arun soman - Academia.edu (original) (raw)

Papers by arun soman

Abstract—This paper is based on morphological analyzer using machine learning approach for comple... more Abstract—This paper is based on morphological analyzer using machine learning approach for complex agglutinative natural languages. Morphological analysis is concerned with retrieving the structure, the syntactic and morphological properties or the meaning of a ...

Plant Foods for Human Nutrition, 2010

Hyperglycemia causes increased protein glycation and the formation of early glycation products an... more Hyperglycemia causes increased protein glycation and the formation of early glycation products and advanced glycation end products (AGEs) which are major factors responsible for the complications associated with diabetes. The aim of the present study was to investigate the antioxidant as well as antiglycative potential of ethyl acetate fraction of guava leaves. Oral administration of the extract at different doses showed a significant decrease in blood glucose level. It also showed an improved antioxidant potential as evidenced by decreased lipid peroxidation and a significant increase in the activity of various antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase. Glycated hemoglobin as well as fructosamine which are indicators of glycation was also reduced significantly in treated groups when compared to diabetic control. In vitro studies also support the antioxidant as well as antiglycative potential of guava leaves.

Microscopy and Microanalysis, 2006

Molecular and Cellular Biochemistry, 2011

Earlier studies from one of the investigator’s laboratory have demonstrated the presence of a hig... more Earlier studies from one of the investigator’s laboratory have demonstrated the presence of a high molecular weight protein (182 kDa) in the blood serum of laboratory animals subjected to pressure-induced cardiac hypertrophy and suggested that this protein may be involved in the development of cardiac hypertrophy. Studies have shown that this protein is also involved in earlier stages of cardiac complications associated with diabetes, but the role of this protein in diabetic heart is less understood. So we aimed to check whether this protein is having any protective role in diabetic heart. The protein was purified from serum of rats induced with cardiac hypertrophy and the purified protein was injected through tail vein of diabetic rats for further studies. The results of various antioxidant enzymes and the TBARS levels have indicated the antioxidant activity of this protein. Real-time PCR analysis of gene expression revealed the upregulation of certain muscle-specific genes like β-MHC, MLC-2, and skeletal α actin in diabetic group and also in presence of 182-kDa protein. The results further showed a down regulation of genes such as cardiac α-actin and α- MHC implicating the role of this protein in the development of cardiac hypertrophy in diabetes. Increased cardiac hypertrophy as revealed by the expression of various genes and improved antioxidant potential in presence of 182 kDa protein in diabetes at the earlier stages is beneficial for counteracting the myocardial damage associated with diabetes.

Tamil Font Recognition is one of the Challenging tasks in Optical Character Recognition and Docum... more Tamil Font Recognition is one of the Challenging tasks in Optical Character Recognition and Document Analysis. Most of the existing methods for font recognition make use of local typographical features and connected component analysis. In this paper, Tamil font recognition is done based on global texture analysis. The main objective of this proposal is to employ support vector machines (SVM) in identifying various fonts in Tamil. The feature vectors are extracted by making use of Gabor filters and the proposed SVM is trained using these features. The method is found to give superior performance over neural networks by avoiding local minima points. The SVM model is formulated tested and the results are presented in this paper. It is observed that this method is content independent and the SVM classifier shows an average accuracy of 92.5%.

... R.Ramanathan, Arun.S.Nair, V.Vidhya Sagar, N.Sriram Department of Electronics &am... more ... R.Ramanathan, Arun.S.Nair, V.Vidhya Sagar, N.Sriram Department of Electronics & Communication Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, India e-mail: r_ramanathan ... REFERENCES [1] Praseeda Lekshmi V, Dr. M Sasikumar, Divya S Vidyadharan ( ...

Journal of Cardiothoracic and Vascular Anesthesia, 2006

... Kerala, India. ,; Rupa Sreedhar, MD: Affiliations. Department of Anaesthesiology, Sree Chitra... more ... Kerala, India. ,; Rupa Sreedhar, MD: Affiliations. Department of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India. ,; SR Krishna Manohar, MS, MCh: Affiliations. Division of Paediatric ...

