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Papers by asman sadino

Pharma Xplore : Jurnal Sains dan Ilmu Farmasi

Ascaris suum is a parasitic worm in pigs that is closely related to the worm in humans, A. lumbri... more Ascaris suum is a parasitic worm in pigs that is closely related to the worm in humans, A. lumbricoides. A literature search shows that A. suum can infect humans. Ascaris is thought to modulate host immune and inflammatory responses, which may lead to immune hyporesponsiveness during chronic infections. Treatment with anthelmintic drugs is considered to increase the risk of resistance. Thus, alternative medicines from natural ingredients are needed that are more effective and have minimal side effects, including Japanese papaya leaves (Cnidoscolus aconitifolius). This research aimed to analyze the anthelmintic activity of ethanol extract and Japanese papaya leaf infusion against A. suum worms and eggs in vitro. Testing was divided into 6 large groups, namely test group (extract and infusion concentrations of 3%, 6%, and 9%), comparison group (pyrantel pamoate 1% and piperazine citrate 2% for testing adult worms and mebendazole 0.25% for testing worm eggs), and control group (NaCl 0....

Farmaka, Aug 26, 2017

ABSTRAK Rambutan merupakan salah satu spesies tumbuhan yang berpotensi untuk dikembangkan sebagai... more ABSTRAK Rambutan merupakan salah satu spesies tumbuhan yang berpotensi untuk dikembangkan sebagai obat herbal. Rambutan mengandung banyak metabolit sekunder yang saling bersinergis dalam memberikan efek. Penggunaan bahan alam sebagai obat sebaiknya berdasarkan bukti ilmiah. Review ini bertujuan untuk memberikan informasi terkait senyawa aktif, aktivitas farmakologis, dan mekanisme kerja rambutan dalam mengatasi berbagai penyakit. Pada review artikel ini digunakan literatur online dan offline . Literatur online didapat dari jurnal dan artikel ilmiah publikasi lokal maupun internasional yang diperoleh melalui hasil pencarian langsung secara online dengan menggunakan mesin pencari online yaitu G oogle dan Google Scholar . Sedangkan literatur offline yang digunakan yaitu buku dan e-book. Diketahui bahwa rambutan memiliki berbagai macam aktivitas farmakologis dalam mengatasi antidiabetes, antihiperkolesterol, antimikroba, antioksidan, antihiperurisemia, antikanker. Senyawa aktif yang umumnya bertanggungjawab terhadap aktivitas farmakologi yaitu kandungan senyawa flavonoid, saponin, kuersetin dan geraniin, Aktivitas farmakologis terjadi dengan berbagai mekanisme kerja dalam mengatasi berbagai penyakit. Kata kunci : Rambutan, Nephelium lappaceum L., Aktivitas farmakologis

Jurnal Ilmu Farmasi dan Farmasi Klinik

Hipertensi merupakan salah satu penyakit kardiovaskular yang menjadi permasalahan utama. Kasus hi... more Hipertensi merupakan salah satu penyakit kardiovaskular yang menjadi permasalahan utama. Kasus hipertensi di Indonesia cenderung meningkat. Hipertensi yang tidak ditangani dengan baik dapat menyebabkan komplikasi penyakit lain sehingga pasien berpotensi mendapatkan polifarmasi. Polifarmasi sendiri secara signifikan bisa meningkatkan resiko terjadinya interaksi obat. Tujuan penelitian ini adalah untuk mengetahui kejadian interaksi obat antihipertensi pada peresepan pasien rawat jalan di salah satu klinik kabupaten garut, pada periode Oktober – Desember 2020. Penelitian yang dilakukan menggunakan metode penelitian observasional dengan data yang diambil merupakan data retrospektif berupa resep dan dianalisis secara deskriptif. Kriteria inklusi yaitu resep pasien rawat jalan yang memuat obat antihipertensi dan dalam resep minimal memuat 2 macam obat, sedangkan kriteria eksklusi yakni resep rawat jalan dengan informasi yang tidak lengkap atau tidak terbaca dengan jelas. Sebanyak 3.724 re...

