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Papers by bilal santoso

Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS), 2021

Tingkat kepuasan pasien terhadap sebuah pelayanan kefarmasian di apotek harus selalu diperbarui a... more Tingkat kepuasan pasien terhadap sebuah pelayanan kefarmasian di apotek harus selalu diperbarui atau dievaluasi minimal 6 bulan sekali, tak terkecuali Apotek Kimia Farma 36 Ijen. Pelayanan kefarmasian menurut Permenkes No.73 Tahun 2016 adalah suatu pelayanan langsung dan bertanggung jawab kepada pasien yang berkaitan dengan sediaan farmasi yang bertujuan untuk mencapai hasil yang pasti agar meningkatkan mutu kehidupan pasien. Tujuan penelitian ini adalah untuk mengetahui kepuasan pasien terhadap pelayanan kefarmasian di Apotek Kimia Farma 36 Ijen. Metode penelitian yang digunakan adalah penelitian deskriptif melalui penyebaran kuesioner untuk mengukur kepuasan pasien menggunakan model SERVQUAL (Service Quality) dengan teknik incidental sampling. Hasil penelitian menyatakan bahwa analisis Gap memiliki nilai negatif yang berarti pasien tidak puas dengan pelayanan kefarmasian di Apotek Kimia Farma 36 Ijen. Dimensi yang mempunyai kepuasan tertinggi secara berturut-turut yaitu emphaty, r...

Jurnal Farmasi Sains dan Praktis, 2022

Herbal medicine as a traditional medicine based on local wisdom in the Covid 19 pandemic is the a... more Herbal medicine as a traditional medicine based on local wisdom in the Covid 19 pandemic is the alternative for the community to keep the health of the body. Specific drugs for the cure of Covid-19 disease have also not been found yet so the death of Covid-19 patients remainsat anytime. In this case this study aims to know the content of secondary metabolite compounds and radical scavenger activity of “kayu jawa” (L. coromandelica) leaf steeping and “Salam” (S. polyanthum) leaves from Southeast Sulawesi as well as their rational combination based on the radical scavenger activity of DPPH (2,2-difenyl-1-picrilhydrazil). The analysis of the content of secondary metabolite compounds in the steeping of DKJ (Daun Kayu Jawa) and DS (Daun Salam) is applied by phytochemical method and radical scavenger activity is determined by the DPPH method. The main focus of steeping is determined by the approach of the picnometer. The combination of DKJ and DS is made each with 6 variations based on th...

Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ), Dec 30, 2020

Kersen (Muntingia calabura) leaf is a kersen plant parts are usually processed by the community i... more Kersen (Muntingia calabura) leaf is a kersen plant parts are usually processed by the community into traditional medicine in the form of a drink by boiling. The boiling process that is too long allows the secondary metabolite compounds contained in kersen leaf to be damaged or reduced, therefore it is necessary to do a screening test of secondary metabolites of decoction of kersen leaf, besides plants containing secondary metabolites can be toxic, so that testing needs to be done components of chemical compounds that have toxic activity. The aims of this study was to know the minimum concentration of acute toxic and component of decoction of kersen leaf. Toxicity testing was carried out using the BSLT method (Brine shrimp lethality test) with test animals using Artemia salina Leach larvae in each treatment with various concentrations

Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ)

ABSTRACTAnnona muricata is a family of Annonaceae that has been known as a medicinal plant. Sirsa... more ABSTRACTAnnona muricata is a family of Annonaceae that has been known as a medicinal plant. Sirsakleaves contain alkaloids, tannins, and several other chemical contents including acetogenin.The aim of this study was to determine the acute toxicity of the infusion of Sirsak leaves onthe Artemia salina larvae by the Brine Shirmp Lethality Test (BSLT) method. This experimentalstudy used 5 treatment concentrations (10 mg/L, 50 mg/L, 100 mg/L, 500 mg/L, 1000mg/L) and 1 negative control. All treatments were repeated 3 times. The number of Artemiasalina larvae used for each concentration was 10 larvae. The number of dead larvae wascounted after 24 hours of treatment. Based on probit analysis, the LC50 value of Sirsak leafinfusion was 38,73 mg/L. The conclusion of this research is the infusion of Sirsak leaves istoxic.Keywords: Sirsak leaves, toxicity, BSLTABSTRAKSirsak (Annona muricata) adalah keluarga Annonaceae yang telah dikenal sebagai tanamanobat. Daun Sirsak mengandung alkaloid, tani...

