ashutosh bagde - Academia.edu (original) (raw)

Papers by ashutosh bagde

Materials Science and Engineering: B

This study proposes the development of a colorimetric non-enzymatic glucose sensor based on TiO 2... more This study proposes the development of a colorimetric non-enzymatic glucose sensor based on TiO 2 /I 2 /CMC (TIC) nanocomposite film. A solution-cast approach was employed for the synthesis of nanocomposite film. The structural and morphological study of the nanocomposite film was analyzed by X-ray diffraction (XRD), X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transforms infrared (FTIR), Raman spectroscopy, photoluminescence, and dynamic light scattering. The XRD graph and Raman spectra indicate the synthesized nanocrystalline anatase form of TiO 2 nanoparticles. The characteristic peak of Ti-O-Ti bonds is observed between 600 and 850 cm − 1 in the FTIR spectrum. Additionally, TIC film exhibited antibacterial properties against E. coli and Bacillus subtilis. The colorimetric method was utilized to determine the glucose concentration. The TIC film reveals that the minimum detectable concentration is 0.4 mM. This easy-to-develop TIC nanocomposite film shows good stability. Therefore, it can be a promising candidate for glucose-sensing applications.

CRC Press eBooks, Apr 6, 2023

Journal of University of Shanghai for Science and Technology, 2020

Jaundice is one of the most common diseases that have a significant impact in the first few days ... more Jaundice is one of the most common diseases that have a significant impact in the first few days of newborn life. Detection and regular monitoring of bilirubin, which is responsible for Jaundice, is an essential phase during the hyperbilirubinemia. In the literature, various clinical assessment methods of Jaundice are available. It motivates us to present a review of these clinical assessment methods in practice, along with their advantages and limitations. In this paper, we have discussed three widely used methods, such as visual assessment, total serum bilirubin and transcutaneous bilirubinometer. From the comparative analysis of these methods, it is concluded that the visual assessment is very subjective in nature, whereas, the total serum bilirubin method is still a gold standard method. The detailed analysis of the methods depicts that the correlation between this two total serum bilirubin and transcutaneous bilirubinometer has enormous potential for improvement resulting in th...

Materials Today: Proceedings

Abstract This review focuses on advances in the field of tendon bioprinting and ligament tissue e... more Abstract This review focuses on advances in the field of tendon bioprinting and ligament tissue engineering, as well as a discussion of the various mechanisms underlying the tendon and ligament tissue. All methods (cellular, non-cellular and both) aim to find complex living tissues capable of growing and maturing, using the same basic technology. To date, co-printing of cellular and non-cellular material has been identified as the most promising method for muscle applications because materials with good performance and good mechanical strength can be integrated within the same structure. Bioprinting publications for tendon and ligament applications are a developing field, and a detailed discussion of current challenges and future ideas is also presented in this review.

IOP Conference Series: Materials Science and Engineering

Cancer therapy has evolved in recent times on diagnostic and therapeutic grounds. Nanotechnology ... more Cancer therapy has evolved in recent times on diagnostic and therapeutic grounds. Nanotechnology is the latest technique used to design nanoparticles having therapeutic applications in diseases like cancer. There are various such nanoparticles types made up of gold, silver, iron, and other compounds. Much recent are the bioinspired and theragnostic nanoparticles which exhibit good biocompatibility and much more effective drug delivery compared to the traditional drug delivery mechanisms. Bioimaging is a visualization process that aids to locate the target cancer cell or tumor-targeted delivered nanoparticles to understand and study the actual status of the disease conditions. In this review, we have discussed these various nanomaterials and its counterparts having applications in cancer.

Journal of Non-Crystalline Solids

Background: Facial mutilation and deformities can be caused by cancer, tumors, injuries, infectio... more Background: Facial mutilation and deformities can be caused by cancer, tumors, injuries, infections, inherited or acquired deformities, and has the potential to degrade one's quality of life by interfering with fundamental tasks like communication, breathing, feeding, and aesthetics. Depending on the type of defect, producing maxillofacial prostheses for the rehabilitation of patients with various defects can be challenging and complex. The prosthesis are used to replace missing or damaged parts of the cranium and face, like the nose, auricle, orbit, and surrounding tissues, as well as missing areas of soft and hard tissue, with the primary goal of increasing the patient's quality of life by rehabilitating oral functions such as speech, swallowing, and mastication [1]. Traditional maxillofacial prosthesis impression and fabrication processes include a number of complicated steps that are costly, time-consuming, and uncomfortable for the patient. These rely on the knowledge o...

