serap akdeniz - Academia.edu (original) (raw)

Papers by serap akdeniz

Research paper thumbnail of Neutrophil-to-lymphocyte ratio as a potential differential diagnostic marker for Alzheimer’s disease, major depressive disorder, and Parkinson’s disease

Dusunen Adam: The Journal of Psychiatry and Neurological Sciences, 2018

Neutrophil-to-lymphocyte ratio as a potential differential diagnostic marker for Alzheimer's dise... more Neutrophil-to-lymphocyte ratio as a potential differential diagnostic marker for Alzheimer's disease, major depressive disorder, and Parkinson's disease Objective: Major depressive disorder, Alzheimer's, and Parkinson's diseases are among the leading causes of dementia in the elderly. These diseases are often misdiagnosed because of overlapping symptoms. This study aimed to evaluate whether neutrophil-to-lymphocyte ratio, which has been used as an indicator of systemic inflammation, can be used for the differential diagnosis of these diseases. Method: A total of 95 patients with major depressive disorder, Alzheimer's, or Parkinson's disease were enrolled. Neutrophil-to-lymphocyte ratios of the participants were calculated using their past complete blood count results. We compared the three groups according to mean neutrophil-to-lymphocyte ratio and mean neutrophil-to-lymphocyte ratio adjusted for age. We used the receiver operating characteristics curve analysis to predict the sensitivity and specificity of this ratio for the differential diagnosis between depression and Alzheimer's disease. Results: The mean neutrophil-to-lymphocyte ratios for the depression, Alzheimer's, and Parkinson's disease groups were 2.2±0.7, 2.9±1.2, and 2.2±0.9, respectively (p=0.005). The age-adjusted mean neutrophil-to-lymphocyte ratios for the depression, Alzheimer's, and Parkinson's disease groups were 2.20±0.93, 2.80±0.97, and 2.20±0.96, respectively (p=0.025). Receiver operating characteristics curve analysis predicted that the sensitivity and specificity for the differential diagnosis between depression and Alzheimer's disease were 54.8% and 80.0%, respectively. Conclusion: This study suggests that a simple arithmetic calculation could help clinicians in the differential diagnosis between depression, Alzheimer's, and Parkinson's disease. Neutrophil-tolymphocyte ratio can be used as a secondary line of evidence, along with the initial clinical assessment.

Research paper thumbnail of Trichotillomania Treatment Based on Trauma: Case Report

Archives of Clinical and Medical Case Reports

Trichotillomania is characterized by recurrent pulling out of hair. It is a chronic disorder that... more Trichotillomania is characterized by recurrent pulling out of hair. It is a chronic disorder that causes functional impairment. Although trichotillomania has been known for a long time, no algorithms for its treatment have been created by now. In its etiology, trauma has also been suggested in addition to other factors. In this case study, a trichotillomania patient of 27 years with increasing severity accompanied by a history of trauma is reported. As medical treatment, aripiprazole augmentation was used, and for trauma therapy, EMDR (Eye Movement Desensitization and Reprocessing) was applied. The effects working through the trauma had on the treatment of our case was observed and discussed.

Research paper thumbnail of Cannabinoid Use and Depression: Comparison of Natural and Synthetic Cannabinoids

Clinical Medical Reviews and Case Reports

Purpose: Patients who predominantly used marijuana (natural cannabis) and patients who predominan... more Purpose: Patients who predominantly used marijuana (natural cannabis) and patients who predominantly used synthetic cannabinoids in their history were evaluated as two separate groups in our study which aimed to compare the sociodemographic characteristics and depressive symptoms of these two groups. Method: The sample of our study consisted of those patients who referred to the Polyclinic of Psychiatry at Ardahan State Hospital and were diagnosed with substance addiction. 30 polyclinic patients who defined predominant use of marijuana and 20 polyclinic patients who defined predominant use of synthetic cannabinoids (bonzai, Jamaika, etc.) (SC) were included in the study. The socio-demographic characteristics of the participants were determined, and the depressive symptoms were assessed by the Beck Depression Inventory. Results: Our study determined the socio-demographic characteristics of the marijuana-using group and the synthetic-cannabinoid-using group as similar. The depression score of the group using synthetic cannabinoids was found to be significantly higher. Discussion: In our study, findings pointing to the fact that cannabinoid use increases depressive symptoms and that synthetic cannabinoids have a strong depressive side effect have been obtained. The cross-sectional characteristic of the study and the low number of subjects constitute the limitations.