PLOS One, 2011

Senescence marker protein (SMP30), also known as regucalcin, is a 34 kDa cytosolic marker protein... more Senescence marker protein (SMP30), also known as regucalcin, is a 34 kDa cytosolic marker protein of aging which plays an important role in intracellular Ca 2+ homeostasis, ascorbic acid biosynthesis, oxidative stress, and detoxification of chemical warfare nerve agents. In our goal to investigate the activity of SMP30 for the detoxification of nerve agents, we have produced a recombinant adenovirus expressing human SMP30 as a fusion protein with a hemaglutinin tag (Ad-SMP30-HA). Ad-SMP30-HA transduced the expression of SMP30-HA and two additional forms of SMP30 with molecular sizes ,28 kDa and 24 kDa in HEK-293A and C3A liver cells in a dose and time-dependent manner. Intravenous administration of Ad-SMP30-HA in mice results in the expression of all the three forms of SMP30 in the liver and diaphragm. LC-MS/MS results confirmed that the lower molecular weight 28 kDa and 24 kDa proteins are related to the 34 kDa SMP30. The 28 kDa and 24 kDa SMP30 forms were also detected in normal rat liver and mice injected with Ad-SMP30-HA suggesting that SMP30 does exist in multiple forms under physiological conditions. Time course experiments in both cell lines suggest that the 28 kDa and 24 kDa SMP30 forms are likely generated from the 34 kDa SMP30. Interestingly, the 28 kDa and 24 kDa SMP30 forms appeared initially in the cytosol and shifted to the particulate fraction. Studies using small molecule inhibitors of proteolytic pathways revealed the potential involvement of b and c-secretases but not calpains, lysosomal proteases, proteasome and caspases. This is the first report describing the existence of multiple forms of SMP30, their preferential distribution to membranes and their generation through proteolysis possibly mediated by secretase enzymes.

... to be published in the Proceedings of International Conference on Advances in Recent Technolo... more ... to be published in the Proceedings of International Conference on Advances in Recent Technologies in Communicaion and Computing – ARTCom 2009, India, 27-28 Oct 2009 [2] R.Ramanathan, Arun.S.Nair ... 6] Praseeda Lekshmi V, Dr. M Sasikumar, Divya S Vidyadharan ( ...

Experimental and Toxicologic Pathology

Non enzymatic glycosylation (glycation) between reducing sugar and protein results in the formati... more Non enzymatic glycosylation (glycation) between reducing sugar and protein results in the formation of advanced glycation end products (AGEs), which is believed to play an important role in diabetes associated cardiovascular complications. Thus agents that inhibit the formation of AGEs are believed to have therapeutic potential against diabetic complications. In the present study we evaluated the antiglycative potential of ethyl acetate fraction of Psidium guajava leaves (PGEt) by administering the extract into streptozotocin induced diabetic rats. Daily administration of the extract for a period of one month significantly decreased the blood glucose, glycated hemoglobin and fructosamine levels in a dose dependent manner. Evaluation of the toxicity markers like SGOT and SGPT revealed the non toxic nature of the extract. Apart from this we evaluated the presence of cardiac isoform of liver alpha 2 macroglobulin, which is a major protein associated with earlier stages of cardiac hypertrophy. SDS-PAGE analysis showed that the level of this protein decreased significantly in extract treated groups compared to diabetic control. These findings support that the administration of PGEt extract may be beneficial for preventing cardiovascular complications associated with diabetes.

Abstract—This paper is based on morphological analyzer using machine learning approach for comple... more Abstract—This paper is based on morphological analyzer using machine learning approach for complex agglutinative natural languages. Morphological analysis is concerned with retrieving the structure, the syntactic and morphological properties or the meaning of a ...

Plant Foods for Human Nutrition, 2010

Hyperglycemia causes increased protein glycation and the formation of early glycation products an... more Hyperglycemia causes increased protein glycation and the formation of early glycation products and advanced glycation end products (AGEs) which are major factors responsible for the complications associated with diabetes. The aim of the present study was to investigate the antioxidant as well as antiglycative potential of ethyl acetate fraction of guava leaves. Oral administration of the extract at different doses showed a significant decrease in blood glucose level. It also showed an improved antioxidant potential as evidenced by decreased lipid peroxidation and a significant increase in the activity of various antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase. Glycated hemoglobin as well as fructosamine which are indicators of glycation was also reduced significantly in treated groups when compared to diabetic control. In vitro studies also support the antioxidant as well as antiglycative potential of guava leaves.

Microscopy and Microanalysis, 2006

Molecular and Cellular Biochemistry, 2011

Earlier studies from one of the investigator’s laboratory have demonstrated the presence of a hig... more Earlier studies from one of the investigator’s laboratory have demonstrated the presence of a high molecular weight protein (182 kDa) in the blood serum of laboratory animals subjected to pressure-induced cardiac hypertrophy and suggested that this protein may be involved in the development of cardiac hypertrophy. Studies have shown that this protein is also involved in earlier stages of cardiac complications associated with diabetes, but the role of this protein in diabetic heart is less understood. So we aimed to check whether this protein is having any protective role in diabetic heart. The protein was purified from serum of rats induced with cardiac hypertrophy and the purified protein was injected through tail vein of diabetic rats for further studies. The results of various antioxidant enzymes and the TBARS levels have indicated the antioxidant activity of this protein. Real-time PCR analysis of gene expression revealed the upregulation of certain muscle-specific genes like β-MHC, MLC-2, and skeletal α actin in diabetic group and also in presence of 182-kDa protein. The results further showed a down regulation of genes such as cardiac α-actin and α- MHC implicating the role of this protein in the development of cardiac hypertrophy in diabetes. Increased cardiac hypertrophy as revealed by the expression of various genes and improved antioxidant potential in presence of 182 kDa protein in diabetes at the earlier stages is beneficial for counteracting the myocardial damage associated with diabetes.