Cureus, Oct 28, 2022

Dental material has emerged in the last few decades with enhanced biological properties. The prim... more Dental material has emerged in the last few decades with enhanced biological properties. The prime characteristics required for dental materials are that they should be compatible with oral cavity fluids such as saliva and gingival crevicular fluids. Their functionality should be enhanced in the presence of such biological factors. Scientific advancements in exploring innovative materials have led to the possibility of achieving beneficial results by using materials that respond more dynamically to the environment in which they are placed. Currently available dental materials are improvised. Restorative materials such as smart composites, smart ceramics, compomers, resin-modified glass ionomer, amorphous calcium phosphate (ACP)-releasing pit and fissure sealants, and other smart burs and orthodontic shape memory alloys have all benefited from the usage of smart materials in dentistry.

Inorganic Chemistry Communications

IOP Conference Series: Materials Science and Engineering, 2022

The recent developments and trends towards the synthesis of alumina nanoparticles are discussed. ... more The recent developments and trends towards the synthesis of alumina nanoparticles are discussed. Different modifications made to synthesis approaches for preparation of alumina nanoparticles are critically analyzed. Special attention is emphasized towards combustion synthesis of alpha alumina.

2022 Second International Conference on Artificial Intelligence and Smart Energy (ICAIS)

Deaf and dumb people communicate with gestures. Number of applications have been developed using ... more Deaf and dumb people communicate with gestures. Number of applications have been developed using gesture recognition computer vision, machine learning etc. A simple technique to recognize gestures is presented in this paper. Here Python libraries such as Opencv, Numpy are used. The technique involves capture of live gestures and recognition of the same using Opencv functions. Parameters such as the area ratio and convexity defects are considered to differentiate between different gestures. The system will also display text message and an audio file will be used for vocalizing the different gestures. A functionality where gestures are recognized for entertainment purpose is presented. This can be of use to blind people for the purpose of entertainment such as playing music, radio or listening to news. Here Multiprocessing library is used. The tasks are assigned to specific gestures.

2021 Seventh International conference on Bio Signals, Images, and Instrumentation (ICBSII), 2021

Aim – To evaluate the metabolic ratios for grading of Glial tumors with histo-pathological gradin... more Aim – To evaluate the metabolic ratios for grading of Glial tumors with histo-pathological grading.Method: Cross sectional hospital based observational study conducted over time period of 2 years. All cases registered with Acharya Vinoba Bhave Rural Hospital Sawangi, Wardha, diagnosed on histo-pathological findings as Glial tumours were included in present study. All patients were examined on GE Brivo MRI machine with 1.5Tesla magnetic field strength in the Department of Radiodiagnosis. Using b value of 1000 s/sq. mm, slice thickness 5mm, interslice gap 2mm applied in the x, y and z axes, central as well as peripheral portions of the tumor were manually sampled, preferably getting rid of any cystic or necrotic areas within them. Histo-pathological diagnostic acumen was augmented with radiological features of brain tumors upon routine MRI SEQUENCES coupled with ADC values.Result: In the present study, out of the total of 142 patients included, the glial tumour cases were 54 in number. Amongst this group of glial tumours, the tumours diagnosed were pleomorphic xanthoastrocytoma, pontine glioma, and thalamic glioma, low grade glioma at other sites, high grade gliomas, grade 3 astrocytomas, glioblastoma multiformae, gliomatosis cerebri and gliosarcoma. Upon application of logistic regression analysis, ‘cut off values’ for different metabolite ratios were calculated towards facilitation of grading of brain tumours. The observed ‘cut off values’ were 0.96 for Mi:Cr, 1.03 for Naa:Cr, Cho:LL showed it to be 1.452, 2.15 for Cho:Cr, 2.06 for Cho:Naa, 2.04 for LL:Cr and 2.48 for Cho:Mi respectively.Conclusion: The research gap analysis towards which research question was framed stands filled up by the generated new knowledge in terms of ‘’metabolic ratios’ with identified cut off / demarcating values for gradation of Glial Tumors into Low Grade / High Grade tumors

