anvil paul - Academia.edu (original) (raw)

Papers by anvil paul

Research paper thumbnail of Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages

Developmental Biology, 2009

Research paper thumbnail of Staggered Core Activation: A circuit/architectural approach for mitigating resonant supply noise issues in multi-core multi-power domain processors

In order to reduce the impact of resonant supply noise on processor performance, a simple, fully-... more In order to reduce the impact of resonant supply noise on processor performance, a simple, fully-digital and scalable technique based on staggering the activation time of the cores sharing the same power domain in a multi-core multi-power domain processor is presented. Measurement data from a 65nm test chip shows an Fmax improvement as large as 20% in a 3core configuration. This is one of the first approaches to utilize the architecture level behavior for mitigating resonant noise issues in a multi-core multi-power domain processor.

Research paper thumbnail of Towards a New Crytographic Protocol for Biometric Security Technologies

Abstract We propose a new cryptographic protocol for remote authentication. This protocol is suit... more Abstract We propose a new cryptographic protocol for remote authentication. This protocol is suitable when the signature key is very large. The emerging paradigm of veri cation through biometric samples, such as ngerprints, retinal images etc., naturally represents such a ...

Research paper thumbnail of Trading Processor Cycles for Communication

"Trade computation for communication whenever possible" has been the conventional wisdom to save ... more "Trade computation for communication whenever possible" has been the conventional wisdom to save bandwidth and power in wireless domain. We glanced at the merging trends of technology and the applications, and identified a number of areas where the processor cycles can be traded for network bandwidth. These areas are-file transfer, shared document edits, remote authentication, and verification of remotely available codes. We collect and present some of the theory-paradigms that have given birth to results potentially usable towards saving bandwidth at the cost of computation. We hope to make a case for incorporating the insights collected in this paper from various fields of complexity theory, into the design of network protocols for the future. In the penumbra of this over-arching goal, we also suggest how the engine of "Probabilistic Checking of Proofs" (PCP) can be used for remote authentication purposes, resulting in much smaller network overhead and leading to very efficient usage of bandwidth and power. While this seems to be an interesting route, we then present the algorithmic challenges that need be solved and argue why such a theoretical cranking may be just as worth.

Research paper thumbnail of Interaction between stampede runtime and operating systems

Emerging application domains such as interactive vision, animation, and multimedia collaboration ... more Emerging application domains such as interactive vision, animation, and multimedia collaboration display dynamic scalable parallelism, and high computational requirements, making them good candidates for executing on parallel architectures such as SMPs and clusters of SMPs. The necessity to reason about program behavior along the time dimension is an important characteristic of these types of applications. Stampede is a cluster programming system that is designed to meet many of the challenges in such applications. Stampede supports time-sequenced data items, and thus facilitates temporally correlating data items from different streams. The system performs automatic garbage collection of data items no longer needed by any application thread. The Stampede system has been built as a runtime library on top of standard operating systems. In this paper, we study the interaction between the Stampede runtime system and the underlying operating system. The study is conducted on two identical hardware platforms running Solaris and Linux, respectively. A cycle accurate event logging facility using the CPU cycle counter is at the core of this study. There are several interesting insights coming from this study. First, memory allocation does not take up a significant amount of the execution time despite the interactive and dynamic nature of the application domain. Second, the Stampede runtime does not pose a significant overhead over raw messaging for structuring such applications. Third, the results suggest that the thread scheduler on Linux may be more responsive than the one on Solaris. Fourth, the messaging layer spends quite a bit of time in synchronization operations.

Research paper thumbnail of Computation-Communication Trade-off for Power and Bandwidth Savings in Remote Authentication over Wireless Networks

We consider the problem of remote authentication over a long range wireless network using large s... more We consider the problem of remote authentication over a long range wireless network using large signature keys such as biometric samples (fingerprint, retinal scans etc.). Because of the large size of these keys, and continual need for authentication, considerable power and bandwidth is consumed by such processes. We show that by using the concept of a holographic proof, it is possible to significantly cut down the number of bytes transferred. While bandwidth savings is obvious, for long range wireless this means huge savings in power which is a critical resource for mobile devices. Our approach trades computaion for communication, the intuition being that power requirement for transmitting one byte over wireless is orders of magnitude higher than executing one instruction on a standard processor. Our simulations provide a detailed analysis of power savings under a reasonable energyconsumption model and indeed demonstrate the effectiveness of such approach.