JPMB (Jurnal Pengabdian Masyarakat Borneo), Feb 23, 2022

Dampak kesehatan dan pendidikan yang disebabkan oleh adanya wabah Virus Corona (Covid-19) memberi... more Dampak kesehatan dan pendidikan yang disebabkan oleh adanya wabah Virus Corona (Covid-19) memberikan pengaruh terhadap masyarakat khususnya anak-anak. Tujuan kegiatan pengabdian masyarakat ini adalah untuk memberikan pengetahuan dan kemampuan kepada siswa SPS PAUD Darussalam Desa Tambakbaya dalam mengantisipasi pencegahan penyebaran COVID-19 melalui gerakan mencuci tangan yang baik dan benar. Hasil yang diperoleh adalah kegiatan ini dapat berjalan dengan baik dan lancar. Para siswa juga sangat antusias dan dapat bekerjasama dengan baik, serta dapat mempraktikkan mencuci tangan dengan sabun dan air mengalir sebagai langkah untuk mencegah penyebaran COVID-19 ditingkat individu, keluarga dan lingkungan. Sosialisasi ini memiliki manfaat besar dalam menimbulkan kesadaran bagi anak dalam pencegahan dari organisme berbahaya seperti virus, bakteri, maupun jamur sebagai sumber suatu penyakit.

Medical sains : jurnal ilmiah kefarmasian, May 27, 2022

Kanker prostat merupakan merupakan kanker yang paling umum diderita oleh pria selama 2016, kasus ... more Kanker prostat merupakan merupakan kanker yang paling umum diderita oleh pria selama 2016, kasus baru pada penderita kanker prostat sudah diperkirakan sebanyak 180.890 dan kasus kematian 26.120 kasus. Terapi yang sering digunakan pada penderita kanker prostat ini salah satunya adalah kemoterapi. Kemoterapi dapat menyebabkan senyawa antikanker tidak sensitif, karena terjadi resistensi sel kanker. Maka dari itu, diperlukan pula metode alternatif pengobatan tradisional atau herbal. Dalam terapi kanker, penggunan tanaman herbal dinilai memiliki efek samping yang lebih kecil dibandingkan dengan terapi menggunakan obat-obat kimia. Daun pepaya (Carica papaya L.) merupakan salah satu tumbuhan yang telah diteliti memiliki aktivitas sitotoksik MiaPaca-2 dan ASPC-1. Dalam penelitian ini, dilakukan uji sitotoksisitas ekstrak etanol dan fraksi-fraksi daun pepaya (Carica papaya L.) terhadap sel kanker DU 145 untuk mengetahui aktivitas antikanker dengan menggunakan metode MTT Assay. Hasil uji sitotoksisitas terhadap sel kanker prostat DU 145 menunjukan esktrak etanol, fraksi n-heksan, fraksi etil asetat, dan fraksi air dengan berbagai konsentrasi 31.25, 62.5, 125, 250, dan 500 µg/mL.Fraksi N-heksan memiliki nilai IC50 sebesar 2,80 µg/mL dengan kategori sangat aktif. Hasil aktivitas sitotoksik tersebut dibuktikan dari hasil penafisan fitokimia dari daun pepaya. Metabolit sekunder yang bersifat nonpolar seperti alkaloid pada penafisan fitokimia memperoleh hasil positif. Hal ini membuktikan bahwa alkaloid (carpaine) berkhasiat melawan kanker. Sedangkan pada fraksi air dengan nilai IC50 sebesar 398 µg/mL, fraksi etil asetat sebesar 134 µg/mL dan ekstrak etanol daun pepaya memiliki nilai IC50 sebesar 151 µg/mL bersifat cukup aktif terhadap sel DU 145.

