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Papers by ambika hingolekar
International Journal for Advance Research and Development, 2017
Diphtheria is an acute infectious disease of upper respiratory tract caused by toxigenic strains ... more Diphtheria is an acute infectious disease of upper respiratory tract caused by toxigenic strains of Corynebacterium diphtheriae (CD) and Corynebacterium other than diphtheria (COD). The organism is locally invasive and causes exotoxin - mediated illness and can lead to complications like stridor, respiratory obstruction, myocarditis, nerve palsy, renal insufficiency and death in severe cases. The objective of The study was to isolate, identify and confirm the organisms in the laboratory from the throat swabs of clinical diphtheria cases, correlate clinical disease and immunization status of the individual and compare serum antibody titers in immunized & non immunized patients with clinical disease. One hundred fifty patients presenting with fever, sore throat and membrane in the throat were included in the study and throat swabs were collected for direct microscopic examination for KLB and culture. In vitro Toxigenicity, testing by Elek’s Gel precipitation test was done for all CD i...
International Journal for Advance Research and Development, 2017
Diphtheria is an acute infectious disease of upper respiratory tract caused by toxigenic strains ... more Diphtheria is an acute infectious disease of upper respiratory tract caused by toxigenic strains of Corynebacterium diphtheriae (CD) and Corynebacterium other than diphtheria (COD). The organism is locally invasive and causes exotoxin - mediated illness and can lead to complications like stridor, respiratory obstruction, myocarditis, nerve palsy, renal insufficiency and death in severe cases. The objective of The study was to isolate, identify and confirm the organisms in the laboratory from the throat swabs of clinical diphtheria cases, correlate clinical disease and immunization status of the individual and compare serum antibody titers in immunized & non immunized patients with clinical disease. One hundred fifty patients presenting with fever, sore throat and membrane in the throat were included in the study and throat swabs were collected for direct microscopic examination for KLB and culture. In vitro Toxigenicity, testing by Elek’s Gel precipitation test was done for all CD i...