abhilasha Mittal - Academia.edu (original) (raw)
Papers by abhilasha Mittal
Current Indian Science, Dec 7, 2023
African Journal of Biological Sciences, Jun 17, 2024
International Journal of Law, Jul 1, 2018
International Journal of Law, 2018
Journal of advanced scientific research, Apr 30, 2022
The scientific novelty of designed work was to develop a specific and precise stability-indicatin... more The scientific novelty of designed work was to develop a specific and precise stability-indicating ultra high performance liquid chromatography (UHPLC) assay method for simultaneous quantification of Sitagliptin and Metforminin extendedrelease fixed dose combinations (FDCs). The reversed-phase UHPLC resolution was analyzed with the assistance of UPLC BEH C 18 (150 mm 2.1 mm) with 1.7 µm particle size column at ambient temperature using a solvent system in a proportion of (90:10 % v/v) acetonitrile: potassium dihydrogen orthophosphate buffer; pH 3.0±0.2 was adjusted with 0.1 % ortho phosphoric acid (OPA), with flow rate of 0.4 mL/min of the solvent system. The analytes were supervised at 267 nm by employing photodiode array recognition. The retention times of Sitagliptin and Metformin were found to be1.903±0.01 and 1.301±0.022, respectively. The Sitagliptin and Metformin have confirmed the linearity ranges of 5-30μg/mL, and 100-600 μg/mL respectively, with 0.9996 and 0.9996 determination coefficients. The UHPLC method was effectually validated concerning the accuracy, precision, sensitivity, robustness, ruggedness, selectivity, and specificity. Moreover, the anticipated UHPLC method's capability to analyze the Sitagliptin and Metformin with no obstruction from degradation products.
Plant Archives, Jan 15, 2021
Pre-ADMET software derived information has significant value in the design of newer potent drug m... more Pre-ADMET software derived information has significant value in the design of newer potent drug molecules. All these predicted data help us to screen the potent and safe compounds for further their synthesis with its biological evaluation. Benzothiazole is versatile heterocyclic rings associated with multiple biological activities that result to inspire continue developing of Benzothiazole analogues. The antidiabetic activity can be evaluated by inducing the diabetic conditions in the experimental model using streptozotocin (STZ). The present research work was focused on screening of potent Benzothiazole derivatives with the help of Pre ADMET toxicity profile and further evaluating their biological activity in the streptozotocin induced diabetes rat model. Among all the selected compounds 6e and 6f were found more potent for anti-diabetic activity at 350 mg/kg (p. o.).
Social Science Research Network, Sep 15, 2018
IP international journal of comprehensive and advanced pharmacology, Feb 15, 2021
International Journal of Research in Pharmaceutical Sciences, Jan 5, 2019
International Journal of Drug Development and Research, 2013
Ricinus communis L. (Euphorbiaceae), known as castor plant, is widespread throughout tropical reg... more Ricinus communis L. (Euphorbiaceae), known as castor plant, is widespread throughout tropical regions of India and grows as an annual or perennial soft wooded small tree. A decoction of the root is administered to relieve lumbago, and a root paste is applied to alleviate toothache. The roots contained glycosides, phenolic compounds, steroids and acidic components. The root bark of R. communis furnished 5.74% of the total ash, 2.03% of the acid insoluble ash and 2.98% of the water soluble ash. There was 9.46 % of water content. Successive extraction of the roots (50 g) yielded 0.362 g, 0.482 g, 1.243 g and 2.643 g of the extracts in petroleum ether, chloroform, methanol and water, respectively. Individual extractions of the roots (15 g) with these solvents produced 0.235 g, 0.727 g, 7.425 g and 12.017 g of the extracts, respectively. Fluorescence behavior of powdered root bark of R. communis indicated that the light yellow powder of the bark powder changed to black at max 366 nm. Among the nine elements, calcium (350.45 ppm) was present in the maximum amount followed by followed by potassium (330.50 ppm), magnesium (230.68 ppm) and cadmium (198.57 ppm). Sodium (56.26 ppm) and lead (8.18 ppm) were detected in trace amounts. The HPTLC scanning of the petroleum ether, chloroform and methanol extracts of the roots exhibited 5, 4 and 4 major bands, respectively.
