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Research paper thumbnail of Anomalias dentárias associadas: o ortodontista decodificando a genética que rege os distúrbios de desenvolvimento dentário

Dental Press Journal of Orthodontics, Apr 1, 2010

Research paper thumbnail of Editor's Comment and Q&A

American Journal of Orthodontics and Dentofacial Orthopedics, Jun 1, 2010

ABSTRACT

Research paper thumbnail of Agenesis of maxillary lateral incisors and associated dental anomalies

American Journal of Orthodontics and Dentofacial Orthopedics, Jun 1, 2010

The objectives of this study were to evaluate the prevalence of dental anomalies in patients with... more The objectives of this study were to evaluate the prevalence of dental anomalies in patients with agenesis of maxillary lateral incisors and to compare the findings with the prevalence of these anomalies in the general population. Methods: A sample of 126 patients, aged 7 to 35 years, with agenesis of at least 1 maxillary lateral incisor was selected. Panoramic and periapical radiographs and dental casts were used to analyze other associated dental anomalies, including agenesis of other permanent teeth, ectopia of unerupted permanent teeth, microdontia of maxillary lateral incisors, and supernumerary teeth. The occurrence of these anomalies was compared with prevalence data previously reported for the general population. Statistical testing was performed with the chi-square test (P \0.05) and the odds ratio. Results: Patients with maxillary lateral incisor agenesis had a significantly increased prevalence rate of permanent tooth agenesis (18.2%), excluding the third molars. The occurrence of third-molar agenesis in a subgroup aged 14 years or older (n 5 76) was 35.5%. The frequencies of maxillary second premolar agenesis (10.3%), mandibular second premolar agenesis (7.9%), microdontia of maxillary lateral incisors (38.8%), and distoangulation of mandibular second premolars (3.9%) were significantly increased in our sample compared with the general population. In a subgroup of patients aged 10 years or older (n 5 115), the prevalence of palatally displaced canines was elevated (5.2%). The prevalences of mesioangulation of mandibular second molars and supernumerary teeth were not higher in the sample. Conclusions: Permanent tooth agenesis, maxillary lateral incisor microdontia, palatally displaced canines, and distoangulation of mandibular second premolars are frequently associated with maxillary lateral incisor agenesis, providing additional evidence of a genetic interrelationship in the causes of these dental anomalies.

Research paper thumbnail of Epidemiological investigation of second premolar agenesis and its relationship with agenesis of other permanent teeth

Revista de Odontologia da Universidade Cidade de São Paulo, Dec 14, 2017

Research paper thumbnail of Anomalias dentárias associadas: o ortodontista decodificando a genética que rege os distúrbios de desenvolvimento dentário

Dental Press Journal of Orthodontics, 2010

O presente trabalho versa sobre o diagnóstico e a abordagem ortodôntica das anomalias dentárias, ... more O presente trabalho versa sobre o diagnóstico e a abordagem ortodôntica das anomalias dentárias, enfatizando os aspectos etiológicos que definem tais irregularidades de desenvolvimento. Parece existir uma inter-relação genética na determinação de algumas dessas anomalias, considerando-se a alta frequência de associações. Um mesmo defeito genético pode originar diferentes manifestações fenotípicas, incluindo agenesias, microdontias, ectopias e atraso no desenvolvimento dentário. As implicações clínicas das anomalias dentárias associadas são muito relevantes, uma vez que o diagnóstico precoce de uma determinada anomalia dentária pode alertar o clínico sobre a possibilidade de desenvolvimento de outras anomalias associadas no mesmo paciente ou em outros membros da família, permitindo a intervenção ortodôntica em época oportuna.

