ayesheh enayati - Academia.edu (original) (raw)

Papers by ayesheh enayati

Archiv der Pharmazie

Stroke is the most common cause of death among neurological diseases. The protective effects of P... more Stroke is the most common cause of death among neurological diseases. The protective effects of Potentilla reptans L. include antioxidative, anti‐inflammatory, and antiapoptotic effects. In this study, the brain protection and beta‐amyloid effects of P. reptans root extract were investigated in the rat brain ischemia/reperfusion (IR) model. Forty male Wistar rats were randomly divided into five groups (n = 8), including IR, sham, and three groups receiving P. reptans with concentrations of 0.025, 0.05, and 0.1 (g/kg/b.w.), which were injected daily for 7 days. For the IR model, the common carotid artery was occluded bilaterally for 8 min. All injections were intraperitoneal (IP). The shuttle box test was used to measure passive avoidance memory. Then the brain tissue was extracted for the histological examination of neuron counts and β‐amyloid plaques using a morphometric technique, and finally, Statistical Package for the Social Sciences software was used for statistical analysis o...

BMC Complementary Medicine and Therapies

The present study aimed to evaluate the effect of the ethyl acetate fraction of P. reptans root (... more The present study aimed to evaluate the effect of the ethyl acetate fraction of P. reptans root (PEF) preconditioning on expressions of lncRNAs H19 and MIAT in H9C2 myoblasts I/R injury.H9C2 cells were treated with different concentrations ranging from (10–400 µg/ml) of PEF for 24 h, followed by simulation of I/R condition. For I/R experiments, H9C2 cells were subjected with the oxygen and glucose deprivation for 2 h.H9C2 cell viability was significantly enhanced by PEF preconditioning under I/R condition in a concentration-dependent manner up to 200 µg/ml as a EC50. The PEF significantly diminished the expression of lncRNA MIAT and rate of apoptosis against the I/R group. In addition, PEF pretreated before stimulation I/R condition increased H19 expression compared to the normal PEF group with no statistically significant differences between groups. Hence, the results suggest that PEF can protect cardiomyocytes during hypoxia-induced myocardial cell injury by targeting specific inv...

Ppar Research, 2022

Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-dependent nuclear r... more Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-dependent nuclear receptor family. PPARs have attracted wide attention as pharmacologic mediators to manage multiple diseases and their underlying signaling targets. They mediate a broad range of specific biological activities and multiple organ toxicity, including cellular differentiation, metabolic syndrome, cancer, atherosclerosis, neurodegeneration, cardiovascular diseases, and inflammation related to their up/ downstream signaling pathways. Consequently, several types of selective PPAR ligands, such as fibrates and thiazolidinediones (TZDs), have been approved as their pharmacological agonists. Despite these advances, the use of PPAR agonists is known to cause adverse effects in various systems. Conversely, some naturally occurring PPAR agonists, including polyunsaturated fatty acids and natural endogenous PPAR agonists curcumin and resveratrol, have been introduced as safe agonists as a result of their clinical evidence or preclinical experiments. This review focuses on research on plant-derived active ingredients (natural phytochemicals) as potential safe and promising PPAR agonists. Moreover, it provides a comprehensive review and critique of the role of phytochemicals in PPARs-related diseases and provides an understanding of phytochemical-mediated PPARdependent and-independent cascades. The findings of this research will help to define the functions of phytochemicals as potent PPAR pharmacological agonists in underlying disease mechanisms and their related complications.

Evidence-Based Complementary and Alternative Medicine, 2022

Aromatic oleo-gum-resin secreted from B. sacra, reputed as frankincense, is widely used in tradit... more Aromatic oleo-gum-resin secreted from B. sacra, reputed as frankincense, is widely used in traditional medicine to treat Alzheimer’s disease, gastric disorders, hepatic disorders, etc. Frankincense is also used in the cosmetic, perfume, and beverage and food industries. Frankincense is a rich resource for bioactive compounds, especially boswellic acids and derivatives. Although several reports have described frankincense’s constituents and pharmacological activities, there is no comprehensive study that covers the valuable information on this species. Therefore, the current review will focus on the phytochemistry, traditional uses, and pharmacological activities of B. sacra.

