maheen adamson - Academia.edu (original) (raw)

Papers by maheen adamson

Neuromodulation: Technology at the Neural Interface

Background Mild Cognitive Impairment (MCI) carries a high risk of progression to Alzheimer's ... more Background Mild Cognitive Impairment (MCI) carries a high risk of progression to Alzheimer's disease (AD) dementia. Previous clinical trials testing whether cholinesterase inhibitors can slow the rate of progression from MCI to AD dementia have yielded disappointing results. However, recent studies of the effects of repetitive transcranial magnetic stimulation (rTMS) in AD have demonstrated improvements in cognitive function. Because few rTMS trials have been conducted in MCI, we designed a trial to test the short-term efficacy of rTMS in MCI. Yet, in both MCI and AD, we know little about what site of stimulation would be ideal for improving cognitive function. Therefore, two cortical sites will be investigated in this trial: (1) the dorsolateral prefrontal cortex (DLPFC), which has been well studied for treatment of major depressive disorder; and (2) the lateral parietal cortex (LPC), a novel site with connectivity to AD-relevant limbic regions. Methods/design In this single-si...

Additional file 1. List of supplementary documents. The detailed study protocol (which includes d... more Additional file 1. List of supplementary documents. The detailed study protocol (which includes details of data collection, AE monitoring, statistical considerations, and data management), exclusionary medications, and two rTMS manuals are available from the authors.

Additional file 3. Informed consent documents. Research consent forms for the clinical trial and ... more Additional file 3. Informed consent documents. Research consent forms for the clinical trial and for an ancillary study involving urine specimens.

Additional file 2: Table S1. Schedule of enrollment, interventions, and assessments.

PsycEXTRA Dataset, 2004

ABSTRACT Thesis (Ph. D.)--University of Southern California, 2004. Includes bibliographical refer... more ABSTRACT Thesis (Ph. D.)--University of Southern California, 2004. Includes bibliographical references (leaves 210-223).

Journal of Alzheimer's disease : JAD, 2011

Alzheimer's & Dementia, 2010

This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit:

Additional file 4. Biological specimens manual. Appendix of procedures for the collection, proces... more Additional file 4. Biological specimens manual. Appendix of procedures for the collection, processing, and storage of biological specimens for the current trial.

COVID

The scale and duration of the worldwide SARS-COVID-2 virus-related quarantine measures presented ... more The scale and duration of the worldwide SARS-COVID-2 virus-related quarantine measures presented the global scientific community with a unique opportunity to study the accompanying psychological stress. Since March 2020, numerous publications have reported similar findings from diverse international studies on psychological stress, depression, and anxiety, which have increased during this pandemic. However, there remains a gap in interpreting the results from one country to another despite the global rise in mental health problems. The objective of our study was to identify global indicators of pandemic-related stress that traverse geographic and cultural boundaries. We amalgamated data from two independent global surveys across twelve countries and spanning four continents collected during the first wave of the mandated public health measures aimed at mitigating COVID-19. We applied machine learning (ML) modelling to these data, and the results revealed a significant positive corre...

Frontiers in Virtual Reality

In Iraq and Afghanistan over 75% of the combat casualties suffered by U.S. troops have involved e... more In Iraq and Afghanistan over 75% of the combat casualties suffered by U.S. troops have involved explosive devices. Improvements in body armor and advances in military medicine have significantly reduced the number of combat-related fatalities, but have greatly increased the number of U.S. active component personnel suffering painful trauma injuries. Unfortunately, so far, advances in pharmacologic analgesia pain medications have not kept pace with advances in survivability. For many active component personnel and Veterans, pain is a top health complaint from patients. The opioid epidemic has increased the urgency of developing powerful non-pharmacologic approaches for the management of pain. Immersive VR is proving to be a powerful non-opioid pain management technique for acute pain. However, the cost and usability limitations of pre-2016 VR clinical products resulted in limited treatment adoption rates for clinical use. In recent years, VR technology has become increasingly immersi...

Background Failure to adhere to treatment recommendations has significant impact on the health ou... more Background Failure to adhere to treatment recommendations has significant impact on the health outcomes of the individual and health care systems. Health coaching is a promising care model that has gained interest in the medical field. This study focused on the impact of health coaching on health behaviors that may have direct impact on successful patient outcomes. Primary Study Objective The objective of this study was to assess the impact of health coaching administered through the Polytrauma Integrative Medicine Initiative (PIMI). Methods/Design This study was a quasiexperimental cohort study. Setting This study occurred at a specialized polytrauma rehabilitation center. Participants Participants were divided into 3 cohorts: (1) 33 patients who served through PIMI enrollment, (2) 22 patients who declined PIMI, and (3) a control cohort of 30 random patients who were not referred to PIMI. Patients were primarily male active duty or veteran military personnel. Intervention The inter...

Objective: To identify alterations in subcortical gray matter (GM) volume in Active Duty Service ... more Objective: To identify alterations in subcortical gray matter (GM) volume in Active Duty Service Members (ADSM) and Veterans of the United States military with history of traumatic brain injury (TBI), with greater power from multi-site mega-analysis. Background: TBI is one of the most common injuries affecting armed service members across the world. Injuries can affect combat readiness and can lead to long-term cognitive impairments and adverse health consequences. Altered subcortical GM volume may contribute to poor outcome. Reliable neuroimaging biomarkers of TBI have been elusive, often due to small sample size. Design/Methods: Participants were assessed through three different projects – DoD Alzheimer’s Disease Neuroimaging Initiative, Imaging Support of Study of Cognitive Rehabilitation Effectiveness in Mild Traumatic Brain Injury, and Chronic Effects of Neurotrauma Consortium, totaling 199 participants reporting at least one TBI (178M/21F) and 170 participants without history ...

$Research paper thumbnail of Effect of rTMS on fractional anisotropy, radial diffusivity, and axonal volume in select fiber tracts in patients with traumatic brain injury$