Research paper thumbnail of On the behaviour of Kirkendall markers in solid-state interdiffusion

The migration of inert markers as a result of unequal mobilities of the components during solid-s... more The migration of inert markers as a result of unequal mobilities of the components during solid-state interdiffusion in a binary system can be rationalized using a Kirkendall velocity construction. It is demonstrated that in a diffusion-controlled interaction the Kirkendall plane, identified by inert particles (markers) placed at the original contact surface of a reaction couple, need not be unique. Multiple planes can develop, but, on the other hand, markers at the original interface sometimes can get dispersed into a diffuse zone on both sides of the contact surface and no unique location of the Kirkendall plans can be defined. It is also shown that the location of the Kirkendall plane(s) inside the diffusion zone can be identified by grain morphology changes within the microstructure of the reaction products. A physico-chemical approach is developed which elucidates the role of the Kirkendall effect in the morphologenesis of interdiffusion systems. The occurence of one or more Kirkendall planes, characterized by morphology changes in the reaction layers, turns out to be related to different nucleation sites of the product grains.

Research paper thumbnail of Diffusion in Co-Ni System Studied by Multifoil Technique

Diffusion couple experiments were performed in the Co-Ni binary system for determining inter-, im... more Diffusion couple experiments were performed in the Co-Ni binary system for determining inter-, impurity- and intrinsic-diffusion coefficients in the temperature range of 1050 - 1250°C. The activation energy and pre-exponential factor estimated for interdiffusion do not vary significantly with composition. The activation energy calculated for impurity diffusion experiments shows is higher than . Intrinsic diffusion coefficients estimated from the multifoil experiment show that Ni is the fastest diffusing species in this system.

Research paper thumbnail of Physico-chemical analysis of compound growth in a diffusion couple with two-phase end-members

A diffusion-controlled growth of intermetallic phases and the role of the Kirkendall effect in mo... more A diffusion-controlled growth of intermetallic phases and the role of the Kirkendall effect in morphological evolution of the product phase layers can be described in terms of an alternative theory considering chemical reactions at the interphase interfaces. Application of this “physicochemical” treatment to diffusional growth of intermediate phases with fairly wide homogeneity ranges is illustrated by the example of interaction in the Ag-Zn system. The model is purely phenomenological, and its use is convenient, since no explicit assumption of the underlying diffusion mechanism is required.

Research paper thumbnail of Time-resolved momentum imaging system for molecular dynamics studies using a tabletop ultrafast extreme-ultraviolet light source

We describe a momentum imaging setup for direct time-resolved studies of ionization-induced molec... more We describe a momentum imaging setup for direct time-resolved studies of ionization-induced molecular dynamics. This system uses a tabletop ultrafast extreme-ultraviolet ͑EUV͒ light source based on high harmonic upconversion of a femtosecond laser. The high photon energy ͑around 42 eV͒ allows access to inner-valence states of a variety of small molecules via single photon excitation, while the sub-10-fs pulse duration makes it possible to follow the resulting dynamics in real time. To obtain a complete picture of molecular dynamics following EUV induced photofragmentation, we apply the versatile cold target recoil ion momentum spectroscopy reaction microscope technique, which makes use of coincident three-dimensional momentum imaging of fragments resulting from photoexcitation. This system is capable of pump-probe spectroscopy by using a combination of EUV and IR laser pulses with either beam as a pump or probe pulse. We report several experiments performed using this system.

