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Papers by alejandra santiago

Research paper thumbnail of ODP135 A New Life-Saving Treatment not yet Included in Guidelines for Recurrent Severe Hypertriglyceridemia-Induced Pancreatitis

Journal of the Endocrine Society

Severe hypertriglyceridemia is a rare cause of acute pancreatitis especially in non-alcoholic, no... more Severe hypertriglyceridemia is a rare cause of acute pancreatitis especially in non-alcoholic, non- gallstones, non-obese, non-diabetic patients and has a few options for its management. Hypertriglyceridemia-induced pancreatitis causes 1 to 14 percent of all cases of acute pancreatitis. The risk of developing acute pancreatitis is approximately 5 percent with serum triglycerides >1000 mg/dL and 10 to 20 percent with triglycerides >2000 mg/dL. This is the case of a 63-year-old female who came to the Emergency Department with acute onset of abdominal pain, located at the mid-epigastric region, radiating to back, 10/10 in a scale of severity, no alleviating or aggravating factor, accompanied by nausea, 5 episodes of bilious emesis. Past medical history includes recurrent acute pancreatitis induced by hypertriglyceridemia (3 episodes last year), arterial hypertension, and dyslipidemia treated with Fenofibrate and Atorvastatin. Denies toxic habits. Physical examination showed abdom...

Research paper thumbnail of Interrelaciones entre la ciudad y el campo : un estudio de los mercados de trabajo en el Valle medio de Río Negro

El propósito de este trabajo es analizar como los procesos de reestructuración y modernización de... more El propósito de este trabajo es analizar como los procesos de reestructuración y modernización de la actividad agropecuaria han impactado en la redefinición de los mercados de trabajo de estas actividades. Tradicionalmente la actividad agraria estuvo asociada a mercados de trabajo rurales pero, en la actualidad, este sector demanda nuevos puestos de trabajo que tienen un origen en tareas típicas de los mercados de trabajo urbanos. Estos cambios también están asociados a transformaciones en los patrones residenciales de la mano de obra ocupada en el sector. Por lo tanto se buscará encontrar las características propias de los mercados de trabajo urbanos y rurales, distinguiendo las condiciones laborales, el tipo de producción (agropecuario/ no agropecuario), las zonas habituales de residencia, entre otras variables. El período a estudiar serán los últimos 10 años, si bien es preciso realizar caracterizaciones de los períodos previos, sobre todo la década de los ’90, para comprender me...

Research paper thumbnail of sj-pdf-1-vaw-10.1177_10778012211013909 – Supplemental material for "We All Get Raped": Sexual Violence Against Latin American Women in Migratory Transit in Mexico

Supplemental material, sj-pdf-1-vaw-10.1177_10778012211013909 for "We All Get Raped": S... more Supplemental material, sj-pdf-1-vaw-10.1177_10778012211013909 for "We All Get Raped": Sexual Violence Against Latin American Women in Migratory Transit in Mexico by Hada Soria-Escalante, Alejandra Alday-Santiago, Erika Alday-Santiago, Natalia Limón-Rodríguez, Pamela Manzanares-Melendres and Adriana Tena-Castro in Violence Against Women

Research paper thumbnail of Trabajadores migrantes del agro en el contexto de la pandemia

Fil: Blanco, Mariela Veronica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficin... more Fil: Blanco, Mariela Veronica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Saavedra 15. Centro de Estudios e Investigaciones Laborales; Argentina

Research paper thumbnail of Phase 3 Study of Danicopan, an Oral Complement Factor D Inhibitor, As Add-on Therapy to a C5 Inhibitor in Patients with Paroxysmal Nocturnal Hemoglobinuria with Clinically Evident Extravascular Hemolysis

Blood, 2020

Background: PNH is a rare, life-threatening disease caused by uncontrolled terminal pathway activ... more Background: PNH is a rare, life-threatening disease caused by uncontrolled terminal pathway activation leading to intravascular hemolysis (IVH). The C5 inhibitors eculizumab (ECU) and ravulizumab (RAV) prevent IVH by inhibiting terminal complement; however, some C5 inhibitor-treated patients may experience persistent anemia due to extravascular hemolysis (EVH) caused by C3 fragment deposition and opsonization driven by constitutive activation of the alternative pathway (AP). Inhibition of factor D (FD), the rate limiting enzyme of the AP, acts on the complement cascade upstream of C3. Danicopan (ALXN2040, ACH-4471) is a first-in-class oral small molecule FD inhibitor. In vitro studies with RBCs collected from PNH patients have shown that danicopan not only inhibited hemolysis but also prevented deposition of C3 fragments on PNH RBCs. In a 24-week Phase 2 study of ECU-treated PNH patients with transfusion-dependent anemia (hemoglobin [Hgb] <10 g/dL), danicopan add-on resulted in c...

