observed.

... me. I am indeed grateful to all my friends Nahid, Ather, Saqawat, Waseem, Khaseem, Abid, Arsh... more ... me. I am indeed grateful to all my friends Nahid, Ather, Saqawat, Waseem, Khaseem, Abid, Arshad, Hasheem, Asfar, Ajay, Naveen, Vinayak, Martand, Riyaz, Patil, Nilesh, Azmat, Rahmat, Haroon, Ali, Page 8. Zubair, Shafeeq, Siraj, Rashed, Sinu, Ashraf, Azeem, Mehraj, Kaleem, ...

Mouth

The gold standard in pharmaceutical industry is the oral delivery because it is the easiest, safe... more The gold standard in pharmaceutical industry is the oral delivery because it is the easiest, safest, economical and convenient method for the drug delivery. Mouth dissolving tablets have becomes the most demanding application during last decades and in the pharmaceutical industry this field has become a rapidly area. Mouth dissolving tablets during insertion in the mouth should have to dissolve or disintegrate in the mouth within 15sec to 3 minutes without the help or need of any drinking agent like water. These mouth dissolving tablets can be given anytime, anywhere to anyone who needs this without the presence of water and these will show the effective action in few minutes.

The aim of this work was to develop a tablet for the buccal delivery of the poorly water-soluble ... more The aim of this work was to develop a tablet for the buccal delivery of the poorly water-soluble drug itraconazole which is a broad spectrum triazole derivative useful in treatment of oropharyngeal candidiasis, for that an attempt was made to solubilizing itraconazole by complexation with β- CD and then delivery via buccal mucosa. HPMC K4M and carbopol 934P were selected as mucoadhesive polymers while ethyl cellulose, as backing material. The complexation was studied by phase solubility method which indicates the formation of complex with 1:1 stoichiometry. Modification of the release for a poorly water-soluble drug, itraconazole, from hydrophilic matrices using βcyclodextrin complexation was evaluated. The buccoadhesive tablets for the delivery of itraconazole were prepared by direct compression of HPMC K4M and Carbopol 934P. The Surface pH of all formulations was found to be within ±1 units of neutral pH hence these formulations should not cause any irritation in buccal cavity. Ca...

International journal of pharma and bio sciences, 2010

Der Pharmacia Lettre, 2010

ORIGINAL RESEARCH ARTICLE ABSTRACT ARTICLE INFORMATION Background: According to World Health Orga... more ORIGINAL RESEARCH ARTICLE ABSTRACT ARTICLE INFORMATION Background: According to World Health Organization, about 80% of the world population relies on traditional systems of medicine for primary health care. The objective of the present study was to evaluate antihyperglycemic activity of aqueous and alcoholic extract of Girardinia diversifolia (AQGD and ALGD respectively). Material and methods: In the present study, the leaves of Girardinia diversifolia were subjected to successive extraction by using petroleum ether, chloroform, acetone, alcohol and water. Animals were divided into seven groups (n=6). Group I served as normal control (normal saline); group II served as alloxan diabetic control (120 mg/kg, i.p.); group III served as positive control, glibenclamide (10 mg/kg, p.o.); group IV and VII served as test groups, two doses of alcoholic extracts of Girardinia diversifolia (200 & 400 mg/kg p.o.), and two doses of aqueous extract of Girardinia diversifolia (200 and 400 mg/kg p....

ORIGINAL RESEARCH ARTICLE ABSTRACT ARTICLE INFORMATION Background: Correct prescription writing h... more ORIGINAL RESEARCH ARTICLE ABSTRACT ARTICLE INFORMATION Background: Correct prescription writing habits could have a great influence on the fate of drug therapy as well as the health of patients. The aim of the study was to determine the prescription writing errors from the outpatient department of pediatrics in a teaching Hospital. Subject and methods: A nine month hospital based prospective study was carried out after obtaining ethical clearance certificate. A total of 220 prescriptions were randomly collected and analyzed. Results: Among them 279 errors of omission related to prescriber and 236 errors of omission related to drugs with an average of 1.26 and1.07 error per prescription were reported respectively. Among errors of omission related to the prescriber, prescribers name was not written in 215 (97.72%) followed by weight18 (8.18%) and illegible prescriptions were 18(8.18%). Regarding errors omission related to the drugs, duration/no. of doses was not mentioned in124 (53.36...