Research paper thumbnail of Binding of Gemini Bisbenzimidazole Drugs with Human Telomeric G-Quadruplex Dimers: Effect of the Spacer in the Design of Potent Telomerase Inhibitors

The study of anticancer agents that act via stabilization of telomeric G-quadruplex DNA (G4DNA) i... more The study of anticancer agents that act via stabilization of telomeric G-quadruplex DNA (G4DNA) is important because such agents often inhibit telomerase activity. Several types of G4DNA binding ligands are known. In these studies, the target structures often involve a single G4 DNA unit formed by short DNA telomeric sequences. However, the 39-terminal singlestranded human telomeric DNA can form higher-order structures by clustering consecutive quadruplex units (dimers or nmers). Herein, we present new synthetic gemini (twin) bisbenzimidazole ligands, in which the oligo-oxyethylene spacers join the two bisbenzimidazole units for the recognition of both monomeric and dimeric G4DNA, derived from d(T2AG3)4 and d(T2AG3)8 human telomeric DNA, respectively. The spacer between the two bisbenzimidazoles in the geminis plays a critical role in the G4DNA stability. We report here (i) synthesis of new effective gemini anticancer agents that are selectively more toxic towards the cancer cells than the corresponding normal cells; (ii) formation and characterization of G4DNA dimers in solution as well as computational construction of the dimeric G4DNA structures. The gemini ligands direct the folding of the single-stranded DNA into an unusually stable parallel-stranded G4DNA when it was formed in presence of the ligands in KCl solution and the gemini ligands show spacer length dependent potent telomerase inhibition properties.

Research paper thumbnail of Dimeric 1, 3-Phenylene-bis (piperazinyl benzimidazole) s: Synthesis and Structure���Activity Investigations on their Binding with Human Telomeric G-Quadruplex DNA and Telomerase Inhibition Properties

Ligand-induced stabilization of G-quadruplex structures formed by the human telomeric DNA is an a... more Ligand-induced stabilization of G-quadruplex structures formed by the human telomeric DNA is an active area of research. The compounds which stabilize the G-quadruplexes often lead to telomerase inhibition. Herein we present the results of interaction of new monomeric and dimeric ligands having 1,3-phenylene-bis(piperazinyl benzimidazole) unit with G-quadruplex DNA (G4DNA) formed by human telomeric repeat d[(G(3)T(2)A)(3)G(3)]. These ligands efficiently stabilize the preformed G4DNA in the presence of 100 mM monovalent alkali metal ions. Also, the G4DNA formed in the presence of low concentrations of ligands in 100 mM K(+) adopts a highly stable parallel-stranded conformation. The G-quadruplexes formed in the presence of the dimeric compound are more stable than that induced by the corresponding monomeric counterpart. The dimeric ligands having oligo-oxyethylene spacers provide much higher stability to the preformed G4DNA and also exert significantly higher telomerase inhibition activity. Computational aspects have also been discussed.

Research paper thumbnail of Steering Entropy Changes As a Function of Microsleeps

… on Human Factors …, 2006

Summary: This study aimed to assess steering entropy as a measure of decrements in driving perfor... more Summary: This study aimed to assess steering entropy as a measure of decrements in driving performance caused by microsleeps. Microsleeps are brief, unintended episodes of loss of attention that last 3-14 seconds. These episodes, which are frequent in drivers with sleep ...

Research paper thumbnail of Transoesophageal echocardiography: a useful tool to diagnose entrapment of pulmonary artery catheter

Anaesthesia, 2006

Placement of a pulmonary artery catheter during cardiac surgery is associated with various compli... more Placement of a pulmonary artery catheter during cardiac surgery is associated with various complications, one of which is entrapment. On the day following surgery unusual resistance was encountered while attempting to remove a pulmonary artery catheter from a patient who had undergone coronary artery bypass grafting. Entrapment of the catheter was confirmed by transoesophageal echocardiography, which demonstrated invagination of the free wall of the pulmonary trunk on gentle traction on the pulmonary artery catheter. Surgical exploration revealed that the catheter was transfixed by the suture used to close the pulmonary artery vent site. Surgical re-exploration and other potential complications related to catheter retrieval can be avoided if catheter entrapment is diagnosed intra-operatively. We suggest that a high index of clinical suspicion along with the use of intra-operative transoesophageal echocardiography is considered in situations where catheter entrapment is a possibility.