Journal of Drug Delivery and Therapeutics, Mar 31, 2019
Nature has offered us diverse curative herbs having with powerful antioxidant phytochemicals. Oci... more Nature has offered us diverse curative herbs having with powerful antioxidant phytochemicals. Ocimum (Lamiaceae) is a notable source of volatile oils and flavouring agents in general and primarily of eugenol, methyl eugenol, linalool, methyl chavicol, etc. Karpoora Thulasi is a member of this genus; nevertheless, not much literature has been reported on its safety and antioxidant potential. In this investigation, we did a pre-clinical safety assessment of concentrate of O. kilimandscharicum on Sprague Dawley rodents. Toxicological concordat of the O. kilimandscharicum concentrate was carried out following OECD guidelines 423. Further, to verify the traditional efficacy and elucidate the mechanism, the present study compared in-vitro antioxidant activity of the plant by DPPH, ABTS and Hydroxyl radical scavenging method using ascorbic acid as the standard. In acute oral toxicity, no treatment-related death or toxic signs were observed. Moreover, the study revealed that the O. kilimandscharicum extract could be well tolerated up to the dose 2000 mg/kg body weight and could be classified as Category 5. Moreover, ABTS free radical activity of the extract was 79.2148 while that of DDPH Inhibition potential was found to be 70.72758. Our findings present substantiation that the crude extracts of O. kilimandscharicum is a likely source of natural antioxidants, and this justified its longestablished uses.
Social Science Research Network, Sep 15, 2018
The objective of the present work is to study the in vitro antioxidant activities of petroleum et... more The objective of the present work is to study the in vitro antioxidant activities of petroleum ether, ethyl acetate, and methanolic extracts of leaves of Salvia splendens. The extracts were studied using 1,1-diphenyl-2-picrylhydrazyl, hydrogen peroxide (H 2 O 2), total phenolic content (TPC), and total flavonoid content (TFC). The TPC and TFC were estimated taking gallic acid and rutin calibration curve, respectively. All the extracts possess in vitro antioxidant activities. However, the order of possessing activities was methanolic > ethyl acetate > petroleum ether extracts of leaves S. splendens. The TPC and TFC were highest in methanolic extract. It can be concluded that the extract of the leaves of S. splendens, possess antioxidant activities. The methanolic extract of leaves of S. splendens possesses highest anti-oxidant activity in-vitro.
Journal of Drug Delivery and Therapeutics, Aug 30, 2019
The newly synthesized compounds are being tested for in vitro anti-cancer activity. Method used f... more The newly synthesized compounds are being tested for in vitro anti-cancer activity. Method used for In Vitro testing is Sulforhodamine B assay also known SRB assay. Cell lines were prepared and homoginised and disassociated with the h elp of trypsin. Then trypsin was inactivated with fetal bovine serum. Then cell concentration was determined. Synthesised molecules where prepared in to four different dillutions and exposed to cell lines. The procedure was also compared with standard drug doxorubicin. All the cell medium was incubated 37 degrees centigrade in a humidified incubator with 5 percentage CO. The plates were stainned and fixed with trichloroacetic acid. Finally the plates w ere incubated in orbital shaker incubater and absorbance was measured in micro plate reader at 510nm.
International Journal of Health Sciences (IJHS), Jul 19, 2022
Assessment of prescribing pattern in chronic liver disease (CLD) patients and rational use of med... more Assessment of prescribing pattern in chronic liver disease (CLD) patients and rational use of medication in a tertiary care teaching hospital: A uni-centric prospective study.
International journal of current research and review, 2021
Introduction: The study focus on its degradation pattern well know antidiabetic drugs are Saxagli... more Introduction: The study focus on its degradation pattern well know antidiabetic drugs are Saxagliptin and Metformin HCl Aim: The research study aims to validate the high-performance liquid chromatography method for the degradation study of Saxagliptin and Metformin HCl. Method: In support of the determination and to study its degradation pattern in various pharmaceutical dosage forms a novel and simple reverse phase liquid chromatographic method has been established. Saxagliptin and Metformin HCl are well known to use in Type 2 Diabetes. The planned work was performed on Younglin (S.K) isocratic System UV Detector C18 column (150 mm × 4.6 mm). A mixture of Potassium Acetonitrile: Pot. Phosphate Buffer (ph 3.2) in the ratio of 25:75 was used as mobile phase in this method and the method was validated as per ICH guidelines along with flow rate 1.0 ml/min (UV detection at 212 nm) Result: By exposing the drug the Saxagliptin and Metformin HCl to acidic, alkaline, H 2 O 2 and Neutral degradations forced degradation studies were performed. This method (RP-HPLC) is suitable for kinetic studies as well as the assay of pharmaceutical dosage forms and was found to be robust and specific. Conclusion: In any pharmacopoeia, Saxagliptin is not an official drug. While MET was determined by United States Pharmacopeia (USP), and British Pharmacopoeia (BP) both suggest a non-aqueous titration method using anhydrous formic acid as a solvent and 0.1 M perchloric acid as titrant for the assay of MET. An endpoint is determined potentiometrically.