Research paper thumbnail of Magneto-optic polymers and devices

For several decades, the field of magneto-optics (MO) has demonstrated applications that have imp... more For several decades, the field of magneto-optics (MO) has demonstrated applications that have impact on every day applications such as in optical data storage, magnetic field sensing, crucial for magnetoencephalography and magnetocardiography; and compact and efficient optical isolators, among others. In the past, many of these applications and the devices designed for them have heavily relied on inorganic materials. Organic materials with a high MO response represent an interesting alternative to the inorganic equivalent by not only being a more cost efficient solution, but also by allowing the user to modify a number of variables to control and optimize the MO performance depending on the application and level of performance desired. In this dissertation I discuss the MO properties of novel organic materials, starting with polythiophene, which has been of interest due to the strong relationship between its high MO performance and its lamellar structure and regioregularity. I will also be discussing another material system that provides several degrees of MO tunability: magnetite based nanocomposites. A unique and novel synthetic approach described in this dissertation yields both highly transparent and MO responsive polymer films. I will be describing a systematic approach that indicates a strong influence of the size of the nanoparticle as well as the nanoparticle concentration in the MO performance of the bulk polymer, while maintaining high optical quality with minimal scattering and absorption in the visible and near infrared. Finally, I will be discussing the implementation of both a magnetite nanocomposite and a cobalt ferrite based nanocomposite in a free space magnetic field system and demonstrate the proof-of-principle operation of a sensing system

Research paper thumbnail of “We All Get Raped”: Sexual Violence Against Latin American Women in Migratory Transit in Mexico

Violence Against Women, 2021

The article addresses some forms of sexual violence suffered by Latin American women during migra... more The article addresses some forms of sexual violence suffered by Latin American women during migratory transit through Mexico. In-depth, semi-structured, qualitative–phenomenological interviews were conducted with 10 women in different stages of major transmigration states. The findings demonstrate the ubiquity of sexual violence during the migration. Five themes were identified: (a) The migration dimension of “being a woman”; (b) Recognition of contextual factors associated with the migratory process: “Intermediaries, road, shelters and sisterhood”; (c) The costs of migration: Abuse, discrimination, and persecution: “Criminal groups, physical violence, and “La Bestia”; (d) Triggers and supports: “Escape and future expectations”; and (e) God as a support.

Research paper thumbnail of Clinical Outcomes in Adults/Adolescents with Hemophilia B Treated Long Term with Recombinant Factor IX Fc Fusion Protein (rFIXFc) Prophylaxis: Interim Results of the B-Yond Extension Study

Blood, 2016

Introduction: The phase 3 B-LONG study (NCT01027364) demonstrated the safety, efficacy, and pharm... more Introduction: The phase 3 B-LONG study (NCT01027364) demonstrated the safety, efficacy, and pharmacokinetics of recombinant factor IX Fc fusion protein (rFIXFc) for the prevention and treatment of bleeding episodes in adults and adolescents with severe hemophilia B. The ongoing rFIXFc extension study B-YOND (NCT01425723) is evaluating long-term safety and efficacy of rFIXFc in children and adults with hemophilia B. Safety and efficacy data for adult and adolescent subjects from the second B-YOND interim data cut are reported here. Methods: The B-LONG study enrolled males aged ≥12 years with severe hemophilia B (≤2 IU/dL endogenous factor IX [FIX] activity) who had received prior treatment with FIX. Subjects completing B-LONG could enroll in 1 of 4 treatment groups in B-YOND: weekly prophylaxis (WP; 20-100 IU/kg every 7 d), individualized prophylaxis (IP: 100 IU/kg every 8-16 d), modified prophylaxis (MP; for subjects not achieving optimal prophylactic dosing with IP or WP), or episo...

Research paper thumbnail of Clinical Outcomes in Children with Hemophilia B Treated Long Term with rFIXFc: Interim Results of the B-YOND Extension Study

Blood, 2015

Background: Early prophylactic replacement of coagulation factor IX (FIX) improves clinical outco... more Background: Early prophylactic replacement of coagulation factor IX (FIX) improves clinical outcomes in children with hemophilia B; however, frequent intravenous infusions (2-3 times/week) are often required due to the short half-life of conventional FIX products. Recombinant FIX Fc fusion protein (rFIXFc), which is produced in a human cell line, binds the neonatal Fc receptor and utilizes the natural IgG recycling pathway to prolong the half-life of FIX.The phase 3 Kids B-LONG study (NCT01425723) demonstrated the safety, efficacy and prolonged half-life of once weekly recombinant factor IX Fc fusion protein (rFIXFc) in children aged <12 years with hemophilia B (endogenous FIX ≤2 IU/dL). Here, we report interim safety and efficacy data for children enrolled in the ongoing rFIXFc extension study, B-YOND (NCT01425723). Methods: Upon completing Kids B-LONG, eligible subjects could participate in one of 3 treatment groups in B-YOND: weekly prophylaxis (WP; 20-100 IU/kg every 7 days),...

Research paper thumbnail of Extended-Interval Prophylaxis with rFIXFc in Adults and Adolescents with Hemophilia B: Interim Results of the B-YOND Extension Study

Blood, 2015

Background: Prophylactic replacement of coagulation factor IX (FIX) in patients with hemophilia B... more Background: Prophylactic replacement of coagulation factor IX (FIX) in patients with hemophilia B improves clinical outcomes; however, the short half-life of conventional FIX products often necessitates frequent intravenous infusions (2-3 times/week). Recombinant FIX Fc fusion protein (rFIXFc), which is produced in a human cell line, binds the neonatal Fc receptor and utilizes the natural IgG recycling pathway to prolong the half-life of FIX. Introduction : The phase 3 B-LONG study (NCT01027364) demonstrated the safety, efficacy and prolonged half-life of recombinant factor IX Fc fusion protein (rFIXFc) in adults and adolescents (aged ≥12 years) with hemophilia B. Here, we report interim safety and efficacy data for adults and adolescents enrolled in the ongoing rFIXFc extension study, B-YOND (NCT01425723). Methods : Upon completing B-LONG, eligible subjects could participate in one of 4 treatment groups in B-YOND: weekly prophylaxis (WP; 20 to 100 IU/kg every 7 days), individualize...