Biomedicine & Pharmacotherapy, 2022

Myocarditis is an inflammatory disease of the myocardium that mostly affects young adults. The di... more Myocarditis is an inflammatory disease of the myocardium that mostly affects young adults. The disease is commonly caused by viral infection, medications, autoimmune disorders, and inflammatory conditions. Nearly 50% of the cases of myocarditis are due to post-viral immune response in a setting of an identifiable or non-identifiable infection. The clinical manifestation is nonspecific ranging from asymptomatic courses to sudden death in infants and young patients. This review describes the properties of phytochemicals as plant-derived active ingredients which can be used in the prevention and treatment of myocarditis and its associated risk factors. Meanwhile, it has illustrated epidemiological analyses, mechanism of action, and the metabolism of phytochemicals in animal and human clinical trials. We also mentioned the precise mechanism of action by which phytochemicals elicit their anti-viral, anti-inflammatory, antioxidant, and immunomodulatory effects and how they regulate signal transduction pathways. Nevertheless, comprehensive clinical trials are required to study the properties of phytochemicals in vivo, in vitro, and in silico for a proper management of myocarditis. Our findings indicate that phytochemicals function as potent adjunctive therapeutic drugs in myocarditis and its related complications.

Dear editor-in-chief; Sumac (Rhus coriaria L., Anacardiaceae family), a popular herb asspices of ... more Dear editor-in-chief; Sumac (Rhus coriaria L., Anacardiaceae family), a popular herb asspices of flowering [1,2], contains some phytochemical constituent including anthocyanins, terpenes, phenolic acids, tannins, vitamins, minerals, and fatty acids [3,4]. Persian medicine (PM) has considered Cold and dry temperament as well as astringent and tonic properties for Sumac [5]. In addition, ancient Persians used Sumac to reduce the symptoms of motion sickness such as nausea and vomiting on sea traveling. They believed that the astringent and tonic effect of sumac prevents the stimulation of some materials in stomach, which can trigger motion sickness [5,6]. It is used for topical application to reduce the swelling and pain [5]. In Persian medicine (PM), Sumac has been mostly prescribed for reinforcement of stomach and gums, bloody diarrhea, infectious, severe uterine bleeding, and gout [7]. Likewise, recent studies confirmed its traditional antidiarrheal,

In this study, the optimal extraction conditions of Phenolics from the root of Euphorbia condyloc... more In this study, the optimal extraction conditions of Phenolics from the root of Euphorbia condylocarpa has been investigated using the Emerson reaction. The influence of different extraction parameters such as time of extraction, temperature, material ratio and ethanol concentration were studied separately 1,2 . Thus, the optimum conditions were obtained at temperature 60, time of extraction 6 h, EtOH concentration 80% and material ratio of dried powder to volume of solvent 1: 10 (w/v). Then the optimal conditions obtained above, were applied to phenolic extraction process and after filtration, the concentrated extract was loaded on a column chromatograph containing silica gel G-60. The extraction in column was eluted with different concentrations of n -hexane, EtOAc and MeOH. Consequently, three widely distributed flavonoids Quercetin, Luteolin and Morin were identified in n-hexane : MeOH (20:80 , v/v) as mobile phase 3 . Keywords : Optimal Extraction, Emerson reaction, Phenolics, E...

The family Euphorbiaceae is rich in flavonoids, particularly flavones and flavonols, which have b... more The family Euphorbiaceae is rich in flavonoids, particularly flavones and flavonols, which have been identified from several genera. 1 The root of Euphorbia condylocarpa M. B.( Euphorbiaceae ) has important applications in folk medicine for the treatment of the cancer, costiveness, and migraine and as an emollient. 2 The purpose of this study was to phytochemically analyze the root of Euphorbia condylocarpa as a relatively unknown plant in phytochemical research to identify compounds for the first time. Studies on methanolic extract of the root of E.condylocarpa using silica gel chromatography (CC) has been investigated and spectroscopically identified ﬂavone glycosid as 5,6,7 ,4 ' , -tetra hydroxyﬂavone-7-O-(6 " -O-acetyl)-β glucopyranoside using PTLC, UV,IR, NMR 3-6 experiments , and compared with literature data. This study demonstrated for the first time the isolation of these constituents from E.condylocarpa M.B. Further study is required to clarify clinical effects of...