2021 Seventh International conference on Bio Signals, Images, and Instrumentation (ICBSII), 2021

Aim: To evaluate the Apparent diffusion co-efficient in grading of Glial tumors with histo-pathol... more Aim: To evaluate the Apparent diffusion co-efficient in grading of Glial tumors with histo-pathological gradingMethod: Cross sectional hospital based observational study conducted over a time period of 2 years. All the cases registered with Acharya Vinoba Bhave Rural Hospital Sawangi, Wardha, diagnosed on histo-pathological findings as Glial tumours were included in this present study. All patients were examined on GE Brivo MRI machine with 1.5 Tesla magnetic field strength in the Department of Radiodiagnosis. Using b value of 1000 s/sq. mm, slice thickness 5mm, interslice gap 2mm applied in the x, y and z axes, central as well as peripheral portions of the tumor were manually sampled, preferably getting rid of any cystic or necrotic areas within them. Histo-pathological diagnostic acumen was augmented with radiological features of the brain tumors upon routine MRI SEQUENCES coupled with ADC values.Result: In the present study, out of the total of 142 patients included, the glial tumour cases were 54 in number. Amongst this group of glial tumours, the tumours diagnosed were pleomorphic xanthoastrocytoma, pontine glioma, and thalamic glioma, low grade glioma at other sites, high grade gliomas, grade 3 astrocytomas, glioblastoma multiformae, gliomatosis cerebri and gliosarcoma. The mean ADC for Pleomorphic xanthoastrocytoma, pontine glioma, thalamic glioma and Low grade gliomas were 0.98, 0.82, 0.95 and 0.89 respectively. While, the mean normalized ADC for Pleomorphic xanthoastrocytoma, pontine glioma, thalamic glioma and Low grade gliomas were 1.23, 1.03, 1.19 and 1.12 respectively.Conclusion: The research gap analysis towards which research question was framed stands filled up by the generated new knowledge in terms of ‘Apparent Diffusion Coefficient’ and ‘Normalised Apparent Diffusion Coefficient’ values with identified cut off / demarcating values for gradation of Glial Tumors into Low Grade / High Grade tumors

Journal of Materials Engineering and Performance, 2021

The application of vacuum in casting technology is very limited. In the present scenario, the vac... more The application of vacuum in casting technology is very limited. In the present scenario, the vacuum is mainly used in die casting or investment casting, but the application of vacuum in sand casting is not known yet. In the present investigation, the author did a sand casting process under a vacuum, where the melting and pouring of metals were carried out in a vacuum atmosphere. AA6061 castings were made by sand casting under vacuum (SCUV) process in two different absolute pressure of 110 mbar and 56 mbar, and conventional sand casting process at atmospheric pressure. The effect of vacuum on the porosity and mechanical properties of the castings were investigated and compared with the conventional sand casting process. The results revealed that SCUV process reduces the porosity and improves the mechanical properties of sand cast AA6061 alloy. The pore size and the amount of porosity were significantly reduced from 1.548% at atmospheric pressure to 0.302% at 56 mbar of absolute pressure, i.e., 80.49% of reduction. The result also revealed that the mechanical properties of sand casting under vacuum were significantly improved, especially with the ultimate tensile strength from 276.2 to 309.8 MPa, i.e., 12.17% improvement, and elongation increased from 9.8 to 13.15%, i.e., 34.18% improvement. The gases present inside the mold cavity become the final gas porosity in SCUV. In addition, scanning electron microscopy analysis shows solidification shrinkages present in sand cast. SCUV reduces the size of porosity defect that can improve the stress distribution and slow down the crack propagation in sand castings. Therefore, the SCUV enhanced the ultimate tensile strength and elongation of sand casting.

The unique capabilities of the Computer Aided Design (CAD) and rapid prototyping (RP) have been u... more The unique capabilities of the Computer Aided Design (CAD) and rapid prototyping (RP) have been useful for designing and manufacturing of the customized surgical guides (CSGs). In complex surgeries the CSGs have been shown to provide an accurate means of transferring virtual surgical planning (VSP) to actual surgery. The main purpose of this study is to highlight the different areas where RP assisted CSGs have been prominently use. This paper describes the successful application of RP for the production of CSGs in twelve different areas of complex surgeries. Rapid manufacturing of CSGs using RP technique and their applications; for drilling, cutting and positioning of the implant in various complex surgeries is given in this paper. Otherwise these types of complex surgeries could not be accurately treated through traditional surgeries. Different case reports are noted in this study to know the various innovative ideas related to the RP assisted CSGs. The detail methodology for devel...