The present study in the development of Hydro dynamically Balanced Systems (HBS) of fenofibrate, ... more The present study in the development of Hydro dynamically Balanced Systems (HBS) of fenofibrate, a lipid regulating drug which are designed to increase the gastric residence time, thus prolonging the drug release. Hydroxy propyl methyl cellulose (HPMC) of different viscosity grades at three different drug to polymer ratios were used to prepare HBS by wet granulation technique. The prepared HBS tablets were evaluated in terms of their pre-compression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, drug polymer interaction studies, invitro floating studies, invitro drug release and short term stability studies. The drug polymer ratio, viscosity grades of HPMC, different diluents and gas generating agents were found to influence the drug release and floating properties of the prepared HBS. The floating properties and drug release characteristics were determined for the prepared HBS in 0.1 N HCl dissolutio...

Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the rig... more Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like capsular systems, osmotic systems, singleand multiple-unit systems based on the use of soluble or erodible polymer coating and use of rupturable membranes have been dealt with in the article. It summarizes the latest technological developments, formulation parameters, and release profiles of these systems. These systems are beneficial for the drugs having chronopharmacological behavior where night time dosing is required, such as anti-arh...

This study presents the results of in vitro dissolution of sustained release propranolol hydrochl... more This study presents the results of in vitro dissolution of sustained release propranolol hydrochloride (PPN) matrix tablets using hydroxypropyl methyl cellulose K100M as a rate retarding polymer. The effects of the proportion of the polymer and the influence of excipient like microcrystalline cellulose on the release rate of drug was investigated. The results of the present study point out that the rate of propranolol hydrochloride release from HPMC K100M matrices are mainly controlled by the drug –HPMC ratio. When the influence of excipients on the release of drug was examined, the excipient microcrystalline cellulose enhanced the release rate of propranolol hydrochlroid.

4-thiazolidinones are a mo n g t h e mo st exten s ive ly i n v e s t ig a te d cla ss of organic... more 4-thiazolidinones are a mo n g t h e mo st exten s ive ly i n v e s t ig a te d cla ss of organic compounds. Thiazolidin-4-one has been considered as magic moiety, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities.They are widely used as anti-inflammatory, anticonvulsant, analgesic, antimicrobial,anti-HIV,CNS depressant, carcinostatic, antihypertensive and cytotoxic. In view of the wide spectrum activities of condensed 4-thiazolidinones, itwas thought worthwhile to undertake the synthesis of heterocyclic systems in which 4-thiazolidinone nucleus is linked to another biologically active moiety.Semicarbazide/Thiosemicarbazide was reacted with b e n z o y l chloride to obtain N-hydrazinocarbonyl benzene-1-carboxamide/N-hydrazinocarbothioyl benzene-1 carboxamide respectively.These were then condensed with various aldehydes to yield the intermediate Schiff bases. Thiazolidin-4-ones were prepared by the reaction of Schiff b...

Quinazolinone derivatives are the versatile nitrogen containing heterocyclic compounds displaying... more Quinazolinone derivatives are the versatile nitrogen containing heterocyclic compounds displaying a wide variety of biological and pharmacological activities like antibacterial, anthelmintic,neuroleptic,antitubercular,platelet,antiaggregating,antifungal,anticancer,anti-inflammatory,antiviral,CNSdepressant activity,antiparkinson,bronchodilator etc. Recently several scientists have elucidated that Quinazolinone system possesses variable sites like position 2 and 3 which can be suitably modified to yield new potent chemotherapeutic and pharmacotherapeutic agents. Further, Schiff bases are use as substrate in the preparation of number of industrial and biologically Active compound via ring closure, cyclo addition and replacement reactions.Morever,Schiff b a s es d e r i v e d from various heterocycles have been reported to posses cytotoxic, anticonvulsant, antiproliferative,antimicrobial, anticancer and antifungal activities. In view of the above mentioned facts and in continuation of o...