Plant Archives, Jan 15, 2021
Drug likeliness and toxicity prediction data determined using Pre-ADMET software plays a vital ro... more Drug likeliness and toxicity prediction data determined using Pre-ADMET software plays a vital role in development of newer potent compounds. Further, its outcomes help us to process their synthesis of selected compounds with their biological evaluation. Benzothiazole is one of the important heterocyclic nucleuses which coupled with number of biological activities resulting to develop the newer class of drugs. The assessment of antidiabetic activity can be done by inducing the diabetic conditions in the experimental model using streptozotocin (STZ). This research work was focused on selection of potent benzothiazole derivatives through Pre ADMET toxicity profile and further evaluating their antidiabetic activity in the streptozotocin induced diabetes rat model. Among the entire selected compounds 7d exhibited more potent anti-diabetic activity at 350 mg/kg (p. o.).
International Journal of Research in Pharmaceutical Sciences, Apr 15, 2019
Auroneis a bicyclic ring where a benzene ring fused with a furanone. Docking is an efficient tool... more Auroneis a bicyclic ring where a benzene ring fused with a furanone. Docking is an efficient tool in the development of new lead molecules. Docking, virtual screening, ADMET prediction are prominent devices in the identification of new lead molecules. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Benzofuranone was synthesized by reacting benzene diols, and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to a ketone with treatment with hydrochloric acid then cyclised with sodium acetate. The compounds identity and purity were confirmed by spectral and analytical methods. Benzofuranone derivatives are screened antineoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compound IIIA was found to be with potent activity.
World journal of public health, 2018
Reproductive rights are seen as dynamic rights that can vary according to the evolution of the so... more Reproductive rights are seen as dynamic rights that can vary according to the evolution of the society. Although the World Health Organization gives a standard definition to explain this set of rights, there is still scope for wider interpretation of terms "mental, social and physical well being". This paper, therefore, attempts to understand and interpret the scope via a list certain factors or indicators that could be applied to determine the standard of reproductive health in a country. The indicators for this paper have been attempted to be chosen in such a way that all the intricate factors are also accounted for under the broad headings. The paper also aims to apply these indicators on the availability of reproductive rights and its standards as given to women in India through various reports and case studies. This analysis will not only reveal the status of these rights in practice but also reveal one of the main reasons for the non-availability i.e. poverty and lack of access. The paper, in its final portion, concludes by recommending the state to enhance their policies with respect to these rights in order to ensure better health for not only improving the health of women, but to also improve the health of infants and men who are directly or indirectly affected by the same.
Research journal of pharmacy and technology, Sep 28, 2022
International Journal of Research in Pharmaceutical Sciences, Jan 5, 2019
Received on: 12.07.2018 Revised on: 06.01.2019 Accepted on: 09.01.2019 Benzofuranone derivatives ... more Received on: 12.07.2018 Revised on: 06.01.2019 Accepted on: 09.01.2019 Benzofuranone derivatives are of great interest in medicinal chemistry and have drawn considerable attention due to their diverse pharmacological profiles including anticancer activity. Similarly, chalcones, which are common substructures of numerous natural products belonging to the flavonoid class, feature strong anticancer properties. A novel series of 5.6dihydroxy-2-phenyl-1-benzofuran-3(2H)-one derivatives were designed, synthesized, and characterized. In vitro antitumor activities of the newly synthesized (VA-F) were determined by using human skin cancer cell lines. Antitumor properties of all compounds were determined by 5.6-dihydroxy2-phenyl-1-benzofuran-3(2H)-one (MTT) assay. Cell viability assay for the tested flavone compounds was performed, and the values of the compounds were calculated after 24-hour treatment. Our results indicate that the tested benzofuranone compounds show antitumor activity against human skin cancer cell lines.
