angelo liguori - Academia.edu (original) (raw)

Papers by angelo liguori

Software Defined Networking (SDN) has attracted a lot of interest in both academia and industry, ... more Software Defined Networking (SDN) has attracted a lot of interest in both academia and industry, and it has started to be adopted in real system implementations. SDN emerged as a new concept with the intent of enabling central programmability of the network, although it can be traced back to earlier concepts like Active Networks, Network Control Point, and Routing Control Platform [1,2,3]. SDN is based on the idea of decoupling the control plane from the data plane, introducing a logically centralized control with open interfaces, and providing an API on abstractions of the network elements to program their forwarding behaviour [4]. SDN opens new opportunities for telecommunications and network operators as well as enterprise networks by providing effective means for fast infrastructure provisioning and dynamic reconfiguration of networks.

International Journal of Mobile Network Design and Innovation, 2017

Since years organisations classify information according to security schemes and various criteria... more Since years organisations classify information according to security schemes and various criteria. The requirement to protect information characterised by a hierarchy of sensitivity levels led to the definition of multilevel security. Multilevel security represents one of the toughest problems that security engineers are still facing, due to the fact that it is difficult to manage securely information at different classification levels on the same electronic device or network. It concerns wired and wireless communications, from personal area and wireless sensor networks to wide area and satellite networks. The problem becomes even more critical when users with various clearances, privileges, and roles need to operate simultaneously on these security-motley data. Recently, a new approach gathered the endorsement of industry and academia, the so-called multiple independent levels of security/safety. In this article, we show the evolution that drove the multilevel security into this new paradigm, highlighting the benefits and the drawbacks of the former together with the improvement of the latter and its open issues. A novel cross-domain solution is presented as the thread in-between the two approaches.

$Research paper thumbnail of {"__content__"=>"Alternative formation of amides and β-enaminones from aroyl chlorides using the TiCl-trialkylamine reagent system.", "sub"=>{"__content__"=>"4"}}$

Organic & biomolecular chemistry, Jan 8, 2018

The TiCl4/NR3 reagent system has been successfully employed for the synthesis of amides and β-ena... more The TiCl4/NR3 reagent system has been successfully employed for the synthesis of amides and β-enaminones. The reaction of variously substituted benzoyl chlorides with the TiCl4/NR3 reagent system, by using two different experimental procedures (Method A and Method B), afforded alternatively the corresponding amides and β-enaminones as unique or major products. The two developed protocols were investigated with a series of tertiary amines. The reactions, modulated by the presence of TiCl4, provided the corresponding amides or β-enaminones with satisfactory yields. This paper reports a new method for carbon-carbon bond formation via the reaction of aroyl chlorides with the TiCl4/NR3 reagent system.

Letters in Organic Chemistry, 2006

... Reduction of N-Methoxy-N-Methylamides to the Corresponding Amines with AlCl 3 /LiAlH 4 . Mari... more ... Reduction of N-Methoxy-N-Methylamides to the Corresponding Amines with AlCl 3 /LiAlH 4 . Maria Luisa Di Gioia,; Antonella Leggio,; Adolfo Le Pera,; Angelo Liguori,; Francesca Perri,; Maria Caterina Viscomi. Article first published online: 21 NOV 2006. ...

Biomolecules, 2021

Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is ... more Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is implicated in a wide range of biological functions that control different processes, such as the regulation of body weight and energy expenditure, reproductive function, immune response, and bone metabolism. In addition, leptin can exert angiogenic and mitogenic actions in peripheral organs. Leptin biological activities are greatly related to its interaction with the leptin receptor. Both leptin excess and leptin deficiency, as well as leptin resistance, are correlated with different human pathologies, such as autoimmune diseases and cancers, making leptin and leptin receptor important drug targets. The development of leptin signaling modulators represents a promising strategy for the treatment of cancers and other leptin-related diseases. In the present manuscript, we provide an update review about leptin-activity modulators, comprising leptin mutants, peptide-based leptin modulators, a...

Mini-Reviews in Medicinal Chemistry, 2016

The simplest and minimal modification of a single amino acid or peptide bonds is represented by N... more The simplest and minimal modification of a single amino acid or peptide bonds is represented by N-methylation. This can improve the pharmacokinetic properties of biologically active peptides as well as resulting in analogues that show specific biological activity such as enzyme inhibitors, receptor antagonists and agonists, building blocks in combinatorial chemistry for the screening of new potential drugs. Further, structural and conformational studies performed with N-methylated analogues of natural amino acids and peptides enabled to (i) produce stable foldamers with different topology with respect to the helix of natural and endogenous peptides, (ii) confer to modified peptides high stability against proteases and (iii) enhance lipophilicity and bioavailability for pharmacological purposes. Consequentially, it is crucial to provide optically pure N-methyl-amino acids and N-methylated peptides with a large supply. The present report will focus on the results obtained in the last decade in the field of chemical synthetic methodologies for the N-methylation of amino acids.