Research paper thumbnail of Mind-Body Medicine Als Bestandteil Der Integrativen Medizin

…, 2006

Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz 2006 · 49:722–728 DOI 10.1007/s00103-... more Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz 2006 · 49:722–728 DOI 10.1007/s00103-006-0001-0 Online publiziert: 20. Juli 2006 © Sprin ger Me di zin Ver lag 2006 ... „Nicht die Umstände bestimmen des Menschen Glück, sondern seine Fähigkeit zur ...

Research paper thumbnail of Inferior Vena Cava Thrombosis After Right Hepatectomy for Live Donor Liver Transplantation: A Major Donor Complication and a Satisfactory Treatment Modality

American Journal of Transplantation, 2007

A 29-year-old Caucasian male with a total liver volume of 1921 mL (Figure 1) volunteered to becom... more A 29-year-old Caucasian male with a total liver volume of 1921 mL (Figure 1) volunteered to become a donor for his uncle suffering of end-stage liver disease. He was properly informed of the risks of the surgical procedure, and underwent our standardized multistep evaluation protocol (2). Routine preoperative evaluation for thrombotic disorders (Factor V-Leiden/APC-resistance, prothrombine-mutation, protein C, protein S, antithrombin, amti-phospholipidantibodies, homocysteine, lipoprotein a, Factor VIII) revealed no abnormalities. The right hepatectomy inclusive of the middle hepatic vein yielded a graft with a volume of 970 mL. The patient was extubated on the first postoperative day and transferred to the ward. Low molecular weight heparin was administered as prophylaxis for venous thromboses. The early postoperative course was uneventful, and a protocol CT on the 10th postoperative day revealed rapid regeneration of the liver remnant, already with a volume of 1660 mL. On the 12th postoperative day, the new onset

Research paper thumbnail of Study of Interdiffusion and Growth of Topologically Closed Packed Phases In the Co–Nb System

Journal of Materials Science

Interdiffusion study of the Co–Nb system is conducted to determine the diffusion parameters in di... more Interdiffusion study of the Co–Nb system is conducted to determine the diffusion parameters in differ-ent phases. The integrated diffusion coefficients at different temperatures are calculated for the Nb2Co7 phase, which has very narrow composition range. The interdiffusion ...

Research paper thumbnail of On formulations of the stochastic uncapacitated lot-sizing problem

Conditions are given under which the Monge-Kantorovich mass transfer problem on general metric sp... more Conditions are given under which the Monge-Kantorovich mass transfer problem on general metric spaces and with unbounded cost function has a feasible solution.

Research paper thumbnail of Measurement and simulation of anisotropic magnetoresistance in single GaAs/MnAs core/shell nanowires

We report four probe measurements of the low field magnetoresistance in single core/shell GaAs/Mn... more We report four probe measurements of the low field magnetoresistance in single core/shell GaAs/MnAs nanowires synthesized by molecular beam epitaxy, demonstrating clear signatures of anisotropic magnetoresistance that track the field-dependent magnetization. A comparison with micromagnetic simulations reveals that the principal characteristics of the magnetoresistance data can be unambiguously attributed to the nanowire segments with a zinc blende GaAs core. The direct correlation between magnetoresistance, magnetization and crystal structure provides a powerful means of characterizing individual hybrid ferromagnet/semiconductor nanostructures.

Research paper thumbnail of On the design and development of webinos: a distributed mobile application middleware

As personal devices become smarter, opportunities arise for sharing services, applications and da... more As personal devices become smarter, opportunities arise for sharing services, applications and data between them. While web technologies hold the promise of being a unifying layer, browsers lack functionality for supporting inter-device communication, synchronization, and security. To address this, we designed webinos: a cross-device distributed middleware providing interoperability, compatibility and security for mobile web applications. In this paper we present a case study of the webinos project, showing how the architecture of webinos was specified, designed and implemented, and reflect on several lessons learned.

