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Research paper thumbnail of Epidemiological Features and Outcomes of COVID-19 in Patients With and Without Cardiovascular Disease

Archives of Iranian Medicine

Background: Cardiovascular diseases (CVDs) are known as an important group of risk factor for pro... more Background: Cardiovascular diseases (CVDs) are known as an important group of risk factor for progression of the Coronavirus-19 disease (COVID-19). The present study compared epidemiological features and outcomes in COVID-19 patients with CVDs versus those without CVDs. Methods: This is a retrospective study performed on 1497 patients with CVDs and 26926 patients without CVDs, all of whom were confirmed to have COVID-19. All clinical signs and comorbidities were investigated in the subjects. Mann-Whitney U test and Pearson’s Chi-square test were applied to compare mortality between the groups. Logistic regression was used to identify the predictors of mortality among patients. Results: The mean age of COVID-19 patients with underlying CVD was 60 years. Totally, about 5.3% of the individuals under study had CVD. Also, 21.6% of all deaths occurred in COVID-19 patients with CVD. Cough, fever, shortness of breath, muscle pain, and underlying diseases such as diabetes, hypertension, chro...

Research paper thumbnail of Epidemiological features and consequences of COVID‐19 in patients with and without gastrointestinal symptoms in southwestern Iran. A retrospective observational study

Health Science Reports

Background and AimsSome studies have shown that in addition to respiratory symptoms, gastrointest... more Background and AimsSome studies have shown that in addition to respiratory symptoms, gastrointestinal (GI) manifestations reported in patients with coronavirus disease 2019 (COVID‐19). The aim of this study was to compare the epidemiological features and consequences of COVID‐19 in patients with and without GI symptoms.MethodsThis retrospective observational study concluded on 15,323 COVID‐19 patients with GI symptoms and 95,724 patients without symptoms. All symptoms and comorbidities of the patients collected. To investigate the differences between qualitative variables in the two groups, χ2 test was used. Logistic regression analysis also used to identify determinants of mortality in patients with COVID‐19.ResultsDuring the course of the study, 111,047 cases of COVID‐19 occurred. Of these, 13.8% of patients had GI symptoms, and 9.9% of deaths due to COVID‐19 occurred in these patients. The most common reported GI symptoms among COVID‐19 patients were nausea, vomiting, and diarrhe...

Research paper thumbnail of Genetic Variants Of Cytochrome b-245, Alpha Polypeptide Gene And Premature Acute Myocardial Infarction Risk In An Iranian Population

Journal of Medical Biochemistry, 2015

SummaryBackground:Oxidative stress induced by superoxide anion plays critical roles in the pathog... more SummaryBackground:Oxidative stress induced by superoxide anion plays critical roles in the pathogenesis of coronary artery disease (CAD) and hence acute myocardial infarction (AMI). The major source of superoxide production in vascular smooth muscle and endothelial cells is the NADPH oxidase complex. An essential component of this complex is p22phox, that is encoded by the cytochrome b-245, alpha polypeptide (CYBA) gene. The aim of this study was to investigate the association of CYBA variants (rs1049255 and rs4673) and premature acute myocardial infarction risk in an Iranian population.Methods:The study population consisted of 158 patients under the age of 50 years, with a diagnosis of premature AMI, and 168 age-matched controls with normal coronary angiograms. Genotyping of the polymorphisms was performed by the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).Results:There was no association between the genotypes and allele frequencies of rs4673 p...

Research paper thumbnail of Investigation of health risk assessment sevoflurane on indoor air quality in the operation room in Ahvaz city, Iran

Toxin Reviews, 2018

One of the important wards in educational hospital due to special conditions of patients is opera... more One of the important wards in educational hospital due to special conditions of patients is operating rooms (ORs). Anesthetic gases sevoflurane among air anesthetic pollutant is very dangerous for health care worker (HCW) and patients. The aim of this study was to associate the concentration of anesthetic toxic sevoflurane gases (ppm) indoor air in Emam, Razi and Golestan teaching hospitals OR during 2016. In the current study, portable pump SKC equipped with sorbent Tube Tenax TA 250 mg was used to sampling and measurements of sevoflurane gases concentration in the ORs. Three detection places were selected for sampling volatile anesthetic gases sevoflurane. In this study, health risks produced by non-cancer causing agents are quantified by calculating the hazard index (HI). Based on result this study, the Emam and Golestan had the lowest and the highest sevoflurane concentrations. According to the results from the current study, level of sevoflurane on indoor air quality in the operation room in Emam, Razi and Golestan hospitals were 2.058, 2.201 and 2.289 ppm, respectively. According result this study HI was under 1.0 and it amount showed that no significant risk of adverse health effects related to exposure to concentration of sevoflurane in Emam, Razi and Golestan teaching hospitals OR during 2016. Result showed that the average concentration of sevoflurane in studied hospitals were more than the standard level (2 ppm) and exposure to this concentration of sevoflurane could be threaten for HCW. Based on result our study, the average level of sevoflurane was significantly higher than that of ORs without standard ventilation in comparison with ORs with standard ventilation system. Performed active for decreasing anesthetic gases can cause decrease health endpoint in OR HCWs and costs. While OR management in ambient air can cause disorders in staffs and causing more spiritual and material costs.

