ahmed awad - Academia.edu (original) (raw)
Papers by ahmed awad
Large Middle Cranial Fossa Schwannoma: A Rare Presentation of Vestibular Schwannoma
Cureus
The Lancet
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Journal of Surgical Case Reports
Multiple primary tumors' incidence is rare, yet more rare is the incidence of multiple primar... more Multiple primary tumors' incidence is rare, yet more rare is the incidence of multiple primary malignant tumors. Co-occurring tumors can be divided into synchronous and non-synchronous. Synchronous tumors are those tumors that present within a period not >6 months from each other. To define synchronous malignant tumors: metastasis should not be present, both tumors have to show criteria of malignancy, and they should differ pathologically from each other. Breast cancer is the most common tumor to be associated with other primaries especially; colorectal cancer, endometrial and ovarian cancer, yet the occurrence of invasive ductal carcinoma with clear cell renal cancer is uncommon. In our case, we present a 59-year-old female with invasive ductal carcinoma and clear cell renal carcinoma.
Synthesis and in silico evaluation of novel uridyl sulfamoylbenzoate derivatives as potential anticancer agents targeting M1 subunit of human ribonucleotide reductase (hRRM1)
Medicinal Chemistry Research
Extralobar bronchopulmonary sequestration supplied by right-sided aortic arch aberrant subclavian artery
Indian Journal of Thoracic and Cardiovascular Surgery
Right aortic arch (RAA) with an aberrant left subclavian artery (LSA) is a very rare anatomical v... more Right aortic arch (RAA) with an aberrant left subclavian artery (LSA) is a very rare anatomical variant of the aorta, which is rarely symptomatic. However, symptoms may vary depending on the relationship of the aberrant subclavian artery to the surrounding structures. In this report, we present a case of an 8-year-old girl who was identified with Edward’s type II RAA with LSA after developing a list of symptoms that led to the diagnosis of pulmonary sequestration, which in turn led to the discovery of her congenital aortic abnormality.
In Silico Pharmacology, 2021
Class B1 metallo-β-lactamases (MBLs) are metalloenzymes found in drug resistant bacteria. The enz... more Class B1 metallo-β-lactamases (MBLs) are metalloenzymes found in drug resistant bacteria. The enzyme requires zinc ions, along with conserved amino acid coordination for nucleophilic attack of the lactam ring to induce hydrolysis and inactivation of β-lactam and some carbapenem antibiotics. To this date there are no clinically relevant class B1 MBL inhibitors, however L-captopril has shown significant results against NDM-1, the most difficult MBL to inhibit. Herein, we report the synthesis and evaluation of novel nucleoside analogues modified with polyethylene glycolamino (PEGA) as potential inhibitors for class B1 MBLs. Molecular dynamics simulations, using internal coordinate mechanics (ICM) algorithm, were performed on subclass B1 enzyme complex models screened with twenty-one possible PEGA-nucleosides. Analogue A, 3′-deoxy-3′-(2-(2-hydroxyethoxy)ethanamino)-β-D-xylofuranosyluracil showed superior binding, with high specificity to the conserved zinc ions in the class B1 MBL active site by utilizing key β-lactam mimic points in the uridine nucleobase. The PEGA moiety showed chelating activity with zinc and disrupted the metal-binding amino acid geometry. In all subclass B1 proteins tested, analogue A had the most effective inhibition when compared to penicillin or L-captopril. Chemical synthesis was performed by condensation of the corresponding keto ribonucleoside with PEGA, followed by enantioselective reduction of the formed imine to produce the amino derivative with desired configuration. Pharmacokinetic and pharmacodynamic screenings revealed that PEGA-pyrimidine nucleosides are not toxic, nor violate Lipinski's rules. These results suggested that analogue A can be proposed as a potential metalloenzyme inhibitor against the widespread antibiotic resistant bacteria and is worth further in vitro and in vivo investigations.
Bechet syndrome is a multisystemic illness that leads to vasculitis. The classic constellation of... more Bechet syndrome is a multisystemic illness that leads to vasculitis. The classic constellation of symptoms is recurrent aphthous ulcers of the mouth and genitalia, hyperreactivity of the skin to penetrating trauma (pathergy reaction), other skin lesions, arthritis, and panuveitis. Vascular involvement can involve arteries and veins of all sizes and types. however venous involvement tends to be more common than arterial vasculitis mostly in the form of lower extremity vein thrombosis. Interestingly the disease manifestation of vasculitis itself seems to favor males than females and with a unique geographical distribution. Arterial vasculitis tends to affect the pulmonary vasculature, though Pulmonary involvement in Bechet’s disease is rare, occurring 1-7.7 of patients. Pulmonary artery aneurysms with or without “in situ" thrombosis is the most common form of arterial involvement and are the leading causes of increased mortality. Different management modalities have been proposed...