Research paper thumbnail of Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages

Developmental Biology, 2009

Research paper thumbnail of Staggered Core Activation: A circuit/architectural approach for mitigating resonant supply noise issues in multi-core multi-power domain processors

In order to reduce the impact of resonant supply noise on processor performance, a simple, fully-... more In order to reduce the impact of resonant supply noise on processor performance, a simple, fully-digital and scalable technique based on staggering the activation time of the cores sharing the same power domain in a multi-core multi-power domain processor is presented. Measurement data from a 65nm test chip shows an Fmax improvement as large as 20% in a 3core configuration. This is one of the first approaches to utilize the architecture level behavior for mitigating resonant noise issues in a multi-core multi-power domain processor.

Research paper thumbnail of Towards a New Crytographic Protocol for Biometric Security Technologies

Abstract We propose a new cryptographic protocol for remote authentication. This protocol is suit... more Abstract We propose a new cryptographic protocol for remote authentication. This protocol is suitable when the signature key is very large. The emerging paradigm of veri cation through biometric samples, such as ngerprints, retinal images etc., naturally represents such a ...

Research paper thumbnail of Trading Processor Cycles for Communication

"Trade computation for communication whenever possible" has been the conventional wisdom to save ... more "Trade computation for communication whenever possible" has been the conventional wisdom to save bandwidth and power in wireless domain. We glanced at the merging trends of technology and the applications, and identified a number of areas where the processor cycles can be traded for network bandwidth. These areas are-file transfer, shared document edits, remote authentication, and verification of remotely available codes. We collect and present some of the theory-paradigms that have given birth to results potentially usable towards saving bandwidth at the cost of computation. We hope to make a case for incorporating the insights collected in this paper from various fields of complexity theory, into the design of network protocols for the future. In the penumbra of this over-arching goal, we also suggest how the engine of "Probabilistic Checking of Proofs" (PCP) can be used for remote authentication purposes, resulting in much smaller network overhead and leading to very efficient usage of bandwidth and power. While this seems to be an interesting route, we then present the algorithmic challenges that need be solved and argue why such a theoretical cranking may be just as worth.

Research paper thumbnail of Interaction between stampede runtime and operating systems

Emerging application domains such as interactive vision, animation, and multimedia collaboration ... more Emerging application domains such as interactive vision, animation, and multimedia collaboration display dynamic scalable parallelism, and high computational requirements, making them good candidates for executing on parallel architectures such as SMPs and clusters of SMPs. The necessity to reason about program behavior along the time dimension is an important characteristic of these types of applications. Stampede is a cluster programming system that is designed to meet many of the challenges in such applications. Stampede supports time-sequenced data items, and thus facilitates temporally correlating data items from different streams. The system performs automatic garbage collection of data items no longer needed by any application thread. The Stampede system has been built as a runtime library on top of standard operating systems. In this paper, we study the interaction between the Stampede runtime system and the underlying operating system. The study is conducted on two identical hardware platforms running Solaris and Linux, respectively. A cycle accurate event logging facility using the CPU cycle counter is at the core of this study. There are several interesting insights coming from this study. First, memory allocation does not take up a significant amount of the execution time despite the interactive and dynamic nature of the application domain. Second, the Stampede runtime does not pose a significant overhead over raw messaging for structuring such applications. Third, the results suggest that the thread scheduler on Linux may be more responsive than the one on Solaris. Fourth, the messaging layer spends quite a bit of time in synchronization operations.

Research paper thumbnail of Computation-Communication Trade-off for Power and Bandwidth Savings in Remote Authentication over Wireless Networks

We consider the problem of remote authentication over a long range wireless network using large s... more We consider the problem of remote authentication over a long range wireless network using large signature keys such as biometric samples (fingerprint, retinal scans etc.). Because of the large size of these keys, and continual need for authentication, considerable power and bandwidth is consumed by such processes. We show that by using the concept of a holographic proof, it is possible to significantly cut down the number of bytes transferred. While bandwidth savings is obvious, for long range wireless this means huge savings in power which is a critical resource for mobile devices. Our approach trades computaion for communication, the intuition being that power requirement for transmitting one byte over wireless is orders of magnitude higher than executing one instruction on a standard processor. Our simulations provide a detailed analysis of power savings under a reasonable energyconsumption model and indeed demonstrate the effectiveness of such approach.

