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Papers by avinash mane

Scholars Journal of Medical Case Reports, 2022

Merkel cell carcinoma is an uncommon primary neuroendocrine carcinoma of skin which affects elder... more Merkel cell carcinoma is an uncommon primary neuroendocrine carcinoma of skin which affects elderly and immunosuppressed patients. The confirmatory diagnosis require histopathological examination as the clinical features are non - specific. Differentiation from metastatic neuroendocrine carcinoma requires clinicopathological correlation plays important role in differentiation. We present a rare case of merkel cell carcinoma. In a 68 year male patient who presented with exophytic growth arising from umbilicus with metastasis in inguinal lymph node.

International Journal of Health Sciences and Research, 2022

Symplastic leiomyoma is a rare variant of leiomyoma, also called as atypical or bizarre leiomyoma... more Symplastic leiomyoma is a rare variant of leiomyoma, also called as atypical or bizarre leiomyoma. Recently introduced term is leiomyoma with bizarre nuclei. These are leiomyomas which show cells with moderate to severe cytoplasmic atypia, but absence of cell necrosis and lower mitotic activity. We present a case of symplastic leiomyoma in a 45-year old female patient who presented with menorrhagia and abdominal pain. Key words: Leiomyoma, Symplastic, Myometrium.

Journal of Pharmaceutical Research International, 2020

The present study was a two year observational study of haematological profile in clinically susp... more The present study was a two year observational study of haematological profile in clinically suspected cases of neonatal sepsis. Study analyzed the haematological findings according to Rodwell’s haematological scoring system in neonates clinically suspicious of having sepsis. It included 108 neonates admitted in NICU of our hospital during the study period of June 2015 to May 2017. According to clinical findings, Rodwell’s hematological score and blood culture positivity 108 neonates were divided into three groups; proven sepsis, probable sepsis and no sepsis. Study show that Rodwell’s haematological scoring system is a simple, quick, cost effective tool which can be used as screening test for early diagnosis of neonatal sepsis.

Introduction: Xanthogranulomatous prostatitis one of the benign inflammatory lesion of prostate u... more Introduction: Xanthogranulomatous prostatitis one of the benign inflammatory lesion of prostate usually mimics as prostatic carcinoma. Histopathological examination is required for confirmatory diagnosis. Case Presentation: A 65 year old male patient presented with 6 months history of retention of urine with dribbling and increased frequency of urine, nocturia, weak flow, intermittency . On digital rectal examination prostate was enlarged with approximate weight of 229 gms. It was tender and felt hard and nodular. His serum PSA was 40 ng/ml . In view of all these obstructive urinary symptoms, significant residual urine, elevated PSA level and hard mass on PR examination, Prostatic carcinoma was suspected and he underwent prostatectomy. Histopathological examination revealed Xanthogranulomatous prostatitis with no evidence of malignancy. Conclusion: Xanthogranulomatous prostatitis is an excellent mimic of prostatic carcinoma, clinically as well as biochemically as PSA is elevated mos...

Endometrial Stromal Sarcoma (ESS) is commonly seen in perimenopausal women, typically presents wi... more Endometrial Stromal Sarcoma (ESS) is commonly seen in perimenopausal women, typically presents with abnormal uterine bleeding and most commonly, pre-operative diagnosis will be leiomyomas. We report a case of 40 year old female presenting with excessive bleeding per vaginum since 2 months with provisional clinical diagnosis of bulky uterus with leiomyomatous polyp, abdominal panhysterectomy was done. Histopathological examination is helpful in the diagnosis of High Grade ESS. The case is presented in view of its rarity and showing very much distinguishing gross and microscopy appearance. It highlights the unsuspected uterine malignant tumor. The histopathological examination again proved as gold standard to diagnose this rare entity.

