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The purpose of this research work was to formulate and evaluate the sustained release tablets of ... more The purpose of this research work was to formulate and evaluate the sustained release tablets of tablets are prepared by direct compression method. The formulations were optimized by incorporating varying composition of Xanthan gum and guar gum as polymers, lactose as flow aid and magnesium stearate drug, which revealed that there was no physical and chemical interaction occurred. The Pre formulation parameters such as bulk density, tapped density, compressibility index and Hausner's percentage yield was evaluated for tablets. The effect of these variables on drug release also studied. The In using pH 0.1N HCl as dissolution media at 75 rpm speed and temperature of 37 sampling was done at periodic time intervals of 1,4,8,12,16,20 and 24 hours and was replaced by equal volume of dissolution media after each withdraw release at different intervals is estimated using UV method. Based on the evaluation result the formulations F kinetics and Higguchi mechanis the drug release through the matrix was fickian diffusion.
The purpose of this research work was to formulate and evaluate the sustained release tablets of ... more The purpose of this research work was to formulate and evaluate the sustained release tablets of tablets are prepared by direct compression method. The formulations were optimized by incorporating varying composition of Xanthan gum and guar gum as polymers, lactose as flow aid and magnesium stearate drug, which revealed that there was no physical and chemical interaction occurred. The Pre formulation parameters such as bulk density, tapped density, compressibility index and Hausner's percentage yield was evaluated for tablets. The effect of these variables on drug release also studied. The In using pH 0.1N HCl as dissolution media at 75 rpm speed and temperature of 37 sampling was done at periodic time intervals of 1,4,8,12,16,20 and 24 hours and was replaced by equal volume of dissolution media after each withdraw release at different intervals is estimated using UV method. Based on the evaluation result the formulations F kinetics and Higguchi mechanis the drug release through the matrix was fickian diffusion.