afrouz alipour - Academia.edu (original) (raw)
Papers by afrouz alipour
Iranian journal of radiology./Iranian journal of radiology, Mar 26, 2024
Neurosciences
To investigate the demographic and clinical characteristics of epilepsy in 2 referral hospitals i... more To investigate the demographic and clinical characteristics of epilepsy in 2 referral hospitals in northern Iran. Methods: In this cross-sectional study, we evaluated 300 patients with the confirmed diagnosis of epilepsy referred to the Neurology clinics of 22-Bahman, and 17-Shahrivar Hospitals, Mashad, Iran, from April 2011 to December 2012. We collected and analyzed demographic and disease information. Results: The mean age of patients was 31.5 ± 15.3 years. The diagnosis of disease had been made approximately 10 months after the onset of symptoms, and the treatment gap was 28%. The most widely used anticonvulsants were sodium valproate, Disclosure. The authors have no affiliation or financial involvement with organizations or entities with a direct financial interest in the subject matter or materials discussed in the manuscript. No funding was received for this work from any organization. Neurosciences 2015; Vol. 20 (3) carbamazepine, and phenobarbital. Generalized seizure was seen in 78%, partial seizure in 22%, and a combination of them in 11% of patients. Toniccolonic seizure (72%) was the most common type of generalized epilepsy, and secondarily generalized seizure was the most frequent type of partial epilepsy. Conclusion: The epidemiological features of epilepsy in our region with regard to age and gender are the same as other parts of the world. The generalized type is the most common form of epilepsy, with toniccolonic seizures being the most frequent type in our area.
We studied the prevalence of microembolic signals (MES) in patients with diagnosis Behcet's d... more We studied the prevalence of microembolic signals (MES) in patients with diagnosis Behcet's disease (BD). We also tried to determine the frequency of MES in BD patients with or without neurological involvement. This study enrolled 40 patients who fulfilled the diagnostic criteria of International Study Group for BD. Bilateral transcranial Doppler ultrasound of the middle cerebral arteries was performed by multigate method. MES were identified based on the criteria of International Consensus group on Microembolus Detection. Patients with BD were divided into two groups in respect of the presence of neurological involvement (n = 5) or not (n = 35), and counts of MES in the two were compared with each other and with normal subjects. We found MES in none of our patients with BD. In patients with neurological involvement there was a positive correlation in regression analysis between the prevalence of MES and disease duration in other studies but in this study we did not detect any M...
Journal of Pediatrics Review
Introduction: Anesthetic medications are frequently used in medical procedures to prevent pain an... more Introduction: Anesthetic medications are frequently used in medical procedures to prevent pain and undesired sensations. Local anesthetic agents are widely used in the form of ointment, gel, cream, drop or spray in minor surgical or in-house pain relieving procedures in children and adults. Case Presentation: A 16-month-old boy ingested an unknown amount of lidocaine and became lethargic after about 15 minutes. After a while, he experienced a generalized tonic-clonic seizure and loss of consciousness. He needed a short course of intubation and mechanical ventilation. A short literature review was also performed on local anesthetic intoxication. Conclusions: Safe-seeming local anesthetic agents can cause life-threatening complications, especially when used at home without enough medical knowledge or supervision.
Turkish Journal Of Neurology, 2016
Objective: Some patients with migraine headache still experience severe migraine attacks despite ... more Objective: Some patients with migraine headache still experience severe migraine attacks despite use of proper prophylactic treatments. There are several treatments for refractory migraine (RM), one of which is abobotulinum toxin A (Dysport). This study aimed to investigate the efficacy of abobotulinum toxin A in the prophylactic treatment of RM. Materials and Methods: In this prospective single-arm clinical trial, 18 patients with RM were included. Patients completed a questionnaire including migraine characteristics one month before the study. Each patient received an injection of 150 U abobotulinum toxin A in the specific head and neck regions. Before and 3 months after treatment, migraine severity was evaluated. Results: The average number of attacks per month before injection was 7.56±4.06, which decreased to 1.89±1.32 3 months after injection (p<0.0001). The average duration of attacks also decreased significantly after 3 months of injection (from 20.33 hrs to 2.56 hrs per month) (p=0.0001). Three patients (16.6%) had no attacks during the follow-up period. Eleven patients (61.1%) reported mild attacks and four patients (22.2%) reported moderate pain. Conclusion: Abobotulinum toxin A (Dysport) can reduce frequency, duration, and severity of migraine attacks in patients with RM and it can be used as a prophylactic treatment in this group of patients.