PERBANDINGAN AKTIVITAS ANTIOKSIDAN ANTARA JUS BUAH MENGKUDU ( Morinda citrifolia ) DAN JUS RIMPAN... more PERBANDINGAN AKTIVITAS ANTIOKSIDAN ANTARA JUS BUAH MENGKUDU ( Morinda citrifolia ) DAN JUS RIMPANG TEMULAWAK ( Curcuma xanthorrhiza ) Bilal SA Santoso 1,4) , Sudarsono 2) , Agung E Nugroho 3) , Yosi B Murti 2) 1) Prodi Doktor Ilmu Farmasi, Fakultas Farmasi Universitas Gadjah Mada, 55281 2) Dept. Biologi Farmasi, Fakultas Farmasi Universitas Gadjah Mada, 55281 3) Dept. Farmakologi & Farmasi Klinik, Fakultas Farmasi Universitas Gadjah Mada, 55281 4) Akademi Farmasi Putra Indonesia Malang, 66126 Koresponden: bilalsas67@gmail.com ABSTRACT The purpose of this study was comparisoned antioxidant activity of mengkudu fruit juice and temulawak rhizome juice. The begin of this study were made mengkudu fruit juice and temulawak rhizome juice by juice extractor. These juices were diluted to various concentration and determined their antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The result showed that mengkudu fruit juice and temulawak rhizome juice had antioxidant activ...

Jamu lancar haid merek “x” merupakan salah satu jamu yang ada di indonesia yang berkhasiat melanc... more Jamu lancar haid merek “x” merupakan salah satu jamu yang ada di indonesia yang berkhasiat melancarkan haid dan nyeri haid mengandung ekstrak rimpang kunyit, rimpang kencur, kapulaga, kulit kayu manis, asam jawa. Penelitian ini bertujuan untuk mengetahui profil fitokimia jamu lancar haid merek “x”. Jenis penelitian ini merupakan penelitian deskriptif. Tahapan penelitian meliputi pembuatan ekstrak menggunakan metode maserasi pelarut etanol 70%, selanjutnya ekstrak kental diuji skrining fitokimia dan kromatografi lapis tipis, didapatkan hasil skrining fitokimia dari jamu lancar haid merek “x” positif flavonoid, saponin, triterpen.dan dari hasil kromatografi lapis tipis didapatkan bercak yang sama dengan farmakope herbal indonesia. Dari penelitian ini dapat disimpulkan bahwa jamu lancar haid merk “x” mengandung ekstrak rimpang kunyit, rimpang kencur, kapulaga, kulit kayu manis, asam jawa. Kata kunci : Profil fitokimia Jamu lancar haid merek “x”, Kromatografi lapis tipis.

Mengkudu fruit ( Morinda citifolia L.) is one of plants which has been known and used by indonesi... more Mengkudu fruit ( Morinda citifolia L.) is one of plants which has been known and used by indonesian society as traditional medicine. This plant contains alkaloid, phenol, steroid, and flavonoid which can cause toxicity. The aim of this study was to know about acute toxicity of mengkudu fruit infusions using brine shrimp lethality test method which will be indicated by LC50 value. This research was experimental research using post test only control group design that used negative control and 5 concentrations of infusion those are 1000 mg/L, 500 mg/L, 100 mg/L, 50 mg/L, and 10 mg/L. Death of larvae observed 24 hours after giving the infusiona. LC50 of mengkudu fruit infusion is 62,3 mg/L. The result of this study showed that mengkudu fruit infusions cause toxic effect. Keywords : Noni Fruit, Toxycity, Brine Shrimp Lethality Test, LC50 ABSTRAK Buah mengkudu ( Morinda citrifolia L.) merupakan salah satu tanaman yang banyak dikenal dan digunakan oleh masyarakat sebagai obat tradisional. ...