Journal of Cyber Security and Mobility, 2017
This paper presents a novel technique to uniquely identify a user using data gathered from a mous... more This paper presents a novel technique to uniquely identify a user using data gathered from a mouse and the users eyes during computer use. The research involves gathering data from users, extracting user features, and training a Neural Network classifier that can identify them. Previous work has attempted to identify users solely by eye or mouse data alone, but we seek to find out if combining the two kinds of data can produce better results. After going through this process and investigating several Neural Network based classification models we conclude that combining both techniques produces better results and will become practical once the hardware is more widespread.
Journal of Surgical Case Reports, 2020
Celiac disease is an immune-mediated inflammatory disease. Symptoms are divided into typical gast... more Celiac disease is an immune-mediated inflammatory disease. Symptoms are divided into typical gastrointestinal manifestations and atypical non-gastrointestinal manifestations. However, the atypical manifestations, which account for the majority of the presenting manifestations among celiac disease patients, include abdominal pain, bloating, vitamin and mineral deficiency, chronic fatigue and osteoporosis, intra-abdominal adhesions as a complication of celiac disease has never been reported. In this case, we report a female patient presented with chronic abdominal pain and steatorrhea. Celiac disease was diagnosed by serological tests and a duodenal biopsy. After the exclusion of gynecological and other gastrointestinal etiologies of intra-abdominal adhesions, the relation was assumed by the resolution of the intra-abdominal adhesions symptoms and improvement of follow-up computed tomography scans after a gluten-free diet. Intra-abdominal adhesion is an end-stage result of multiple ga...
International Journal of Intelligent Engineering and Systems, 2021
In recent years, there has been increasing interest in cloud computing research, especially repli... more In recent years, there has been increasing interest in cloud computing research, especially replication strategies and their applications. When the number of replicas is increased and placed in different places, maintaining the system's data availability, performance and reliability will increase the cost. In this paper, two multi-objectives swarm intelligence algorithms are used to optimize the data replication selection and placement in a cloud environment. These algorithms are namely, multi-objective particle swarm optimization (MOPSO) and multi-objective ant colony optimization (MOACO). The first algorithm, (MOPSO), is used to find the best selected data replica according to the most popular data replication strategy. The improved time-based decay function (ITBDF), is used to enhance the proposed model. The second algorithm, (MOACO), is used to find the best data replica placement according to the minimum distance, the number of data transmissions and the availability of data replication. A simulation of the suggested strategy has been performed using CloudSim. the Cloud is formed to simulate different kinds of datacenters (DCs) with different structures. Moreover, 21 DCs are used. Each DC consists of a host that contains a set of virtual machines (VMs) that provides blocks of available data replications. Three different data placements for high datacenters were created. A total of one thousand cloudlets are randomly confirmed for the data replication order. All replication files are placed in high datacenters and randomly distributed in the suggested system. The performance of proposed strategy was evaluated relative to many well-known strategies such as, Enhance Fast Spread (EFS), Dynamic Cost-aware Re-replication and Re-balancing Strategy (DCR2S), Genetic Algorithm (GA), Genetic adaptive Selection Algorithm (GASA), Replica Selection and Placement (RSP), Dynamic Replica Selection Ant Colony Optimization (DRSACO), Adaptive Replica Dynamic Strategy (ARDS), Popular File Replication First (PFRF). The experimental results show that MOPSO, achieves better data replication than compared algorithms. Additionally, MOACO, achieves higher data availability, lower cost, and less bandwidth consumption than compared algorithms.
Background: The goal of this retrospective cohort study was to determine the different recurrence... more Background: The goal of this retrospective cohort study was to determine the different recurrence patterns, sites and determinants impacting primary varicose vein recurrence after endovenous laser ablation (EVLA).Methods: 127 symptomatic patients (127 limbs) with great saphenous vein incompetence who underwent EVLA were followed up for recurrence. Twenty-seven patients were lost to follow-up, leaving 100 patients (100 limbs) for analysis. Outcomes: Recurrence defined by venous clinical severity score (VCSS) or patterns of reflux on the duplex ultrasound examination. Assessments were done at 1, 6, 12 and 24 months after the procedure.Results: Two-year life table analysis showed varicose vein recurrence in 9(7.1%) of limbs. Varicose vein recurrence was due to refluxing anterior accessory saphenous vein in 77.8% patients (p <0.001, 95% CI 3.2 to 1669.1), re-canalization (66.6%), non-truncal varicosities (55.5 %) and incompetent perforators 77.8% patients (p <0.001, 95% CI 2.7 to ...