Jurnal Farmasi Sains dan Praktis

Kersen (Muntingia calabura L.) is known as a plant that is often used as a tree to absorb air po... more Kersen (Muntingia calabura L.) is known as a plant that is often used as a tree to absorb air pollution and shade on the roadside. Low economic value and public knowledge about the benefits of cherry as a medicinal and food ingredient is still minimal. The part that can be used as a medicinal ingredient comes from cherry leaves. The purpose of this review article is to provide information related to the chemical content and pharmacological activity of cherry leaves that can treat various diseases. The method used in making this article review is a literature study. The literature sources in this article review were obtained from national journals and international journals published in the last 10 years (2010-2020), which were carried out online through the search engines Google Scholar, Pubmed, and NCBI, using the keywords "Kersen leaves", "Activities cherry leaf”, “Pharmacological activity of Muntingia calabura”, “Chemical content of cherry leaf”, “Muntingia calabu...

JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM), 2022

ABSTRAKPandemi Covid-19 yang terjadi saat ini beberapa waktu yang lalu menyebabkan kelangkaan han... more ABSTRAKPandemi Covid-19 yang terjadi saat ini beberapa waktu yang lalu menyebabkan kelangkaan hand sanitizer dipasaran, hal ini membuat resah sebagian masyarakat. Pembuatan hand sanitizer yang dibuat dengan komposisi yang kurang tepat maka efektivitas hand sanitizer dalam membunuh bakteri dan virus tentunya akan berkurang. Pemanfaatan bahan alam sebagai bahan alternatif dalam pembuatan hand sanitizer. Diketahui beberapa tanaman yang memiliki kemampuan daya hambat terhadap bakteri yang bisa digunakan sebagai zat aktif maupun zat tambahan di dalam produksi hand sanitizer salah satunya adalah lidah buaya. Tujuan dari kegiatan pengabdian ini adalah menghasilkan suatu produk kesehatan yang dapat dimanfaatkan baik untuk diri sendiri, keluarga dan masyarakat sekitar dalam rangka untuk mencegah penyebaran virus Covid-19. Metode yang digunakan dengan memberi penjelasan kegunaan dan keunggulan sediaan hand sanitizer yang terbuat dari bahan alami yaitu lidah buaya (Aloe vera) melalui video da...

Proceedings of BROMO Conference, 2018

International Research Journal Of Pharmacy, 2018

Medicinal plants play an important role in the management of diabetes mellitus, especially in dev... more Medicinal plants play an important role in the management of diabetes mellitus, especially in developing countries. A comprehensive review is conducted to accumulate information about medicinal plants with hypoglycemic properties. Rubiaceae represents one of five families of the most species-rich flowering plants. The Rubiaceae family is the largest plant family of 617 genera and about 13,137 species found worldwide, especially in the tropics and subtropics. Based on searches in several scientific journals, 617 genera of authors get about 34 species of plants that have antidiabetic activity. This review aims to provide information on the antidiabetic activity of the Rubiaceae family based on primary data from various literature and scientific articles collected by the search through online sites. The profile presented includes information on scientific and family names, plant parts and test models used, dosage and active chemicals. Information on antidiabetic medicinal plants can stimulate researchers to conduct further research on the potential use of medicinal plants that have antidiabetic potential.

Pharmacology and Clinical Pharmacy Research, 2018

The emergence of resistant bacteria strain has become a global health concern. It encourages the ... more The emergence of resistant bacteria strain has become a global health concern. It encourages the exploration of potential antibacterial agents, particularly from natural sources. The aim of this study was to investigate the antibacterial activity of ethanol extract of root, stems, leaves, and flowers of Polygonum pulchrum Blume against Staphylococcus aureus and Escherichia coli, through disc diffusion method using cup-plate method. Inhibition zone against S. aureus from roots, stems, leaves, and flowers ethanol extract were 3.5 mm, 2.5 mm, 2.25 mm, and 2.62 mm, respectively, while the inhibition zone against E. coli were 2.25 mm, 2.12 mm, 1.62 mm, and 1.75 mm, respectively. In conclusion, ethanol extract of root, stem, leaves, and flower of P. pulchrum Bl possessed weak antibacterial activity against S. aureus and E. coli.Keywords: P. pulchrum Bl, antibacterial, E. coli, S. aureus, cup-plate technique