Research paper thumbnail of Epidemiological Features and Predictors of Mortality in Patients with COVID-19 with and without Underlying Hypertension

International Journal of Hypertension, 2021

Backgrounds Individuals with hypertension are at higher risk of COVID-19 infection and related mo... more Backgrounds Individuals with hypertension are at higher risk of COVID-19 infection and related mortality. This study was carried out to assess the epidemiological features and predictors of mortality in patients with COVID-19 with hypertension. Methods In this retrospective study, the epidemiological characteristics of two groups of patients with COVID-19 with hypertension (1927) and without hypertension (39030) were compared. Chi-square test was applied to evaluate the differences between qualitative variables in two study groups. Logistic regression was also used to determine predictors of mortality in patients with COVID-19 and in patients with COVID-19 with hypertension. Results The prevalence of hypertension in patients with COVID-19 was 4.7%, and 24.37% of COVID-19 related deaths occurred in these individuals. The average age of hypertension and nonhypertension patients was 61 and 37 years, respectively. Fever, cough, headache, anorexia, fatigue, and comorbid diseases, such as...

Research paper thumbnail of Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)

Background The Middle East and North Africa (MENA) is postulated to have the highest increase in ... more Background The Middle East and North Africa (MENA) is postulated to have the highest increase in the prevalence of diabetes by 2030; however, studies on the epidemiology of diabetes are rather limited across the region, including in Iran. Methods This study was conducted between 2016 and 2018 among Iranian adults aged 20 to 65 years residing in Khuzestan province, southwestern Iran. Diabetes was defined as the fasting blood glucose (FBG) level of 126 mg/dl or higher, and/or taking antidiabetic medications, and/or self-declared diabetes. Prediabetes was defined as FBG 100 to 125 mg/dl. Multinomial logistic regression models were used to examine the association of multiple risk factors that attained significance on the outcome. Results Overall, 30,498 participants were recruited; the mean (±SD) age was 41.6 (±11.9) years. The prevalence of prediabetes and diabetes were 30.8 and 15.3%, respectively. We found a similar prevalence of diabetes in both sexes, although it was higher among i...

Research paper thumbnail of Epidemiological characteristics and outcomes of COVID-19 in diabetic versus non-diabetic patients

International Journal of Diabetes in Developing Countries

Objectives and background People with diabetes (PWD) are one of the high-risk groups for coronavi... more Objectives and background People with diabetes (PWD) are one of the high-risk groups for coronavirus disease 2019 (COVID-19) infection, increasing the disease mortality. This study was aimed to compare the epidemiological characteristics and outcomes of COVID-19 in diabetic versus non-diabetic individuals. Methods In this retrospective observational study, the epidemiological characteristics of the two groups of diabetic (n=1365) and non-diabetic (n=15,026) subjects with definite diagnosis of COVID-19 in the southwestern region of Iran were compared. All clinical signs and comorbidities of the patients were evaluated. Chi-square test was used to examine the differences in qualitative variables between diabetic and non-diabetic groups. Results Of 16,391 enrolled subjects, 8.3% had diabetes, and 28.3% of COVID-19-related deaths occurred in diabetics. Also, the mortality rate among diabetics was reported as 14.3%. The average age of diabetic patients and non-diabetic patients was 59 and 37 years, respectively. The odds of fever, cough, shortness of breath, headache, and underlying diseases, such as hypertension, cardiovascular disease, chronic lung disease, immune deficiency, and hyperlipidemia, were significantly higher in diabetic patients than in non-diabetics. Conclusion Diabetes is associated with increased mortality rate in patients with COVID-19 and is considered as a major risk factor for COVID-19 infection, posing a major public health challenge for health policymakers in managing and controlling the disease. Therefore, development of prevention and treatment strategies aimed at reducing COVID-19 morbidity and mortality in diabetes patients is of significant importance.