Current Indian Science, Dec 7, 2023
African Journal of Biological Sciences, Jun 17, 2024
International Journal of Law, Jul 1, 2018
International Journal of Law, 2018
Journal of advanced scientific research, Apr 30, 2022
The scientific novelty of designed work was to develop a specific and precise stability-indicatin... more The scientific novelty of designed work was to develop a specific and precise stability-indicating ultra high performance liquid chromatography (UHPLC) assay method for simultaneous quantification of Sitagliptin and Metforminin extendedrelease fixed dose combinations (FDCs). The reversed-phase UHPLC resolution was analyzed with the assistance of UPLC BEH C 18 (150 mm 2.1 mm) with 1.7 µm particle size column at ambient temperature using a solvent system in a proportion of (90:10 % v/v) acetonitrile: potassium dihydrogen orthophosphate buffer; pH 3.0±0.2 was adjusted with 0.1 % ortho phosphoric acid (OPA), with flow rate of 0.4 mL/min of the solvent system. The analytes were supervised at 267 nm by employing photodiode array recognition. The retention times of Sitagliptin and Metformin were found to be1.903±0.01 and 1.301±0.022, respectively. The Sitagliptin and Metformin have confirmed the linearity ranges of 5-30μg/mL, and 100-600 μg/mL respectively, with 0.9996 and 0.9996 determination coefficients. The UHPLC method was effectually validated concerning the accuracy, precision, sensitivity, robustness, ruggedness, selectivity, and specificity. Moreover, the anticipated UHPLC method's capability to analyze the Sitagliptin and Metformin with no obstruction from degradation products.
Plant Archives, Jan 15, 2021
Pre-ADMET software derived information has significant value in the design of newer potent drug m... more Pre-ADMET software derived information has significant value in the design of newer potent drug molecules. All these predicted data help us to screen the potent and safe compounds for further their synthesis with its biological evaluation. Benzothiazole is versatile heterocyclic rings associated with multiple biological activities that result to inspire continue developing of Benzothiazole analogues. The antidiabetic activity can be evaluated by inducing the diabetic conditions in the experimental model using streptozotocin (STZ). The present research work was focused on screening of potent Benzothiazole derivatives with the help of Pre ADMET toxicity profile and further evaluating their biological activity in the streptozotocin induced diabetes rat model. Among all the selected compounds 6e and 6f were found more potent for anti-diabetic activity at 350 mg/kg (p. o.).
Social Science Research Network, Sep 15, 2018
IP international journal of comprehensive and advanced pharmacology, Feb 15, 2021
International Journal of Research in Pharmaceutical Sciences, Jan 5, 2019
International Journal of Drug Development and Research, 2013
Ricinus communis L. (Euphorbiaceae), known as castor plant, is widespread throughout tropical reg... more Ricinus communis L. (Euphorbiaceae), known as castor plant, is widespread throughout tropical regions of India and grows as an annual or perennial soft wooded small tree. A decoction of the root is administered to relieve lumbago, and a root paste is applied to alleviate toothache. The roots contained glycosides, phenolic compounds, steroids and acidic components. The root bark of R. communis furnished 5.74% of the total ash, 2.03% of the acid insoluble ash and 2.98% of the water soluble ash. There was 9.46 % of water content. Successive extraction of the roots (50 g) yielded 0.362 g, 0.482 g, 1.243 g and 2.643 g of the extracts in petroleum ether, chloroform, methanol and water, respectively. Individual extractions of the roots (15 g) with these solvents produced 0.235 g, 0.727 g, 7.425 g and 12.017 g of the extracts, respectively. Fluorescence behavior of powdered root bark of R. communis indicated that the light yellow powder of the bark powder changed to black at max 366 nm. Among the nine elements, calcium (350.45 ppm) was present in the maximum amount followed by followed by potassium (330.50 ppm), magnesium (230.68 ppm) and cadmium (198.57 ppm). Sodium (56.26 ppm) and lead (8.18 ppm) were detected in trace amounts. The HPTLC scanning of the petroleum ether, chloroform and methanol extracts of the roots exhibited 5, 4 and 4 major bands, respectively.