IRBM - In Press.Proof corrected by the author Available online since mercredi 20 mars 2019

Materials Today: Proceedings, 2021

Abstract This short review focuses on developments in the field of bioprinting for cartilage tiss... more Abstract This short review focuses on developments in the field of bioprinting for cartilage tissue engineering, along with discussion on the various approaches for cartilage fabrication. The methods (cell-laden, cell-free and a combination of both) involved intended to obtain microenvironment to cells for better development and cell growth using the said methods. The controlled dimension of the scaffold can be decided with great precision. The hybrid bioprinting of cell laden and cell-free materials gives the most promising results for cartilage tissue engineering with multiple materials bio-print including high strength polymers. Although hybrid technology is new but currently 3D-printing for cartilage applications is in high demand, and complete conversation on the current and future viewpoints is presented in this review.

IRBM, 2019

Background: Critical size bone defect and fracture unable to regenerate itself, inspire the origi... more Background: Critical size bone defect and fracture unable to regenerate itself, inspire the origination and technological advancement in the field of bone tissue engineering (BTE). The strategies of bone tissue engineering are often classified into three groups: First, is a direct injection of cells into the tissue of interest; second is grafting of cell-scaffold constructs; and third is scaffold-based signaling molecules, drug delivery or both. Much research was available on the first two categories, still finding the structure and property of scaffold close towards the natural tissue is yet to achieve. Aim of the Review: The proposed mini review focus on ceramic biomaterials uses for bone regeneration and drug delivery. It covers the fabrication process of scaffold including conventional and nonconventional i.e. rapid prototyping approach along with it advantage. The use of scaffold for drug delivery and signaling molecules such as growth factor is an emerging field of research in tissue engineering. Conclusion: The biodegradable beads used as a local drug delivery system are ubiquitous in surgery to treat post-operative infections but does not play any role in tissue regeneration. The use of this clinically accepted drug delivery technique in bone regeneration is an alternative way for the treatment on several bone infections (especially osteomyelitis and arthritis associated with tuberculosis). It is predicted to be the future of organ replacement and treatment.

Materials Science and Engineering: B

This study proposes the development of a colorimetric non-enzymatic glucose sensor based on TiO 2... more This study proposes the development of a colorimetric non-enzymatic glucose sensor based on TiO 2 /I 2 /CMC (TIC) nanocomposite film. A solution-cast approach was employed for the synthesis of nanocomposite film. The structural and morphological study of the nanocomposite film was analyzed by X-ray diffraction (XRD), X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, Fourier transforms infrared (FTIR), Raman spectroscopy, photoluminescence, and dynamic light scattering. The XRD graph and Raman spectra indicate the synthesized nanocrystalline anatase form of TiO 2 nanoparticles. The characteristic peak of Ti-O-Ti bonds is observed between 600 and 850 cm − 1 in the FTIR spectrum. Additionally, TIC film exhibited antibacterial properties against E. coli and Bacillus subtilis. The colorimetric method was utilized to determine the glucose concentration. The TIC film reveals that the minimum detectable concentration is 0.4 mM. This easy-to-develop TIC nanocomposite film shows good stability. Therefore, it can be a promising candidate for glucose-sensing applications.

CRC Press eBooks, Apr 6, 2023

Journal of University of Shanghai for Science and Technology, 2020

Jaundice is one of the most common diseases that have a significant impact in the first few days ... more Jaundice is one of the most common diseases that have a significant impact in the first few days of newborn life. Detection and regular monitoring of bilirubin, which is responsible for Jaundice, is an essential phase during the hyperbilirubinemia. In the literature, various clinical assessment methods of Jaundice are available. It motivates us to present a review of these clinical assessment methods in practice, along with their advantages and limitations. In this paper, we have discussed three widely used methods, such as visual assessment, total serum bilirubin and transcutaneous bilirubinometer. From the comparative analysis of these methods, it is concluded that the visual assessment is very subjective in nature, whereas, the total serum bilirubin method is still a gold standard method. The detailed analysis of the methods depicts that the correlation between this two total serum bilirubin and transcutaneous bilirubinometer has enormous potential for improvement resulting in th...