4-thiazolidinones are among t he most extensively investigated class of organic compounds. Thiazo... more 4-thiazolidinones are among t he most extensively investigated class of organic compounds. Thiazolidin-4-one has been considered as magic moiety, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities.They are widely used as anti-inflammatory, anticonvulsant, analgesic, antimicrobial,anti-HIV,CNS depressant, carcinostatic, antihypertensive and cytotoxic. In view of the wide spectrum activities of condensed 4-thiazolidinones, itwas thought worthwhile to undertake the synthesis of heterocyclic systems in which 4-thiazolidinone nucleus is linked to another biologically active moiety.Semicarbazide/Thiosemicarbazide was reacted with b e n z o y l chloride to obtain N-hydrazinocarbonyl benzene-1-carboxamide/N-hydrazinocarbothioyl benzene-1 carboxamide respectively.These were then condensed with various aldehydes to yield the intermediate Schiff bases. Thiazolidin-4-ones were prepared by the reaction of Schiff bases with mercapto...

Surgical management cannot be completed without the use of antimicrobial and analgesic drugs. Pha... more Surgical management cannot be completed without the use of antimicrobial and analgesic drugs. Pharmacotherapy with multiple agents before, during and after surgery is marked in present day indoor hospital settings.Irrational prescription may lead to severe postoperative complications.The present prospective observational study aims to evaluate the drug utilization patterns using WHO core indicators and to assess how much it confirms to standard treatment guidelines in the inpatient ward of surgery in a tertiary care hospital, by collecting the admitted cases of surgery as per the study criteria. A total of 104 cases were enrolled into the study for a period of 9 months.The results shown that, majority (43.26%) of the surgery cases were in the age group of 21-40 years. The majority of patients were males (67.30%) compared to females (32.70%). Majority of them were from rural area (74.03%) and the remaining is from urban area (25.97%). The majority of surgeries performed were clean- c...

In the present work, mouth dissolving tablets of Carvedilol were designed with a view to enhance ... more In the present work, mouth dissolving tablets of Carvedilol were designed with a view to enhance patient compliance, by direct compression methods. In the direct compression method, treated agar was used as disintegarnt. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio, in vitro dispersion time. The tablets prepared by direct compression method, formulation TAM3 (containing 2:1 ratio of directly compressible excipient and treated agar) were found to be promising. These formulations were tested for in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40 ± 2°C/75± 5% RH for 3 months) and drug–excipient interaction (IR spectroscopy). Among the promising formulations, the formulation TAM3 prepared by direct compression method emerged as the overall best formulation based on drug release characteristics (in vitro dispersion tome of 12 s and t50% value of 8.51 min) compare...

The sustained release system includes any drug delivery system that achieves slow and extended re... more The sustained release system includes any drug delivery system that achieves slow and extended release of drug over an extended period of time. The present study was carried out to develop and evaluate the matrix tablets of Metoprolol succinate containing cellulose derivatives as release modifying polymer. Metoprolol succinate sustained release matrix tablets were prepared successfully by wet granulation using HPMC K100M and EC as polymers in different proportion, to retard the release and achieve required dissolution profile. The results of invitro drug release studies in simulated GI fluids showed that matrix tablets containing 1:1 ratio of HPMC K100M and EC (F-5) are able tocontrol the release of water-soluble Metoprolol succinate. Therefore it was concluded that HPMCK100M and EC in the ratio of 1:1 (F-5) is suitable for the formulating matrix system of Metoprolol succinate. The data generated from in-vitro studies showed, the drug release from matrices containing HPMCK100M and E...

