ajay kumar pal - Academia.edu (original) (raw)
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University of Texas Southwestern Medical Center at Dallas
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Papers by ajay kumar pal
Pathophysiology
Cancer cells undergo transient EMT and MET phenomena or vice versa, along with the parallel inter... more Cancer cells undergo transient EMT and MET phenomena or vice versa, along with the parallel interplay of various markers, often correlated as the determining factor in decoding metabolic profiling of breast cancers. Moreover, various cancer signaling pathways and metabolic changes occurring in breast cancer cells modulate the expression of such markers to varying extents. The existing research completed so far considers the expression of such markers as determinants regulating the invasiveness and survival of breast cancer cells. Therefore, this manuscript is crosstalk among the expression levels of such markers and their correlation in regulating the aggressiveness and invasiveness of breast cancer. We also attempted to cover the possible EMT-based metabolic targets to retard migration and invasion of breast cancer.
Obesity Medicine, 2020
Background: The body fat reduction has been a major health goal of obese individuals throughout t... more Background: The body fat reduction has been a major health goal of obese individuals throughout the world and identifying functional foods that can assist in alleviatingthe excess body fat has been the objective of various studies. Objective: The current study was investigated to evaluate the anti-obesity profile of Butea monosperma (BM) flower extract on the high-fat diet (HFD) induced obese rats. Material & methods: CD and AD diet was fed for 40 days to induce obesity in Female albino rats. Three different doses of BM flower extract (100, 200 and 400 mg/kg, per oral) were administered every day to the drug treatment groups. The observations were made for body weight measured at every 5 day interval, various organs and body fat pad weights, body temperature, locomotor activities along with total cholesterol, triglyceridesand glucose levels were analyzed on the 39th and 40th day. Result: BM flower extract 400 mg/kg (high dose) treated rats showed a significant decrease in body weight, total cholesterol, triglycerides levels, and glucose levels with marked elevation in locomotor activities and body temperatures. Conclusion: The findings suggests that the supplemented BM flower extract in the CD and AD have normalized the weight gain parameters and can be a future herbal candidate for reversing obese individual to normal.
Pathophysiology
Cancer cells undergo transient EMT and MET phenomena or vice versa, along with the parallel inter... more Cancer cells undergo transient EMT and MET phenomena or vice versa, along with the parallel interplay of various markers, often correlated as the determining factor in decoding metabolic profiling of breast cancers. Moreover, various cancer signaling pathways and metabolic changes occurring in breast cancer cells modulate the expression of such markers to varying extents. The existing research completed so far considers the expression of such markers as determinants regulating the invasiveness and survival of breast cancer cells. Therefore, this manuscript is crosstalk among the expression levels of such markers and their correlation in regulating the aggressiveness and invasiveness of breast cancer. We also attempted to cover the possible EMT-based metabolic targets to retard migration and invasion of breast cancer.
Obesity Medicine, 2020
Background: The body fat reduction has been a major health goal of obese individuals throughout t... more Background: The body fat reduction has been a major health goal of obese individuals throughout the world and identifying functional foods that can assist in alleviatingthe excess body fat has been the objective of various studies. Objective: The current study was investigated to evaluate the anti-obesity profile of Butea monosperma (BM) flower extract on the high-fat diet (HFD) induced obese rats. Material & methods: CD and AD diet was fed for 40 days to induce obesity in Female albino rats. Three different doses of BM flower extract (100, 200 and 400 mg/kg, per oral) were administered every day to the drug treatment groups. The observations were made for body weight measured at every 5 day interval, various organs and body fat pad weights, body temperature, locomotor activities along with total cholesterol, triglyceridesand glucose levels were analyzed on the 39th and 40th day. Result: BM flower extract 400 mg/kg (high dose) treated rats showed a significant decrease in body weight, total cholesterol, triglycerides levels, and glucose levels with marked elevation in locomotor activities and body temperatures. Conclusion: The findings suggests that the supplemented BM flower extract in the CD and AD have normalized the weight gain parameters and can be a future herbal candidate for reversing obese individual to normal.