Current Traditional Medicine, 2021

: The tendency to use herbal and complementary therapies has been increased dramatically in the l... more : The tendency to use herbal and complementary therapies has been increased dramatically in the last decades. The aim of this study is to review nephrotonic and nephroprotective medicinal herbs in traditional Persian Medicine (TPM) historical books and assess relevant scientific evidence and possible mechanisms of action. In this study, seven major references among pharmaceutical books of PM from the 11th to 19th centuries were selected and were searched with keywords equivalent to “nephroprotection”. To find new studies, the scientific names of medicinal herbs which have been repeated twice or more were searched using databases, including PubMed and Google scholar, with keywords of nephroprotective, renal disorder, renal failure and kidney. Also, probable effective mechanisms were explored with keywords, including oxidative stress, antioxidant, inflammation, anti-inflammatory and angiotensin-converting-enzyme inhibitor. 210 herbal remedies were found with kidney strengthening, nephroprotective, and atrophy prevention effects in reviewed books. The most repeated herbs were 41. Results of scientific evidence showed that the possible functional mechanisms of these plants include anti-inflammatory, anti-oxidative, blood pressure/glucose-lowering effect as well as improvement of glomerular filtration, prevention of tissue damage, and enhancing reconstructive power of cells. The list of medicinal herbs in this study can be used as a basis of future studies on the production of new medicines for the prevention or treatment of renal failure and for the enhancement of renalfunction.

Current Medicinal Chemistry, 2021

Cardiovascular diseases are the leading cause of death in the world. Atherosclerosis is character... more Cardiovascular diseases are the leading cause of death in the world. Atherosclerosis is characterized by oxidized lipid deposition and inflammation in the arterial wall and represents a significant problem in public health and medicine. Some dietary spices have been widely used in many countries; however, the mechanism of their action as it relates to the prevention and treatment of atherosclerosis is still poorly understood. In this review, we focus on the properties of various spice-derived active ingredients used in the prevention and treatment of atherosclerosis, as well as associated atherosclerotic risk factors. We provide a summary of the mechanisms of action, epidemiological analyses, and studies of various components of spice used in the clinic, animal models, and cell lines related to atherosclerosis. Most notably, we focused on mechanisms of action by which these spice-derived compounds elicit their lipid-lowering, anti-inflammatory, antioxidant, and immunomodulatory prop...

Circulation, 2010

Background— Heme oxygenase-1 (HO-1) is an inducible stress-response protein that imparts antioxid... more Background— Heme oxygenase-1 (HO-1) is an inducible stress-response protein that imparts antioxidant and antiapoptotic effects. However, its pathophysiological role in cardiac remodeling and chronic heart failure (HF) is unknown. We hypothesized that induction of HO-1 in HF alleviates pathological remodeling. Methods and Results— Adult male nontransgenic and myocyte-restricted HO-1 transgenic mice underwent either sham operation or coronary ligation to induce HF. Four weeks after ligation, nontransgenic HF mice exhibited postinfarction left ventricular (LV) remodeling and dysfunction, hypertrophy, fibrosis, oxidative stress, apoptosis, and reduced capillary density, associated with a 2-fold increase in HO-1 expression in noninfarcted myocardium. Compared with nontransgenic mice, HO-1 transgenic HF mice exhibited significantly ( P <0.05) improved postinfarction survival (94% versus 57%) and less LV dilatation (end-diastolic volume, 46±8 versus 85±32 μL), mechanical dysfunction (ej...