International Journal of Health Sciences and Research, 2015

Hereditary elliptocytosis is a disorder of red cell membrane which results from mutation in genes... more Hereditary elliptocytosis is a disorder of red cell membrane which results from mutation in genes encoding various red cell membrane and skeletal proteins. Peripheral smear of these patients reveal elliptical RBCs. Usually the patients are asymptomatic and rarely present with hemolysis. We report a case of hereditary elliptocytosis in a 16 year old female patient diagnosed accidentally when she was admitted for dengue fever.

International Journal of Health Sciences and Research, 2015

Hypoplastic left heart syndrome (HLHS) is one of the major congenital anomaly reported to occur i... more Hypoplastic left heart syndrome (HLHS) is one of the major congenital anomaly reported to occur in 0.016-0.036% of all live births. Generally, these children if born alive, present with profound cyanosis, non-specific heart murmur and signs of cardiogenic shock. In our case, HLHS was diagnosed antenatally on ultrasonography and further confirmed on fetal echocardiography. However, intra-uterine death occurred at 20 weeks of pregnancy. Autopsy findings confirmed HLHS.

International Journal of Health Sciences and Research, 2019

Background - Benign cystadenofibroma of ovary is a rare, slow growing benign epithelial neoplasm ... more Background - Benign cystadenofibroma of ovary is a rare, slow growing benign epithelial neoplasm of unknown etiology, mostly seen in 15 to 65 years of women. It contains epithelial and fibrous stromal components. Most tumours are asymptomatic and are usually detected incidentally during an abdominal ultrasound, performed for other reasons. Case history - In our case while operating for tubal ligation in 25 years old non symptomatic female, a left ovarian cystic mass was incidentally found. Microscopic findings revealed serous papillary cystadenofibroma. Discussion - Benign cystadenofibroma in majority of cases present as single mass within ovary, though rarely can present as multiple masses. These are usually detected incidentally and may resemble a malignant neoplasm.

International Journal of Research in Pharmaceutical Sciences, 2020

The present study was a five years descriptive type of study. In this five years study period Jun... more The present study was a five years descriptive type of study. In this five years study period June 2012 to May 2017, a total number of 62 surgically removed specimens of testing were received in the Department of Pathology of Krishna Institute of Medical sciences and research centre, Karad for histopathological examination. All orchidectomy specimens received from the surgery department in the period of June 2015 to May 2017. Archival data of cases were studied from June 2012. For prospective cases detail record brief clinical history with age, registration number, biopsy number, presenting signs & symptoms were noted, required serum marker assay for Alpha-fetoprotein, Human chorionic gonadotropin and Lactate dehydrogenase were noted wherever possible. The gross specimens received, they were fixed in 10% neutral buffered formalin/ Bouin‘s solution for overnight fixation. In the present study, the maximum number of cases involving the right side of testis. In this study, Germ cell tu...

International Journal of Research in Pharmaceutical Sciences, 2020

The present research has been conducted to find the utility of image-guided fine-needle aspiratio... more The present research has been conducted to find the utility of image-guided fine-needle aspiration cytology in the diagnosis of thoracoabdominal lesions. It also has attempted to study the frequency of distribution of thoracoabdominal lesions. At the same time tried to classify various thoracoabdominal lesions with the help of image-guided fine-needle aspiration cytology. The study of image-guided FNAC of thoracoabdominal lesions was carried out for twenty-four months, i.e. from MAY 2014 to APRIL 2016, which included 80 cases. Most patients (80%) were in the 5th-7th decade of life. All cases of ovarian lesions were diagnosed as malignant tumours on cytology, 08 were diagnosed as adenocarcinoma and one case of granulosa cell tumour. 06 out of 08 cases which diagnosed as adenocarcinoma on cytology, were confirmed on histology and diagnosed as mucinous cystadenocarcinoma(03 cases) and papillary serous carcinoma (03 cases). A case of malignant granulosa cell tumour was diagnosed on cyto...