Materials Today: Proceedings

Abstract This review focuses on advances in the field of tendon bioprinting and ligament tissue e... more Abstract This review focuses on advances in the field of tendon bioprinting and ligament tissue engineering, as well as a discussion of the various mechanisms underlying the tendon and ligament tissue. All methods (cellular, non-cellular and both) aim to find complex living tissues capable of growing and maturing, using the same basic technology. To date, co-printing of cellular and non-cellular material has been identified as the most promising method for muscle applications because materials with good performance and good mechanical strength can be integrated within the same structure. Bioprinting publications for tendon and ligament applications are a developing field, and a detailed discussion of current challenges and future ideas is also presented in this review.

IOP Conference Series: Materials Science and Engineering

Cancer therapy has evolved in recent times on diagnostic and therapeutic grounds. Nanotechnology ... more Cancer therapy has evolved in recent times on diagnostic and therapeutic grounds. Nanotechnology is the latest technique used to design nanoparticles having therapeutic applications in diseases like cancer. There are various such nanoparticles types made up of gold, silver, iron, and other compounds. Much recent are the bioinspired and theragnostic nanoparticles which exhibit good biocompatibility and much more effective drug delivery compared to the traditional drug delivery mechanisms. Bioimaging is a visualization process that aids to locate the target cancer cell or tumor-targeted delivered nanoparticles to understand and study the actual status of the disease conditions. In this review, we have discussed these various nanomaterials and its counterparts having applications in cancer.

Journal of Non-Crystalline Solids

Background: Facial mutilation and deformities can be caused by cancer, tumors, injuries, infectio... more Background: Facial mutilation and deformities can be caused by cancer, tumors, injuries, infections, inherited or acquired deformities, and has the potential to degrade one's quality of life by interfering with fundamental tasks like communication, breathing, feeding, and aesthetics. Depending on the type of defect, producing maxillofacial prostheses for the rehabilitation of patients with various defects can be challenging and complex. The prosthesis are used to replace missing or damaged parts of the cranium and face, like the nose, auricle, orbit, and surrounding tissues, as well as missing areas of soft and hard tissue, with the primary goal of increasing the patient's quality of life by rehabilitating oral functions such as speech, swallowing, and mastication [1]. Traditional maxillofacial prosthesis impression and fabrication processes include a number of complicated steps that are costly, time-consuming, and uncomfortable for the patient. These rely on the knowledge o...

Cureus, Oct 28, 2022

Dental material has emerged in the last few decades with enhanced biological properties. The prim... more Dental material has emerged in the last few decades with enhanced biological properties. The prime characteristics required for dental materials are that they should be compatible with oral cavity fluids such as saliva and gingival crevicular fluids. Their functionality should be enhanced in the presence of such biological factors. Scientific advancements in exploring innovative materials have led to the possibility of achieving beneficial results by using materials that respond more dynamically to the environment in which they are placed. Currently available dental materials are improvised. Restorative materials such as smart composites, smart ceramics, compomers, resin-modified glass ionomer, amorphous calcium phosphate (ACP)-releasing pit and fissure sealants, and other smart burs and orthodontic shape memory alloys have all benefited from the usage of smart materials in dentistry.

Inorganic Chemistry Communications

IOP Conference Series: Materials Science and Engineering, 2022

The recent developments and trends towards the synthesis of alumina nanoparticles are discussed. ... more The recent developments and trends towards the synthesis of alumina nanoparticles are discussed. Different modifications made to synthesis approaches for preparation of alumina nanoparticles are critically analyzed. Special attention is emphasized towards combustion synthesis of alpha alumina.

2022 Second International Conference on Artificial Intelligence and Smart Energy (ICAIS)

Deaf and dumb people communicate with gestures. Number of applications have been developed using ... more Deaf and dumb people communicate with gestures. Number of applications have been developed using gesture recognition computer vision, machine learning etc. A simple technique to recognize gestures is presented in this paper. Here Python libraries such as Opencv, Numpy are used. The technique involves capture of live gestures and recognition of the same using Opencv functions. Parameters such as the area ratio and convexity defects are considered to differentiate between different gestures. The system will also display text message and an audio file will be used for vocalizing the different gestures. A functionality where gestures are recognized for entertainment purpose is presented. This can be of use to blind people for the purpose of entertainment such as playing music, radio or listening to news. Here Multiprocessing library is used. The tasks are assigned to specific gestures.

