amin arefi - Academia.edu (original) (raw)
Papers by amin arefi
Muṭāli̒āt-i Mudīriyyat-i Gardishgarī, 2020
The purpose of this research is identifying the specific characteristics and the logical benefits... more The purpose of this research is identifying the specific characteristics and the logical benefits of hotel Hospital with Halal brand. The research methodology is based on the philosophical interpretation, fundamental orientation, deductive approach and method of doing is qualitatively. The statistical population in this research was the staff, managers and patients of Gandi Hotel Hospital and Helal Complex of Iran. Sampling was done by judiciary and to extract tangible features and logical benefits with 15 employees and managers and for the extraction of emotional features, 20 patients were interviewed by this hotels hospital. The interview data was analyzed by thematic analysis technique using MAX QDA software. The results of this research are based on the Pyramid brand model which includes 14 tangible features and 67 Logical benefits.
Physical Biology, 2020
We propose a biomechanical model for the extravasation of a tumor cell (TC) through the endotheli... more We propose a biomechanical model for the extravasation of a tumor cell (TC) through the endothelium of a blood vessel. Based on prior in vitro observations, we assume that the TC extends a protrusion between adjacent endothelial cells (ECs) that adheres to the basement membrane via focal adhesions. As the protrusion grows in size and branches out, the actomyosin contraction along the stress fibers inside the protrusion pulls the relatively rigid nucleus through the endothelial opening. We model the chemo-mechanics of the stress fibers and the focal adhesions by following the kinetics of the active myosin motors and high-affinity integrins, subject to mechanical feedback. This is incorporated into a finite-element simulation of the extravasation process, with the contractile force pulling the nucleus of the tumor cell against elastic resistance of the ECs. To account for the interaction between the TC nucleus and the
Introduction: Antibiotics are widely prescribed in dentistry. However, the indications of antibio... more Introduction: Antibiotics are widely prescribed in dentistry. However, the indications of antibiotic therapy are limited, especially in endodontics. There is little information available concerning the pattern of antibiotic prescription among dentists. The aim of this study was to evaluate and determine pattern of antibiotic prescription among general dental practitioners in Isfahan, Iran . Materials and Methods: In this cross-sectional, descriptive study, 280 general dental practitioners of Isfahan were included. A questionnaire containing 15 questions was prepared. Before the study was initiated the reliability and reproducibility of the questionnaire were determined. Data was analyzed by descriptive statistical tests using SPSS software . Results: For non-allergic patients, amoxicillin 500 mg, 3 times daily (63.3%) and penicillin VK 500 mg, 4 times daily (11.4%), were the most commonly prescribed antibiotics, respectively. For patients allergic to penicillins, clindamycin 300 mg,...
The European Physical Journal E, 2021
In the original publication of the article the references 41 and 42 have been displayed incorrect... more In the original publication of the article the references 41 and 42 have been displayed incorrectly on a separate page due to typesetting errors.
The European Physical Journal E, 2021
As part of the immune response, leukocytes can directly transmigrate through the body of endothel... more As part of the immune response, leukocytes can directly transmigrate through the body of endothelial cells or through the gap between adjacent endothelial cells. These are known, respectively, as the transcellular and paracellular route of diapedesis. What determines the usage of one route over the other is unclear. A recently proposed tenertaxis hypothesis claims that leukocytes choose the path with less mechanical resistance against leukocyte protrusions. We examined this hypothesis using numerical simulation of the mechanical resistance during paracellular and transcellular protrusions. By using parameters based on human lung endothelium, our results show that the required force to breach the endothelium through the transcellular route is greater than paracellular route, in agreement with experiments. Moreover, experiments have demonstrated that manipulation of the relative strength between the two routes can make the transcellular route preferable. Our simulations have demonstrated this reversal and thus tentatively confirmed the hypothesis of tenertaxis.
Biomicrofluidics, 2020
The e↵ect of airborne nanoparticles (NPs) on human health is an active area of research, with cli... more The e↵ect of airborne nanoparticles (NPs) on human health is an active area of research, with clinical relevance evidenced by the current COVID-19 pandemic. As in vitro models for such studies, lung-on-a-chip (LOAC) devices can represent key physical and physiological aspects of alveolar tissues. However, widespread adoption of the LOAC device for NP testing has been hampered by low intralaboratory and inter-laboratory reproducibility. To complement ongoing experimental work, we carried out finite-element simulations of the deposition of NPs on the epithelial layer of a well-established LOAC design. We solved the Navier-Stokes equations for the fluid flow in a three-dimensional domain, and studied the particle transport using Eulerian advection-di↵usion for fine NPs and Lagrangian particle tracking for coarse NPs. Using Langmuir and Frumkin kinetics for surface adsorption and desorption, we investigated NP adsorption under di↵erent exercise and breath-holding patterns. Conditions mimicking physical exercise, through changes in air-flow volume and breathing frequency, enhance particle deposition. Pu↵ profiles typical of smoking, with breath-holding between inhalation and exhalation, also increase particle deposition per breathing cycle. Lagrangian particle tracking shows Brownian motion and gravitational settling to be two key factors, which may cooperate or compete with each other for di↵erent particle sizes. Comparisons are made with experimental data where possible, and show qualitative and semi-quantitative agreement. These results suggest that computer simulations can potentially inform and accelerate the design and application of LOAC devices for analyzing particulate-and microbe-alveolar interactions.