Scholars Journal of Applied Medical Sciences, 2020

Case Report Neuroendocrine tumors (NET) in gastrointestinal tract are uncommon yet distinctive le... more Case Report Neuroendocrine tumors (NET) in gastrointestinal tract are uncommon yet distinctive lesions. Primary duodenal neuroendocrine tumor is rare entity accounting for less than 2% of all gastrointestinal neuroendocrine tumors. We present a case of 70 years female with complaint of generalized bodyache, weakness, weight loss, fever and abdominal pain since 1 month. She also had a history of passing black colored stool since 15 to 20 days and had history of low grade fever since 6 months. Ultrasound of the abdomen revealed duodenal wall thickening and upper gastrointestinal endoscopy revealed large polypoidal growth on anterior duodenal wall. Endoscopic biopsy was done and sent to our histopathology department where it was reported as low grade duodenal neuroendocrinal tumor. As duodenal neuroendocrinal tumor is rare it is important to be aware of microscopic findings and differential diagnosis of duodenal neuroendocrinal tumor.

International Journal of Research in Pharmaceutical Sciences, 2020

Pap test is a simple yet effective screening method to detect cervical cancer in its early stage,... more Pap test is a simple yet effective screening method to detect cervical cancer in its early stage, and thus it helps to reduce morbidity and mortality from cancer. A total of 430 cases were studied after taking ethical clearance. The cytological diagnoses were made by Cytopathologist using Bethesda 2014 system for categorization of cervical smears. Cytological results were correlated with clinical features and histopathological results wherever biopsy was available. The total of the 430 cases studied 24 (5.58%) were inadequate to report, excluding these, of the total 406 cases 260 (64.04%) cases were symptomatic, and 146 (35.96%) were asymptomatic. Cytologic diagnoses were NILM –normal- 140 (55.23%)with a mean age of 38.48 years, NILM- inflammatory 128 (47.76%) with a mean age of 35.96 years, ASC-US 36 (8.86%) with a mean age of 36.69 years, ASC-H 18 (4.43%) with a mean age of 45 years, LSIL 42 (10.34%) with a mean age of 41.90, HSIL 22 (5.42%) with a mean age of 51.22 years, and inv...

Scholars Journal of Medical Case Reports, 2020

Case Report Case Report: A 28-year-old female presented with multiple subcutaneous nodules since ... more Case Report Case Report: A 28-year-old female presented with multiple subcutaneous nodules since last five years. Initially, lesions started on the back, hands and gluteal region. They were slowly progressive, persistent and asymptomatic. Patient was unmarried and her only concern was cosmetic appearance, so she underwent excisional biopsy of the lesion from gluteal region in our hospital. Routine haematological investigations and coagulation profile was normal. Grossly, we received yellowish, soft, cheesy mass measuring 1.8 x 1.1 x 1.0 cm. Cut section showed soft, yellowish, cheesy areas. Microscopic study revealed skin showing epidermis and dermis lined by stratified squamous epithelium. Epidermis was thin with no dysplasia. Dermis showed diffuse infiltration of foamy macrophages along with many classical Tuoton type giant cells. Based on these findings and clinical details, diagnosis of tuberous xanthoma was offered. Discussion: Xanthoma is a localised collection of tissue histiocytes containing lipids. It is a pseudotumor which particularly occurs in response to alterations in lipid metabolism. Tuberous xanthomas generally present as discrete painless nodules or large plaque like lesions of the subcutis. In our patient, lipid profile was found to be deranged and cholesterol was on higher side i.e. 380mg/dl. Because of prompt diagnosis, patient was shifted on cholesterol lowering agents to prevent cardiovascular complications. Conclusion: In conclusion, we are presenting a case of Multiple Tuberous Xanthomas in a young female not only for its histopathological diagnosis but also for putting more emphasis on correction of lipid profile through prompt administration of cholesterol lowering agents. This will lower the risk of mortality due to cardiovascular complications.