Research paper thumbnail of Treatment Patterns and Costs of Care in Commercially-Insured and Medicaid Patients with Transfusion-Dependent SS-Thalassemia

Value in Health, 2018

DT claims during pre-index period). Included patients had a diagnosis of SCD or thalassemia, were... more DT claims during pre-index period). Included patients had a diagnosis of SCD or thalassemia, were 2-63 years of age, and were continuously enrolled in Texas Medicaid during the study period. Kruskall Wallis and Chi-square tests were used for continuous and categorical variables, respectively. Results: A total of 201 Texas Medicaid patients met the study criteria (24.4% DFX-DT-Only, 20.4% DFX-FCT-Only, 55.2% Switched). Patients who switched from DFX-DT to DFX-FCT had fewer hospitalizations and emergency department (ED) visits compared to DFX-DT-Only and DFX-FCT-Only groups (P< 0.001). Annual inpatient expenditures were lower for patients who switched compared to DFX-DT-Only and DFX-FCT-Only patients (P= 0.001). Mean annual medical expenditures (inpatient, ED, outpatient visits) were lowest for patients who switched, followed by DFX-FCT-Only patients (+11.5%) and DFX-DT-Only patients (+35.9%). ConClusions: In study patients taking DFX, medical resource utilization and expenditures varied by type of DFX (DT vs. FCT). The patient group that switched from DFX-DT to DFX-FCT had fewer hospitalizations, fewer ED visits, and lower medical expenditures. To optimize patient health outcomes and resource use, health care providers and decision-makers should be aware of differences in these measures by DFX formulation.

Research paper thumbnail of Recombinant factor IX Fc fusion protein in children with haemophilia B (Kids B-LONG): results from a multicentre, non-randomised phase 3 study

The Lancet. Haematology, 2017

Kids B-LONG was a multicentre, open-label, phase 3 study assessing the safety, efficacy, and phar... more Kids B-LONG was a multicentre, open-label, phase 3 study assessing the safety, efficacy, and pharmacokinetics of recombinant factor IX Fc fusion protein (rFIXFc) in previously treated paediatric patients younger than 12 years with severe haemophilia B. The study enrolled 30 previously treated boys younger than 12 years with haemophilia B (≤2 IU/dL [≤2%] endogenous coagulation factor IX [FIX] activity). All patients were initially given rFIXFc prophylaxis (50-60 IU/kg) once per week with adjustments to dose (≤100 IU/kg per infusion) or dosing frequency (up to two times per week) as needed. The primary outcome measure was development of inhibitors (neutralising antibodies). Secondary outcomes were pharmacokinetics, annual bleeding rate (ABR), spontaneous joint ABR, the number of infusions and dose required to resolve a bleed, time from last infusion of rFIXFc to a bleeding episode, assessment of response to treatment, and total annualised rFIXFc consumption for prevention and treatmen...

Research paper thumbnail of Long-term safety and efficacy of extended-interval prophylaxis with recombinant factor IX Fc fusion protein (rFIXFc) in subjects with haemophilia B

Thrombosis and haemostasis, Feb 22, 2016

The safety, efficacy, and prolonged half-life of recombinant factor IX Fc fusion protein (rFIXFc)... more The safety, efficacy, and prolonged half-life of recombinant factor IX Fc fusion protein (rFIXFc) were demonstrated in the Phase 3 B-LONG (adults/adolescents ≥12 years) and Kids B-LONG (children <12 years) studies of subjects with haemophilia B (≤2 IU/dl). Here, we report interim, long-term safety and efficacy data from B-YOND, the rFIXFc extension study. Eligible subjects who completed B-LONG or Kids B-LONG could enrol in B-YOND. There were four treatment groups: weekly prophylaxis (20-100 IU/kg every 7 days), individualised prophylaxis (100 IU/kg every 8-16 days), modified prophylaxis (further dosing personalisation to optimise prophylaxis), and episodic (on-demand) treatment. Subjects could change treatment groups at any point. Primary endpoint was inhibitor development. One hundred sixteen subjects enrolled in B-YOND. From the start of the parent studies to the B-YOND interim data cut, median duration of rFIXFc treatment was 39.5 months and 21.9 months among adults/adolescent...

Research paper thumbnail of Pueblo Qom, una lucha hacia la libertad

Eje 3: Protesta, conflicto y cambio social. Prácticas de organización y procesos de transformació... more Eje 3: Protesta, conflicto y cambio social. Prácticas de organización y procesos de transformación Pueblo Q'om, una lucha hacia la libertad En el presente trabajo se abordará la problemática actual del pueblo Q'om haciendo foco sobre la lucha por el territorio para desengranar las prácticas de dominación efectuadas por el Estado. Se relatará la historia cultural, social, económica y política que funda las raíces de la actual protesta social 1. Se tendrá en cuenta que la lucha por el territorio ancestral debate la idea de constituirse como comunidad previamente a que se consolide el Estado Nacional argentino como tal. Vale aclarar que, dado que la comunidad siente como un insulto la denominación Toba impuesta por los españoles, en adelante, sólo se utilizará la palabra Q'om como el nombre que los identifica. 2

Research paper thumbnail of Long‐term safety and efficacy of recombinant factor VIII Fc fusion protein (rFVIIIFc) in subjects with haemophilia A