Ethyl p-methoxycinnamate effectively inhibit the growth of cancer through a mechanism related to ... more Ethyl p-methoxycinnamate effectively inhibit the growth of cancer through a mechanism related to cell cycle regulation and apoptosis induction. We determined Kaempferia galanga that containing ethyl p-methoxycinnamate can increase the apoptosis activity in colon cancer cells. This study was designed to investigate effect of oil fraction from Kaempferia galanga alcoholic extract on apoptosis activity in mice colon cancer. Dimethylbenz(a)anthracene (DMBA)-induced colon cancer in mice is a useful model to investigate the changes of epithelial cells that occur during colon cancer progression. Colon cancer model was induced six times once a week by oral DMBA 50 mg/kg body weight. Administration of three different doses ethyl p-methoxycinnamate of oil fraction are 7.8 mg/kg, 23.4 mg/kg and 78 mg/kg which given to models during 30 days. Data analysis of immunohistochemical preparations was obtained and processed with one-way ANOVA statistical test, followed with post hoc test. Results show...

POTENSI EKSTRAK UMBI RUMPUT TEKI (Cyperus rotundus L.) SEBAGAI LARVASIDA TERHADAP LARVA NYAMUK Cu... more POTENSI EKSTRAK UMBI RUMPUT TEKI (Cyperus rotundus L.) SEBAGAI LARVASIDA TERHADAP LARVA NYAMUK Culex sp Bilal Subchan Agus Santoso1), Mochammad Haminudin1) 1)Akademi Farmasi Putra Indonesia Malang, Malang 65123. Koresponden: bilalsas67@gmail.com ABSTRACT Cyperus rotundus contains several secondary metabolites. In previous studies of plants containing alkaloid, flavonoid and saponin could be used as larvicide. The purpose of this study was to determine the potential of Cyperus rotundus extract as larvacide and look for the value of Lethal Concentration 50% (LC50) of Cyperus rotundus extract as larvicide on Culex sp. Cyperus rotundus were extracted by maceration method using 95% ethanol. After that phytochemical screening was carried out and testing larvicidal activity on Culex sp. Result showed that the secondary metabolite was alkaloids, flavonoids and saponins. The LC50 value of the Cyperus rotundus extract as larvacide on Culex sp larvae in each sample was 0.291% w/v, 0.335% w/v, ...

Parasetamol mempunyai sifat alir dan kompresibilitas yang kurang baik sehingga pada tabletasi sec... more Parasetamol mempunyai sifat alir dan kompresibilitas yang kurang baik sehingga pada tabletasi secara cetak langsung selalu terjadi "capping”. Dalam penelitian ini sifat tersebut diperbaiki dengan cara parasetamol digranulasi terlebih dr.hulu dengan bahan pengikat. Granul parasetamol dengan bahan pengikat polivinilpirolidon K-90 dan granul parasetamol dengan bahan pengikat metilselulosa ditambah dengan bahan pengisi avicel PH 102 dan pelincir magnesium stearat kemudian dilakukan cetak langsung. Hasil penelitian menunjukkan bahua penambahan bahan pengikat polivinilpirolidon K-90 dan metilselulosa pada berbagai kadar memberikan pengaruh terhadap sifat granul parasetamol yang dihasilkan. Campuran antara masing-maeing granul parasetamol dengan bahan pembawa serta pclincir memberikan karakteristik yang sesuai untuk’ digunakan dalam pembuatan tablet secara cetak langsung. Tablet yang dihasilkan diuji mutu fisiknya. Untuk mengatahui kekuatan daya ikat dari bahan pengikat dilakukan - pe...

INDONESIAN JOURNAL OF PHARMACY

Mengkudu fruit and temulawak rhizome which contains scopoletin and curcumin, respectively, were u... more Mengkudu fruit and temulawak rhizome which contains scopoletin and curcumin, respectively, were used traditionally as antidiabetic. Both compounds have strong antioxidant activity. This research aimed to determined the antihyperglycemic and pancreas protection of combination of mengkudu fruit juice (MFJ) and temulawak rhizome juice (TRJ) on streptozotocin (STZ) induced diabetic rats. Rats were divided into 7 groups, each group consist of 5 rats. All groups, except normal group were treated accordingly for 28 days. Blood samples were taken from the plexus retroorbitalis for examination of blood glucose levels on day-8 th , 15 th , 22 nd , and 29 th. On the day-29 th , blood samples were examined for malondialdehyde (MDA) levels. At the end of the experiment, the rats were sacrificed for examination of pancreatic morphological conditions. The results showed that diabetic rats given MFJ-TRJ combination experienced a significant decrease in blood glucose levels, a significant decrease in MDA levels and improvement pancreas morphology when compared with the negative control group. The conclusion of this research showed the combination of MFJ-TRJ has hypoglycemic activity and can fix condition of pancreas morphology.

Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS), 2021

Tingkat kepuasan pasien terhadap sebuah pelayanan kefarmasian di apotek harus selalu diperbarui a... more Tingkat kepuasan pasien terhadap sebuah pelayanan kefarmasian di apotek harus selalu diperbarui atau dievaluasi minimal 6 bulan sekali, tak terkecuali Apotek Kimia Farma 36 Ijen. Pelayanan kefarmasian menurut Permenkes No.73 Tahun 2016 adalah suatu pelayanan langsung dan bertanggung jawab kepada pasien yang berkaitan dengan sediaan farmasi yang bertujuan untuk mencapai hasil yang pasti agar meningkatkan mutu kehidupan pasien. Tujuan penelitian ini adalah untuk mengetahui kepuasan pasien terhadap pelayanan kefarmasian di Apotek Kimia Farma 36 Ijen. Metode penelitian yang digunakan adalah penelitian deskriptif melalui penyebaran kuesioner untuk mengukur kepuasan pasien menggunakan model SERVQUAL (Service Quality) dengan teknik incidental sampling. Hasil penelitian menyatakan bahwa analisis Gap memiliki nilai negatif yang berarti pasien tidak puas dengan pelayanan kefarmasian di Apotek Kimia Farma 36 Ijen. Dimensi yang mempunyai kepuasan tertinggi secara berturut-turut yaitu emphaty, r...

Jurnal Farmasi Sains dan Praktis, 2022

Herbal medicine as a traditional medicine based on local wisdom in the Covid 19 pandemic is the a... more Herbal medicine as a traditional medicine based on local wisdom in the Covid 19 pandemic is the alternative for the community to keep the health of the body. Specific drugs for the cure of Covid-19 disease have also not been found yet so the death of Covid-19 patients remainsat anytime. In this case this study aims to know the content of secondary metabolite compounds and radical scavenger activity of “kayu jawa” (L. coromandelica) leaf steeping and “Salam” (S. polyanthum) leaves from Southeast Sulawesi as well as their rational combination based on the radical scavenger activity of DPPH (2,2-difenyl-1-picrilhydrazil). The analysis of the content of secondary metabolite compounds in the steeping of DKJ (Daun Kayu Jawa) and DS (Daun Salam) is applied by phytochemical method and radical scavenger activity is determined by the DPPH method. The main focus of steeping is determined by the approach of the picnometer. The combination of DKJ and DS is made each with 6 variations based on th...

Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ), Dec 30, 2020

Kersen (Muntingia calabura) leaf is a kersen plant parts are usually processed by the community i... more Kersen (Muntingia calabura) leaf is a kersen plant parts are usually processed by the community into traditional medicine in the form of a drink by boiling. The boiling process that is too long allows the secondary metabolite compounds contained in kersen leaf to be damaged or reduced, therefore it is necessary to do a screening test of secondary metabolites of decoction of kersen leaf, besides plants containing secondary metabolites can be toxic, so that testing needs to be done components of chemical compounds that have toxic activity. The aims of this study was to know the minimum concentration of acute toxic and component of decoction of kersen leaf. Toxicity testing was carried out using the BSLT method (Brine shrimp lethality test) with test animals using Artemia salina Leach larvae in each treatment with various concentrations

Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ)

ABSTRACTAnnona muricata is a family of Annonaceae that has been known as a medicinal plant. Sirsa... more ABSTRACTAnnona muricata is a family of Annonaceae that has been known as a medicinal plant. Sirsakleaves contain alkaloids, tannins, and several other chemical contents including acetogenin.The aim of this study was to determine the acute toxicity of the infusion of Sirsak leaves onthe Artemia salina larvae by the Brine Shirmp Lethality Test (BSLT) method. This experimentalstudy used 5 treatment concentrations (10 mg/L, 50 mg/L, 100 mg/L, 500 mg/L, 1000mg/L) and 1 negative control. All treatments were repeated 3 times. The number of Artemiasalina larvae used for each concentration was 10 larvae. The number of dead larvae wascounted after 24 hours of treatment. Based on probit analysis, the LC50 value of Sirsak leafinfusion was 38,73 mg/L. The conclusion of this research is the infusion of Sirsak leaves istoxic.Keywords: Sirsak leaves, toxicity, BSLTABSTRAKSirsak (Annona muricata) adalah keluarga Annonaceae yang telah dikenal sebagai tanamanobat. Daun Sirsak mengandung alkaloid, tani...