Research paper thumbnail of Estudo epidemiológico da agenesia de segundos pré-molares e sua relação com a agenesia de outros dentes permanentes; Epidemiological investigation of second premolar agenesis and its relationship with agenesis of other permanent teeth

Research paper thumbnail of Tooth-color assessment after orthodontic treatment: The fundamental role of evidence-based medicine

American Journal of Orthodontics and Dentofacial Orthopedics, 2011

Long-term stability of surgical-orthodontic open bite treatment: Le Fort I versus 4-piece segment... more Long-term stability of surgical-orthodontic open bite treatment: Le Fort I versus 4-piece segmental Le Fort I osteotomy Introduction: This vertical malocclusion has the potential of causing functional and esthetic impairment, impacting patients´ quality of life negatively. The long-term stability of anterior open bite surgical-orthodontic treatment is an important and controversial issue. A variety of factors such as surgery type, surgery fixation, and the anteroposterior discrepancy is related to and can influence long-term overbite stability. The controversy of stability arises in the inherent difficulty of collecting a homogeneous sample, with considerable sample size and adequate long-term followup, leading the current literature to an inconclusive status. Therefore this thesis aimed to test 2 null hypotheses: 1-There is no difference in the long-term stability of the surgical-orthodontic correction of anterior open bite when comparing Le Fort I to 4-piece segmental Le Fort I osteotomies. 2-To test the null hypothesis that there is no difference in the long-term stability of the surgical-orthodontic correction of anterior open bite when comparing Class II to Class III patients. Materials and Methods: The sample of the first investigation comprised the lateral cephs of 29 open bite subjects treated with 1-piece Lefort I osteotomy compared to the lateral cephs of 24 open bite subjects treated with 4-piece Lefort I osteotomy; in both groups Class I, II and III subjects were included. The groups were matched regarding age and were compared with t-tests. To test the second null hypothesis, lateral cephs of 21 Class II open bite subjects were compared to lateral cephs of 25 Class III open bite subjects. Overbite changes were compared at 3-time points: T1 (pretreatment), T2 (posttreatment) and T3 (follow-up) by using t-test. Overbite clinical stability percentage at T3 was assessed with the chi-square test. Results: In 1-piece Le Fort I Group 65.52% of patients presented with clinically significant overbite stability, while in 4-piece Group 83.33% remained stable in the long-term, however it was not statistically significant. In Class II Group 57.14% of patients presented with clinically significant overbite stability, while in Class III Group 88% remained clinically stable, and it was statistically significant. Conclusions: The first null hypothesis regarding maxillary segmentation was accepted because there was no significant intergroup difference regarding the percentage of clinically stable patients. The type of fixation seems to influence the long-term stability of open bite surgical-orthodontic correction more than maxillary segmentation. The second null hypothesis was rejected because clinical stability of Class II malocclusion open bite surgical-orthodontic treatment was significantly smaller than in Class III malocclusions.

Research paper thumbnail of Agenesis of maxillary lateral incisors and associated dental anomalies

American Journal of Orthodontics and Dentofacial Orthopedics, 2010

The objectives of this study were to evaluate the prevalence of dental anomalies in patients with... more The objectives of this study were to evaluate the prevalence of dental anomalies in patients with agenesis of maxillary lateral incisors and to compare the findings with the prevalence of these anomalies in the general population. Methods: A sample of 126 patients, aged 7 to 35 years, with agenesis of at least 1 maxillary lateral incisor was selected. Panoramic and periapical radiographs and dental casts were used to analyze other associated dental anomalies, including agenesis of other permanent teeth, ectopia of unerupted permanent teeth, microdontia of maxillary lateral incisors, and supernumerary teeth. The occurrence of these anomalies was compared with prevalence data previously reported for the general population. Statistical testing was performed with the chi-square test (P \0.05) and the odds ratio. Results: Patients with maxillary lateral incisor agenesis had a significantly increased prevalence rate of permanent tooth agenesis (18.2%), excluding the third molars. The occurrence of third-molar agenesis in a subgroup aged 14 years or older (n 5 76) was 35.5%. The frequencies of maxillary second premolar agenesis (10.3%), mandibular second premolar agenesis (7.9%), microdontia of maxillary lateral incisors (38.8%), and distoangulation of mandibular second premolars (3.9%) were significantly increased in our sample compared with the general population. In a subgroup of patients aged 10 years or older (n 5 115), the prevalence of palatally displaced canines was elevated (5.2%). The prevalences of mesioangulation of mandibular second molars and supernumerary teeth were not higher in the sample. Conclusions: Permanent tooth agenesis, maxillary lateral incisor microdontia, palatally displaced canines, and distoangulation of mandibular second premolars are frequently associated with maxillary lateral incisor agenesis, providing additional evidence of a genetic interrelationship in the causes of these dental anomalies.