Haemophilia, 2015

Introduction: The safety, efficacy and prolonged half-life of recombinant factor VIII Fc fusion p... more Introduction: The safety, efficacy and prolonged half-life of recombinant factor VIII Fc fusion protein (rFVIIIFc) in previously treated patients with severe haemophilia A was demonstrated in the phase 3 ALONG and Kids ALONG studies. Here, we report interim safety and efficacy data from the rFVIIIFc extension study, ASPIRE (ClinicalTrials.gov #NCT01454739). Methods: Eligible subjects could enrol in ASPIRE upon completing ALONG or Kids ALONG. There were four treatment groups: individualized prophylaxis; weekly prophylaxis; modified prophylaxis (for subjects in whom optimal treatment could not be achieved with individualized or weekly prophylaxis); and episodic treatment. The primary endpoint was development of inhibitors. Results: A total of 150 ALONG subjects and 61 Kids ALONG subjects enrolled in ASPIRE. As of the interim data cut (6 January 2014), the median time on study was 80.9 (A-LONG) and 23.9 (Kids ALONG) weeks. The majority of subjects (A-LONG, 92.0%; Kids ALONG , 57.4%) had ≥100 cumulative rFVIIIFc exposure days. No inhibitors were observed. Adverse events were generally consistent with those expected in the general haemophilia A population. Median annualized bleeding rates (ABRs) were low with individualized [A-LONG: 0.66; Kids ALONG: 0.00 (<6 years old), 1.54 (6 to <12 years old)], weekly (A-LONG: 2.03) and modified (A-LONG: 1.97) prophylaxis. There was no change in prophylactic infusion frequency or total weekly prophylactic dose in the majority of subjects from ALONG and Kids ALONG. Conclusion: Interim data from ASPIRE confirm the long-term safety of rFVIIIFc and the maintenance of a low ABR with extended-interval prophylactic dosing in patients with severe haemophilia A.

Research paper thumbnail of New Materials for Magneto Optic In-fiber and Waveguide Isolators

Lasers, Sources, and Related Photonic Devices, 2012

ABSTRACT We report recent advances in new magneto optic materials including novel colorless magne... more ABSTRACT We report recent advances in new magneto optic materials including novel colorless magnetic ionic liquids and magnetic nanoparticle-core polymer-shell nanocomposites for non-reciprocal in-fiber and waveguide operation for isolation and circulation.

Research paper thumbnail of All-Optical Magnetometer Based on Magnetite Core-Polymer Shell Nanocomposite Material

Frontiers in Optics 2009/Laser Science XXV/Fall 2009 OSA Optics & Photonics Technical Digest, 2009

ABSTRACT An all-optical magnetometer has been constructed based on magnetite core polymer shell n... more ABSTRACT An all-optical magnetometer has been constructed based on magnetite core polymer shell nanocomposite material. A noise equivalent magnetic field sensitivity of 5 nT/?Hz was observed using a 1 ?T 500 Hz control magnetic field.

Research paper thumbnail of Salt taste threshold and salt good taste sensitivity in a community of students of the southern area of Puerto Rico

Boletín de la Asociación Médica de Puerto Rico

Sodium appetite reflects the importance of sodium homeostasis. The sodium ion is one of the most ... more Sodium appetite reflects the importance of sodium homeostasis. The sodium ion is one of the most important risk factors in the development of hypertension. Humans, for various reasons, seem to have a specific preference for salt which is consumed in excess of need and this has been characterized as an important contributor to hypertension. Salt intake is related to the salt taste sensitivity threshold and the salt good taste level. Gustatory sensibility responds to various physiological mechanisms and salt taste is directly modified by cultural and socio-economical factors. We measured the salt taste sensitivity threshold and salt good taste level of a young student population. Air popped popcorn sprayed with different Molar concentrations of salt where given to students to taste and a questionnaire to evaluate diet salt intake preferences. Both salt taste sensitivity threshold and salt good taste level graph patterns are different from each other. Salt taste sensitivity threshold h...

Research paper thumbnail of Zinc Fortification Decreases ZIP1 Gene Expression of Some Adolescent Females with Appropriate Plasma Zinc Levels

Nutrients, 2014

Zinc homeostasis is achieved after intake variation by changes in the expression levels of zinc t... more Zinc homeostasis is achieved after intake variation by changes in the expression levels of zinc transporters. The aim of this study was to evaluate dietary intake (by 24-h recall), absorption, plasma zinc (by absorption spectrophotometry) and the expression levels (by quantitative PCR), of the transporters ZIP1 (zinc importer) and ZnT1 (zinc exporter) in peripheral white blood cells from 24 adolescent girls before and after drinking zinc-fortified milk for 27 day. Zinc intake increased (p < 0.001) from 10.5 ± 3.9 mg/day to 17.6 ± 4.4 mg/day, and its estimated absorption from 3.1 ± 1.2 to 5.3 ± 1.3 mg/day. Mean plasma zinc concentration remained unchanged (p > 0.05) near 150 µg/dL, but increased by 31 µg/dL (p < 0.05) for 6/24 adolescents (group A) and decreased by 25 µg/dL (p < 0.05) for other 6/24 adolescents (group B). Expression of ZIP1 in blood leukocytes was reduced 1.4-fold (p < 0.006) in group A, while for the expression of ZnT1 there was no difference after intervention (p = 0.39). An increase of dietary zinc after 27-days consumption of fortified-milk did not increase (p > 0.05) the plasma level of adolescent girls but for 6/24 participants from group A in spite of the formerly appropriation, which cellular zinc uptake decreased as assessed by reduction of the expression of ZIP1.

Research paper thumbnail of Capital cultural, escuela y espacio social

Revista Mexicana de Sociología, 1999

... Y agrega que en la actualidad se llama teoría únicamente ... (p. 113). La estructura del capi... more ... Y agrega que en la actualidad se llama teoría únicamente ... (p. 113). La estructura del capital, conformada por el capital económico y cultural, se retraduce en el sistema de preferencias para que los adolescentes privilegien ...