Research paper thumbnail of Neutrophil-to-lymphocyte ratio as a potential differential diagnostic marker for Alzheimer’s disease, major depressive disorder, and Parkinson’s disease

Dusunen Adam: The Journal of Psychiatry and Neurological Sciences, 2018

Neutrophil-to-lymphocyte ratio as a potential differential diagnostic marker for Alzheimer's dise... more Neutrophil-to-lymphocyte ratio as a potential differential diagnostic marker for Alzheimer's disease, major depressive disorder, and Parkinson's disease Objective: Major depressive disorder, Alzheimer's, and Parkinson's diseases are among the leading causes of dementia in the elderly. These diseases are often misdiagnosed because of overlapping symptoms. This study aimed to evaluate whether neutrophil-to-lymphocyte ratio, which has been used as an indicator of systemic inflammation, can be used for the differential diagnosis of these diseases. Method: A total of 95 patients with major depressive disorder, Alzheimer's, or Parkinson's disease were enrolled. Neutrophil-to-lymphocyte ratios of the participants were calculated using their past complete blood count results. We compared the three groups according to mean neutrophil-to-lymphocyte ratio and mean neutrophil-to-lymphocyte ratio adjusted for age. We used the receiver operating characteristics curve analysis to predict the sensitivity and specificity of this ratio for the differential diagnosis between depression and Alzheimer's disease. Results: The mean neutrophil-to-lymphocyte ratios for the depression, Alzheimer's, and Parkinson's disease groups were 2.2±0.7, 2.9±1.2, and 2.2±0.9, respectively (p=0.005). The age-adjusted mean neutrophil-to-lymphocyte ratios for the depression, Alzheimer's, and Parkinson's disease groups were 2.20±0.93, 2.80±0.97, and 2.20±0.96, respectively (p=0.025). Receiver operating characteristics curve analysis predicted that the sensitivity and specificity for the differential diagnosis between depression and Alzheimer's disease were 54.8% and 80.0%, respectively. Conclusion: This study suggests that a simple arithmetic calculation could help clinicians in the differential diagnosis between depression, Alzheimer's, and Parkinson's disease. Neutrophil-tolymphocyte ratio can be used as a secondary line of evidence, along with the initial clinical assessment.

Research paper thumbnail of Trichotillomania Treatment Based on Trauma: Case Report

Archives of Clinical and Medical Case Reports

Trichotillomania is characterized by recurrent pulling out of hair. It is a chronic disorder that... more Trichotillomania is characterized by recurrent pulling out of hair. It is a chronic disorder that causes functional impairment. Although trichotillomania has been known for a long time, no algorithms for its treatment have been created by now. In its etiology, trauma has also been suggested in addition to other factors. In this case study, a trichotillomania patient of 27 years with increasing severity accompanied by a history of trauma is reported. As medical treatment, aripiprazole augmentation was used, and for trauma therapy, EMDR (Eye Movement Desensitization and Reprocessing) was applied. The effects working through the trauma had on the treatment of our case was observed and discussed.

Research paper thumbnail of Cannabinoid Use and Depression: Comparison of Natural and Synthetic Cannabinoids

Clinical Medical Reviews and Case Reports

Purpose: Patients who predominantly used marijuana (natural cannabis) and patients who predominan... more Purpose: Patients who predominantly used marijuana (natural cannabis) and patients who predominantly used synthetic cannabinoids in their history were evaluated as two separate groups in our study which aimed to compare the sociodemographic characteristics and depressive symptoms of these two groups. Method: The sample of our study consisted of those patients who referred to the Polyclinic of Psychiatry at Ardahan State Hospital and were diagnosed with substance addiction. 30 polyclinic patients who defined predominant use of marijuana and 20 polyclinic patients who defined predominant use of synthetic cannabinoids (bonzai, Jamaika, etc.) (SC) were included in the study. The socio-demographic characteristics of the participants were determined, and the depressive symptoms were assessed by the Beck Depression Inventory. Results: Our study determined the socio-demographic characteristics of the marijuana-using group and the synthetic-cannabinoid-using group as similar. The depression score of the group using synthetic cannabinoids was found to be significantly higher. Discussion: In our study, findings pointing to the fact that cannabinoid use increases depressive symptoms and that synthetic cannabinoids have a strong depressive side effect have been obtained. The cross-sectional characteristic of the study and the low number of subjects constitute the limitations.