Research paper thumbnail of Anomalias dentárias associadas: o ortodontista decodificando a genética que rege os distúrbios de desenvolvimento dentário

Dental Press Journal of Orthodontics, Apr 1, 2010

Research paper thumbnail of Editor's Comment and Q&A

American Journal of Orthodontics and Dentofacial Orthopedics, Jun 1, 2010

ABSTRACT

Research paper thumbnail of Agenesis of maxillary lateral incisors and associated dental anomalies

American Journal of Orthodontics and Dentofacial Orthopedics, Jun 1, 2010

The objectives of this study were to evaluate the prevalence of dental anomalies in patients with... more The objectives of this study were to evaluate the prevalence of dental anomalies in patients with agenesis of maxillary lateral incisors and to compare the findings with the prevalence of these anomalies in the general population. Methods: A sample of 126 patients, aged 7 to 35 years, with agenesis of at least 1 maxillary lateral incisor was selected. Panoramic and periapical radiographs and dental casts were used to analyze other associated dental anomalies, including agenesis of other permanent teeth, ectopia of unerupted permanent teeth, microdontia of maxillary lateral incisors, and supernumerary teeth. The occurrence of these anomalies was compared with prevalence data previously reported for the general population. Statistical testing was performed with the chi-square test (P \0.05) and the odds ratio. Results: Patients with maxillary lateral incisor agenesis had a significantly increased prevalence rate of permanent tooth agenesis (18.2%), excluding the third molars. The occurrence of third-molar agenesis in a subgroup aged 14 years or older (n 5 76) was 35.5%. The frequencies of maxillary second premolar agenesis (10.3%), mandibular second premolar agenesis (7.9%), microdontia of maxillary lateral incisors (38.8%), and distoangulation of mandibular second premolars (3.9%) were significantly increased in our sample compared with the general population. In a subgroup of patients aged 10 years or older (n 5 115), the prevalence of palatally displaced canines was elevated (5.2%). The prevalences of mesioangulation of mandibular second molars and supernumerary teeth were not higher in the sample. Conclusions: Permanent tooth agenesis, maxillary lateral incisor microdontia, palatally displaced canines, and distoangulation of mandibular second premolars are frequently associated with maxillary lateral incisor agenesis, providing additional evidence of a genetic interrelationship in the causes of these dental anomalies.

Research paper thumbnail of Epidemiological investigation of second premolar agenesis and its relationship with agenesis of other permanent teeth

Revista de Odontologia da Universidade Cidade de São Paulo, Dec 14, 2017

Research paper thumbnail of Anomalias dentárias associadas: o ortodontista decodificando a genética que rege os distúrbios de desenvolvimento dentário

Dental Press Journal of Orthodontics, 2010

O presente trabalho versa sobre o diagnóstico e a abordagem ortodôntica das anomalias dentárias, ... more O presente trabalho versa sobre o diagnóstico e a abordagem ortodôntica das anomalias dentárias, enfatizando os aspectos etiológicos que definem tais irregularidades de desenvolvimento. Parece existir uma inter-relação genética na determinação de algumas dessas anomalias, considerando-se a alta frequência de associações. Um mesmo defeito genético pode originar diferentes manifestações fenotípicas, incluindo agenesias, microdontias, ectopias e atraso no desenvolvimento dentário. As implicações clínicas das anomalias dentárias associadas são muito relevantes, uma vez que o diagnóstico precoce de uma determinada anomalia dentária pode alertar o clínico sobre a possibilidade de desenvolvimento de outras anomalias associadas no mesmo paciente ou em outros membros da família, permitindo a intervenção ortodôntica em época oportuna.