International Journal of Hematology, Mar 21, 2012
Acute lymphoblastic leukemia (ALL) affects both children and adults. Survival in ALL has improved... more Acute lymphoblastic leukemia (ALL) affects both children and adults. Survival in ALL has improved in recent decades due to recognition of its biological heterogeneity. Although children have higher remission and cure rates than adults, both populations have benefited from these improvements. Our aim in this study is to determine the association between HLA-DQB1 genes with childhood and adult ALL patients. To define this association, we compared HLA-DQB1 allele frequencies and allele carrier frequencies in a cohort of 135 adults and children with ALL with 150 controls, using polymerase chain reaction with sequence-specific primers. Allele carrier frequencies in childhood ALL show a deficiency in DQ2 (*0201) (P 0.049 and RR 0.75), but an increase in DQ5 (*0501-*0504) and DQ7 (*0301, *0304) compared to the control group (P 0.001 RR 1.89, P 0.003 RR 1.48, respectively). Allele carrier frequencies in adult ALL indicated an increase in DQ5 (*0501-*0504) (P0.045 RR 2.28). Allelic frequencies in childhood ALL revealed the same increase in DQ5 and DQ7, and a decrease in DQ2. In adult ALL it shows a decrease in DQ7. Therefore, our results in adult ALL were similar to childhood ALL addressing DQ5 allele carriers, which showed an increase in both age groups. We suggest that DQ5 could be more strongly considered as an ALL susceptibility allele, and that this allele may underlie a pathogenic phenotype with a major role in the immunologic process involved in both adults and children with ALL.
Iranian journal of radiology./Iranian journal of radiology, Mar 26, 2024
Neurosciences
To investigate the demographic and clinical characteristics of epilepsy in 2 referral hospitals i... more To investigate the demographic and clinical characteristics of epilepsy in 2 referral hospitals in northern Iran. Methods: In this cross-sectional study, we evaluated 300 patients with the confirmed diagnosis of epilepsy referred to the Neurology clinics of 22-Bahman, and 17-Shahrivar Hospitals, Mashad, Iran, from April 2011 to December 2012. We collected and analyzed demographic and disease information. Results: The mean age of patients was 31.5 ± 15.3 years. The diagnosis of disease had been made approximately 10 months after the onset of symptoms, and the treatment gap was 28%. The most widely used anticonvulsants were sodium valproate, Disclosure. The authors have no affiliation or financial involvement with organizations or entities with a direct financial interest in the subject matter or materials discussed in the manuscript. No funding was received for this work from any organization. Neurosciences 2015; Vol. 20 (3) carbamazepine, and phenobarbital. Generalized seizure was seen in 78%, partial seizure in 22%, and a combination of them in 11% of patients. Toniccolonic seizure (72%) was the most common type of generalized epilepsy, and secondarily generalized seizure was the most frequent type of partial epilepsy. Conclusion: The epidemiological features of epilepsy in our region with regard to age and gender are the same as other parts of the world. The generalized type is the most common form of epilepsy, with toniccolonic seizures being the most frequent type in our area.
We studied the prevalence of microembolic signals (MES) in patients with diagnosis Behcet's d... more We studied the prevalence of microembolic signals (MES) in patients with diagnosis Behcet's disease (BD). We also tried to determine the frequency of MES in BD patients with or without neurological involvement. This study enrolled 40 patients who fulfilled the diagnostic criteria of International Study Group for BD. Bilateral transcranial Doppler ultrasound of the middle cerebral arteries was performed by multigate method. MES were identified based on the criteria of International Consensus group on Microembolus Detection. Patients with BD were divided into two groups in respect of the presence of neurological involvement (n = 5) or not (n = 35), and counts of MES in the two were compared with each other and with normal subjects. We found MES in none of our patients with BD. In patients with neurological involvement there was a positive correlation in regression analysis between the prevalence of MES and disease duration in other studies but in this study we did not detect any M...