Journal of Surgical Case Reports, 2020
Acute perforated duodenal ulcers are considered one of the most encountered emergency surgical co... more Acute perforated duodenal ulcers are considered one of the most encountered emergency surgical conditions leading to mortality. Different approaches have been proposed for management based on the clinical status of the patient. The use of omental patch closure is widely accepted either via an open or laparoscopic approach. However, not all patients are candidates owing to the availability and viability of the greater omentum. In these patients, the falciform ligament can be used as an alternative and efficient method for repair. In this case, we present a male patient with a perforated ulcer in the first part of the duodenum which was managed by falciform ligament patch instead of the usual omental patch. In cases of a deficient or unhealthy greater omentum, or if it cannot be brought in the upper part of the abdominal cavity due to severe adhesions, the falciform ligament can be used efficiently in the closure of perforated duodenal ulcer.
Journal of Hazardous Materials, 2020
A bacterial consortium for efficient decontamination of high-concentration Fe-Mn acid mine draina... more A bacterial consortium for efficient decontamination of high-concentration Fe-Mn acid mine drainage (AMD) was successfully isolated. The removal efficiencies of Fe and Mn were effective, reaching 99.8 % and 98.6 %, respectively. High-throughput sequencing of the 16S rRNA genes demonstrated that the microbial community had changed substantially during the treatment. The Fe-Mn oxidizing bacteria Flavobacterium, Brevundimonas, Stenotrophomonas and Thermomonas became dominant genera, suggesting that they might play vital roles in Fe and Mn removal. Moreover, the pH of culture increased obviously after incubation, which was benefit for depositing Fe and Mn from AMD. The specific surface area of the biogenic Fe-Mn oxides was 108-121 m 2 /g, and the surface contained reactive oxygen functional groups (-OH and −COOH), which also improved Fe and Mn removal efficiency. Thus, this study provides an alternative method to treat AMD containing high concentrations of Fe and Mn. 1. Introduction Acid mine drainage (AMD) is severely threatening the safety of aquatic and terrestrial ecosystems (Aguinaga et al., 2018; Auld et al., 2017). Available methods for AMD treatment include traditional neutralization techniques, magnetic nanoparticles, lignite and zeolite, and membrane methods, among others (Rand and Ranville, 2019). Traditional neutralization techniques require additions of commercially produced alkali, which is expensive and generate a large volume of sludge, especially in AMD that contains high levels of iron/ferrous ions
Journal of Neuro-Oncology, 2018
Introduction The impact of multiple primary tumors, in the setting of malignant glioma (MG), has ... more Introduction The impact of multiple primary tumors, in the setting of malignant glioma (MG), has not been heavily explored. Methods We extracted demographics and clinical data from the SEER-18 registry for adult patients with MGs. The cases were separated based on the sequence of MG diagnosis relative to the other primary tumors: Group (A) One primary only or first primary of multiple primaries and Group (B) second primary or subsequent primary tumor. Incidences, frequencies, and glioma-related survivals were analyzed. Results Group B constituted 12.8% of new MG. The incidences of group B, relative to those of all new MG, range from 0.14 to 0.18. Compared to group A, group B exhibited an older age. Moreover, group B exhibited a higher proportion of females, Caucasians, smaller tumors, non-operative cases, and those receiving radiation (p < 0.05); the proportion with GTR remained comparable. Multiple groupings (oral cavity, digestive system, respiratory system, skin, breast, genital systems, urinary system, lymphoma) exhibited lower glioma-related observed survival (p < 0.05) compared to Group A. An active diagnosis of "leukemia" appears to confer longer glioma-related survival while a history of "breast" or "digestive system" malignancies portends a shorter glioma-related survival. Conclusion For newly diagnosed MG, a high proportion does have history of extra-CNS primary tumors. Generally, these patients appear to have worse glioma-related observed survival compare to those with malignant glioma as the only primary or the first of multiple primary tumors. Knowledge regarding epidemiology, clinical factors, and observed survival can help guide clinical management/consultation for this subset of patients.
Oncotarget, Jan 7, 2018
Secondary glioblastomas (GBs) constitute a small subset of all GBs and tend to arise after a lowe... more Secondary glioblastomas (GBs) constitute a small subset of all GBs and tend to arise after a lower grade glioma. Though knowledge regarding this subset has gained traction in recent years, its definition continues to evolve, complicating its clinical management. Investigation of epidemiology and survival patterns may help provide needed insights. The age at GB diagnosis is significantly lower (46.22 vs 60.25 years) for group B. The distribution among type of GB (glioblastoma, giant cell glioblastoma, or gliosarcoma) was significantly different, with no diagnosis of giant cell GB in Group B. Compared to Group A, Group B exhibited a higher proportion of females, not married, smaller tumors, no GTR, and no radiation (all p < 0.05). GB-related observed survivals were comparable. Cox regression with inclusion of co-variates reveal no significant influence of GB group on observed survival. Regarding group B, mean age was 40.197 for diagnosis of initial lower grade glioma. The most comm...