Research paper thumbnail of ODP135 A New Life-Saving Treatment not yet Included in Guidelines for Recurrent Severe Hypertriglyceridemia-Induced Pancreatitis

Journal of the Endocrine Society

Severe hypertriglyceridemia is a rare cause of acute pancreatitis especially in non-alcoholic, no... more Severe hypertriglyceridemia is a rare cause of acute pancreatitis especially in non-alcoholic, non- gallstones, non-obese, non-diabetic patients and has a few options for its management. Hypertriglyceridemia-induced pancreatitis causes 1 to 14 percent of all cases of acute pancreatitis. The risk of developing acute pancreatitis is approximately 5 percent with serum triglycerides >1000 mg/dL and 10 to 20 percent with triglycerides >2000 mg/dL. This is the case of a 63-year-old female who came to the Emergency Department with acute onset of abdominal pain, located at the mid-epigastric region, radiating to back, 10/10 in a scale of severity, no alleviating or aggravating factor, accompanied by nausea, 5 episodes of bilious emesis. Past medical history includes recurrent acute pancreatitis induced by hypertriglyceridemia (3 episodes last year), arterial hypertension, and dyslipidemia treated with Fenofibrate and Atorvastatin. Denies toxic habits. Physical examination showed abdom...

Research paper thumbnail of Interrelaciones entre la ciudad y el campo : un estudio de los mercados de trabajo en el Valle medio de Río Negro

El propósito de este trabajo es analizar como los procesos de reestructuración y modernización de... more El propósito de este trabajo es analizar como los procesos de reestructuración y modernización de la actividad agropecuaria han impactado en la redefinición de los mercados de trabajo de estas actividades. Tradicionalmente la actividad agraria estuvo asociada a mercados de trabajo rurales pero, en la actualidad, este sector demanda nuevos puestos de trabajo que tienen un origen en tareas típicas de los mercados de trabajo urbanos. Estos cambios también están asociados a transformaciones en los patrones residenciales de la mano de obra ocupada en el sector. Por lo tanto se buscará encontrar las características propias de los mercados de trabajo urbanos y rurales, distinguiendo las condiciones laborales, el tipo de producción (agropecuario/ no agropecuario), las zonas habituales de residencia, entre otras variables. El período a estudiar serán los últimos 10 años, si bien es preciso realizar caracterizaciones de los períodos previos, sobre todo la década de los ’90, para comprender me...

Research paper thumbnail of sj-pdf-1-vaw-10.1177_10778012211013909 – Supplemental material for "We All Get Raped": Sexual Violence Against Latin American Women in Migratory Transit in Mexico

Supplemental material, sj-pdf-1-vaw-10.1177_10778012211013909 for "We All Get Raped": S... more Supplemental material, sj-pdf-1-vaw-10.1177_10778012211013909 for "We All Get Raped": Sexual Violence Against Latin American Women in Migratory Transit in Mexico by Hada Soria-Escalante, Alejandra Alday-Santiago, Erika Alday-Santiago, Natalia Limón-Rodríguez, Pamela Manzanares-Melendres and Adriana Tena-Castro in Violence Against Women

Research paper thumbnail of Trabajadores migrantes del agro en el contexto de la pandemia

Fil: Blanco, Mariela Veronica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficin... more Fil: Blanco, Mariela Veronica. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Saavedra 15. Centro de Estudios e Investigaciones Laborales; Argentina

Research paper thumbnail of Phase 3 Study of Danicopan, an Oral Complement Factor D Inhibitor, As Add-on Therapy to a C5 Inhibitor in Patients with Paroxysmal Nocturnal Hemoglobinuria with Clinically Evident Extravascular Hemolysis

Blood, 2020

Background: PNH is a rare, life-threatening disease caused by uncontrolled terminal pathway activ... more Background: PNH is a rare, life-threatening disease caused by uncontrolled terminal pathway activation leading to intravascular hemolysis (IVH). The C5 inhibitors eculizumab (ECU) and ravulizumab (RAV) prevent IVH by inhibiting terminal complement; however, some C5 inhibitor-treated patients may experience persistent anemia due to extravascular hemolysis (EVH) caused by C3 fragment deposition and opsonization driven by constitutive activation of the alternative pathway (AP). Inhibition of factor D (FD), the rate limiting enzyme of the AP, acts on the complement cascade upstream of C3. Danicopan (ALXN2040, ACH-4471) is a first-in-class oral small molecule FD inhibitor. In vitro studies with RBCs collected from PNH patients have shown that danicopan not only inhibited hemolysis but also prevented deposition of C3 fragments on PNH RBCs. In a 24-week Phase 2 study of ECU-treated PNH patients with transfusion-dependent anemia (hemoglobin [Hgb] <10 g/dL), danicopan add-on resulted in c...