PERBANDINGAN AKTIVITAS ANTIOKSIDAN ANTARA JUS BUAH MENGKUDU ( Morinda citrifolia ) DAN JUS RIMPAN... more PERBANDINGAN AKTIVITAS ANTIOKSIDAN ANTARA JUS BUAH MENGKUDU ( Morinda citrifolia ) DAN JUS RIMPANG TEMULAWAK ( Curcuma xanthorrhiza ) Bilal SA Santoso 1,4) , Sudarsono 2) , Agung E Nugroho 3) , Yosi B Murti 2) 1) Prodi Doktor Ilmu Farmasi, Fakultas Farmasi Universitas Gadjah Mada, 55281 2) Dept. Biologi Farmasi, Fakultas Farmasi Universitas Gadjah Mada, 55281 3) Dept. Farmakologi & Farmasi Klinik, Fakultas Farmasi Universitas Gadjah Mada, 55281 4) Akademi Farmasi Putra Indonesia Malang, 66126 Koresponden: bilalsas67@gmail.com ABSTRACT The purpose of this study was comparisoned antioxidant activity of mengkudu fruit juice and temulawak rhizome juice. The begin of this study were made mengkudu fruit juice and temulawak rhizome juice by juice extractor. These juices were diluted to various concentration and determined their antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The result showed that mengkudu fruit juice and temulawak rhizome juice had antioxidant activ...

Jamu lancar haid merek “x” merupakan salah satu jamu yang ada di indonesia yang berkhasiat melanc... more Jamu lancar haid merek “x” merupakan salah satu jamu yang ada di indonesia yang berkhasiat melancarkan haid dan nyeri haid mengandung ekstrak rimpang kunyit, rimpang kencur, kapulaga, kulit kayu manis, asam jawa. Penelitian ini bertujuan untuk mengetahui profil fitokimia jamu lancar haid merek “x”. Jenis penelitian ini merupakan penelitian deskriptif. Tahapan penelitian meliputi pembuatan ekstrak menggunakan metode maserasi pelarut etanol 70%, selanjutnya ekstrak kental diuji skrining fitokimia dan kromatografi lapis tipis, didapatkan hasil skrining fitokimia dari jamu lancar haid merek “x” positif flavonoid, saponin, triterpen.dan dari hasil kromatografi lapis tipis didapatkan bercak yang sama dengan farmakope herbal indonesia. Dari penelitian ini dapat disimpulkan bahwa jamu lancar haid merk “x” mengandung ekstrak rimpang kunyit, rimpang kencur, kapulaga, kulit kayu manis, asam jawa. Kata kunci : Profil fitokimia Jamu lancar haid merek “x”, Kromatografi lapis tipis.

Mengkudu fruit ( Morinda citifolia L.) is one of plants which has been known and used by indonesi... more Mengkudu fruit ( Morinda citifolia L.) is one of plants which has been known and used by indonesian society as traditional medicine. This plant contains alkaloid, phenol, steroid, and flavonoid which can cause toxicity. The aim of this study was to know about acute toxicity of mengkudu fruit infusions using brine shrimp lethality test method which will be indicated by LC50 value. This research was experimental research using post test only control group design that used negative control and 5 concentrations of infusion those are 1000 mg/L, 500 mg/L, 100 mg/L, 50 mg/L, and 10 mg/L. Death of larvae observed 24 hours after giving the infusiona. LC50 of mengkudu fruit infusion is 62,3 mg/L. The result of this study showed that mengkudu fruit infusions cause toxic effect. Keywords : Noni Fruit, Toxycity, Brine Shrimp Lethality Test, LC50 ABSTRAK Buah mengkudu ( Morinda citrifolia L.) merupakan salah satu tanaman yang banyak dikenal dan digunakan oleh masyarakat sebagai obat tradisional. ...