Oncotarget, Jan 15, 2018
Intracranial hemangioblastoma (HB) is a rare pathology. Limited data exist regarding its epidemio... more Intracranial hemangioblastoma (HB) is a rare pathology. Limited data exist regarding its epidemiology. With the SEER-18 registry database, information from all patients diagnosed with intracranial HB from 2004 to 2013 were extracted, including age, gender, race, marital status, presence of surgery, extent of surgery, receipt of radiation, tumor size, tumor location, and follow-up data. Age-adjusted incidence rates and overall survival (OS). Cox proportional hazards model was employed for both univariate and multivariate analyses. A total of 1307 cases were identified. The overall incidence of intracranial hemangioblastoma is 0.153 per 100,000 person-years [95% confidence interval (CI)=0.145-0.162]. Through univariate analysis, age < 40 [hazard ratio (HR)=0.277, p<0.001], no radiation [HR=0.56, p=0.047], and presence of surgery [HR=0.576, p=0.012] are significant positive prognostic factors. Caucasian race [HR=1.42, p=0.071] and female gender [HR=0.744, p=0.087] exhibit noticea...
World neurosurgery, Jan 29, 2018
Subependymal giant cell astrocytoma (SEGA) is a rare, benign neoplasm predominantly associated wi... more Subependymal giant cell astrocytoma (SEGA) is a rare, benign neoplasm predominantly associated with tuberous sclerosis complex (TSC). Clinical outcomes have largely been conveyed via small- and medium-sized case series. With the SEER-18 registry database, information from all patients diagnosed with SEGA from 2004 to 2013 were obtained (age, gender, race, marital status, tumor size, tumor location, occurrence of surgery, receipt of radiation, and follow-up data). Age-adjusted incidence rates and overall survival (OS) were determined. Cox proportional hazards model was employed for both univariate and multivariate analyses. The overall incidence of SEGA within the SEER-18 database is 0.027 per 100,000 person-years [95 % confidence interval (CI) = 0.024-0.031]. A total of 226 cases were identified. For OS, univariate analysis revealed age < 18 [hazard ratio (HR) = 0.214, p = 0.004] and occurrence of surgery [HR = 0.328, p = 0.039] were significant positive prognostic factors. Gende...
International journal of molecular sciences, Jan 14, 2018
Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system. With... more Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system. With its overall dismal prognosis (the median survival is 14 months), GBMs demonstrate a resounding resilience against all current treatment modalities. The absence of a major progress in the treatment of GBM maybe a result of our poor understanding of both GBM tumor biology and the mechanisms underlying the acquirement of treatment resistance in recurrent GBMs. A comprehensive understanding of these markers is mandatory for the development of treatments against therapy-resistant GBMs. This review also provides an overview of a novel marker called acid ceramidase and its implication in the development of radioresistant GBMs. Multiple signaling pathways were found altered in radioresistant GBMs. Given these global alterations of multiple signaling pathways found in radioresistant GBMs, an effective treatment for radioresistant GBMs may require a cocktail containing multiple agents targeting m...
Journal of ophthalmology, 2018
To compare clinical outcome of IVCD combined with oral therapy with IVCD alone in patients with t... more To compare clinical outcome of IVCD combined with oral therapy with IVCD alone in patients with toxoplasmic retinochoroiditis. Thirty eyes were reviewed. Two equal groups were identified (15 eyes each). Clinical outcome measures were resolution of active inflammation, changes in BCVA and CMT, adverse drug reactions, and rate of recurrence. Mean baseline of BCVA 1.08 ± 0.17 and 1.03 ± 0.15 improved to 0.64 ± 0.18 and 0.69 ± 0.17 at the end of follow-up in group I and II, respectively. No statistically significant difference was observed. CMT was 392.6 ± 33.16 m and 397.3 ± 14.6 m significantly decreased to 314.7 ± 4.43 m and 319.6 ± 7.8 m. Resolution of acute inflammation was achieved in all cases in both groups. There were no recurrent cases in group I, and only one out of 15 (6.7%) in group II. No ocular or systemic adverse events were recorded. IVCD is an effective route of treatment for active toxoplasmic retinochoroiditis that can be used solely without the need to use systemic ...
World neurosurgery, Jan 13, 2018
Spontaneous resolution of acute subdural hematomas occurring as the result of a traumatic injury ... more Spontaneous resolution of acute subdural hematomas occurring as the result of a traumatic injury is well reported in the literature and rapidly resolving subdural hematomas have been reported as well. While the mechanism behind the rapid resolution of a subdural hematoma has not been well-understood, there are postulated mechanisms for this phenomenon. The aim of this report is to present a patient who experienced the rapid resolution of a traumatic subdural hematoma, which was replaced by a subdural hygroma. This 25-year-old male presented to the hospital with an acute left sided subdural hematoma following a head-on motor vehicle collision. At the time of presentation, the patient had an acute subdural hematoma with 11mm of midline shift. The hematoma resolved spontaneously within 48 hours and was replaced by a thin subdural hygroma. Rapidly resolving subdural hematomas represent a phenomenon that has been well described although is not entirely understood. The imaging findings of...