Journal of Drug Delivery and Therapeutics, Mar 31, 2019
Nature has offered us diverse curative herbs having with powerful antioxidant phytochemicals. Oci... more Nature has offered us diverse curative herbs having with powerful antioxidant phytochemicals. Ocimum (Lamiaceae) is a notable source of volatile oils and flavouring agents in general and primarily of eugenol, methyl eugenol, linalool, methyl chavicol, etc. Karpoora Thulasi is a member of this genus; nevertheless, not much literature has been reported on its safety and antioxidant potential. In this investigation, we did a pre-clinical safety assessment of concentrate of O. kilimandscharicum on Sprague Dawley rodents. Toxicological concordat of the O. kilimandscharicum concentrate was carried out following OECD guidelines 423. Further, to verify the traditional efficacy and elucidate the mechanism, the present study compared in-vitro antioxidant activity of the plant by DPPH, ABTS and Hydroxyl radical scavenging method using ascorbic acid as the standard. In acute oral toxicity, no treatment-related death or toxic signs were observed. Moreover, the study revealed that the O. kilimandscharicum extract could be well tolerated up to the dose 2000 mg/kg body weight and could be classified as Category 5. Moreover, ABTS free radical activity of the extract was 79.2148 while that of DDPH Inhibition potential was found to be 70.72758. Our findings present substantiation that the crude extracts of O. kilimandscharicum is a likely source of natural antioxidants, and this justified its longestablished uses.
Social Science Research Network, Sep 15, 2018
The objective of the present work is to study the in vitro antioxidant activities of petroleum et... more The objective of the present work is to study the in vitro antioxidant activities of petroleum ether, ethyl acetate, and methanolic extracts of leaves of Salvia splendens. The extracts were studied using 1,1-diphenyl-2-picrylhydrazyl, hydrogen peroxide (H 2 O 2), total phenolic content (TPC), and total flavonoid content (TFC). The TPC and TFC were estimated taking gallic acid and rutin calibration curve, respectively. All the extracts possess in vitro antioxidant activities. However, the order of possessing activities was methanolic > ethyl acetate > petroleum ether extracts of leaves S. splendens. The TPC and TFC were highest in methanolic extract. It can be concluded that the extract of the leaves of S. splendens, possess antioxidant activities. The methanolic extract of leaves of S. splendens possesses highest anti-oxidant activity in-vitro.
Journal of Drug Delivery and Therapeutics, Aug 30, 2019
The newly synthesized compounds are being tested for in vitro anti-cancer activity. Method used f... more The newly synthesized compounds are being tested for in vitro anti-cancer activity. Method used for In Vitro testing is Sulforhodamine B assay also known SRB assay. Cell lines were prepared and homoginised and disassociated with the h elp of trypsin. Then trypsin was inactivated with fetal bovine serum. Then cell concentration was determined. Synthesised molecules where prepared in to four different dillutions and exposed to cell lines. The procedure was also compared with standard drug doxorubicin. All the cell medium was incubated 37 degrees centigrade in a humidified incubator with 5 percentage CO. The plates were stainned and fixed with trichloroacetic acid. Finally the plates w ere incubated in orbital shaker incubater and absorbance was measured in micro plate reader at 510nm.
International Journal of Health Sciences (IJHS), Jul 19, 2022
Assessment of prescribing pattern in chronic liver disease (CLD) patients and rational use of med... more Assessment of prescribing pattern in chronic liver disease (CLD) patients and rational use of medication in a tertiary care teaching hospital: A uni-centric prospective study.
International journal of current research and review, 2021
Introduction: The study focus on its degradation pattern well know antidiabetic drugs are Saxagli... more Introduction: The study focus on its degradation pattern well know antidiabetic drugs are Saxagliptin and Metformin HCl Aim: The research study aims to validate the high-performance liquid chromatography method for the degradation study of Saxagliptin and Metformin HCl. Method: In support of the determination and to study its degradation pattern in various pharmaceutical dosage forms a novel and simple reverse phase liquid chromatographic method has been established. Saxagliptin and Metformin HCl are well known to use in Type 2 Diabetes. The planned work was performed on Younglin (S.K) isocratic System UV Detector C18 column (150 mm × 4.6 mm). A mixture of Potassium Acetonitrile: Pot. Phosphate Buffer (ph 3.2) in the ratio of 25:75 was used as mobile phase in this method and the method was validated as per ICH guidelines along with flow rate 1.0 ml/min (UV detection at 212 nm) Result: By exposing the drug the Saxagliptin and Metformin HCl to acidic, alkaline, H 2 O 2 and Neutral degradations forced degradation studies were performed. This method (RP-HPLC) is suitable for kinetic studies as well as the assay of pharmaceutical dosage forms and was found to be robust and specific. Conclusion: In any pharmacopoeia, Saxagliptin is not an official drug. While MET was determined by United States Pharmacopeia (USP), and British Pharmacopoeia (BP) both suggest a non-aqueous titration method using anhydrous formic acid as a solvent and 0.1 M perchloric acid as titrant for the assay of MET. An endpoint is determined potentiometrically.