Research paper thumbnail of On the behaviour of Kirkendall markers in solid-state interdiffusion

The migration of inert markers as a result of unequal mobilities of the components during solid-s... more The migration of inert markers as a result of unequal mobilities of the components during solid-state interdiffusion in a binary system can be rationalized using a Kirkendall velocity construction. It is demonstrated that in a diffusion-controlled interaction the Kirkendall plane, identified by inert particles (markers) placed at the original contact surface of a reaction couple, need not be unique. Multiple planes can develop, but, on the other hand, markers at the original interface sometimes can get dispersed into a diffuse zone on both sides of the contact surface and no unique location of the Kirkendall plans can be defined. It is also shown that the location of the Kirkendall plane(s) inside the diffusion zone can be identified by grain morphology changes within the microstructure of the reaction products. A physico-chemical approach is developed which elucidates the role of the Kirkendall effect in the morphologenesis of interdiffusion systems. The occurence of one or more Kirkendall planes, characterized by morphology changes in the reaction layers, turns out to be related to different nucleation sites of the product grains.

Research paper thumbnail of Diffusion in Co-Ni System Studied by Multifoil Technique

Diffusion couple experiments were performed in the Co-Ni binary system for determining inter-, im... more Diffusion couple experiments were performed in the Co-Ni binary system for determining inter-, impurity- and intrinsic-diffusion coefficients in the temperature range of 1050 - 1250°C. The activation energy and pre-exponential factor estimated for interdiffusion do not vary significantly with composition. The activation energy calculated for impurity diffusion experiments shows is higher than . Intrinsic diffusion coefficients estimated from the multifoil experiment show that Ni is the fastest diffusing species in this system.

Research paper thumbnail of Physico-chemical analysis of compound growth in a diffusion couple with two-phase end-members

A diffusion-controlled growth of intermetallic phases and the role of the Kirkendall effect in mo... more A diffusion-controlled growth of intermetallic phases and the role of the Kirkendall effect in morphological evolution of the product phase layers can be described in terms of an alternative theory considering chemical reactions at the interphase interfaces. Application of this “physicochemical” treatment to diffusional growth of intermediate phases with fairly wide homogeneity ranges is illustrated by the example of interaction in the Ag-Zn system. The model is purely phenomenological, and its use is convenient, since no explicit assumption of the underlying diffusion mechanism is required.

Research paper thumbnail of Time-resolved momentum imaging system for molecular dynamics studies using a tabletop ultrafast extreme-ultraviolet light source

We describe a momentum imaging setup for direct time-resolved studies of ionization-induced molec... more We describe a momentum imaging setup for direct time-resolved studies of ionization-induced molecular dynamics. This system uses a tabletop ultrafast extreme-ultraviolet ͑EUV͒ light source based on high harmonic upconversion of a femtosecond laser. The high photon energy ͑around 42 eV͒ allows access to inner-valence states of a variety of small molecules via single photon excitation, while the sub-10-fs pulse duration makes it possible to follow the resulting dynamics in real time. To obtain a complete picture of molecular dynamics following EUV induced photofragmentation, we apply the versatile cold target recoil ion momentum spectroscopy reaction microscope technique, which makes use of coincident three-dimensional momentum imaging of fragments resulting from photoexcitation. This system is capable of pump-probe spectroscopy by using a combination of EUV and IR laser pulses with either beam as a pump or probe pulse. We report several experiments performed using this system.

