bhavya bhavya - Academia.edu (original) (raw)

Papers by bhavya bhavya

Research paper thumbnail of Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes

The SARS-CoV-2 viral genome is mutating and evolving into new variations, including the recently ... more The SARS-CoV-2 viral genome is mutating and evolving into new variations, including the recently discovered Delta and Omicron. In this study, we used and evaluated our notion of differential targeting of SARS-CoV-2 variant genomes by microRNAs (miRNAs) of the infected human pancreas. We discovered that even with UTR mutations, the Delta, Omicron, and original Wuhan variations' genomes would be differentially targeted by the host pancreas cell's native miRNAs in the same way. The miRNAs have a distinct Minimal Free Energy (MFE) with the different viral types' genomes, but they are nonetheless responsible for the activation of Diabetes-associated genes.

Research paper thumbnail of Covid 19 Impact on Multi Ethnic Communities and Perspectives on Vaccine Acceptability

Annals of Behavioral Medicine, 2021

Research paper thumbnail of Parathyroid Adenoma with Unusual Clinical Features

Journal of Evolution of Medical and Dental Sciences, 2020

Research paper thumbnail of A Retrospective Analysis of Efficacy of Hemoadsorption (Cytosorb®) in Refractory Septic Shock Patients as an Adjuvant

INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2019

Dysregulated response of cytokines can result in hyper-inflammatory conditions called cytokine st... more Dysregulated response of cytokines can result in hyper-inflammatory conditions called cytokine storm,commonly seen in sepsis and septic shock..The current study assessed hemoadsorption device - CytoSorb® for its efficiency as an adjuvant in treating patients suffering from septic shock. Total 8 patients enrolled were subjected to hemoadsorption therapy along with the standard treatment.The results of the study revealed significant improvement in clinical and haemodynamic parameters before and after initiation of CytoSorb® therapy. Out of 8 patients, 6 showed a positive outcome while 2 did not survive.The results of this study show that the use of hemoadsorption therapy can be considered in critically ill ICU patients as a safe and effective adjuvant therapy along with the standard treatment for a better outcome in patients.

Research paper thumbnail of The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole

Research paper thumbnail of Succenturiate Placenta: An Incidental Finding During Cesarean Section

A 30 years, 4th Gravida with 3 abortions with history of 8 months amenorrhea was admitted to the ... more A 30 years, 4th Gravida with 3 abortions with history of 8 months amenorrhea was admitted to the hospital with chief complaints of leaking per vagina since 4 hours and was not associated with pain abdomen or bleeding per vaginum. Perceiving decreased fetal movements since 6 hours. She had 3 previous missed abortions followed by D and E. In the present pregnancy, gestational age was 32 weeks at the time of admission. Patient's general condition was stable, all other investigation were found to be normal her pulse was 100 beats/min, tachycardia present, BP-100/70mmHg. On obstetric examination, uterus was 30 weeks size, 1-2 contraction lasting for 15-20 seconds, Breech presentation, FHR was 124 per minute, regular, decreased liquor clinically. On vulvovaginal examination-Frank leaking per vagina present. Ultrasound showed single live intrauterine pregnancy of 29 weeks 3 days with breech presentation with oligohydramnios, Placenta was at fundal region, Biophysical profile was 6/8, FHR 124 bpm. After taking high risk consent in view of fetal prematurity, patient was posted for Emergency LSCS. And extracted a single live preterm female baby of weight of 1.45 kg by breech. During the cesarean section, on opening abdomen lower segment was found to be congested with torturous vessels. So we suspected missed diagnosis of placenta previa. After delivery of the baby, we found succenturiate lobe of the placenta occupying lower uterine segment with vessels running across the membrane.

Research paper thumbnail of Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes

The SARS-CoV-2 viral genome is mutating and evolving into new variations, including the recently ... more The SARS-CoV-2 viral genome is mutating and evolving into new variations, including the recently discovered Delta and Omicron. In this study, we used and evaluated our notion of differential targeting of SARS-CoV-2 variant genomes by microRNAs (miRNAs) of the infected human pancreas. We discovered that even with UTR mutations, the Delta, Omicron, and original Wuhan variations' genomes would be differentially targeted by the host pancreas cell's native miRNAs in the same way. The miRNAs have a distinct Minimal Free Energy (MFE) with the different viral types' genomes, but they are nonetheless responsible for the activation of Diabetes-associated genes.

Research paper thumbnail of Covid 19 Impact on Multi Ethnic Communities and Perspectives on Vaccine Acceptability

Annals of Behavioral Medicine, 2021

Research paper thumbnail of Parathyroid Adenoma with Unusual Clinical Features

Journal of Evolution of Medical and Dental Sciences, 2020

Research paper thumbnail of A Retrospective Analysis of Efficacy of Hemoadsorption (Cytosorb®) in Refractory Septic Shock Patients as an Adjuvant

INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2019

Dysregulated response of cytokines can result in hyper-inflammatory conditions called cytokine st... more Dysregulated response of cytokines can result in hyper-inflammatory conditions called cytokine storm,commonly seen in sepsis and septic shock..The current study assessed hemoadsorption device - CytoSorb® for its efficiency as an adjuvant in treating patients suffering from septic shock. Total 8 patients enrolled were subjected to hemoadsorption therapy along with the standard treatment.The results of the study revealed significant improvement in clinical and haemodynamic parameters before and after initiation of CytoSorb® therapy. Out of 8 patients, 6 showed a positive outcome while 2 did not survive.The results of this study show that the use of hemoadsorption therapy can be considered in critically ill ICU patients as a safe and effective adjuvant therapy along with the standard treatment for a better outcome in patients.

Research paper thumbnail of The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole

Research paper thumbnail of Succenturiate Placenta: An Incidental Finding During Cesarean Section

A 30 years, 4th Gravida with 3 abortions with history of 8 months amenorrhea was admitted to the ... more A 30 years, 4th Gravida with 3 abortions with history of 8 months amenorrhea was admitted to the hospital with chief complaints of leaking per vagina since 4 hours and was not associated with pain abdomen or bleeding per vaginum. Perceiving decreased fetal movements since 6 hours. She had 3 previous missed abortions followed by D and E. In the present pregnancy, gestational age was 32 weeks at the time of admission. Patient's general condition was stable, all other investigation were found to be normal her pulse was 100 beats/min, tachycardia present, BP-100/70mmHg. On obstetric examination, uterus was 30 weeks size, 1-2 contraction lasting for 15-20 seconds, Breech presentation, FHR was 124 per minute, regular, decreased liquor clinically. On vulvovaginal examination-Frank leaking per vagina present. Ultrasound showed single live intrauterine pregnancy of 29 weeks 3 days with breech presentation with oligohydramnios, Placenta was at fundal region, Biophysical profile was 6/8, FHR 124 bpm. After taking high risk consent in view of fetal prematurity, patient was posted for Emergency LSCS. And extracted a single live preterm female baby of weight of 1.45 kg by breech. During the cesarean section, on opening abdomen lower segment was found to be congested with torturous vessels. So we suspected missed diagnosis of placenta previa. After delivery of the baby, we found succenturiate lobe of the placenta occupying lower uterine segment with vessels running across the membrane.