agrata sharma - Academia.edu (original) (raw)
Papers by agrata sharma
Journal of Neurosciences in Rural Practice, Mar 10, 2022
Background Restless legs syndrome (RLS), a prevalent and treatable entity, has high impact on qua... more Background Restless legs syndrome (RLS), a prevalent and treatable entity, has high impact on quality of life, requiring a better screening tool for its early detection. Thus, present study aimed to derive a Hindi RLS (RLS-H) screening tool for its use in Indian population. Materials and Methods RLS-H screening tool, derived by translating first four criteria of 2012 revised International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria in Hindi and was validated in 50 RLS and 50 non-RLS patients. This validated RLS-H tool was used to screen 1,066 patients attending neurology clinic for assessing its diagnostic accuracy. Internal consistency, discriminatory validity, and various diagnostic yields were calculated. IRLSSG was used as gold standard for final diagnosis of RLS. Results RLS-H screening tool had an internal consistency of 0.910. No correlation was found between RLS-H screening tool and Epworth sleepiness scale, Pittsburgh sleep quality index, or International Restless Legs Syndrome Study Group rating scale indicating satisfactory discriminant validity. Prevalence of RLS was 13.6%. The question (Q)1 had highest sensitivity (97.9%) and Q4 had highest specificity (92.66%). Thus, its combinations (Q1 þ Q4) along with addition of Q2 or Q3 were compared for best combination of diagnostic accuracy. A minimum cutoff value of RLS-H screening tool was 2.5 for considering patients requiring detailed RLS evaluation. Conclusion RLS-H screening tool can be used as a screening tool for early detection of RLS among susceptible patients. Patients answering "yes" to more than two questions (cutoff ¼ 2.5) or "yes" to Q1 and Q4 should be interviewed and assessed for RLS.
ABSTRACTBackground and purposeThe benefit of endovascular treatment in large anterior circulation... more ABSTRACTBackground and purposeThe benefit of endovascular treatment in large anterior circulation ischemic strokes with low ASPECTS score(<6) is uncertain. Recent studies have demonstrated the benefit of endovascular treatment (EVT) in large ischemic strokes. The present meta-analysis aims to assess the combined effect of these studies on efficacy and safety of endovascular treatment in this group of patients.Materials and MethodsWe conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Databases MEDLINE, PubMed, EMBASE, SCOPUS, Google Scholar, Tripdatabase were searched for randomised controlled trials with at least 50 participants. The primary efficacy outcome analysed was the relative risk of functional independence defined as mRS-0-2 at 90 days. Secondary efficacy outcomes included early neurological improvement, death due to any cause at 90 days and proportion of patients requiring decomp...
European Stroke Journal
Introduction: The benefit of endovascular treatment in large anterior circulation ischaemic strok... more Introduction: The benefit of endovascular treatment in large anterior circulation ischaemic strokes with low ASPECTS score (<6) is uncertain. Recent randomised studies have demonstrated the benefit of endovascular treatment (EVT) in large ischaemic strokes. The present meta-analysis aims to assess the combined effect of these studies on efficacy and safety of endovascular treatment in this group of patients. Materials and methods: We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Databases MEDLINE, PubMed, EMBASE, SCOPUS, Google Scholar, Tripdatabase were searched for randomised controlled trials with at least 50 participants from inception until February 16, 2023. The primary efficacy outcome analysed was the relative risk of functional independence defined as mRS – 0–2 at 90 days. Secondary efficacy outcomes included early neurological improvement, death due to any cause at 90 days a...
Journal of Neurosciences in Rural Practice
Background Restless legs syndrome (RLS), a prevalent and treatable entity, has high impact on qua... more Background Restless legs syndrome (RLS), a prevalent and treatable entity, has high impact on quality of life, requiring a better screening tool for its early detection. Thus, present study aimed to derive a Hindi RLS (RLS-H) screening tool for its use in Indian population. Materials and Methods RLS-H screening tool, derived by translating first four criteria of 2012 revised International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria in Hindi and was validated in 50 RLS and 50 non-RLS patients. This validated RLS-H tool was used to screen 1,066 patients attending neurology clinic for assessing its diagnostic accuracy. Internal consistency, discriminatory validity, and various diagnostic yields were calculated. IRLSSG was used as gold standard for final diagnosis of RLS. Results RLS-H screening tool had an internal consistency of 0.910. No correlation was found between RLS-H screening tool and Epworth sleepiness scale, Pittsburgh sleep quality index, or Internationa...
International Journal of Advanced Research
Neucysticercosis (NCC) is the most common Helminthic infection of the central nervous system and ... more Neucysticercosis (NCC) is the most common Helminthic infection of the central nervous system and its epidemiology is changing due to increasing travel and migration. Evidence to guide management of the intraventricular form is limited. The intraventricularvariant of NCC is less common than parenchymal disease and usually presents with acutely raised intracranial pressure and untreated it progresses rapidly with high mortality. It is considered as a potentially life threatening emergency. We report an acute case of 30 year old female who suffered from cephalalgia which rapidly worsened and ended in her sudden and unexpected death. Magnetic resonance imaging (MRI) of the brain was obtained. Features demonstrated on MRI scan were consistent with a diagnosis of intraventricular NCC.