The Open Food Science Journal, 2015

The present investigation reports a study about the evolution, during ripening, of the fatty acid... more The present investigation reports a study about the evolution, during ripening, of the fatty acid profile and the fatty acid composition in acylglycerols of three different fermented sausages industrially produced in the Calabria region (Southern Italy). Statistical analysis (ANOVA) was applied to the results obtained for the profiles to check all the differences between samples. The study comprised also an evaluation of the lipid oxidation level. All kind of sausages showed a free fatty acids profile in which the monounsaturated fatty acids were predominant, followed by saturated and polyunsaturated fatty acids. In acylglycerols, a low content in linoleic acid (approximately 2% of total methyl esters) was displayed, while that found in the free fatty acids profile was higher (approximately 17% of total FFAs). In addition, the generation of aldehydes through secondary lipid oxidation was clearly confirmed after long ripening period by classical qualitative colorimetric method suppor...

RSC Adv., 2016

We report on a one-pot synthesis of secondary and tertiary amides from carboxylic acids and amine... more We report on a one-pot synthesis of secondary and tertiary amides from carboxylic acids and amines in the presence of a tertiary amine by using thionyl chloride.

Chemistry Central journal, Jan 2, 2017

This work compares the composition at different temperatures of gaseous phase of bergamot essenti... more This work compares the composition at different temperatures of gaseous phase of bergamot essential oil at equilibrium with the liquid phase. A new GC-MS methodology to determine quantitatively the volatile aroma compounds was developed. The adopted methodology involved the direct injection of headspace gas into injection port of GC-MS system and of known amounts of the corresponding authentic volatile compounds. The methodology was validated. This study showed that gaseous phase composition is different from that of the liquid phase at equilibrium with it.

Chemistry Central Journal

ChemInform

ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Nucleosides Nucleotides, 1997

Abstract The 1, 3 dipolar cycloaddition approach represents the most valuable strategy for the pr... more Abstract The 1, 3 dipolar cycloaddition approach represents the most valuable strategy for the preparation of isoxazolidine nucleosides. The latter posses more conformational degrees of freedom than the corresponding dideoxyribosides. Side reactions due to the ...

Tetrahedron, 2007

A highly efficient and practical synthesis of peptides in solution phase has been developed. The ... more A highly efficient and practical synthesis of peptides in solution phase has been developed. The procedure is based on the use of p-nitrobenzenesulfonyl (nosyl) group for the protection of the amino function of α-amino acids. Every step of the procedure, protection of the amino function by the nosyl group, formation of the peptide bond, and removal of the sulfonamide group, is characterized by high yields and excellent purity of the final products. The described strategy allows the preparation of short peptide sequences keeping the chiral integrity of amino acid precursors. Compatibility of nosyl group with the side-chain protecting groups used in Fmoc-based strategy is demonstrated. The method here presented is an alternative strategy that could provide advantages for future peptide synthesis.

Cheminform, 2010

ABSTRACT The [3 + 2] dipolar cycloaddition of nitrones to N-9-vinyladenine provides a regioselect... more ABSTRACT The [3 + 2] dipolar cycloaddition of nitrones to N-9-vinyladenine provides a regioselective and stereoselective method for the obtainment of 4′-aza-analogues of 2′,3′-dideoxyadenosine. The latter may act as antiviral agents by analogy with the behaviour in vitro of the corresponding thymine analogue. The formation of the unsubstituted isoxazolidino derivative requires the protection of the 6-NH2 function of the dipolarophile, which is not necessary when preformed nitrones are used. The obtainment of a specific enantiomer has been exploited by enzyme-catalysed hydrolysis of an ester function introduced into the isoxazolidino nucleus.

Tetrahedron, 2011

In this work we present the results obtained for the N-alkylation of a series of N-arylsulfonyl-α... more In this work we present the results obtained for the N-alkylation of a series of N-arylsulfonyl-α-amino acid methyl esters bearing different substituents at the 4-position of the sulfonamide aromatic ring. In particular, we compare the reactivity of these species with diazomethane and trimethyloxonium tetrafluoroborate in N-methylation processes. Diazomethylation is unsuccessful for N-arylsulfonamide derivatives containing electron-releasing groups on the aromatic ring. In these cases trimethyloxonium tetrafluoroborate is the reagent of choice for the direct and quantitative N-methylation. Further we extend our evaluation to the use of triethyloxonium tetrafluoroborate. This reagent shows to be very efficient in order to prepare N-ethyl derivatives of N-arylsulfonyl-α-amino acid methyl esters. An experimental protocol similar to that used for N-methylation with trimethyloxonium tetrafluoroborate is applied for the N-ethylation.

Journal of Organic Chemistry, 2007

The Journal of Organic Chemistry, Oct 1, 2003

N-Nosyl-alpha-amino acid methyl esters are methylated quantitatively with diazomethane. After pro... more N-Nosyl-alpha-amino acid methyl esters are methylated quantitatively with diazomethane. After proper deprotection of the amino function by treatment with the reagent system mercaptoacetic acid/sodium methoxide, the obtained N-methyl amino acid methyl esters are coupled with N-Fmoc amino acid chlorides to afford the corresponding dipeptides. The obtained products do not show any detectable extent of racemization by (1)H NMR and HPLC.