Research paper thumbnail of Epidemiological Features and Outcomes of COVID-19 in Patients With and Without Cardiovascular Disease

Archives of Iranian Medicine

Background: Cardiovascular diseases (CVDs) are known as an important group of risk factor for pro... more Background: Cardiovascular diseases (CVDs) are known as an important group of risk factor for progression of the Coronavirus-19 disease (COVID-19). The present study compared epidemiological features and outcomes in COVID-19 patients with CVDs versus those without CVDs. Methods: This is a retrospective study performed on 1497 patients with CVDs and 26926 patients without CVDs, all of whom were confirmed to have COVID-19. All clinical signs and comorbidities were investigated in the subjects. Mann-Whitney U test and Pearson’s Chi-square test were applied to compare mortality between the groups. Logistic regression was used to identify the predictors of mortality among patients. Results: The mean age of COVID-19 patients with underlying CVD was 60 years. Totally, about 5.3% of the individuals under study had CVD. Also, 21.6% of all deaths occurred in COVID-19 patients with CVD. Cough, fever, shortness of breath, muscle pain, and underlying diseases such as diabetes, hypertension, chro...

Research paper thumbnail of Epidemiological features and consequences of COVID‐19 in patients with and without gastrointestinal symptoms in southwestern Iran. A retrospective observational study

Health Science Reports

Background and AimsSome studies have shown that in addition to respiratory symptoms, gastrointest... more Background and AimsSome studies have shown that in addition to respiratory symptoms, gastrointestinal (GI) manifestations reported in patients with coronavirus disease 2019 (COVID‐19). The aim of this study was to compare the epidemiological features and consequences of COVID‐19 in patients with and without GI symptoms.MethodsThis retrospective observational study concluded on 15,323 COVID‐19 patients with GI symptoms and 95,724 patients without symptoms. All symptoms and comorbidities of the patients collected. To investigate the differences between qualitative variables in the two groups, χ2 test was used. Logistic regression analysis also used to identify determinants of mortality in patients with COVID‐19.ResultsDuring the course of the study, 111,047 cases of COVID‐19 occurred. Of these, 13.8% of patients had GI symptoms, and 9.9% of deaths due to COVID‐19 occurred in these patients. The most common reported GI symptoms among COVID‐19 patients were nausea, vomiting, and diarrhe...

Research paper thumbnail of Genetic Variants Of Cytochrome b-245, Alpha Polypeptide Gene And Premature Acute Myocardial Infarction Risk In An Iranian Population

Journal of Medical Biochemistry, 2015

SummaryBackground:Oxidative stress induced by superoxide anion plays critical roles in the pathog... more SummaryBackground:Oxidative stress induced by superoxide anion plays critical roles in the pathogenesis of coronary artery disease (CAD) and hence acute myocardial infarction (AMI). The major source of superoxide production in vascular smooth muscle and endothelial cells is the NADPH oxidase complex. An essential component of this complex is p22phox, that is encoded by the cytochrome b-245, alpha polypeptide (CYBA) gene. The aim of this study was to investigate the association of CYBA variants (rs1049255 and rs4673) and premature acute myocardial infarction risk in an Iranian population.Methods:The study population consisted of 158 patients under the age of 50 years, with a diagnosis of premature AMI, and 168 age-matched controls with normal coronary angiograms. Genotyping of the polymorphisms was performed by the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).Results:There was no association between the genotypes and allele frequencies of rs4673 p...

Research paper thumbnail of Investigation of health risk assessment sevoflurane on indoor air quality in the operation room in Ahvaz city, Iran

Toxin Reviews, 2018

One of the important wards in educational hospital due to special conditions of patients is opera... more One of the important wards in educational hospital due to special conditions of patients is operating rooms (ORs). Anesthetic gases sevoflurane among air anesthetic pollutant is very dangerous for health care worker (HCW) and patients. The aim of this study was to associate the concentration of anesthetic toxic sevoflurane gases (ppm) indoor air in Emam, Razi and Golestan teaching hospitals OR during 2016. In the current study, portable pump SKC equipped with sorbent Tube Tenax TA 250 mg was used to sampling and measurements of sevoflurane gases concentration in the ORs. Three detection places were selected for sampling volatile anesthetic gases sevoflurane. In this study, health risks produced by non-cancer causing agents are quantified by calculating the hazard index (HI). Based on result this study, the Emam and Golestan had the lowest and the highest sevoflurane concentrations. According to the results from the current study, level of sevoflurane on indoor air quality in the operation room in Emam, Razi and Golestan hospitals were 2.058, 2.201 and 2.289 ppm, respectively. According result this study HI was under 1.0 and it amount showed that no significant risk of adverse health effects related to exposure to concentration of sevoflurane in Emam, Razi and Golestan teaching hospitals OR during 2016. Result showed that the average concentration of sevoflurane in studied hospitals were more than the standard level (2 ppm) and exposure to this concentration of sevoflurane could be threaten for HCW. Based on result our study, the average level of sevoflurane was significantly higher than that of ORs without standard ventilation in comparison with ORs with standard ventilation system. Performed active for decreasing anesthetic gases can cause decrease health endpoint in OR HCWs and costs. While OR management in ambient air can cause disorders in staffs and causing more spiritual and material costs.