Health, Spirituality and Medical Ethics, 2018
Background and Objectives: Halal branding covers a wide range of economic activities including ph... more Background and Objectives: Halal branding covers a wide range of economic activities including pharmaceuticals, cosmetics, health, textiles, clothing, leather, financial services, banking and tourism. Among the various forms of tourism, medical tourism has grown rapidly due to its competitive advantages. Therefore, the purpose of this study is to investigate halal branding as a strategy to develop medical tourism. Methods: A qualitative research method and a case study were used. Data were drawn from semi-structured interviews and analyzed by using thematic analysis. A total of 20 interviews with patients, accompanying persons and hotel hospital staff were conducted. Results: A total of 110 main themes were drawn. These themes had two general orientations within themselves: The nature of the requirement that was either materialistic or spiritual and were simultaneously applicable to short-term and long-term affairs. Certain codes such as not serving haram foods and drinks, not performing abortion and the availability of prayer room in the facilities were specific to halal hotel hospitals. Conclusion: From the combination of these two orientations, four organizing themes, i.e. spiritual and long-term purposes, short-term requirements, materialistic and long-term requirements and short-term purposes were drawn. The inclusive themes were determined by the nature of the requirement and the time orientation of the requirement.
مجله دانشکده دندانپزشکی اصفهان, Dec 11, 2012
Introduction: Antibiotics are widely administered in dentistry, but use of systemic antibiotics i... more Introduction: Antibiotics are widely administered in dentistry, but use of systemic antibiotics in dentistry, especially in endodontics, is limited. There is little information available about the pattern of antibiotic administration among dentists. The aim of this study was to evaluate and determine pattern of antibiotic administration among general dental practitioners in Isfahan. Materials and Methods: In this cross-sectional descriptive/analytical study in 2010, 280 general dental practitioners in Isfahan were included. A questionnaire containing 15 questions was prepared. Before the study was instituted the reliability and reproducibility of the questionnaire were determined. Data was analyzed by descriptive statistical tests using SPSS software. Results: For non-allergic patients, amoxicillin 500 mg 3 times a day (63.3%) and penicillin VK 500 mg 4 times a day (11.4%) were the most commonly administered antibiotics, respectively. For patients allergic to penicillins, clindamyci...
Muṭāli̒āt-i Mudīriyyat-i Gardishgarī, 2020
The purpose of this research is identifying the specific characteristics and the logical benefits... more The purpose of this research is identifying the specific characteristics and the logical benefits of hotel Hospital with Halal brand. The research methodology is based on the philosophical interpretation, fundamental orientation, deductive approach and method of doing is qualitatively. The statistical population in this research was the staff, managers and patients of Gandi Hotel Hospital and Helal Complex of Iran. Sampling was done by judiciary and to extract tangible features and logical benefits with 15 employees and managers and for the extraction of emotional features, 20 patients were interviewed by this hotels hospital. The interview data was analyzed by thematic analysis technique using MAX QDA software. The results of this research are based on the Pyramid brand model which includes 14 tangible features and 67 Logical benefits.
Physical Biology, 2020
We propose a biomechanical model for the extravasation of a tumor cell (TC) through the endotheli... more We propose a biomechanical model for the extravasation of a tumor cell (TC) through the endothelium of a blood vessel. Based on prior in vitro observations, we assume that the TC extends a protrusion between adjacent endothelial cells (ECs) that adheres to the basement membrane via focal adhesions. As the protrusion grows in size and branches out, the actomyosin contraction along the stress fibers inside the protrusion pulls the relatively rigid nucleus through the endothelial opening. We model the chemo-mechanics of the stress fibers and the focal adhesions by following the kinetics of the active myosin motors and high-affinity integrins, subject to mechanical feedback. This is incorporated into a finite-element simulation of the extravasation process, with the contractile force pulling the nucleus of the tumor cell against elastic resistance of the ECs. To account for the interaction between the TC nucleus and the
Introduction: Antibiotics are widely prescribed in dentistry. However, the indications of antibio... more Introduction: Antibiotics are widely prescribed in dentistry. However, the indications of antibiotic therapy are limited, especially in endodontics. There is little information available concerning the pattern of antibiotic prescription among dentists. The aim of this study was to evaluate and determine pattern of antibiotic prescription among general dental practitioners in Isfahan, Iran . Materials and Methods: In this cross-sectional, descriptive study, 280 general dental practitioners of Isfahan were included. A questionnaire containing 15 questions was prepared. Before the study was initiated the reliability and reproducibility of the questionnaire were determined. Data was analyzed by descriptive statistical tests using SPSS software . Results: For non-allergic patients, amoxicillin 500 mg, 3 times daily (63.3%) and penicillin VK 500 mg, 4 times daily (11.4%), were the most commonly prescribed antibiotics, respectively. For patients allergic to penicillins, clindamycin 300 mg,...