Indian Journal of Nephrology
Journal of Neurosciences in Rural Practice, Mar 10, 2022
Background Restless legs syndrome (RLS), a prevalent and treatable entity, has high impact on qua... more Background Restless legs syndrome (RLS), a prevalent and treatable entity, has high impact on quality of life, requiring a better screening tool for its early detection. Thus, present study aimed to derive a Hindi RLS (RLS-H) screening tool for its use in Indian population. Materials and Methods RLS-H screening tool, derived by translating first four criteria of 2012 revised International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria in Hindi and was validated in 50 RLS and 50 non-RLS patients. This validated RLS-H tool was used to screen 1,066 patients attending neurology clinic for assessing its diagnostic accuracy. Internal consistency, discriminatory validity, and various diagnostic yields were calculated. IRLSSG was used as gold standard for final diagnosis of RLS. Results RLS-H screening tool had an internal consistency of 0.910. No correlation was found between RLS-H screening tool and Epworth sleepiness scale, Pittsburgh sleep quality index, or International Restless Legs Syndrome Study Group rating scale indicating satisfactory discriminant validity. Prevalence of RLS was 13.6%. The question (Q)1 had highest sensitivity (97.9%) and Q4 had highest specificity (92.66%). Thus, its combinations (Q1 þ Q4) along with addition of Q2 or Q3 were compared for best combination of diagnostic accuracy. A minimum cutoff value of RLS-H screening tool was 2.5 for considering patients requiring detailed RLS evaluation. Conclusion RLS-H screening tool can be used as a screening tool for early detection of RLS among susceptible patients. Patients answering "yes" to more than two questions (cutoff ¼ 2.5) or "yes" to Q1 and Q4 should be interviewed and assessed for RLS.
ABSTRACTBackground and purposeThe benefit of endovascular treatment in large anterior circulation... more ABSTRACTBackground and purposeThe benefit of endovascular treatment in large anterior circulation ischemic strokes with low ASPECTS score(<6) is uncertain. Recent studies have demonstrated the benefit of endovascular treatment (EVT) in large ischemic strokes. The present meta-analysis aims to assess the combined effect of these studies on efficacy and safety of endovascular treatment in this group of patients.Materials and MethodsWe conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Databases MEDLINE, PubMed, EMBASE, SCOPUS, Google Scholar, Tripdatabase were searched for randomised controlled trials with at least 50 participants. The primary efficacy outcome analysed was the relative risk of functional independence defined as mRS-0-2 at 90 days. Secondary efficacy outcomes included early neurological improvement, death due to any cause at 90 days and proportion of patients requiring decomp...
European Stroke Journal
Introduction: The benefit of endovascular treatment in large anterior circulation ischaemic strok... more Introduction: The benefit of endovascular treatment in large anterior circulation ischaemic strokes with low ASPECTS score (<6) is uncertain. Recent randomised studies have demonstrated the benefit of endovascular treatment (EVT) in large ischaemic strokes. The present meta-analysis aims to assess the combined effect of these studies on efficacy and safety of endovascular treatment in this group of patients. Materials and methods: We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Databases MEDLINE, PubMed, EMBASE, SCOPUS, Google Scholar, Tripdatabase were searched for randomised controlled trials with at least 50 participants from inception until February 16, 2023. The primary efficacy outcome analysed was the relative risk of functional independence defined as mRS – 0–2 at 90 days. Secondary efficacy outcomes included early neurological improvement, death due to any cause at 90 days a...
Journal of Neurosciences in Rural Practice
Background Restless legs syndrome (RLS), a prevalent and treatable entity, has high impact on qua... more Background Restless legs syndrome (RLS), a prevalent and treatable entity, has high impact on quality of life, requiring a better screening tool for its early detection. Thus, present study aimed to derive a Hindi RLS (RLS-H) screening tool for its use in Indian population. Materials and Methods RLS-H screening tool, derived by translating first four criteria of 2012 revised International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria in Hindi and was validated in 50 RLS and 50 non-RLS patients. This validated RLS-H tool was used to screen 1,066 patients attending neurology clinic for assessing its diagnostic accuracy. Internal consistency, discriminatory validity, and various diagnostic yields were calculated. IRLSSG was used as gold standard for final diagnosis of RLS. Results RLS-H screening tool had an internal consistency of 0.910. No correlation was found between RLS-H screening tool and Epworth sleepiness scale, Pittsburgh sleep quality index, or Internationa...
International Journal of Advanced Research
Neucysticercosis (NCC) is the most common Helminthic infection of the central nervous system and ... more Neucysticercosis (NCC) is the most common Helminthic infection of the central nervous system and its epidemiology is changing due to increasing travel and migration. Evidence to guide management of the intraventricular form is limited. The intraventricularvariant of NCC is less common than parenchymal disease and usually presents with acutely raised intracranial pressure and untreated it progresses rapidly with high mortality. It is considered as a potentially life threatening emergency. We report an acute case of 30 year old female who suffered from cephalalgia which rapidly worsened and ended in her sudden and unexpected death. Magnetic resonance imaging (MRI) of the brain was obtained. Features demonstrated on MRI scan were consistent with a diagnosis of intraventricular NCC.
Indian Journal of Nephrology