Scholars Journal of Medical Case Reports, 2020

Scholars Journal of Medical Case Reports, 2020

Angioleiomyoma is a benign mesenchymal neoplasm composed of smooth muscle cell and thick walled b... more Angioleiomyoma is a benign mesenchymal neoplasm composed of smooth muscle cell and thick walled blood vessels. Angioleiomyomas are most commonly seen in the skin of extremities and it is uncommon in uterus. Broad ligament angioleiomyomas is more uncommon than uterine. Patient with uterine angioleiomyomas usually present with excessive bleeding per vaginum compared to uterine leiomyomas. Abdominal pain is also observed in many cases of angioleiomyomas of pelvic cavity which is believed to be related to ischemia due to vascular contracture. Histologically, angioleiomyomas are divided into 3 subtypes namely-Capillary, Cavernous and Mixed. Here we present a rare case of Capillary Angioleiomyoma of broad ligament in a case of 42 yr old female presented with pelvic mass.

Indian Journal of Pathology and Microbiology, 2019

The estimated incidence of primary cardiac tumors is extremely rare. Among it, cardiac myxoma rep... more The estimated incidence of primary cardiac tumors is extremely rare. Among it, cardiac myxoma represents the most common benign cardiac tumor constituting about 80% of cases. We are presenting a 30–year-old female with large left atrial myxoma. She was presented with severe dyspnea, palpitations, and systolic murmurs. On 2D echocardiography, left atrial mass obstructing mitral flow was noted. On cardiac magnetic resonance imaging, a single, large, mobile pedunculated mass lesion in left atrium attached to inferior interatrial septum with heterogeneous enhancement was noted, which was likely represented to be myxoma. The mass was surgically excised and valve repairing was done. We received large, solid, lobulated, gray white, soft-to-firm mass measuring 4.5 × 4.1 × 2.5 cm, and on microscopy showed cardiac myxoma with cartilaginous differentiation. We are presenting this case for its clinical, imaging, and uncommon histological features.

IP Archives of Cytology and Histopathology Research, 2019

A 55 year male patient presented with progressive growth over left lower eyelid measuring 1.5 x 1... more A 55 year male patient presented with progressive growth over left lower eyelid measuring 1.5 x 1 cm. The local examination showed ulceroproliferative growth with irregular margins and everted edges. On histopathological examination diagnosed as basal cell carcinoma of lower eyelid. We are presenting this case for its clinical manifestations and histopathological findings.

Journal of Cytology, 2017

A diffuse, chronic, usually bilateral, noninflammatory, nonneoplastic enlargement of major saliva... more A diffuse, chronic, usually bilateral, noninflammatory, nonneoplastic enlargement of major salivary glands is termed as Sialosis or Sialadenosis. It is an extremely uncommon cause for enlargement of the parotid gland. We hereby present a case of a 45-year-old female patient having a swelling at the left preauricular region. The swelling was gradually increasing in size since 6 months. On clinical examination, the swelling was 3 cm × 3 cm, mobile, and nontender. On ultrasonography, it was suggestive of benign parotid lesion or parotitis with cervical lymphadenopathy. On fine needle aspiration cytology, it was suggestive of sialadenosis. This is an extremely rare salivary gland lesion with specific cellular features. It is very important to distinguish sialadenosis from other causes of enlargement of the parotid gland as treatment modality differs.

International Journal of Research in Pharmaceutical Sciences, 2020

Carcinoma of the cervix is a common cause of mortality in women regardless of effective screening... more Carcinoma of the cervix is a common cause of mortality in women regardless of effective screening methods. Screening for (MN) in cells has been one among the tests used in cancer screening. Several containing cells rises in carcinogen- exposed tissues much earlier than the symptoms. Here in this study usefulness of (MN) in screening cervical lesions was evaluated. We studied comparison of MN score among different cervical lesions and the significance of the difference in the score. We evaluated 406 cervical smears, categorized them using the “Bethesda 2014 system". Mean MN scores among the different cervical lesion categories were compared, and the differences were studied statistically for its significance. Results showed a gradual increase in mean MN score with increasing severity of the cervical lesion and the differences in these scores were statistically significant (P < 0.05) among all the categories, with significantly higher mean MN scores in high grade squamous woun...