2021 Seventh International conference on Bio Signals, Images, and Instrumentation (ICBSII), 2021

Aim – To evaluate the metabolic ratios for grading of Glial tumors with histo-pathological gradin... more Aim – To evaluate the metabolic ratios for grading of Glial tumors with histo-pathological grading.Method: Cross sectional hospital based observational study conducted over time period of 2 years. All cases registered with Acharya Vinoba Bhave Rural Hospital Sawangi, Wardha, diagnosed on histo-pathological findings as Glial tumours were included in present study. All patients were examined on GE Brivo MRI machine with 1.5Tesla magnetic field strength in the Department of Radiodiagnosis. Using b value of 1000 s/sq. mm, slice thickness 5mm, interslice gap 2mm applied in the x, y and z axes, central as well as peripheral portions of the tumor were manually sampled, preferably getting rid of any cystic or necrotic areas within them. Histo-pathological diagnostic acumen was augmented with radiological features of brain tumors upon routine MRI SEQUENCES coupled with ADC values.Result: In the present study, out of the total of 142 patients included, the glial tumour cases were 54 in number. Amongst this group of glial tumours, the tumours diagnosed were pleomorphic xanthoastrocytoma, pontine glioma, and thalamic glioma, low grade glioma at other sites, high grade gliomas, grade 3 astrocytomas, glioblastoma multiformae, gliomatosis cerebri and gliosarcoma. Upon application of logistic regression analysis, ‘cut off values’ for different metabolite ratios were calculated towards facilitation of grading of brain tumours. The observed ‘cut off values’ were 0.96 for Mi:Cr, 1.03 for Naa:Cr, Cho:LL showed it to be 1.452, 2.15 for Cho:Cr, 2.06 for Cho:Naa, 2.04 for LL:Cr and 2.48 for Cho:Mi respectively.Conclusion: The research gap analysis towards which research question was framed stands filled up by the generated new knowledge in terms of ‘’metabolic ratios’ with identified cut off / demarcating values for gradation of Glial Tumors into Low Grade / High Grade tumors

2021 Seventh International conference on Bio Signals, Images, and Instrumentation (ICBSII), 2021

Aim: To evaluate the Apparent diffusion co-efficient in grading of Glial tumors with histo-pathol... more Aim: To evaluate the Apparent diffusion co-efficient in grading of Glial tumors with histo-pathological gradingMethod: Cross sectional hospital based observational study conducted over a time period of 2 years. All the cases registered with Acharya Vinoba Bhave Rural Hospital Sawangi, Wardha, diagnosed on histo-pathological findings as Glial tumours were included in this present study. All patients were examined on GE Brivo MRI machine with 1.5 Tesla magnetic field strength in the Department of Radiodiagnosis. Using b value of 1000 s/sq. mm, slice thickness 5mm, interslice gap 2mm applied in the x, y and z axes, central as well as peripheral portions of the tumor were manually sampled, preferably getting rid of any cystic or necrotic areas within them. Histo-pathological diagnostic acumen was augmented with radiological features of the brain tumors upon routine MRI SEQUENCES coupled with ADC values.Result: In the present study, out of the total of 142 patients included, the glial tumour cases were 54 in number. Amongst this group of glial tumours, the tumours diagnosed were pleomorphic xanthoastrocytoma, pontine glioma, and thalamic glioma, low grade glioma at other sites, high grade gliomas, grade 3 astrocytomas, glioblastoma multiformae, gliomatosis cerebri and gliosarcoma. The mean ADC for Pleomorphic xanthoastrocytoma, pontine glioma, thalamic glioma and Low grade gliomas were 0.98, 0.82, 0.95 and 0.89 respectively. While, the mean normalized ADC for Pleomorphic xanthoastrocytoma, pontine glioma, thalamic glioma and Low grade gliomas were 1.23, 1.03, 1.19 and 1.12 respectively.Conclusion: The research gap analysis towards which research question was framed stands filled up by the generated new knowledge in terms of ‘Apparent Diffusion Coefficient’ and ‘Normalised Apparent Diffusion Coefficient’ values with identified cut off / demarcating values for gradation of Glial Tumors into Low Grade / High Grade tumors