Large Middle Cranial Fossa Schwannoma: A Rare Presentation of Vestibular Schwannoma
Cureus
The Lancet
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Journal of Surgical Case Reports
Multiple primary tumors' incidence is rare, yet more rare is the incidence of multiple primar... more Multiple primary tumors' incidence is rare, yet more rare is the incidence of multiple primary malignant tumors. Co-occurring tumors can be divided into synchronous and non-synchronous. Synchronous tumors are those tumors that present within a period not >6 months from each other. To define synchronous malignant tumors: metastasis should not be present, both tumors have to show criteria of malignancy, and they should differ pathologically from each other. Breast cancer is the most common tumor to be associated with other primaries especially; colorectal cancer, endometrial and ovarian cancer, yet the occurrence of invasive ductal carcinoma with clear cell renal cancer is uncommon. In our case, we present a 59-year-old female with invasive ductal carcinoma and clear cell renal carcinoma.
Synthesis and in silico evaluation of novel uridyl sulfamoylbenzoate derivatives as potential anticancer agents targeting M1 subunit of human ribonucleotide reductase (hRRM1)
Medicinal Chemistry Research
Extralobar bronchopulmonary sequestration supplied by right-sided aortic arch aberrant subclavian artery
Indian Journal of Thoracic and Cardiovascular Surgery
Right aortic arch (RAA) with an aberrant left subclavian artery (LSA) is a very rare anatomical v... more Right aortic arch (RAA) with an aberrant left subclavian artery (LSA) is a very rare anatomical variant of the aorta, which is rarely symptomatic. However, symptoms may vary depending on the relationship of the aberrant subclavian artery to the surrounding structures. In this report, we present a case of an 8-year-old girl who was identified with Edward’s type II RAA with LSA after developing a list of symptoms that led to the diagnosis of pulmonary sequestration, which in turn led to the discovery of her congenital aortic abnormality.
In Silico Pharmacology, 2021
Class B1 metallo-β-lactamases (MBLs) are metalloenzymes found in drug resistant bacteria. The enz... more Class B1 metallo-β-lactamases (MBLs) are metalloenzymes found in drug resistant bacteria. The enzyme requires zinc ions, along with conserved amino acid coordination for nucleophilic attack of the lactam ring to induce hydrolysis and inactivation of β-lactam and some carbapenem antibiotics. To this date there are no clinically relevant class B1 MBL inhibitors, however L-captopril has shown significant results against NDM-1, the most difficult MBL to inhibit. Herein, we report the synthesis and evaluation of novel nucleoside analogues modified with polyethylene glycolamino (PEGA) as potential inhibitors for class B1 MBLs. Molecular dynamics simulations, using internal coordinate mechanics (ICM) algorithm, were performed on subclass B1 enzyme complex models screened with twenty-one possible PEGA-nucleosides. Analogue A, 3′-deoxy-3′-(2-(2-hydroxyethoxy)ethanamino)-β-D-xylofuranosyluracil showed superior binding, with high specificity to the conserved zinc ions in the class B1 MBL active site by utilizing key β-lactam mimic points in the uridine nucleobase. The PEGA moiety showed chelating activity with zinc and disrupted the metal-binding amino acid geometry. In all subclass B1 proteins tested, analogue A had the most effective inhibition when compared to penicillin or L-captopril. Chemical synthesis was performed by condensation of the corresponding keto ribonucleoside with PEGA, followed by enantioselective reduction of the formed imine to produce the amino derivative with desired configuration. Pharmacokinetic and pharmacodynamic screenings revealed that PEGA-pyrimidine nucleosides are not toxic, nor violate Lipinski's rules. These results suggested that analogue A can be proposed as a potential metalloenzyme inhibitor against the widespread antibiotic resistant bacteria and is worth further in vitro and in vivo investigations.
Bechet syndrome is a multisystemic illness that leads to vasculitis. The classic constellation of... more Bechet syndrome is a multisystemic illness that leads to vasculitis. The classic constellation of symptoms is recurrent aphthous ulcers of the mouth and genitalia, hyperreactivity of the skin to penetrating trauma (pathergy reaction), other skin lesions, arthritis, and panuveitis. Vascular involvement can involve arteries and veins of all sizes and types. however venous involvement tends to be more common than arterial vasculitis mostly in the form of lower extremity vein thrombosis. Interestingly the disease manifestation of vasculitis itself seems to favor males than females and with a unique geographical distribution. Arterial vasculitis tends to affect the pulmonary vasculature, though Pulmonary involvement in Bechet’s disease is rare, occurring 1-7.7 of patients. Pulmonary artery aneurysms with or without “in situ" thrombosis is the most common form of arterial involvement and are the leading causes of increased mortality. Different management modalities have been proposed...