Ethyl p-methoxycinnamate effectively inhibit the growth of cancer through a mechanism related to ... more Ethyl p-methoxycinnamate effectively inhibit the growth of cancer through a mechanism related to cell cycle regulation and apoptosis induction. We determined Kaempferia galanga that containing ethyl p-methoxycinnamate can increase the apoptosis activity in colon cancer cells. This study was designed to investigate effect of oil fraction from Kaempferia galanga alcoholic extract on apoptosis activity in mice colon cancer. Dimethylbenz(a)anthracene (DMBA)-induced colon cancer in mice is a useful model to investigate the changes of epithelial cells that occur during colon cancer progression. Colon cancer model was induced six times once a week by oral DMBA 50 mg/kg body weight. Administration of three different doses ethyl p-methoxycinnamate of oil fraction are 7.8 mg/kg, 23.4 mg/kg and 78 mg/kg which given to models during 30 days. Data analysis of immunohistochemical preparations was obtained and processed with one-way ANOVA statistical test, followed with post hoc test. Results show...

POTENSI EKSTRAK UMBI RUMPUT TEKI (Cyperus rotundus L.) SEBAGAI LARVASIDA TERHADAP LARVA NYAMUK Cu... more POTENSI EKSTRAK UMBI RUMPUT TEKI (Cyperus rotundus L.) SEBAGAI LARVASIDA TERHADAP LARVA NYAMUK Culex sp Bilal Subchan Agus Santoso1), Mochammad Haminudin1) 1)Akademi Farmasi Putra Indonesia Malang, Malang 65123. Koresponden: bilalsas67@gmail.com ABSTRACT Cyperus rotundus contains several secondary metabolites. In previous studies of plants containing alkaloid, flavonoid and saponin could be used as larvicide. The purpose of this study was to determine the potential of Cyperus rotundus extract as larvacide and look for the value of Lethal Concentration 50% (LC50) of Cyperus rotundus extract as larvicide on Culex sp. Cyperus rotundus were extracted by maceration method using 95% ethanol. After that phytochemical screening was carried out and testing larvicidal activity on Culex sp. Result showed that the secondary metabolite was alkaloids, flavonoids and saponins. The LC50 value of the Cyperus rotundus extract as larvacide on Culex sp larvae in each sample was 0.291% w/v, 0.335% w/v, ...

Parasetamol mempunyai sifat alir dan kompresibilitas yang kurang baik sehingga pada tabletasi sec... more Parasetamol mempunyai sifat alir dan kompresibilitas yang kurang baik sehingga pada tabletasi secara cetak langsung selalu terjadi "capping”. Dalam penelitian ini sifat tersebut diperbaiki dengan cara parasetamol digranulasi terlebih dr.hulu dengan bahan pengikat. Granul parasetamol dengan bahan pengikat polivinilpirolidon K-90 dan granul parasetamol dengan bahan pengikat metilselulosa ditambah dengan bahan pengisi avicel PH 102 dan pelincir magnesium stearat kemudian dilakukan cetak langsung. Hasil penelitian menunjukkan bahua penambahan bahan pengikat polivinilpirolidon K-90 dan metilselulosa pada berbagai kadar memberikan pengaruh terhadap sifat granul parasetamol yang dihasilkan. Campuran antara masing-maeing granul parasetamol dengan bahan pembawa serta pclincir memberikan karakteristik yang sesuai untuk’ digunakan dalam pembuatan tablet secara cetak langsung. Tablet yang dihasilkan diuji mutu fisiknya. Untuk mengatahui kekuatan daya ikat dari bahan pengikat dilakukan - pe...

INDONESIAN JOURNAL OF PHARMACY

Mengkudu fruit and temulawak rhizome which contains scopoletin and curcumin, respectively, were u... more Mengkudu fruit and temulawak rhizome which contains scopoletin and curcumin, respectively, were used traditionally as antidiabetic. Both compounds have strong antioxidant activity. This research aimed to determined the antihyperglycemic and pancreas protection of combination of mengkudu fruit juice (MFJ) and temulawak rhizome juice (TRJ) on streptozotocin (STZ) induced diabetic rats. Rats were divided into 7 groups, each group consist of 5 rats. All groups, except normal group were treated accordingly for 28 days. Blood samples were taken from the plexus retroorbitalis for examination of blood glucose levels on day-8 th , 15 th , 22 nd , and 29 th. On the day-29 th , blood samples were examined for malondialdehyde (MDA) levels. At the end of the experiment, the rats were sacrificed for examination of pancreatic morphological conditions. The results showed that diabetic rats given MFJ-TRJ combination experienced a significant decrease in blood glucose levels, a significant decrease in MDA levels and improvement pancreas morphology when compared with the negative control group. The conclusion of this research showed the combination of MFJ-TRJ has hypoglycemic activity and can fix condition of pancreas morphology.