Chemistry of Natural Compounds, 2011

Avicenna Journal of Phytomedicine, 2022

Objective: The effect of lavender syrup on COVID-19-induced olfactory dysfunction (OD) has been a... more Objective: The effect of lavender syrup on COVID-19-induced olfactory dysfunction (OD) has been assessed in this study. Materials and Methods: This pilot clinical trial was conducted in Gonbad-E-Kavoos (Golestan province, Iran). Twenty-three outpatients with COVID-19 and OD in lavender group took 9 ml of lavender syrup/bid for 3 weeks along with the standard COVID-19 treatments and 20 patients in control group took only standard COVID-19 treatments. The severity of OD was assessed by the visual analogue scale (VAS). Data analysis was performed by Friedman and Mann-Whitney tests using SPSS software. Results: The mean± standard deviation of age was 36.6±9.1, and 42.6±10.4 years (p=0.05), and the duration of symptoms was 7.4±3.5, and 7.5±3.4 days (p=0.98) in the lavender and control group, respectively. The VAS score for OD decreased from 6.8±3.04 to 0.26±0.86 in the lavender group and from 5.3±3.4 to 1±2.61 in the control group. Although, VAS for OD was significantly decreased in both...

Arabian Journal of Chemistry

In the novel SARS-CoV-2 (COVID-19) as a global emergency event, the main reason of the cardiac in... more In the novel SARS-CoV-2 (COVID-19) as a global emergency event, the main reason of the cardiac injury from COVID-19 is angiotensin-converting enzyme 2 (ACE2) targeting in SARS-CoV-2 infection. The inhibition of ACE2 induces an increase in the angiotensin II (Ang II) and the angiotensin II receptor type 1 (AT1R) leading to impaired cardiac function or cardiac inflammatory responses. The ethyl acetate fraction of Potentilla reptans L. root can rescue heart dysfunction, oxidative stress, cardiac arrhythmias and apoptosis. Therefore, isolated components of P. reptans evaluated to identify natural anti-SARS-CoV-2 agents via molecular docking. In silico molecular docking study were carried out using the Auto Dock software on the isolated compounds of Potentilla reptans root. The protein targets of selective ACE and others obtained from Protein Data Bank (PDB). The best binding pose between amino acid residues involved in active site of the targets and compounds was discovered via molecular docking. Furthermore, ADMET properties of the compounds were evaluated. The triterpenoids of P. reptans showed more ACE inhibitory potential than catechin in both domains. They were selective on the nACE domain, especially compound 5. Also, the compound 5 & 6 had the highest binding affinity toward active site of nACE, cACE, AT1R, ACE2, and TNF-α receptors. Meanwhile, compound 3 showed more activity to inhibit TXA2. Drug likeness and ADMET analysis showed that the compounds passed the criteria of drug likeness and Lipinski rules. The current study depicted that P. reptans root showed cardioprotective effect in COVID-19 infection and manipulation of angiotensin II-induced side effects.

Journal of Islamic and Iranian Traditional Medicine, May 10, 2020

Iranian Journal of Pharmaceutical Research : IJPR, 2021

The anticancer and immunomodulatory effects of medicinal plants from Golestan province, as a prom... more The anticancer and immunomodulatory effects of medicinal plants from Golestan province, as a promising source of cancer therapy against gastrointestinal cancer cell lines, were investigated in this study. The ethanolic root/aerial part extracts of 9 medicinal plants were screened for their cytotoxicity against normal mouse fibroblast cells (L-929) and three human cancer cell lines including gastric adenocarcinoma (AGS), colorectal adenocarcinoma (HT-29), and esophagus adenocarcinoma (KYSE-30) by performing MTT assay to determine the IC50 of the extracts. The in-vitro antioxidant activity, total phenolic (TPC), and total flavonoid content (TFC) of extracts was evaluated. Flow cytometry and Real-Time PCR were used for apoptosis assay and evaluation of expression of some genes involved in cell signaling; TLR-4, AKT, ERK1/2, and NFκB. Out of the 9 plant extracts screened, Arctiumlappa root (ALR), showed the most potent cytotoxicity against AGS, KYSE-30, and HT-29 cells with IC50 values ...

Archives of Anesthesia and Critical Care, 2022