Tamil Font Recognition is one of the Challenging tasks in Optical Character Recognition and Docum... more Tamil Font Recognition is one of the Challenging tasks in Optical Character Recognition and Document Analysis. Most of the existing methods for font recognition make use of local typographical features and connected component analysis. In this paper, Tamil font recognition is done based on global texture analysis. The main objective of this proposal is to employ support vector machines (SVM) in identifying various fonts in Tamil. The feature vectors are extracted by making use of Gabor filters and the proposed SVM is trained using these features. The method is found to give superior performance over neural networks by avoiding local minima points. The SVM model is formulated tested and the results are presented in this paper. It is observed that this method is content independent and the SVM classifier shows an average accuracy of 92.5%.

... R.Ramanathan, Arun.S.Nair, V.Vidhya Sagar, N.Sriram Department of Electronics &am... more ... R.Ramanathan, Arun.S.Nair, V.Vidhya Sagar, N.Sriram Department of Electronics & Communication Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, India e-mail: r_ramanathan ... REFERENCES [1] Praseeda Lekshmi V, Dr. M Sasikumar, Divya S Vidyadharan ( ...

Journal of Cardiothoracic and Vascular Anesthesia, 2006

... Kerala, India. ,; Rupa Sreedhar, MD: Affiliations. Department of Anaesthesiology, Sree Chitra... more ... Kerala, India. ,; Rupa Sreedhar, MD: Affiliations. Department of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India. ,; SR Krishna Manohar, MS, MCh: Affiliations. Division of Paediatric ...

PLOS One, 2011

Senescence marker protein (SMP30), also known as regucalcin, is a 34 kDa cytosolic marker protein... more Senescence marker protein (SMP30), also known as regucalcin, is a 34 kDa cytosolic marker protein of aging which plays an important role in intracellular Ca 2+ homeostasis, ascorbic acid biosynthesis, oxidative stress, and detoxification of chemical warfare nerve agents. In our goal to investigate the activity of SMP30 for the detoxification of nerve agents, we have produced a recombinant adenovirus expressing human SMP30 as a fusion protein with a hemaglutinin tag (Ad-SMP30-HA). Ad-SMP30-HA transduced the expression of SMP30-HA and two additional forms of SMP30 with molecular sizes ,28 kDa and 24 kDa in HEK-293A and C3A liver cells in a dose and time-dependent manner. Intravenous administration of Ad-SMP30-HA in mice results in the expression of all the three forms of SMP30 in the liver and diaphragm. LC-MS/MS results confirmed that the lower molecular weight 28 kDa and 24 kDa proteins are related to the 34 kDa SMP30. The 28 kDa and 24 kDa SMP30 forms were also detected in normal rat liver and mice injected with Ad-SMP30-HA suggesting that SMP30 does exist in multiple forms under physiological conditions. Time course experiments in both cell lines suggest that the 28 kDa and 24 kDa SMP30 forms are likely generated from the 34 kDa SMP30. Interestingly, the 28 kDa and 24 kDa SMP30 forms appeared initially in the cytosol and shifted to the particulate fraction. Studies using small molecule inhibitors of proteolytic pathways revealed the potential involvement of b and c-secretases but not calpains, lysosomal proteases, proteasome and caspases. This is the first report describing the existence of multiple forms of SMP30, their preferential distribution to membranes and their generation through proteolysis possibly mediated by secretase enzymes.

... to be published in the Proceedings of International Conference on Advances in Recent Technolo... more ... to be published in the Proceedings of International Conference on Advances in Recent Technologies in Communicaion and Computing – ARTCom 2009, India, 27-28 Oct 2009 [2] R.Ramanathan, Arun.S.Nair ... 6] Praseeda Lekshmi V, Dr. M Sasikumar, Divya S Vidyadharan ( ...

Experimental and Toxicologic Pathology

Non enzymatic glycosylation (glycation) between reducing sugar and protein results in the formati... more Non enzymatic glycosylation (glycation) between reducing sugar and protein results in the formation of advanced glycation end products (AGEs), which is believed to play an important role in diabetes associated cardiovascular complications. Thus agents that inhibit the formation of AGEs are believed to have therapeutic potential against diabetic complications. In the present study we evaluated the antiglycative potential of ethyl acetate fraction of Psidium guajava leaves (PGEt) by administering the extract into streptozotocin induced diabetic rats. Daily administration of the extract for a period of one month significantly decreased the blood glucose, glycated hemoglobin and fructosamine levels in a dose dependent manner. Evaluation of the toxicity markers like SGOT and SGPT revealed the non toxic nature of the extract. Apart from this we evaluated the presence of cardiac isoform of liver alpha 2 macroglobulin, which is a major protein associated with earlier stages of cardiac hypertrophy. SDS-PAGE analysis showed that the level of this protein decreased significantly in extract treated groups compared to diabetic control. These findings support that the administration of PGEt extract may be beneficial for preventing cardiovascular complications associated with diabetes.