Scholars Journal of Medical Case Reports, 2022

Merkel cell carcinoma is an uncommon primary neuroendocrine carcinoma of skin which affects elder... more Merkel cell carcinoma is an uncommon primary neuroendocrine carcinoma of skin which affects elderly and immunosuppressed patients. The confirmatory diagnosis require histopathological examination as the clinical features are non - specific. Differentiation from metastatic neuroendocrine carcinoma requires clinicopathological correlation plays important role in differentiation. We present a rare case of merkel cell carcinoma. In a 68 year male patient who presented with exophytic growth arising from umbilicus with metastasis in inguinal lymph node.

International Journal of Health Sciences and Research, 2022

Symplastic leiomyoma is a rare variant of leiomyoma, also called as atypical or bizarre leiomyoma... more Symplastic leiomyoma is a rare variant of leiomyoma, also called as atypical or bizarre leiomyoma. Recently introduced term is leiomyoma with bizarre nuclei. These are leiomyomas which show cells with moderate to severe cytoplasmic atypia, but absence of cell necrosis and lower mitotic activity. We present a case of symplastic leiomyoma in a 45-year old female patient who presented with menorrhagia and abdominal pain. Key words: Leiomyoma, Symplastic, Myometrium.

Journal of Pharmaceutical Research International, 2020

The present study was a two year observational study of haematological profile in clinically susp... more The present study was a two year observational study of haematological profile in clinically suspected cases of neonatal sepsis. Study analyzed the haematological findings according to Rodwell’s haematological scoring system in neonates clinically suspicious of having sepsis. It included 108 neonates admitted in NICU of our hospital during the study period of June 2015 to May 2017. According to clinical findings, Rodwell’s hematological score and blood culture positivity 108 neonates were divided into three groups; proven sepsis, probable sepsis and no sepsis. Study show that Rodwell’s haematological scoring system is a simple, quick, cost effective tool which can be used as screening test for early diagnosis of neonatal sepsis.

Introduction: Xanthogranulomatous prostatitis one of the benign inflammatory lesion of prostate u... more Introduction: Xanthogranulomatous prostatitis one of the benign inflammatory lesion of prostate usually mimics as prostatic carcinoma. Histopathological examination is required for confirmatory diagnosis. Case Presentation: A 65 year old male patient presented with 6 months history of retention of urine with dribbling and increased frequency of urine, nocturia, weak flow, intermittency . On digital rectal examination prostate was enlarged with approximate weight of 229 gms. It was tender and felt hard and nodular. His serum PSA was 40 ng/ml . In view of all these obstructive urinary symptoms, significant residual urine, elevated PSA level and hard mass on PR examination, Prostatic carcinoma was suspected and he underwent prostatectomy. Histopathological examination revealed Xanthogranulomatous prostatitis with no evidence of malignancy. Conclusion: Xanthogranulomatous prostatitis is an excellent mimic of prostatic carcinoma, clinically as well as biochemically as PSA is elevated mos...

Endometrial Stromal Sarcoma (ESS) is commonly seen in perimenopausal women, typically presents wi... more Endometrial Stromal Sarcoma (ESS) is commonly seen in perimenopausal women, typically presents with abnormal uterine bleeding and most commonly, pre-operative diagnosis will be leiomyomas. We report a case of 40 year old female presenting with excessive bleeding per vaginum since 2 months with provisional clinical diagnosis of bulky uterus with leiomyomatous polyp, abdominal panhysterectomy was done. Histopathological examination is helpful in the diagnosis of High Grade ESS. The case is presented in view of its rarity and showing very much distinguishing gross and microscopy appearance. It highlights the unsuspected uterine malignant tumor. The histopathological examination again proved as gold standard to diagnose this rare entity.