Research Journal of Pharmacy and Technology, 2018

The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist o... more The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist over the years mainly because they possess diverse biological properties. The literature survey on 1,2,4-triazoles revealed that they are endowed with wide variety of biological activities .During the present investigation a series of new 1,2,4-triazole derivatives N-(3-(2-(3hydrazinyl-3-oxoalkanoyl)hydrazinyl)-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide(6a6e)were synthesized by reacting withN-(5-mercapto-3-(phenoxymethyl)-4H-1,2,4-triazol-4yl)isonicotinamide (5) and aliphatic dicarboxylic acid hydrazides (a-e). The structures of the newly All the compounds synthesised 6a to 6e were evaluated for antifungal activity against Candida albicans and Aspergillus Niger was carried out and MIC values were determined synthesized compounds were estblished by FT-IR, 1H-NMR and MASS spectral analysis. The compound 6a (n=0) was found to be the most potent antifungal agent.

Research Journal of Pharmacy and Technology, 2010

The present study in the development of Hydrodynamically Balanced Systems (HBS) of Simvastatin an... more The present study in the development of Hydrodynamically Balanced Systems (HBS) of Simvastatin an hypolipidemic drug which are designed to increase the gastric residence time, thus prolonging the drug release. Hydroxy propyl methyl cellulose (HPMC) of different viscosity grades at three different drugs to polymer ratios were used to prepare HBS by direct compression technique. The prepared HBS tablets were evaluated in terms of their pre-compression parameters, post-compression parameters and short term stability studies. The drug polymer ratio, viscosity grades of HPMC, different diluents and gas generating agents were found to influence the drug release and floating properties of the prepared HBS. The floating properties and drug release characteristics were determined for the prepared HBS in 0.1 N HCl dissolution media. All the HBS formulations showed good invitro floating properties with an optimum concentration of gas generating agents sodium bicarbonate and citric acid. The rate of drug release decreased with increased polymer concentration. It was found that HPMC viscosity had significant impact on the drug release from the prepared HBS. Among the three viscosity grades of HPMC (K4M, K15M, K100M), HPMC K4M along with lactose as diluents was found to be beneficial in improving the drug release rate and floating properties The short term stability study indicated that there was no much differences observed.

... me. I am indeed grateful to all my friends Nahid, Ather, Saqawat, Waseem, Khaseem, Abid, Arsh... more ... me. I am indeed grateful to all my friends Nahid, Ather, Saqawat, Waseem, Khaseem, Abid, Arshad, Hasheem, Asfar, Ajay, Naveen, Vinayak, Martand, Riyaz, Patil, Nilesh, Azmat, Rahmat, Haroon, Ali, Page 8. Zubair, Shafeeq, Siraj, Rashed, Sinu, Ashraf, Azeem, Mehraj, Kaleem, ...

Mouth

The gold standard in pharmaceutical industry is the oral delivery because it is the easiest, safe... more The gold standard in pharmaceutical industry is the oral delivery because it is the easiest, safest, economical and convenient method for the drug delivery. Mouth dissolving tablets have becomes the most demanding application during last decades and in the pharmaceutical industry this field has become a rapidly area. Mouth dissolving tablets during insertion in the mouth should have to dissolve or disintegrate in the mouth within 15sec to 3 minutes without the help or need of any drinking agent like water. These mouth dissolving tablets can be given anytime, anywhere to anyone who needs this without the presence of water and these will show the effective action in few minutes.

The aim of this work was to develop a tablet for the buccal delivery of the poorly water-soluble ... more The aim of this work was to develop a tablet for the buccal delivery of the poorly water-soluble drug itraconazole which is a broad spectrum triazole derivative useful in treatment of oropharyngeal candidiasis, for that an attempt was made to solubilizing itraconazole by complexation with β- CD and then delivery via buccal mucosa. HPMC K4M and carbopol 934P were selected as mucoadhesive polymers while ethyl cellulose, as backing material. The complexation was studied by phase solubility method which indicates the formation of complex with 1:1 stoichiometry. Modification of the release for a poorly water-soluble drug, itraconazole, from hydrophilic matrices using βcyclodextrin complexation was evaluated. The buccoadhesive tablets for the delivery of itraconazole were prepared by direct compression of HPMC K4M and Carbopol 934P. The Surface pH of all formulations was found to be within ±1 units of neutral pH hence these formulations should not cause any irritation in buccal cavity. Ca...