Research paper thumbnail of Estudo epidemiológico da agenesia de segundos pré-molares e sua relação com a agenesia de outros dentes permanentes; Epidemiological investigation of second premolar agenesis and its relationship with agenesis of other permanent teeth

Research paper thumbnail of Tooth-color assessment after orthodontic treatment: The fundamental role of evidence-based medicine

American Journal of Orthodontics and Dentofacial Orthopedics, 2011

Long-term stability of surgical-orthodontic open bite treatment: Le Fort I versus 4-piece segment... more Long-term stability of surgical-orthodontic open bite treatment: Le Fort I versus 4-piece segmental Le Fort I osteotomy Introduction: This vertical malocclusion has the potential of causing functional and esthetic impairment, impacting patients´ quality of life negatively. The long-term stability of anterior open bite surgical-orthodontic treatment is an important and controversial issue. A variety of factors such as surgery type, surgery fixation, and the anteroposterior discrepancy is related to and can influence long-term overbite stability. The controversy of stability arises in the inherent difficulty of collecting a homogeneous sample, with considerable sample size and adequate long-term followup, leading the current literature to an inconclusive status. Therefore this thesis aimed to test 2 null hypotheses: 1-There is no difference in the long-term stability of the surgical-orthodontic correction of anterior open bite when comparing Le Fort I to 4-piece segmental Le Fort I osteotomies. 2-To test the null hypothesis that there is no difference in the long-term stability of the surgical-orthodontic correction of anterior open bite when comparing Class II to Class III patients. Materials and Methods: The sample of the first investigation comprised the lateral cephs of 29 open bite subjects treated with 1-piece Lefort I osteotomy compared to the lateral cephs of 24 open bite subjects treated with 4-piece Lefort I osteotomy; in both groups Class I, II and III subjects were included. The groups were matched regarding age and were compared with t-tests. To test the second null hypothesis, lateral cephs of 21 Class II open bite subjects were compared to lateral cephs of 25 Class III open bite subjects. Overbite changes were compared at 3-time points: T1 (pretreatment), T2 (posttreatment) and T3 (follow-up) by using t-test. Overbite clinical stability percentage at T3 was assessed with the chi-square test. Results: In 1-piece Le Fort I Group 65.52% of patients presented with clinically significant overbite stability, while in 4-piece Group 83.33% remained stable in the long-term, however it was not statistically significant. In Class II Group 57.14% of patients presented with clinically significant overbite stability, while in Class III Group 88% remained clinically stable, and it was statistically significant. Conclusions: The first null hypothesis regarding maxillary segmentation was accepted because there was no significant intergroup difference regarding the percentage of clinically stable patients. The type of fixation seems to influence the long-term stability of open bite surgical-orthodontic correction more than maxillary segmentation. The second null hypothesis was rejected because clinical stability of Class II malocclusion open bite surgical-orthodontic treatment was significantly smaller than in Class III malocclusions.

Research paper thumbnail of Agenesis of maxillary lateral incisors and associated dental anomalies

American Journal of Orthodontics and Dentofacial Orthopedics, 2010

The objectives of this study were to evaluate the prevalence of dental anomalies in patients with... more The objectives of this study were to evaluate the prevalence of dental anomalies in patients with agenesis of maxillary lateral incisors and to compare the findings with the prevalence of these anomalies in the general population. Methods: A sample of 126 patients, aged 7 to 35 years, with agenesis of at least 1 maxillary lateral incisor was selected. Panoramic and periapical radiographs and dental casts were used to analyze other associated dental anomalies, including agenesis of other permanent teeth, ectopia of unerupted permanent teeth, microdontia of maxillary lateral incisors, and supernumerary teeth. The occurrence of these anomalies was compared with prevalence data previously reported for the general population. Statistical testing was performed with the chi-square test (P \0.05) and the odds ratio. Results: Patients with maxillary lateral incisor agenesis had a significantly increased prevalence rate of permanent tooth agenesis (18.2%), excluding the third molars. The occurrence of third-molar agenesis in a subgroup aged 14 years or older (n 5 76) was 35.5%. The frequencies of maxillary second premolar agenesis (10.3%), mandibular second premolar agenesis (7.9%), microdontia of maxillary lateral incisors (38.8%), and distoangulation of mandibular second premolars (3.9%) were significantly increased in our sample compared with the general population. In a subgroup of patients aged 10 years or older (n 5 115), the prevalence of palatally displaced canines was elevated (5.2%). The prevalences of mesioangulation of mandibular second molars and supernumerary teeth were not higher in the sample. Conclusions: Permanent tooth agenesis, maxillary lateral incisor microdontia, palatally displaced canines, and distoangulation of mandibular second premolars are frequently associated with maxillary lateral incisor agenesis, providing additional evidence of a genetic interrelationship in the causes of these dental anomalies.