Journal of Materials Engineering and Performance, 2021

The application of vacuum in casting technology is very limited. In the present scenario, the vac... more The application of vacuum in casting technology is very limited. In the present scenario, the vacuum is mainly used in die casting or investment casting, but the application of vacuum in sand casting is not known yet. In the present investigation, the author did a sand casting process under a vacuum, where the melting and pouring of metals were carried out in a vacuum atmosphere. AA6061 castings were made by sand casting under vacuum (SCUV) process in two different absolute pressure of 110 mbar and 56 mbar, and conventional sand casting process at atmospheric pressure. The effect of vacuum on the porosity and mechanical properties of the castings were investigated and compared with the conventional sand casting process. The results revealed that SCUV process reduces the porosity and improves the mechanical properties of sand cast AA6061 alloy. The pore size and the amount of porosity were significantly reduced from 1.548% at atmospheric pressure to 0.302% at 56 mbar of absolute pressure, i.e., 80.49% of reduction. The result also revealed that the mechanical properties of sand casting under vacuum were significantly improved, especially with the ultimate tensile strength from 276.2 to 309.8 MPa, i.e., 12.17% improvement, and elongation increased from 9.8 to 13.15%, i.e., 34.18% improvement. The gases present inside the mold cavity become the final gas porosity in SCUV. In addition, scanning electron microscopy analysis shows solidification shrinkages present in sand cast. SCUV reduces the size of porosity defect that can improve the stress distribution and slow down the crack propagation in sand castings. Therefore, the SCUV enhanced the ultimate tensile strength and elongation of sand casting.

The unique capabilities of the Computer Aided Design (CAD) and rapid prototyping (RP) have been u... more The unique capabilities of the Computer Aided Design (CAD) and rapid prototyping (RP) have been useful for designing and manufacturing of the customized surgical guides (CSGs). In complex surgeries the CSGs have been shown to provide an accurate means of transferring virtual surgical planning (VSP) to actual surgery. The main purpose of this study is to highlight the different areas where RP assisted CSGs have been prominently use. This paper describes the successful application of RP for the production of CSGs in twelve different areas of complex surgeries. Rapid manufacturing of CSGs using RP technique and their applications; for drilling, cutting and positioning of the implant in various complex surgeries is given in this paper. Otherwise these types of complex surgeries could not be accurately treated through traditional surgeries. Different case reports are noted in this study to know the various innovative ideas related to the RP assisted CSGs. The detail methodology for devel...

IRBM - In Press.Proof corrected by the author Available online since mercredi 20 mars 2019

Materials Today: Proceedings, 2021

Abstract This short review focuses on developments in the field of bioprinting for cartilage tiss... more Abstract This short review focuses on developments in the field of bioprinting for cartilage tissue engineering, along with discussion on the various approaches for cartilage fabrication. The methods (cell-laden, cell-free and a combination of both) involved intended to obtain microenvironment to cells for better development and cell growth using the said methods. The controlled dimension of the scaffold can be decided with great precision. The hybrid bioprinting of cell laden and cell-free materials gives the most promising results for cartilage tissue engineering with multiple materials bio-print including high strength polymers. Although hybrid technology is new but currently 3D-printing for cartilage applications is in high demand, and complete conversation on the current and future viewpoints is presented in this review.

IRBM, 2019

Background: Critical size bone defect and fracture unable to regenerate itself, inspire the origi... more Background: Critical size bone defect and fracture unable to regenerate itself, inspire the origination and technological advancement in the field of bone tissue engineering (BTE). The strategies of bone tissue engineering are often classified into three groups: First, is a direct injection of cells into the tissue of interest; second is grafting of cell-scaffold constructs; and third is scaffold-based signaling molecules, drug delivery or both. Much research was available on the first two categories, still finding the structure and property of scaffold close towards the natural tissue is yet to achieve. Aim of the Review: The proposed mini review focus on ceramic biomaterials uses for bone regeneration and drug delivery. It covers the fabrication process of scaffold including conventional and nonconventional i.e. rapid prototyping approach along with it advantage. The use of scaffold for drug delivery and signaling molecules such as growth factor is an emerging field of research in tissue engineering. Conclusion: The biodegradable beads used as a local drug delivery system are ubiquitous in surgery to treat post-operative infections but does not play any role in tissue regeneration. The use of this clinically accepted drug delivery technique in bone regeneration is an alternative way for the treatment on several bone infections (especially osteomyelitis and arthritis associated with tuberculosis). It is predicted to be the future of organ replacement and treatment.