Research paper thumbnail of Magneto-optic polymers and devices

For several decades, the field of magneto-optics (MO) has demonstrated applications that have imp... more For several decades, the field of magneto-optics (MO) has demonstrated applications that have impact on every day applications such as in optical data storage, magnetic field sensing, crucial for magnetoencephalography and magnetocardiography; and compact and efficient optical isolators, among others. In the past, many of these applications and the devices designed for them have heavily relied on inorganic materials. Organic materials with a high MO response represent an interesting alternative to the inorganic equivalent by not only being a more cost efficient solution, but also by allowing the user to modify a number of variables to control and optimize the MO performance depending on the application and level of performance desired. In this dissertation I discuss the MO properties of novel organic materials, starting with polythiophene, which has been of interest due to the strong relationship between its high MO performance and its lamellar structure and regioregularity. I will also be discussing another material system that provides several degrees of MO tunability: magnetite based nanocomposites. A unique and novel synthetic approach described in this dissertation yields both highly transparent and MO responsive polymer films. I will be describing a systematic approach that indicates a strong influence of the size of the nanoparticle as well as the nanoparticle concentration in the MO performance of the bulk polymer, while maintaining high optical quality with minimal scattering and absorption in the visible and near infrared. Finally, I will be discussing the implementation of both a magnetite nanocomposite and a cobalt ferrite based nanocomposite in a free space magnetic field system and demonstrate the proof-of-principle operation of a sensing system

Research paper thumbnail of “We All Get Raped”: Sexual Violence Against Latin American Women in Migratory Transit in Mexico

Violence Against Women, 2021

The article addresses some forms of sexual violence suffered by Latin American women during migra... more The article addresses some forms of sexual violence suffered by Latin American women during migratory transit through Mexico. In-depth, semi-structured, qualitative–phenomenological interviews were conducted with 10 women in different stages of major transmigration states. The findings demonstrate the ubiquity of sexual violence during the migration. Five themes were identified: (a) The migration dimension of “being a woman”; (b) Recognition of contextual factors associated with the migratory process: “Intermediaries, road, shelters and sisterhood”; (c) The costs of migration: Abuse, discrimination, and persecution: “Criminal groups, physical violence, and “La Bestia”; (d) Triggers and supports: “Escape and future expectations”; and (e) God as a support.

Research paper thumbnail of Clinical Outcomes in Adults/Adolescents with Hemophilia B Treated Long Term with Recombinant Factor IX Fc Fusion Protein (rFIXFc) Prophylaxis: Interim Results of the B-Yond Extension Study

Blood, 2016

Introduction: The phase 3 B-LONG study (NCT01027364) demonstrated the safety, efficacy, and pharm... more Introduction: The phase 3 B-LONG study (NCT01027364) demonstrated the safety, efficacy, and pharmacokinetics of recombinant factor IX Fc fusion protein (rFIXFc) for the prevention and treatment of bleeding episodes in adults and adolescents with severe hemophilia B. The ongoing rFIXFc extension study B-YOND (NCT01425723) is evaluating long-term safety and efficacy of rFIXFc in children and adults with hemophilia B. Safety and efficacy data for adult and adolescent subjects from the second B-YOND interim data cut are reported here. Methods: The B-LONG study enrolled males aged ≥12 years with severe hemophilia B (≤2 IU/dL endogenous factor IX [FIX] activity) who had received prior treatment with FIX. Subjects completing B-LONG could enroll in 1 of 4 treatment groups in B-YOND: weekly prophylaxis (WP; 20-100 IU/kg every 7 d), individualized prophylaxis (IP: 100 IU/kg every 8-16 d), modified prophylaxis (MP; for subjects not achieving optimal prophylactic dosing with IP or WP), or episo...

Research paper thumbnail of Clinical Outcomes in Children with Hemophilia B Treated Long Term with rFIXFc: Interim Results of the B-YOND Extension Study

Blood, 2015

Background: Early prophylactic replacement of coagulation factor IX (FIX) improves clinical outco... more Background: Early prophylactic replacement of coagulation factor IX (FIX) improves clinical outcomes in children with hemophilia B; however, frequent intravenous infusions (2-3 times/week) are often required due to the short half-life of conventional FIX products. Recombinant FIX Fc fusion protein (rFIXFc), which is produced in a human cell line, binds the neonatal Fc receptor and utilizes the natural IgG recycling pathway to prolong the half-life of FIX.The phase 3 Kids B-LONG study (NCT01425723) demonstrated the safety, efficacy and prolonged half-life of once weekly recombinant factor IX Fc fusion protein (rFIXFc) in children aged <12 years with hemophilia B (endogenous FIX ≤2 IU/dL). Here, we report interim safety and efficacy data for children enrolled in the ongoing rFIXFc extension study, B-YOND (NCT01425723). Methods: Upon completing Kids B-LONG, eligible subjects could participate in one of 3 treatment groups in B-YOND: weekly prophylaxis (WP; 20-100 IU/kg every 7 days),...

Research paper thumbnail of Extended-Interval Prophylaxis with rFIXFc in Adults and Adolescents with Hemophilia B: Interim Results of the B-YOND Extension Study

Blood, 2015

Background: Prophylactic replacement of coagulation factor IX (FIX) in patients with hemophilia B... more Background: Prophylactic replacement of coagulation factor IX (FIX) in patients with hemophilia B improves clinical outcomes; however, the short half-life of conventional FIX products often necessitates frequent intravenous infusions (2-3 times/week). Recombinant FIX Fc fusion protein (rFIXFc), which is produced in a human cell line, binds the neonatal Fc receptor and utilizes the natural IgG recycling pathway to prolong the half-life of FIX. Introduction : The phase 3 B-LONG study (NCT01027364) demonstrated the safety, efficacy and prolonged half-life of recombinant factor IX Fc fusion protein (rFIXFc) in adults and adolescents (aged ≥12 years) with hemophilia B. Here, we report interim safety and efficacy data for adults and adolescents enrolled in the ongoing rFIXFc extension study, B-YOND (NCT01425723). Methods : Upon completing B-LONG, eligible subjects could participate in one of 4 treatment groups in B-YOND: weekly prophylaxis (WP; 20 to 100 IU/kg every 7 days), individualize...