Journal of Cyber Security and Mobility, 2017
This paper presents a novel technique to uniquely identify a user using data gathered from a mous... more This paper presents a novel technique to uniquely identify a user using data gathered from a mouse and the users eyes during computer use. The research involves gathering data from users, extracting user features, and training a Neural Network classifier that can identify them. Previous work has attempted to identify users solely by eye or mouse data alone, but we seek to find out if combining the two kinds of data can produce better results. After going through this process and investigating several Neural Network based classification models we conclude that combining both techniques produces better results and will become practical once the hardware is more widespread.
Journal of Surgical Case Reports, 2020
Celiac disease is an immune-mediated inflammatory disease. Symptoms are divided into typical gast... more Celiac disease is an immune-mediated inflammatory disease. Symptoms are divided into typical gastrointestinal manifestations and atypical non-gastrointestinal manifestations. However, the atypical manifestations, which account for the majority of the presenting manifestations among celiac disease patients, include abdominal pain, bloating, vitamin and mineral deficiency, chronic fatigue and osteoporosis, intra-abdominal adhesions as a complication of celiac disease has never been reported. In this case, we report a female patient presented with chronic abdominal pain and steatorrhea. Celiac disease was diagnosed by serological tests and a duodenal biopsy. After the exclusion of gynecological and other gastrointestinal etiologies of intra-abdominal adhesions, the relation was assumed by the resolution of the intra-abdominal adhesions symptoms and improvement of follow-up computed tomography scans after a gluten-free diet. Intra-abdominal adhesion is an end-stage result of multiple ga...
International Journal of Intelligent Engineering and Systems, 2021
In recent years, there has been increasing interest in cloud computing research, especially repli... more In recent years, there has been increasing interest in cloud computing research, especially replication strategies and their applications. When the number of replicas is increased and placed in different places, maintaining the system's data availability, performance and reliability will increase the cost. In this paper, two multi-objectives swarm intelligence algorithms are used to optimize the data replication selection and placement in a cloud environment. These algorithms are namely, multi-objective particle swarm optimization (MOPSO) and multi-objective ant colony optimization (MOACO). The first algorithm, (MOPSO), is used to find the best selected data replica according to the most popular data replication strategy. The improved time-based decay function (ITBDF), is used to enhance the proposed model. The second algorithm, (MOACO), is used to find the best data replica placement according to the minimum distance, the number of data transmissions and the availability of data replication. A simulation of the suggested strategy has been performed using CloudSim. the Cloud is formed to simulate different kinds of datacenters (DCs) with different structures. Moreover, 21 DCs are used. Each DC consists of a host that contains a set of virtual machines (VMs) that provides blocks of available data replications. Three different data placements for high datacenters were created. A total of one thousand cloudlets are randomly confirmed for the data replication order. All replication files are placed in high datacenters and randomly distributed in the suggested system. The performance of proposed strategy was evaluated relative to many well-known strategies such as, Enhance Fast Spread (EFS), Dynamic Cost-aware Re-replication and Re-balancing Strategy (DCR2S), Genetic Algorithm (GA), Genetic adaptive Selection Algorithm (GASA), Replica Selection and Placement (RSP), Dynamic Replica Selection Ant Colony Optimization (DRSACO), Adaptive Replica Dynamic Strategy (ARDS), Popular File Replication First (PFRF). The experimental results show that MOPSO, achieves better data replication than compared algorithms. Additionally, MOACO, achieves higher data availability, lower cost, and less bandwidth consumption than compared algorithms.
Background: The goal of this retrospective cohort study was to determine the different recurrence... more Background: The goal of this retrospective cohort study was to determine the different recurrence patterns, sites and determinants impacting primary varicose vein recurrence after endovenous laser ablation (EVLA).Methods: 127 symptomatic patients (127 limbs) with great saphenous vein incompetence who underwent EVLA were followed up for recurrence. Twenty-seven patients were lost to follow-up, leaving 100 patients (100 limbs) for analysis. Outcomes: Recurrence defined by venous clinical severity score (VCSS) or patterns of reflux on the duplex ultrasound examination. Assessments were done at 1, 6, 12 and 24 months after the procedure.Results: Two-year life table analysis showed varicose vein recurrence in 9(7.1%) of limbs. Varicose vein recurrence was due to refluxing anterior accessory saphenous vein in 77.8% patients (p <0.001, 95% CI 3.2 to 1669.1), re-canalization (66.6%), non-truncal varicosities (55.5 %) and incompetent perforators 77.8% patients (p <0.001, 95% CI 2.7 to ...