International Journal of Health Sciences and Research, 2015

Hereditary elliptocytosis is a disorder of red cell membrane which results from mutation in genes... more Hereditary elliptocytosis is a disorder of red cell membrane which results from mutation in genes encoding various red cell membrane and skeletal proteins. Peripheral smear of these patients reveal elliptical RBCs. Usually the patients are asymptomatic and rarely present with hemolysis. We report a case of hereditary elliptocytosis in a 16 year old female patient diagnosed accidentally when she was admitted for dengue fever.

International Journal of Health Sciences and Research, 2015

Hypoplastic left heart syndrome (HLHS) is one of the major congenital anomaly reported to occur i... more Hypoplastic left heart syndrome (HLHS) is one of the major congenital anomaly reported to occur in 0.016-0.036% of all live births. Generally, these children if born alive, present with profound cyanosis, non-specific heart murmur and signs of cardiogenic shock. In our case, HLHS was diagnosed antenatally on ultrasonography and further confirmed on fetal echocardiography. However, intra-uterine death occurred at 20 weeks of pregnancy. Autopsy findings confirmed HLHS.

International Journal of Health Sciences and Research, 2019

Background - Benign cystadenofibroma of ovary is a rare, slow growing benign epithelial neoplasm ... more Background - Benign cystadenofibroma of ovary is a rare, slow growing benign epithelial neoplasm of unknown etiology, mostly seen in 15 to 65 years of women. It contains epithelial and fibrous stromal components. Most tumours are asymptomatic and are usually detected incidentally during an abdominal ultrasound, performed for other reasons. Case history - In our case while operating for tubal ligation in 25 years old non symptomatic female, a left ovarian cystic mass was incidentally found. Microscopic findings revealed serous papillary cystadenofibroma. Discussion - Benign cystadenofibroma in majority of cases present as single mass within ovary, though rarely can present as multiple masses. These are usually detected incidentally and may resemble a malignant neoplasm.

International Journal of Research in Pharmaceutical Sciences, 2020

The present study was a five years descriptive type of study. In this five years study period Jun... more The present study was a five years descriptive type of study. In this five years study period June 2012 to May 2017, a total number of 62 surgically removed specimens of testing were received in the Department of Pathology of Krishna Institute of Medical sciences and research centre, Karad for histopathological examination. All orchidectomy specimens received from the surgery department in the period of June 2015 to May 2017. Archival data of cases were studied from June 2012. For prospective cases detail record brief clinical history with age, registration number, biopsy number, presenting signs & symptoms were noted, required serum marker assay for Alpha-fetoprotein, Human chorionic gonadotropin and Lactate dehydrogenase were noted wherever possible. The gross specimens received, they were fixed in 10% neutral buffered formalin/ Bouin‘s solution for overnight fixation. In the present study, the maximum number of cases involving the right side of testis. In this study, Germ cell tu...

International Journal of Research in Pharmaceutical Sciences, 2020

The present research has been conducted to find the utility of image-guided fine-needle aspiratio... more The present research has been conducted to find the utility of image-guided fine-needle aspiration cytology in the diagnosis of thoracoabdominal lesions. It also has attempted to study the frequency of distribution of thoracoabdominal lesions. At the same time tried to classify various thoracoabdominal lesions with the help of image-guided fine-needle aspiration cytology. The study of image-guided FNAC of thoracoabdominal lesions was carried out for twenty-four months, i.e. from MAY 2014 to APRIL 2016, which included 80 cases. Most patients (80%) were in the 5th-7th decade of life. All cases of ovarian lesions were diagnosed as malignant tumours on cytology, 08 were diagnosed as adenocarcinoma and one case of granulosa cell tumour. 06 out of 08 cases which diagnosed as adenocarcinoma on cytology, were confirmed on histology and diagnosed as mucinous cystadenocarcinoma(03 cases) and papillary serous carcinoma (03 cases). A case of malignant granulosa cell tumour was diagnosed on cyto...