Research paper thumbnail of Epidemiological Features and Predictors of Mortality in Patients with COVID-19 with and without Underlying Hypertension

International Journal of Hypertension, 2021

Backgrounds Individuals with hypertension are at higher risk of COVID-19 infection and related mo... more Backgrounds Individuals with hypertension are at higher risk of COVID-19 infection and related mortality. This study was carried out to assess the epidemiological features and predictors of mortality in patients with COVID-19 with hypertension. Methods In this retrospective study, the epidemiological characteristics of two groups of patients with COVID-19 with hypertension (1927) and without hypertension (39030) were compared. Chi-square test was applied to evaluate the differences between qualitative variables in two study groups. Logistic regression was also used to determine predictors of mortality in patients with COVID-19 and in patients with COVID-19 with hypertension. Results The prevalence of hypertension in patients with COVID-19 was 4.7%, and 24.37% of COVID-19 related deaths occurred in these individuals. The average age of hypertension and nonhypertension patients was 61 and 37 years, respectively. Fever, cough, headache, anorexia, fatigue, and comorbid diseases, such as...

Research paper thumbnail of Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)

Background The Middle East and North Africa (MENA) is postulated to have the highest increase in ... more Background The Middle East and North Africa (MENA) is postulated to have the highest increase in the prevalence of diabetes by 2030; however, studies on the epidemiology of diabetes are rather limited across the region, including in Iran. Methods This study was conducted between 2016 and 2018 among Iranian adults aged 20 to 65 years residing in Khuzestan province, southwestern Iran. Diabetes was defined as the fasting blood glucose (FBG) level of 126 mg/dl or higher, and/or taking antidiabetic medications, and/or self-declared diabetes. Prediabetes was defined as FBG 100 to 125 mg/dl. Multinomial logistic regression models were used to examine the association of multiple risk factors that attained significance on the outcome. Results Overall, 30,498 participants were recruited; the mean (±SD) age was 41.6 (±11.9) years. The prevalence of prediabetes and diabetes were 30.8 and 15.3%, respectively. We found a similar prevalence of diabetes in both sexes, although it was higher among i...

Research paper thumbnail of Epidemiological characteristics and outcomes of COVID-19 in diabetic versus non-diabetic patients

International Journal of Diabetes in Developing Countries

Objectives and background People with diabetes (PWD) are one of the high-risk groups for coronavi... more Objectives and background People with diabetes (PWD) are one of the high-risk groups for coronavirus disease 2019 (COVID-19) infection, increasing the disease mortality. This study was aimed to compare the epidemiological characteristics and outcomes of COVID-19 in diabetic versus non-diabetic individuals. Methods In this retrospective observational study, the epidemiological characteristics of the two groups of diabetic (n=1365) and non-diabetic (n=15,026) subjects with definite diagnosis of COVID-19 in the southwestern region of Iran were compared. All clinical signs and comorbidities of the patients were evaluated. Chi-square test was used to examine the differences in qualitative variables between diabetic and non-diabetic groups. Results Of 16,391 enrolled subjects, 8.3% had diabetes, and 28.3% of COVID-19-related deaths occurred in diabetics. Also, the mortality rate among diabetics was reported as 14.3%. The average age of diabetic patients and non-diabetic patients was 59 and 37 years, respectively. The odds of fever, cough, shortness of breath, headache, and underlying diseases, such as hypertension, cardiovascular disease, chronic lung disease, immune deficiency, and hyperlipidemia, were significantly higher in diabetic patients than in non-diabetics. Conclusion Diabetes is associated with increased mortality rate in patients with COVID-19 and is considered as a major risk factor for COVID-19 infection, posing a major public health challenge for health policymakers in managing and controlling the disease. Therefore, development of prevention and treatment strategies aimed at reducing COVID-19 morbidity and mortality in diabetes patients is of significant importance.