Plant Archives, Jan 15, 2021
Drug likeliness and toxicity prediction data determined using Pre-ADMET software plays a vital ro... more Drug likeliness and toxicity prediction data determined using Pre-ADMET software plays a vital role in development of newer potent compounds. Further, its outcomes help us to process their synthesis of selected compounds with their biological evaluation. Benzothiazole is one of the important heterocyclic nucleuses which coupled with number of biological activities resulting to develop the newer class of drugs. The assessment of antidiabetic activity can be done by inducing the diabetic conditions in the experimental model using streptozotocin (STZ). This research work was focused on selection of potent benzothiazole derivatives through Pre ADMET toxicity profile and further evaluating their antidiabetic activity in the streptozotocin induced diabetes rat model. Among the entire selected compounds 7d exhibited more potent anti-diabetic activity at 350 mg/kg (p. o.).
International Journal of Research in Pharmaceutical Sciences, Apr 15, 2019
Auroneis a bicyclic ring where a benzene ring fused with a furanone. Docking is an efficient tool... more Auroneis a bicyclic ring where a benzene ring fused with a furanone. Docking is an efficient tool in the development of new lead molecules. Docking, virtual screening, ADMET prediction are prominent devices in the identification of new lead molecules. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Benzofuranone was synthesized by reacting benzene diols, and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to a ketone with treatment with hydrochloric acid then cyclised with sodium acetate. The compounds identity and purity were confirmed by spectral and analytical methods. Benzofuranone derivatives are screened antineoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compound IIIA was found to be with potent activity.
World journal of public health, 2018
Reproductive rights are seen as dynamic rights that can vary according to the evolution of the so... more Reproductive rights are seen as dynamic rights that can vary according to the evolution of the society. Although the World Health Organization gives a standard definition to explain this set of rights, there is still scope for wider interpretation of terms "mental, social and physical well being". This paper, therefore, attempts to understand and interpret the scope via a list certain factors or indicators that could be applied to determine the standard of reproductive health in a country. The indicators for this paper have been attempted to be chosen in such a way that all the intricate factors are also accounted for under the broad headings. The paper also aims to apply these indicators on the availability of reproductive rights and its standards as given to women in India through various reports and case studies. This analysis will not only reveal the status of these rights in practice but also reveal one of the main reasons for the non-availability i.e. poverty and lack of access. The paper, in its final portion, concludes by recommending the state to enhance their policies with respect to these rights in order to ensure better health for not only improving the health of women, but to also improve the health of infants and men who are directly or indirectly affected by the same.
Research journal of pharmacy and technology, Sep 28, 2022
International Journal of Research in Pharmaceutical Sciences, Jan 5, 2019
Received on: 12.07.2018 Revised on: 06.01.2019 Accepted on: 09.01.2019 Benzofuranone derivatives ... more Received on: 12.07.2018 Revised on: 06.01.2019 Accepted on: 09.01.2019 Benzofuranone derivatives are of great interest in medicinal chemistry and have drawn considerable attention due to their diverse pharmacological profiles including anticancer activity. Similarly, chalcones, which are common substructures of numerous natural products belonging to the flavonoid class, feature strong anticancer properties. A novel series of 5.6dihydroxy-2-phenyl-1-benzofuran-3(2H)-one derivatives were designed, synthesized, and characterized. In vitro antitumor activities of the newly synthesized (VA-F) were determined by using human skin cancer cell lines. Antitumor properties of all compounds were determined by 5.6-dihydroxy2-phenyl-1-benzofuran-3(2H)-one (MTT) assay. Cell viability assay for the tested flavone compounds was performed, and the values of the compounds were calculated after 24-hour treatment. Our results indicate that the tested benzofuranone compounds show antitumor activity against human skin cancer cell lines.