Scholars Journal of Applied Medical Sciences, 2020

Case Report Neuroendocrine tumors (NET) in gastrointestinal tract are uncommon yet distinctive le... more Case Report Neuroendocrine tumors (NET) in gastrointestinal tract are uncommon yet distinctive lesions. Primary duodenal neuroendocrine tumor is rare entity accounting for less than 2% of all gastrointestinal neuroendocrine tumors. We present a case of 70 years female with complaint of generalized bodyache, weakness, weight loss, fever and abdominal pain since 1 month. She also had a history of passing black colored stool since 15 to 20 days and had history of low grade fever since 6 months. Ultrasound of the abdomen revealed duodenal wall thickening and upper gastrointestinal endoscopy revealed large polypoidal growth on anterior duodenal wall. Endoscopic biopsy was done and sent to our histopathology department where it was reported as low grade duodenal neuroendocrinal tumor. As duodenal neuroendocrinal tumor is rare it is important to be aware of microscopic findings and differential diagnosis of duodenal neuroendocrinal tumor.

International Journal of Research in Pharmaceutical Sciences, 2020

Pap test is a simple yet effective screening method to detect cervical cancer in its early stage,... more Pap test is a simple yet effective screening method to detect cervical cancer in its early stage, and thus it helps to reduce morbidity and mortality from cancer. A total of 430 cases were studied after taking ethical clearance. The cytological diagnoses were made by Cytopathologist using Bethesda 2014 system for categorization of cervical smears. Cytological results were correlated with clinical features and histopathological results wherever biopsy was available. The total of the 430 cases studied 24 (5.58%) were inadequate to report, excluding these, of the total 406 cases 260 (64.04%) cases were symptomatic, and 146 (35.96%) were asymptomatic. Cytologic diagnoses were NILM –normal- 140 (55.23%)with a mean age of 38.48 years, NILM- inflammatory 128 (47.76%) with a mean age of 35.96 years, ASC-US 36 (8.86%) with a mean age of 36.69 years, ASC-H 18 (4.43%) with a mean age of 45 years, LSIL 42 (10.34%) with a mean age of 41.90, HSIL 22 (5.42%) with a mean age of 51.22 years, and inv...

Scholars Journal of Medical Case Reports, 2020

Case Report Case Report: A 28-year-old female presented with multiple subcutaneous nodules since ... more Case Report Case Report: A 28-year-old female presented with multiple subcutaneous nodules since last five years. Initially, lesions started on the back, hands and gluteal region. They were slowly progressive, persistent and asymptomatic. Patient was unmarried and her only concern was cosmetic appearance, so she underwent excisional biopsy of the lesion from gluteal region in our hospital. Routine haematological investigations and coagulation profile was normal. Grossly, we received yellowish, soft, cheesy mass measuring 1.8 x 1.1 x 1.0 cm. Cut section showed soft, yellowish, cheesy areas. Microscopic study revealed skin showing epidermis and dermis lined by stratified squamous epithelium. Epidermis was thin with no dysplasia. Dermis showed diffuse infiltration of foamy macrophages along with many classical Tuoton type giant cells. Based on these findings and clinical details, diagnosis of tuberous xanthoma was offered. Discussion: Xanthoma is a localised collection of tissue histiocytes containing lipids. It is a pseudotumor which particularly occurs in response to alterations in lipid metabolism. Tuberous xanthomas generally present as discrete painless nodules or large plaque like lesions of the subcutis. In our patient, lipid profile was found to be deranged and cholesterol was on higher side i.e. 380mg/dl. Because of prompt diagnosis, patient was shifted on cholesterol lowering agents to prevent cardiovascular complications. Conclusion: In conclusion, we are presenting a case of Multiple Tuberous Xanthomas in a young female not only for its histopathological diagnosis but also for putting more emphasis on correction of lipid profile through prompt administration of cholesterol lowering agents. This will lower the risk of mortality due to cardiovascular complications.