Journal of Surgical Case Reports, 2020
Acute perforated duodenal ulcers are considered one of the most encountered emergency surgical co... more Acute perforated duodenal ulcers are considered one of the most encountered emergency surgical conditions leading to mortality. Different approaches have been proposed for management based on the clinical status of the patient. The use of omental patch closure is widely accepted either via an open or laparoscopic approach. However, not all patients are candidates owing to the availability and viability of the greater omentum. In these patients, the falciform ligament can be used as an alternative and efficient method for repair. In this case, we present a male patient with a perforated ulcer in the first part of the duodenum which was managed by falciform ligament patch instead of the usual omental patch. In cases of a deficient or unhealthy greater omentum, or if it cannot be brought in the upper part of the abdominal cavity due to severe adhesions, the falciform ligament can be used efficiently in the closure of perforated duodenal ulcer.
Journal of Hazardous Materials, 2020
A bacterial consortium for efficient decontamination of high-concentration Fe-Mn acid mine draina... more A bacterial consortium for efficient decontamination of high-concentration Fe-Mn acid mine drainage (AMD) was successfully isolated. The removal efficiencies of Fe and Mn were effective, reaching 99.8 % and 98.6 %, respectively. High-throughput sequencing of the 16S rRNA genes demonstrated that the microbial community had changed substantially during the treatment. The Fe-Mn oxidizing bacteria Flavobacterium, Brevundimonas, Stenotrophomonas and Thermomonas became dominant genera, suggesting that they might play vital roles in Fe and Mn removal. Moreover, the pH of culture increased obviously after incubation, which was benefit for depositing Fe and Mn from AMD. The specific surface area of the biogenic Fe-Mn oxides was 108-121 m 2 /g, and the surface contained reactive oxygen functional groups (-OH and −COOH), which also improved Fe and Mn removal efficiency. Thus, this study provides an alternative method to treat AMD containing high concentrations of Fe and Mn. 1. Introduction Acid mine drainage (AMD) is severely threatening the safety of aquatic and terrestrial ecosystems (Aguinaga et al., 2018; Auld et al., 2017). Available methods for AMD treatment include traditional neutralization techniques, magnetic nanoparticles, lignite and zeolite, and membrane methods, among others (Rand and Ranville, 2019). Traditional neutralization techniques require additions of commercially produced alkali, which is expensive and generate a large volume of sludge, especially in AMD that contains high levels of iron/ferrous ions
Journal of Neuro-Oncology, 2018
Introduction The impact of multiple primary tumors, in the setting of malignant glioma (MG), has ... more Introduction The impact of multiple primary tumors, in the setting of malignant glioma (MG), has not been heavily explored. Methods We extracted demographics and clinical data from the SEER-18 registry for adult patients with MGs. The cases were separated based on the sequence of MG diagnosis relative to the other primary tumors: Group (A) One primary only or first primary of multiple primaries and Group (B) second primary or subsequent primary tumor. Incidences, frequencies, and glioma-related survivals were analyzed. Results Group B constituted 12.8% of new MG. The incidences of group B, relative to those of all new MG, range from 0.14 to 0.18. Compared to group A, group B exhibited an older age. Moreover, group B exhibited a higher proportion of females, Caucasians, smaller tumors, non-operative cases, and those receiving radiation (p < 0.05); the proportion with GTR remained comparable. Multiple groupings (oral cavity, digestive system, respiratory system, skin, breast, genital systems, urinary system, lymphoma) exhibited lower glioma-related observed survival (p < 0.05) compared to Group A. An active diagnosis of "leukemia" appears to confer longer glioma-related survival while a history of "breast" or "digestive system" malignancies portends a shorter glioma-related survival. Conclusion For newly diagnosed MG, a high proportion does have history of extra-CNS primary tumors. Generally, these patients appear to have worse glioma-related observed survival compare to those with malignant glioma as the only primary or the first of multiple primary tumors. Knowledge regarding epidemiology, clinical factors, and observed survival can help guide clinical management/consultation for this subset of patients.
Oncotarget, Jan 7, 2018
Secondary glioblastomas (GBs) constitute a small subset of all GBs and tend to arise after a lowe... more Secondary glioblastomas (GBs) constitute a small subset of all GBs and tend to arise after a lower grade glioma. Though knowledge regarding this subset has gained traction in recent years, its definition continues to evolve, complicating its clinical management. Investigation of epidemiology and survival patterns may help provide needed insights. The age at GB diagnosis is significantly lower (46.22 vs 60.25 years) for group B. The distribution among type of GB (glioblastoma, giant cell glioblastoma, or gliosarcoma) was significantly different, with no diagnosis of giant cell GB in Group B. Compared to Group A, Group B exhibited a higher proportion of females, not married, smaller tumors, no GTR, and no radiation (all p < 0.05). GB-related observed survivals were comparable. Cox regression with inclusion of co-variates reveal no significant influence of GB group on observed survival. Regarding group B, mean age was 40.197 for diagnosis of initial lower grade glioma. The most comm...