Advances in Pharmacological and Pharmaceutical Sciences

For centuries, communities have used medicinal plants to treat various diseases, such as Sansevie... more For centuries, communities have used medicinal plants to treat various diseases, such as Sansevieria trifasciata (Asparagaceae), for wound healing. However, a study on the wound-healing activity of this plant has not been conducted. Therefore, this study aimed to evaluate the hydrogel formulations of S. trifasciata extract (HESt) and its activity in wound healing. The HESt formulations were subjected to physical examination, pH measurement, spreading coefficient, rheological study, stability test, and wound-healing activity. Furthermore, the HPMC and carbopol 940 gel-forming agents were used to obtain this formulation. In the incision wound model, the experiment was divided into 5 groups, each consisting of 4 mice. Groups 1 and 2 served as a negative and positive control (octenidine gel), while 3, 4, and 5 were given HESt formulations of 15%, 20%, and 25% (w/w), respectively, for 15 days. Based on the wound healing activity test, HESt 20% and 25% (w/w) groups showed significant ( p ...

ArXiv, 2019

Recently, Attention-Gated Convolutional Neural Networks (AGCNNs) perform well on several essentia... more Recently, Attention-Gated Convolutional Neural Networks (AGCNNs) perform well on several essential sentence classification tasks and show robust performance in practical applications. However, AGCNNs are required to set many hyperparameters, and it is not known how sensitive the model's performance changes with them. In this paper, we conduct a sensitivity analysis on the effect of different hyperparameters s of AGCNNs, e.g., the kernel window size and the number of feature maps. Also, we investigate the effect of different combinations of hyperparameters settings on the model's performance to analyze to what extent different parameters settings contribute to AGCNNs' performance. Meanwhile, we draw practical advice from a wide range of empirical results. Through the sensitivity analysis experiment, we improve the hyperparameters settings of AGCNNs. Experiments show that our proposals achieve an average of 0.81% and 0.67% improvements on AGCNN-NLReLU-rand and AGCNN-SELU-r...

Intelligent Data Analysis, 2019

The classification of sentences is very challenging, since sentences contain the limited contextu... more The classification of sentences is very challenging, since sentences contain the limited contextual information. In this paper, we proposed an Attention-Gated Convolutional Neural Network (AGCNN) for sentence classification, which generates attention weights from the feature's context windows of different sizes by using specialized convolution encoders. It makes full use of limited contextual information to extract and enhance the influence of important features in predicting the sentence's category. Experimental results demonstrated that our model can achieve up to 3.1% higher accuracy than standard CNN models, and gain competitive results over the baselines on four out of the six tasks. Besides, we designed an activation function, namely, Natural Logarithm rescaled Rectified Linear Unit (NLReLU). Experiments showed that NLReLU can outperform ReLU and is comparable to other well-known activation functions on AGCNN.

JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM)

ABSTRAK Pengetahuan akan pencegahan penyebaran penularan virus Covid-19 bagi anak-anak usia dini ... more ABSTRAK Pengetahuan akan pencegahan penyebaran penularan virus Covid-19 bagi anak-anak usia dini sangat penting untuk dilakukan karena seringkali anak susah untuk diminta memakai masker dan kebanyakan anak-anak tidak sadar akan pentingnya membersihkan tangan terlebih dahulu sebelum dan sesudah melakukan aktivitasnya baik didalam maupun diluar sekolah. Tujuan kegiatan pengabdian masyarakat ini adalah untuk memberikan pengetahuan kepada siswa SPS PAUD Darussalam Desa Tambakbaya dalam mengantisipasi pencegahan penyebaran penularan Covid-19 melalui gerakan menggunakan masker dan mencuci tangan yang baik dan benar. Metode penyuluhan terdiri dari tahap persiapan, pelaksanaan dan evaluasi. Dimulai dari kegiatan mempersiapkan lokasi, peserta yaitu siswa SPS PAUD Darussalam, Desa Tambakbaya, Kecamatan Cisurupan, Kabupaten Garut, Provinsi Jawa Barat. Pada tahap pelaksaan diberikan dengan beberapa tahapan seperti penjelasan, diskusi, dan praktek. Rincian kegiatan yaitu penjelasan leaflet menge...