The European Physical Journal E, 2021
In the original publication of the article the references 41 and 42 have been displayed incorrect... more In the original publication of the article the references 41 and 42 have been displayed incorrectly on a separate page due to typesetting errors.
The European Physical Journal E, 2021
As part of the immune response, leukocytes can directly transmigrate through the body of endothel... more As part of the immune response, leukocytes can directly transmigrate through the body of endothelial cells or through the gap between adjacent endothelial cells. These are known, respectively, as the transcellular and paracellular route of diapedesis. What determines the usage of one route over the other is unclear. A recently proposed tenertaxis hypothesis claims that leukocytes choose the path with less mechanical resistance against leukocyte protrusions. We examined this hypothesis using numerical simulation of the mechanical resistance during paracellular and transcellular protrusions. By using parameters based on human lung endothelium, our results show that the required force to breach the endothelium through the transcellular route is greater than paracellular route, in agreement with experiments. Moreover, experiments have demonstrated that manipulation of the relative strength between the two routes can make the transcellular route preferable. Our simulations have demonstrated this reversal and thus tentatively confirmed the hypothesis of tenertaxis.
Biomicrofluidics, 2020
The e↵ect of airborne nanoparticles (NPs) on human health is an active area of research, with cli... more The e↵ect of airborne nanoparticles (NPs) on human health is an active area of research, with clinical relevance evidenced by the current COVID-19 pandemic. As in vitro models for such studies, lung-on-a-chip (LOAC) devices can represent key physical and physiological aspects of alveolar tissues. However, widespread adoption of the LOAC device for NP testing has been hampered by low intralaboratory and inter-laboratory reproducibility. To complement ongoing experimental work, we carried out finite-element simulations of the deposition of NPs on the epithelial layer of a well-established LOAC design. We solved the Navier-Stokes equations for the fluid flow in a three-dimensional domain, and studied the particle transport using Eulerian advection-di↵usion for fine NPs and Lagrangian particle tracking for coarse NPs. Using Langmuir and Frumkin kinetics for surface adsorption and desorption, we investigated NP adsorption under di↵erent exercise and breath-holding patterns. Conditions mimicking physical exercise, through changes in air-flow volume and breathing frequency, enhance particle deposition. Pu↵ profiles typical of smoking, with breath-holding between inhalation and exhalation, also increase particle deposition per breathing cycle. Lagrangian particle tracking shows Brownian motion and gravitational settling to be two key factors, which may cooperate or compete with each other for di↵erent particle sizes. Comparisons are made with experimental data where possible, and show qualitative and semi-quantitative agreement. These results suggest that computer simulations can potentially inform and accelerate the design and application of LOAC devices for analyzing particulate-and microbe-alveolar interactions.
Health, Spirituality and Medical Ethics, 2018
Background and Objectives: Halal branding covers a wide range of economic activities including ph... more Background and Objectives: Halal branding covers a wide range of economic activities including pharmaceuticals, cosmetics, health, textiles, clothing, leather, financial services, banking and tourism. Among the various forms of tourism, medical tourism has grown rapidly due to its competitive advantages. Therefore, the purpose of this study is to investigate halal branding as a strategy to develop medical tourism. Methods: A qualitative research method and a case study were used. Data were drawn from semi-structured interviews and analyzed by using thematic analysis. A total of 20 interviews with patients, accompanying persons and hotel hospital staff were conducted. Results: A total of 110 main themes were drawn. These themes had two general orientations within themselves: The nature of the requirement that was either materialistic or spiritual and were simultaneously applicable to short-term and long-term affairs. Certain codes such as not serving haram foods and drinks, not performing abortion and the availability of prayer room in the facilities were specific to halal hotel hospitals. Conclusion: From the combination of these two orientations, four organizing themes, i.e. spiritual and long-term purposes, short-term requirements, materialistic and long-term requirements and short-term purposes were drawn. The inclusive themes were determined by the nature of the requirement and the time orientation of the requirement.
مجله دانشکده دندانپزشکی اصفهان, Dec 11, 2012
Introduction: Antibiotics are widely administered in dentistry, but use of systemic antibiotics i... more Introduction: Antibiotics are widely administered in dentistry, but use of systemic antibiotics in dentistry, especially in endodontics, is limited. There is little information available about the pattern of antibiotic administration among dentists. The aim of this study was to evaluate and determine pattern of antibiotic administration among general dental practitioners in Isfahan. Materials and Methods: In this cross-sectional descriptive/analytical study in 2010, 280 general dental practitioners in Isfahan were included. A questionnaire containing 15 questions was prepared. Before the study was instituted the reliability and reproducibility of the questionnaire were determined. Data was analyzed by descriptive statistical tests using SPSS software. Results: For non-allergic patients, amoxicillin 500 mg 3 times a day (63.3%) and penicillin VK 500 mg 4 times a day (11.4%) were the most commonly administered antibiotics, respectively. For patients allergic to penicillins, clindamyci...