Journal of Pediatrics Review
Introduction: Anesthetic medications are frequently used in medical procedures to prevent pain an... more Introduction: Anesthetic medications are frequently used in medical procedures to prevent pain and undesired sensations. Local anesthetic agents are widely used in the form of ointment, gel, cream, drop or spray in minor surgical or in-house pain relieving procedures in children and adults. Case Presentation: A 16-month-old boy ingested an unknown amount of lidocaine and became lethargic after about 15 minutes. After a while, he experienced a generalized tonic-clonic seizure and loss of consciousness. He needed a short course of intubation and mechanical ventilation. A short literature review was also performed on local anesthetic intoxication. Conclusions: Safe-seeming local anesthetic agents can cause life-threatening complications, especially when used at home without enough medical knowledge or supervision.
Turkish Journal Of Neurology, 2016
Objective: Some patients with migraine headache still experience severe migraine attacks despite ... more Objective: Some patients with migraine headache still experience severe migraine attacks despite use of proper prophylactic treatments. There are several treatments for refractory migraine (RM), one of which is abobotulinum toxin A (Dysport). This study aimed to investigate the efficacy of abobotulinum toxin A in the prophylactic treatment of RM. Materials and Methods: In this prospective single-arm clinical trial, 18 patients with RM were included. Patients completed a questionnaire including migraine characteristics one month before the study. Each patient received an injection of 150 U abobotulinum toxin A in the specific head and neck regions. Before and 3 months after treatment, migraine severity was evaluated. Results: The average number of attacks per month before injection was 7.56±4.06, which decreased to 1.89±1.32 3 months after injection (p<0.0001). The average duration of attacks also decreased significantly after 3 months of injection (from 20.33 hrs to 2.56 hrs per month) (p=0.0001). Three patients (16.6%) had no attacks during the follow-up period. Eleven patients (61.1%) reported mild attacks and four patients (22.2%) reported moderate pain. Conclusion: Abobotulinum toxin A (Dysport) can reduce frequency, duration, and severity of migraine attacks in patients with RM and it can be used as a prophylactic treatment in this group of patients.
International Journal of Hematology, Mar 21, 2012
Acute lymphoblastic leukemia (ALL) affects both children and adults. Survival in ALL has improved... more Acute lymphoblastic leukemia (ALL) affects both children and adults. Survival in ALL has improved in recent decades due to recognition of its biological heterogeneity. Although children have higher remission and cure rates than adults, both populations have benefited from these improvements. Our aim in this study is to determine the association between HLA-DQB1 genes with childhood and adult ALL patients. To define this association, we compared HLA-DQB1 allele frequencies and allele carrier frequencies in a cohort of 135 adults and children with ALL with 150 controls, using polymerase chain reaction with sequence-specific primers. Allele carrier frequencies in childhood ALL show a deficiency in DQ2 (*0201) (P 0.049 and RR 0.75), but an increase in DQ5 (*0501-*0504) and DQ7 (*0301, *0304) compared to the control group (P 0.001 RR 1.89, P 0.003 RR 1.48, respectively). Allele carrier frequencies in adult ALL indicated an increase in DQ5 (*0501-*0504) (P0.045 RR 2.28). Allelic frequencies in childhood ALL revealed the same increase in DQ5 and DQ7, and a decrease in DQ2. In adult ALL it shows a decrease in DQ7. Therefore, our results in adult ALL were similar to childhood ALL addressing DQ5 allele carriers, which showed an increase in both age groups. We suggest that DQ5 could be more strongly considered as an ALL susceptibility allele, and that this allele may underlie a pathogenic phenotype with a major role in the immunologic process involved in both adults and children with ALL.