Research Journal of Pharmacy and Technology, 2019

Complementary medicine for diabetes mellitus using medicinal plants is the solution chosen as an ... more Complementary medicine for diabetes mellitus using medicinal plants is the solution chosen as an alternative treatment. Mengkudu fruit (Morinda citrifolia L.) is empirically used by the community for the treatment of diabetes mellitus. To study the hypoglycemic activity of subfraction mengkudu fruit in mice induced alloxan. The test results on subfraction of ethyl acetate fraction (dose 150 mg/kgBW) induced alloxan (dose 175 mg/kgBW) showed that there was a decrease in blood glucose levels including Mc-IIb (33.94%), Mc-IIc (32.21%), Mc-IIa (29.58%), Mc-IId (18.16%) and Mc-IIe (8.09%) were significantly different compared to the negative control (p<0.05). Subfraction Mc-IIb shows that the most active hypoglycemic activity may be due to some secondary metabolites such as flavonoids, saponins, alkaloids, and polyphenols as antidiabetic bioactive principles. These research showed that Mc-IIb subfraction indicates the highest hypoglycemic activity. However, the research for the active hypoglycemic compound of Mc-IIb subfraction needs to be explored further.

Pharmacology and Clinical Pharmacy Research, Aug 1, 2016

The use of antioxidants from natural resources has attracted increasing interest. One of the plan... more The use of antioxidants from natural resources has attracted increasing interest. One of the plant that was empirically used as an antioxidant dietary supplement was Polygonum pulchrum Blume (P. pulchrum Blume). This study aimed to investigate antioxidant activity of roots, stems, leaves and flowers ethanol extract of P. pulchrum Blume. The extract was obtained by maceration method using ethanol solvent. Antioxidant activity was determined with 1,1-diphenyl-picrylhydrazyl (DPPH) method. We found that ethanol extracts of P. pulchrum Blume roots and stems had strong antioxidant activity with IC 50 values of 25.2 mg/l and 43.26 mg/l, respectively. Ethanol extract of flowers had the weakest antioxidant activity with IC 50 value of 202.96 mg/l. Vitamin C had very strong antioxidant activity with IC 50 value of 3.97 mg/l. In conclusion, this study revealed that ethanol extract of P. pulchrum Blume roots and stems had strong antioxidant activity, therefore, this plant might be potential as an excellent source for natural antioxidant agents for medical application.

Pharmacology and Clinical Pharmacy Research, Aug 1, 2017

The potential toxicity effect presents in the medicinal plants is important to be identified for ... more The potential toxicity effect presents in the medicinal plants is important to be identified for the safety assurance. Accute toxicity study is an initial step in the drug safety assurance test. Thus, the aim of this study is to identify the potential acute toxicity of roots, stems, leaves, and flowers ethanol extracts of bamboo bamboo plants (Polygonum pulchrum Blume). This study used brine shrimp lethality test (BSLT) method. The total number of larvae used in each concentrations in three times replications was 330 larvae. Each group was given consecutively roots, stems, leaves and flowers ethanol extracts of P. pulchrum Blume plants with variation concentrations 12.

Journal of Pharmaceutical Research International

Aims: This study aims to test the antioxidant activity of red and purple H. sabdariffa flower pet... more Aims: This study aims to test the antioxidant activity of red and purple H. sabdariffa flower petals extract and conduct qualitative phytochemical screening. Study Design: Antioxidant potential of red and purple H. sabdariffa flower petal extract analyzed by spectrometric assays. Place and Duration of Study: This study was carried out at School of Pharmacy Muhammadiyah Cirebon, Cirebon, West Java, Indonesia from the year of 2020 to 2021. Methodology: Red and purple H. sabdariffa petals extracted with 70% ethanol. The extract was then examined for its antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, after the qualitative phytochemical screening. Results: In this study, the concentration of red and purple H. sabdariffa petals extract dependently demonstrated the ability to scavenge DPPH. In the DPPH radical scavenging activity test, the red and purple H. sabdariffa petasl extracts designating IC50 values of 63.77 and 37.19 µg/ml and fall into the category of...