Research paper thumbnail of Treatment Patterns and Costs of Care in Commercially-Insured and Medicaid Patients with Transfusion-Dependent SS-Thalassemia

Value in Health, 2018

DT claims during pre-index period). Included patients had a diagnosis of SCD or thalassemia, were... more DT claims during pre-index period). Included patients had a diagnosis of SCD or thalassemia, were 2-63 years of age, and were continuously enrolled in Texas Medicaid during the study period. Kruskall Wallis and Chi-square tests were used for continuous and categorical variables, respectively. Results: A total of 201 Texas Medicaid patients met the study criteria (24.4% DFX-DT-Only, 20.4% DFX-FCT-Only, 55.2% Switched). Patients who switched from DFX-DT to DFX-FCT had fewer hospitalizations and emergency department (ED) visits compared to DFX-DT-Only and DFX-FCT-Only groups (P< 0.001). Annual inpatient expenditures were lower for patients who switched compared to DFX-DT-Only and DFX-FCT-Only patients (P= 0.001). Mean annual medical expenditures (inpatient, ED, outpatient visits) were lowest for patients who switched, followed by DFX-FCT-Only patients (+11.5%) and DFX-DT-Only patients (+35.9%). ConClusions: In study patients taking DFX, medical resource utilization and expenditures varied by type of DFX (DT vs. FCT). The patient group that switched from DFX-DT to DFX-FCT had fewer hospitalizations, fewer ED visits, and lower medical expenditures. To optimize patient health outcomes and resource use, health care providers and decision-makers should be aware of differences in these measures by DFX formulation.

Research paper thumbnail of Recombinant factor IX Fc fusion protein in children with haemophilia B (Kids B-LONG): results from a multicentre, non-randomised phase 3 study

The Lancet. Haematology, 2017

Kids B-LONG was a multicentre, open-label, phase 3 study assessing the safety, efficacy, and phar... more Kids B-LONG was a multicentre, open-label, phase 3 study assessing the safety, efficacy, and pharmacokinetics of recombinant factor IX Fc fusion protein (rFIXFc) in previously treated paediatric patients younger than 12 years with severe haemophilia B. The study enrolled 30 previously treated boys younger than 12 years with haemophilia B (≤2 IU/dL [≤2%] endogenous coagulation factor IX [FIX] activity). All patients were initially given rFIXFc prophylaxis (50-60 IU/kg) once per week with adjustments to dose (≤100 IU/kg per infusion) or dosing frequency (up to two times per week) as needed. The primary outcome measure was development of inhibitors (neutralising antibodies). Secondary outcomes were pharmacokinetics, annual bleeding rate (ABR), spontaneous joint ABR, the number of infusions and dose required to resolve a bleed, time from last infusion of rFIXFc to a bleeding episode, assessment of response to treatment, and total annualised rFIXFc consumption for prevention and treatmen...

Research paper thumbnail of Long-term safety and efficacy of extended-interval prophylaxis with recombinant factor IX Fc fusion protein (rFIXFc) in subjects with haemophilia B

Thrombosis and haemostasis, Feb 22, 2016

The safety, efficacy, and prolonged half-life of recombinant factor IX Fc fusion protein (rFIXFc)... more The safety, efficacy, and prolonged half-life of recombinant factor IX Fc fusion protein (rFIXFc) were demonstrated in the Phase 3 B-LONG (adults/adolescents ≥12 years) and Kids B-LONG (children <12 years) studies of subjects with haemophilia B (≤2 IU/dl). Here, we report interim, long-term safety and efficacy data from B-YOND, the rFIXFc extension study. Eligible subjects who completed B-LONG or Kids B-LONG could enrol in B-YOND. There were four treatment groups: weekly prophylaxis (20-100 IU/kg every 7 days), individualised prophylaxis (100 IU/kg every 8-16 days), modified prophylaxis (further dosing personalisation to optimise prophylaxis), and episodic (on-demand) treatment. Subjects could change treatment groups at any point. Primary endpoint was inhibitor development. One hundred sixteen subjects enrolled in B-YOND. From the start of the parent studies to the B-YOND interim data cut, median duration of rFIXFc treatment was 39.5 months and 21.9 months among adults/adolescent...

Research paper thumbnail of Pueblo Qom, una lucha hacia la libertad

Eje 3: Protesta, conflicto y cambio social. Prácticas de organización y procesos de transformació... more Eje 3: Protesta, conflicto y cambio social. Prácticas de organización y procesos de transformación Pueblo Q'om, una lucha hacia la libertad En el presente trabajo se abordará la problemática actual del pueblo Q'om haciendo foco sobre la lucha por el territorio para desengranar las prácticas de dominación efectuadas por el Estado. Se relatará la historia cultural, social, económica y política que funda las raíces de la actual protesta social 1. Se tendrá en cuenta que la lucha por el territorio ancestral debate la idea de constituirse como comunidad previamente a que se consolide el Estado Nacional argentino como tal. Vale aclarar que, dado que la comunidad siente como un insulto la denominación Toba impuesta por los españoles, en adelante, sólo se utilizará la palabra Q'om como el nombre que los identifica. 2

Research paper thumbnail of Long‐term safety and efficacy of recombinant factor VIII Fc fusion protein (rFVIIIFc) in subjects with haemophilia A