Research paper thumbnail of Binding of Gemini Bisbenzimidazole Drugs with Human Telomeric G-Quadruplex Dimers: Effect of the Spacer in the Design of Potent Telomerase Inhibitors

The study of anticancer agents that act via stabilization of telomeric G-quadruplex DNA (G4DNA) i... more The study of anticancer agents that act via stabilization of telomeric G-quadruplex DNA (G4DNA) is important because such agents often inhibit telomerase activity. Several types of G4DNA binding ligands are known. In these studies, the target structures often involve a single G4 DNA unit formed by short DNA telomeric sequences. However, the 39-terminal singlestranded human telomeric DNA can form higher-order structures by clustering consecutive quadruplex units (dimers or nmers). Herein, we present new synthetic gemini (twin) bisbenzimidazole ligands, in which the oligo-oxyethylene spacers join the two bisbenzimidazole units for the recognition of both monomeric and dimeric G4DNA, derived from d(T2AG3)4 and d(T2AG3)8 human telomeric DNA, respectively. The spacer between the two bisbenzimidazoles in the geminis plays a critical role in the G4DNA stability. We report here (i) synthesis of new effective gemini anticancer agents that are selectively more toxic towards the cancer cells than the corresponding normal cells; (ii) formation and characterization of G4DNA dimers in solution as well as computational construction of the dimeric G4DNA structures. The gemini ligands direct the folding of the single-stranded DNA into an unusually stable parallel-stranded G4DNA when it was formed in presence of the ligands in KCl solution and the gemini ligands show spacer length dependent potent telomerase inhibition properties.

Research paper thumbnail of Dimeric 1, 3-Phenylene-bis (piperazinyl benzimidazole) s: Synthesis and Structure���Activity Investigations on their Binding with Human Telomeric G-Quadruplex DNA and Telomerase Inhibition Properties

Ligand-induced stabilization of G-quadruplex structures formed by the human telomeric DNA is an a... more Ligand-induced stabilization of G-quadruplex structures formed by the human telomeric DNA is an active area of research. The compounds which stabilize the G-quadruplexes often lead to telomerase inhibition. Herein we present the results of interaction of new monomeric and dimeric ligands having 1,3-phenylene-bis(piperazinyl benzimidazole) unit with G-quadruplex DNA (G4DNA) formed by human telomeric repeat d[(G(3)T(2)A)(3)G(3)]. These ligands efficiently stabilize the preformed G4DNA in the presence of 100 mM monovalent alkali metal ions. Also, the G4DNA formed in the presence of low concentrations of ligands in 100 mM K(+) adopts a highly stable parallel-stranded conformation. The G-quadruplexes formed in the presence of the dimeric compound are more stable than that induced by the corresponding monomeric counterpart. The dimeric ligands having oligo-oxyethylene spacers provide much higher stability to the preformed G4DNA and also exert significantly higher telomerase inhibition activity. Computational aspects have also been discussed.

Research paper thumbnail of Steering Entropy Changes As a Function of Microsleeps

… on Human Factors …, 2006

Summary: This study aimed to assess steering entropy as a measure of decrements in driving perfor... more Summary: This study aimed to assess steering entropy as a measure of decrements in driving performance caused by microsleeps. Microsleeps are brief, unintended episodes of loss of attention that last 3-14 seconds. These episodes, which are frequent in drivers with sleep ...

Research paper thumbnail of Transoesophageal echocardiography: a useful tool to diagnose entrapment of pulmonary artery catheter

Anaesthesia, 2006

Placement of a pulmonary artery catheter during cardiac surgery is associated with various compli... more Placement of a pulmonary artery catheter during cardiac surgery is associated with various complications, one of which is entrapment. On the day following surgery unusual resistance was encountered while attempting to remove a pulmonary artery catheter from a patient who had undergone coronary artery bypass grafting. Entrapment of the catheter was confirmed by transoesophageal echocardiography, which demonstrated invagination of the free wall of the pulmonary trunk on gentle traction on the pulmonary artery catheter. Surgical exploration revealed that the catheter was transfixed by the suture used to close the pulmonary artery vent site. Surgical re-exploration and other potential complications related to catheter retrieval can be avoided if catheter entrapment is diagnosed intra-operatively. We suggest that a high index of clinical suspicion along with the use of intra-operative transoesophageal echocardiography is considered in situations where catheter entrapment is a possibility.