Oncotarget, Jan 15, 2018
Intracranial hemangioblastoma (HB) is a rare pathology. Limited data exist regarding its epidemio... more Intracranial hemangioblastoma (HB) is a rare pathology. Limited data exist regarding its epidemiology. With the SEER-18 registry database, information from all patients diagnosed with intracranial HB from 2004 to 2013 were extracted, including age, gender, race, marital status, presence of surgery, extent of surgery, receipt of radiation, tumor size, tumor location, and follow-up data. Age-adjusted incidence rates and overall survival (OS). Cox proportional hazards model was employed for both univariate and multivariate analyses. A total of 1307 cases were identified. The overall incidence of intracranial hemangioblastoma is 0.153 per 100,000 person-years [95% confidence interval (CI)=0.145-0.162]. Through univariate analysis, age < 40 [hazard ratio (HR)=0.277, p<0.001], no radiation [HR=0.56, p=0.047], and presence of surgery [HR=0.576, p=0.012] are significant positive prognostic factors. Caucasian race [HR=1.42, p=0.071] and female gender [HR=0.744, p=0.087] exhibit noticea...
World neurosurgery, Jan 29, 2018
Subependymal giant cell astrocytoma (SEGA) is a rare, benign neoplasm predominantly associated wi... more Subependymal giant cell astrocytoma (SEGA) is a rare, benign neoplasm predominantly associated with tuberous sclerosis complex (TSC). Clinical outcomes have largely been conveyed via small- and medium-sized case series. With the SEER-18 registry database, information from all patients diagnosed with SEGA from 2004 to 2013 were obtained (age, gender, race, marital status, tumor size, tumor location, occurrence of surgery, receipt of radiation, and follow-up data). Age-adjusted incidence rates and overall survival (OS) were determined. Cox proportional hazards model was employed for both univariate and multivariate analyses. The overall incidence of SEGA within the SEER-18 database is 0.027 per 100,000 person-years [95 % confidence interval (CI) = 0.024-0.031]. A total of 226 cases were identified. For OS, univariate analysis revealed age < 18 [hazard ratio (HR) = 0.214, p = 0.004] and occurrence of surgery [HR = 0.328, p = 0.039] were significant positive prognostic factors. Gende...
International journal of molecular sciences, Jan 14, 2018
Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system. With... more Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system. With its overall dismal prognosis (the median survival is 14 months), GBMs demonstrate a resounding resilience against all current treatment modalities. The absence of a major progress in the treatment of GBM maybe a result of our poor understanding of both GBM tumor biology and the mechanisms underlying the acquirement of treatment resistance in recurrent GBMs. A comprehensive understanding of these markers is mandatory for the development of treatments against therapy-resistant GBMs. This review also provides an overview of a novel marker called acid ceramidase and its implication in the development of radioresistant GBMs. Multiple signaling pathways were found altered in radioresistant GBMs. Given these global alterations of multiple signaling pathways found in radioresistant GBMs, an effective treatment for radioresistant GBMs may require a cocktail containing multiple agents targeting m...
Journal of ophthalmology, 2018
To compare clinical outcome of IVCD combined with oral therapy with IVCD alone in patients with t... more To compare clinical outcome of IVCD combined with oral therapy with IVCD alone in patients with toxoplasmic retinochoroiditis. Thirty eyes were reviewed. Two equal groups were identified (15 eyes each). Clinical outcome measures were resolution of active inflammation, changes in BCVA and CMT, adverse drug reactions, and rate of recurrence. Mean baseline of BCVA 1.08 ± 0.17 and 1.03 ± 0.15 improved to 0.64 ± 0.18 and 0.69 ± 0.17 at the end of follow-up in group I and II, respectively. No statistically significant difference was observed. CMT was 392.6 ± 33.16 m and 397.3 ± 14.6 m significantly decreased to 314.7 ± 4.43 m and 319.6 ± 7.8 m. Resolution of acute inflammation was achieved in all cases in both groups. There were no recurrent cases in group I, and only one out of 15 (6.7%) in group II. No ocular or systemic adverse events were recorded. IVCD is an effective route of treatment for active toxoplasmic retinochoroiditis that can be used solely without the need to use systemic ...
World neurosurgery, Jan 13, 2018
Spontaneous resolution of acute subdural hematomas occurring as the result of a traumatic injury ... more Spontaneous resolution of acute subdural hematomas occurring as the result of a traumatic injury is well reported in the literature and rapidly resolving subdural hematomas have been reported as well. While the mechanism behind the rapid resolution of a subdural hematoma has not been well-understood, there are postulated mechanisms for this phenomenon. The aim of this report is to present a patient who experienced the rapid resolution of a traumatic subdural hematoma, which was replaced by a subdural hygroma. This 25-year-old male presented to the hospital with an acute left sided subdural hematoma following a head-on motor vehicle collision. At the time of presentation, the patient had an acute subdural hematoma with 11mm of midline shift. The hematoma resolved spontaneously within 48 hours and was replaced by a thin subdural hygroma. Rapidly resolving subdural hematomas represent a phenomenon that has been well described although is not entirely understood. The imaging findings of...