Scholars Journal of Medical Case Reports, 2020

Scholars Journal of Medical Case Reports, 2020

Angioleiomyoma is a benign mesenchymal neoplasm composed of smooth muscle cell and thick walled b... more Angioleiomyoma is a benign mesenchymal neoplasm composed of smooth muscle cell and thick walled blood vessels. Angioleiomyomas are most commonly seen in the skin of extremities and it is uncommon in uterus. Broad ligament angioleiomyomas is more uncommon than uterine. Patient with uterine angioleiomyomas usually present with excessive bleeding per vaginum compared to uterine leiomyomas. Abdominal pain is also observed in many cases of angioleiomyomas of pelvic cavity which is believed to be related to ischemia due to vascular contracture. Histologically, angioleiomyomas are divided into 3 subtypes namely-Capillary, Cavernous and Mixed. Here we present a rare case of Capillary Angioleiomyoma of broad ligament in a case of 42 yr old female presented with pelvic mass.

Indian Journal of Pathology and Microbiology, 2019

The estimated incidence of primary cardiac tumors is extremely rare. Among it, cardiac myxoma rep... more The estimated incidence of primary cardiac tumors is extremely rare. Among it, cardiac myxoma represents the most common benign cardiac tumor constituting about 80% of cases. We are presenting a 30–year-old female with large left atrial myxoma. She was presented with severe dyspnea, palpitations, and systolic murmurs. On 2D echocardiography, left atrial mass obstructing mitral flow was noted. On cardiac magnetic resonance imaging, a single, large, mobile pedunculated mass lesion in left atrium attached to inferior interatrial septum with heterogeneous enhancement was noted, which was likely represented to be myxoma. The mass was surgically excised and valve repairing was done. We received large, solid, lobulated, gray white, soft-to-firm mass measuring 4.5 × 4.1 × 2.5 cm, and on microscopy showed cardiac myxoma with cartilaginous differentiation. We are presenting this case for its clinical, imaging, and uncommon histological features.

IP Archives of Cytology and Histopathology Research, 2019

A 55 year male patient presented with progressive growth over left lower eyelid measuring 1.5 x 1... more A 55 year male patient presented with progressive growth over left lower eyelid measuring 1.5 x 1 cm. The local examination showed ulceroproliferative growth with irregular margins and everted edges. On histopathological examination diagnosed as basal cell carcinoma of lower eyelid. We are presenting this case for its clinical manifestations and histopathological findings.

Journal of Cytology, 2017

A diffuse, chronic, usually bilateral, noninflammatory, nonneoplastic enlargement of major saliva... more A diffuse, chronic, usually bilateral, noninflammatory, nonneoplastic enlargement of major salivary glands is termed as Sialosis or Sialadenosis. It is an extremely uncommon cause for enlargement of the parotid gland. We hereby present a case of a 45-year-old female patient having a swelling at the left preauricular region. The swelling was gradually increasing in size since 6 months. On clinical examination, the swelling was 3 cm × 3 cm, mobile, and nontender. On ultrasonography, it was suggestive of benign parotid lesion or parotitis with cervical lymphadenopathy. On fine needle aspiration cytology, it was suggestive of sialadenosis. This is an extremely rare salivary gland lesion with specific cellular features. It is very important to distinguish sialadenosis from other causes of enlargement of the parotid gland as treatment modality differs.

International Journal of Research in Pharmaceutical Sciences, 2020

Carcinoma of the cervix is a common cause of mortality in women regardless of effective screening... more Carcinoma of the cervix is a common cause of mortality in women regardless of effective screening methods. Screening for (MN) in cells has been one among the tests used in cancer screening. Several containing cells rises in carcinogen- exposed tissues much earlier than the symptoms. Here in this study usefulness of (MN) in screening cervical lesions was evaluated. We studied comparison of MN score among different cervical lesions and the significance of the difference in the score. We evaluated 406 cervical smears, categorized them using the “Bethesda 2014 system". Mean MN scores among the different cervical lesion categories were compared, and the differences were studied statistically for its significance. Results showed a gradual increase in mean MN score with increasing severity of the cervical lesion and the differences in these scores were statistically significant (P < 0.05) among all the categories, with significantly higher mean MN scores in high grade squamous woun...