Haemophilia, 2015

Introduction: The safety, efficacy and prolonged half-life of recombinant factor VIII Fc fusion p... more Introduction: The safety, efficacy and prolonged half-life of recombinant factor VIII Fc fusion protein (rFVIIIFc) in previously treated patients with severe haemophilia A was demonstrated in the phase 3 ALONG and Kids ALONG studies. Here, we report interim safety and efficacy data from the rFVIIIFc extension study, ASPIRE (ClinicalTrials.gov #NCT01454739). Methods: Eligible subjects could enrol in ASPIRE upon completing ALONG or Kids ALONG. There were four treatment groups: individualized prophylaxis; weekly prophylaxis; modified prophylaxis (for subjects in whom optimal treatment could not be achieved with individualized or weekly prophylaxis); and episodic treatment. The primary endpoint was development of inhibitors. Results: A total of 150 ALONG subjects and 61 Kids ALONG subjects enrolled in ASPIRE. As of the interim data cut (6 January 2014), the median time on study was 80.9 (A-LONG) and 23.9 (Kids ALONG) weeks. The majority of subjects (A-LONG, 92.0%; Kids ALONG , 57.4%) had ≥100 cumulative rFVIIIFc exposure days. No inhibitors were observed. Adverse events were generally consistent with those expected in the general haemophilia A population. Median annualized bleeding rates (ABRs) were low with individualized [A-LONG: 0.66; Kids ALONG: 0.00 (<6 years old), 1.54 (6 to <12 years old)], weekly (A-LONG: 2.03) and modified (A-LONG: 1.97) prophylaxis. There was no change in prophylactic infusion frequency or total weekly prophylactic dose in the majority of subjects from ALONG and Kids ALONG. Conclusion: Interim data from ASPIRE confirm the long-term safety of rFVIIIFc and the maintenance of a low ABR with extended-interval prophylactic dosing in patients with severe haemophilia A.

Research paper thumbnail of New Materials for Magneto Optic In-fiber and Waveguide Isolators

Lasers, Sources, and Related Photonic Devices, 2012

ABSTRACT We report recent advances in new magneto optic materials including novel colorless magne... more ABSTRACT We report recent advances in new magneto optic materials including novel colorless magnetic ionic liquids and magnetic nanoparticle-core polymer-shell nanocomposites for non-reciprocal in-fiber and waveguide operation for isolation and circulation.

Research paper thumbnail of All-Optical Magnetometer Based on Magnetite Core-Polymer Shell Nanocomposite Material

Frontiers in Optics 2009/Laser Science XXV/Fall 2009 OSA Optics & Photonics Technical Digest, 2009

ABSTRACT An all-optical magnetometer has been constructed based on magnetite core polymer shell n... more ABSTRACT An all-optical magnetometer has been constructed based on magnetite core polymer shell nanocomposite material. A noise equivalent magnetic field sensitivity of 5 nT/?Hz was observed using a 1 ?T 500 Hz control magnetic field.

Research paper thumbnail of Salt taste threshold and salt good taste sensitivity in a community of students of the southern area of Puerto Rico

Boletín de la Asociación Médica de Puerto Rico

Sodium appetite reflects the importance of sodium homeostasis. The sodium ion is one of the most ... more Sodium appetite reflects the importance of sodium homeostasis. The sodium ion is one of the most important risk factors in the development of hypertension. Humans, for various reasons, seem to have a specific preference for salt which is consumed in excess of need and this has been characterized as an important contributor to hypertension. Salt intake is related to the salt taste sensitivity threshold and the salt good taste level. Gustatory sensibility responds to various physiological mechanisms and salt taste is directly modified by cultural and socio-economical factors. We measured the salt taste sensitivity threshold and salt good taste level of a young student population. Air popped popcorn sprayed with different Molar concentrations of salt where given to students to taste and a questionnaire to evaluate diet salt intake preferences. Both salt taste sensitivity threshold and salt good taste level graph patterns are different from each other. Salt taste sensitivity threshold h...

Research paper thumbnail of Zinc Fortification Decreases ZIP1 Gene Expression of Some Adolescent Females with Appropriate Plasma Zinc Levels

Nutrients, 2014

Zinc homeostasis is achieved after intake variation by changes in the expression levels of zinc t... more Zinc homeostasis is achieved after intake variation by changes in the expression levels of zinc transporters. The aim of this study was to evaluate dietary intake (by 24-h recall), absorption, plasma zinc (by absorption spectrophotometry) and the expression levels (by quantitative PCR), of the transporters ZIP1 (zinc importer) and ZnT1 (zinc exporter) in peripheral white blood cells from 24 adolescent girls before and after drinking zinc-fortified milk for 27 day. Zinc intake increased (p < 0.001) from 10.5 ± 3.9 mg/day to 17.6 ± 4.4 mg/day, and its estimated absorption from 3.1 ± 1.2 to 5.3 ± 1.3 mg/day. Mean plasma zinc concentration remained unchanged (p > 0.05) near 150 µg/dL, but increased by 31 µg/dL (p < 0.05) for 6/24 adolescents (group A) and decreased by 25 µg/dL (p < 0.05) for other 6/24 adolescents (group B). Expression of ZIP1 in blood leukocytes was reduced 1.4-fold (p < 0.006) in group A, while for the expression of ZnT1 there was no difference after intervention (p = 0.39). An increase of dietary zinc after 27-days consumption of fortified-milk did not increase (p > 0.05) the plasma level of adolescent girls but for 6/24 participants from group A in spite of the formerly appropriation, which cellular zinc uptake decreased as assessed by reduction of the expression of ZIP1.

Research paper thumbnail of Capital cultural, escuela y espacio social

Revista Mexicana de Sociología, 1999

... Y agrega que en la actualidad se llama teoría únicamente ... (p. 113). La estructura del capi... more ... Y agrega que en la actualidad se llama teoría únicamente ... (p. 113). La estructura del capital, conformada por el capital económico y cultural, se retraduce en el sistema de preferencias para que los adolescentes privilegien ...