Research paper thumbnail of Mind-Body Medicine Als Bestandteil Der Integrativen Medizin

…, 2006

Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz 2006 · 49:722–728 DOI 10.1007/s00103-... more Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz 2006 · 49:722–728 DOI 10.1007/s00103-006-0001-0 Online publiziert: 20. Juli 2006 © Sprin ger Me di zin Ver lag 2006 ... „Nicht die Umstände bestimmen des Menschen Glück, sondern seine Fähigkeit zur ...

Research paper thumbnail of Inferior Vena Cava Thrombosis After Right Hepatectomy for Live Donor Liver Transplantation: A Major Donor Complication and a Satisfactory Treatment Modality

American Journal of Transplantation, 2007

A 29-year-old Caucasian male with a total liver volume of 1921 mL (Figure 1) volunteered to becom... more A 29-year-old Caucasian male with a total liver volume of 1921 mL (Figure 1) volunteered to become a donor for his uncle suffering of end-stage liver disease. He was properly informed of the risks of the surgical procedure, and underwent our standardized multistep evaluation protocol (2). Routine preoperative evaluation for thrombotic disorders (Factor V-Leiden/APC-resistance, prothrombine-mutation, protein C, protein S, antithrombin, amti-phospholipidantibodies, homocysteine, lipoprotein a, Factor VIII) revealed no abnormalities. The right hepatectomy inclusive of the middle hepatic vein yielded a graft with a volume of 970 mL. The patient was extubated on the first postoperative day and transferred to the ward. Low molecular weight heparin was administered as prophylaxis for venous thromboses. The early postoperative course was uneventful, and a protocol CT on the 10th postoperative day revealed rapid regeneration of the liver remnant, already with a volume of 1660 mL. On the 12th postoperative day, the new onset

Research paper thumbnail of Study of Interdiffusion and Growth of Topologically Closed Packed Phases In the Co–Nb System

Journal of Materials Science

Interdiffusion study of the Co–Nb system is conducted to determine the diffusion parameters in di... more Interdiffusion study of the Co–Nb system is conducted to determine the diffusion parameters in differ-ent phases. The integrated diffusion coefficients at different temperatures are calculated for the Nb2Co7 phase, which has very narrow composition range. The interdiffusion ...

Research paper thumbnail of On formulations of the stochastic uncapacitated lot-sizing problem

Conditions are given under which the Monge-Kantorovich mass transfer problem on general metric sp... more Conditions are given under which the Monge-Kantorovich mass transfer problem on general metric spaces and with unbounded cost function has a feasible solution.

Research paper thumbnail of Measurement and simulation of anisotropic magnetoresistance in single GaAs/MnAs core/shell nanowires

We report four probe measurements of the low field magnetoresistance in single core/shell GaAs/Mn... more We report four probe measurements of the low field magnetoresistance in single core/shell GaAs/MnAs nanowires synthesized by molecular beam epitaxy, demonstrating clear signatures of anisotropic magnetoresistance that track the field-dependent magnetization. A comparison with micromagnetic simulations reveals that the principal characteristics of the magnetoresistance data can be unambiguously attributed to the nanowire segments with a zinc blende GaAs core. The direct correlation between magnetoresistance, magnetization and crystal structure provides a powerful means of characterizing individual hybrid ferromagnet/semiconductor nanostructures.

Research paper thumbnail of On the design and development of webinos: a distributed mobile application middleware

As personal devices become smarter, opportunities arise for sharing services, applications and da... more As personal devices become smarter, opportunities arise for sharing services, applications and data between them. While web technologies hold the promise of being a unifying layer, browsers lack functionality for supporting inter-device communication, synchronization, and security. To address this, we designed webinos: a cross-device distributed middleware providing interoperability, compatibility and security for mobile web applications. In this paper we present a case study of the webinos project, showing how the architecture of webinos was specified, designed and implemented, and reflect on several lessons learned.